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| 1 | MicroRNAs as a potential prognostic factor in gastric cancer显示文摘AIM:To compare the microRNA (miR) profiles in the primary tumor of patients with recurrent and non-recurrent gastric cancer.METHODS:The study group included 45 patients who underwent curative gastrectomies from 1995 to 2005 without adjuvant or neoadjuvant therapy and for whom adequate tumor content was available.Total RNA was extracted from formalin-fixed paraffin-embedded tumor samples,preserving the small RNA fraction.Initial profiling using miR microarrays was performed to identify potential biomarkers of recurrence after resection.The expression of the differential miRs was later verified by quantitative real-time polymerase chain reaction (qRT-PCR).Findings were compared between patients who had a recurrence within 36 mo of surgery (bad-prognosis group,n=14,31%) and those who did not (good-prognosis group,n=31,69%).RESULTS:Three miRs,miR-451,miR-199a-3p and miR-195 were found to be differentially expressed in tumors from patients with good prognosis vs patients with bad prognosis (P<0.0002,0.0027 and 0.0046 respectively).High expression of each miR was associated with poorer prognosis for both recurrence and survival.Using miR-451,the positive predictive value for non-recurrence was 100% (13/13).The expression of the differential miRs was verified by qRT-PCR,showing high correlation to the microarray data and similar separation into prognosis groups.CONCLUSION:This study identified three miRs,miR-451,miR-199a-3p and miR-195 to be predictive of recurrence of gastric cancer.Of these,miR-451 had the strongest prognostic impact. | Baruch Brenner Moshe B Hoshen Ofer Purim Miriam Ben David Karin Ashkenazi Gideon Marshak Yulia Kundel Ronen Brenner Sara Morgenstern Marisa Halpern Nitzan Rosenfeld Ayelet Chajut Yaron Niv Michal Kushnir | 2011 | World Journal of Gastroenterology2011，17，35： | 31 |
| 2 | Effect of resistance training on non-alcoholic fatty-liver disease a randomized-clinical trial显示文摘AIM:To evaluate the effect of resistance training(RT)on non alcoholic liver disease(NAFLD)patients.METHODS:A randomized clinical trial enrolling NAFLD patients without secondary liver disease(e.g.,without hepatitis B virus,hepatitis C virus or excessive alcohol consumption).Patients were randomly allocated either to RT,three times weekly,for 3 mo or a control arm consisting of home stretching.The RT included leg press,chest press,seated rowing,latissimus pull down etc.with 8-12 repetitions,3 sets for each exercise,for a total duration of 40 min.Hepatic ultrasound,fasting blood tests,anthropometrics and body composition by dual energy X-ray absorptiometry were assessed.At baseline and follow-up,patients filled out a detailed semi-quantitative food frequency questionnaire reporting their habitual nutritional intake.Steatosis was quantified by the hepatorenal-ultrasound index(HRI)representing the ratio between the brightness level of the liver and the right kidney.The HRI has been previously demonstrated to be highly reproducible and was validated against liver biopsy and proton magnetic resonance spectroscopy.RESULTS:Eighty two patients with primary NAFLD were randomized to receive 3 mo of either RT or stretching.After dropout or exclusion from analysis because of protocol violation(weight change>3 kg),thirty three patients in the RT arm and 31 in the stretching arm completed the study per protocol.All baseline characteristics were similar for the two treatment groups with respect to demographics,anthropometrics and body composition,blood tests and liver steatosis on imaging.HRI score was reduced significantly in the RT arm as compared to the stretching arm(-0.25±0.37 vs-0.05±0.28,P=0.017).The RT arm had a significantly higher reduction in total,trunk and android fat with increase in lean body mass.There was no correlation between the reduction in HRI in the RT arm and weight change during the study,but it was positively correlated with the change in trunk fat(r=0.37,P=0.048).The RT arm had a significant reduction in serum ferritin and total cholesterol.There was no significant difference between arms in dