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| 1 | From the Gla domain to a novel small-molecule detector of apoptosis显示文摘Apoptosis 在众多的医药混乱的病原学或致病起一个枢轴的作用,并且这样, apoptotic 房间指向可以实质地推进耐心的照顾。在我们为为 apoptosis 的新奇 low-molecular-weight 探针的探索,我们集中了于不平常的氨基酸纬 - carboxyglutamic 酸(Gla ) ,它在 clotting 因素的绑定起一个重要作用到否定地控告的 phospholipid 表面。基于 Gla 的 alkyl-malonic 酸主题,我们开发了并且现在介绍 ML-10 (2-(5-fluoro-pentyl )-2-methyl-malonic 酸, MW=206 Da ) , apoptosis 的小分子的察觉者的一个新奇家庭的原型的成员。ML-10 被发现在 apoptotic 房间执行选择举起和累积,当从可行或坏死的房间被排除时。有 caspase 激活, Annexin-V 绑定和 mitochondrial 膜潜力的混乱的 apoptotic 特点的 ML-10 举起相互关联。malonate 一半被发现为在 apoptosis 察觉的 ML-10 功能关键。ML-10 在早 apoptosis 对房间的特征的唯一的建筑群作出回应,包括膜潜力,房间膜和细胞质的永久使发酸,和膜正直的保藏的不可逆的损失。ML-10 因此是迄今为止知道的最紧缩的 apoptosis 探查。由于它的氟的符号原子, ML-10 对顺从与 18F 同位素标记收音机,向它为 apoptosis 的临床的正电子排放断层摄影术成像的潜在的未来使用。 | Avi Cohen Anat Shirvan Galit Levin Hagit Grimberg Ayelet Reshef Ilan Ziv | 2009 | Cell Research2009，19，5： | 12 |
| 2 | 虚拟 nonenhanced 腹的双精力的 MDCT : 图象特征的分析显示文摘 AIM:To evaluate abdominal and pelvic image characteristics and artifacts on virtual nonenhanced(VNE) images generated from contrast-enhanced dual-energy multidetector computed tomography(MDCT)studies.METHODS:Hadassah-Hebrew University Medical Institutional Review Board approval was obtained;22 patients underwent clinically-indicated abdominal and pelvic single-source dual-energy MDCT(Philips Healthcare,Cleveland,OH,USA),pre-and post-IV administration of Omnipaque 300 contrast(100 cc).Various solid and vascular structures were evaluated.VNE images were generated from the portal contrast-enhanced phase using probabilistic separation.Contrast-enhanced-,regular nonenhanced(RNE)-,and VNE images were evaluated with a total of 1494 density measurements.The ratio of iodine contrast deletion was calculated.Visualization of calcifications,urinary tract stones,and image artifacts in VNE images were assessed.RESULTS:VNE images were successfully generated in all patients.Significant portal-phase iodine contrast deletion was seen in the kidney(61.7%),adrenal gland(55.3%),iliac artery(55.0%),aorta(51.6%),and spleen(34.5%).Contrast deletion was also significant in the right atrium(RA)(51.5%)and portal vein(39.3%),but insignificant in the iliac vein and inferior vena cava(IVC).Average post contrast-to-VNE HU differences were significant(P<0.05)in the:RA-135.3(SD 121.8),aorta-114.1(SD 48.5),iliac artery-104.6(SD 53.7),kidney-30.3(SD 34.9),spleen-9.2(SD 8.8),and portal vein-7.7(SD 13.2).Average VNE-toRNE HU differences were significant in all organs but the prostate and subcutaneous fat:aorta 38.0(SD 9.3),RA 37.8(SD 16.1),portal vein 21.8(SD 12.0),IVC 12.2(SD 11.6),muscle 3.3(SD 4.9),liver 5.7(SD 6.4),spleen 22.3(SD 9.8),kidney 40.5(SD 6.8),and adrenal 20.7(SD 13.5).On VNE images,196/213 calcifications(92%)and 5/6 renal stones(84%)were visualized.Lytic-like artifacts in the vertebral bodies were seen in all studies.CONCLUSION:Iodine deletion in VNE images is most significant in arteries,and less significant in solid organs and veins.Most vascular and intra-abdominal organ calcifications are preserved. | Jacob Sosna Shmuel Mahgerefteh Liran Goshen Galit Kafri Galit Aviram Arye Blachar | 2012 | World Journal of Radiology2012，4，4： | 4 |
| 3 | α1-antitrypsin increases interleukin-1 receptor antagonist production during pancreatic islet graft transplantation显示文摘尽管为有类型 1 糖尿病的个人的小岛移植被显示了产出优异的血葡萄糖控制,它为长期的控制仍然保持不适当。这是部分,由于小岛损害和压力,那能导致贝它房间损失。过量 IL-1β 的抑制;活动可能最小化小岛损害,因此保存工作。IL-1 受体对手(IL-1Ra ) , IL-1β 的一个内长的禁止者;,保护小岛免受导致 cytokine 的坏死和 apoptosis 的伤害。因此,在 IL-1β 之间的不平衡;并且 IL-1Ra 可能影响到小岛的 allogeneic 和自体免疫的回答的功课。我们的组以前证明传播丝氨酸朊酶禁止者人 alpha-1-antitrypsin (hAAT ) ,以及 immunomodulatory 活动。在现在的学习,我们寻求了决定是否胰腺的小岛 hAAT 的 allograft 保护的活动被 IL-1Ra 调停感应。我们的结果证明 hAAT 在刺激巨噬细胞在 IL-1Ra 表示导致了 2.04 褶层增加并且 hAAT-pre-treated 小岛接枝在 IL-1Ra 抄本层次展出了 4.851 褶层增加,它与中等煽动性的侧面被联系。出人意料地,从 IL-1Ra-knockout 鼠标被孤立并且在 grafting 前与 hAAT 预先对待进野类型的鼠标的小岛在大概从渗入主机房间被导出的 intragraft IL-1Ra 表示产出增加,当主机的 hAAT 处理不在时的虽然。确实, hAAT-pre-treated 小岛产生了能在有教养的巨噬细胞导致 IL-1Ra 生产的 hAAT 免费的调节媒介。最后,我们证明 hAAT 为 p65 支持了不同 phosphorylation 和原子 translocation 模式,为 IL-1Ra 要求的一个关键抄写因素表示。 | Avishag Abecassis Ronen Schuster Galit Shahaf Eyal Ozeri Ross Green David E Ochayon Peleg Rider Eli C Lewis | 2014 | Cellular & Molecular Immunology2014，11，4： | 2 |
| 4 | Guanine nucleotide exchange factors for RhoGTPases: Good therapeutic targets for cancer therapy?显示文摘 | Galit Lazer Shulamit Katzav | 2010 | Cellular Signalling2010，，6： | 1 |
| 5 | Evaluation of shrinkage prediction models for self-consolidating concrete显示文摘 | Jaine R G Galit A L | 2007 | ACI Material Journal2007，104，5： | 1 |
| 6 | The decline of motivation? from commitment to dropping out of volunteering 显示文摘 | Galit Ventura Yanay Niza Yanay | 2008 | Nonprofit Management & Lead- ership2008，19，1： | 1 |
| 7 | The synthetic teUurium compound, AS101, is a novel inhibitor of IL-1 beta converting enzyme显示文摘 | Brodsky M Yosef S Galit R | 2007 | J Interferon Cytokine Res2007，27，6： | 1 |
| 8 | The Genetic Variation of RELN Expression in Schizophrenia and Bipolar Disorder显示文摘 | Galit Ovadia Sagiv Shifman | | 0，，05： | 1 |
| 9 | Early statistical detection of anthrax outbreaks by tracking over-the-counter medication sales显示文摘 | Anna Goldcnberg Galit Shmueli Richard A | 2002 | PNAS2002，99，8： | 1 |
| 10 | Type I chaperonins: not all are created equal显示文摘 | Galit LR Rachel EB | 2002 | FEBS Letters2002，529，： | 1 |
| 11 | Cardiorespiratory fitness andplasma homocysteine levels in adult males and females 显示文摘 | Rachel D Galit G Nimrod F | 2009 | IMAJ2009，12，2： | 1 |
| 12 | Biolistic inoculation of plants with Tomato yellow leaf curl virus DNA显示文摘 | Moshe Lapidot Galit Weil Lidya Cohen Limor Segev Victor Gaba | 2007 | Journal of Virological Methods2007，，1： | 1 |
| 13 | Biolistic inoculation of plants with Tomato yellow leaf curl virus DNA显示文摘 | Moshe L Galit W Lidya C | 2007 | Journal of Virological Methods2007，144，： | 1 |
| 14 | Higher natural killer cell activity in schizophrenic patients: the impact of serum factors,medication,and smoking显示文摘 | Galit Yovel Pinkhas Sirota | 2000 | Brain Behavior and Immunity2000，2000，14： | 1 |
| 15 | Biolistie inoculation of plants with tomato yellow leaf curl vires DNA显示文摘 | Moshe Lapidot Galit Well Lidya Cohen | 2007 | Journal of Virological Methods2007，144，： | 1 |
| 16 | HLA Class I Subtype-Dependent Expansion of KIR3DS1 and KIR3DL1 + NK Cells during Acute Human Immunodeciency Virus Type 1 Infec- tion显示文摘 | Galit Alter Suzannah Rihn Katharine Walter | 2009 | J Virol2009，83，13： | 1 |
| 17 | A unified Markov chain approach for computing the run length distribution in control charts with simple or compound rules显示文摘 | Fu J C Galit S Chang Y M | 2003 | Statistics and Probability Letters2003，65，2： | 1 |
| 18 | Ventilator-associated pneumonia in extremely preterm neonates in a neonatal intensive care unit : characteristics, risk factors, and outcomes 显示文摘 | Anucha Apisarnthanarak Galit Holzmann-Pazgal Aaron Hamvas | 2003 | Pediatrics2003，112，6： | 1 |
| 19 | Consumer Surplus in Online Auctions显示文摘 | Ravi Bapna Wolfgang Jank Galit Shmueli | 2008 | Information Systems Research2008，，4： | 1 |
| 20 | ApoSense: a novel technology for functional molecular imaging of cell death in models of acute renal tubular necrosis显示文摘 | Maya Damianovich Ilan Ziv Samuel N. Heyman Seymour Rosen Ahuva Shina Dvora Kidron Tali Aloya Hagit Grimberg Galit Levin Ayelet Reshef Alfonso Bentolila Avi Cohen Anat Shirvan | 2006 | European Journal of Nuclear Medicine and Molecular Imaging2006，，3： | 1 |
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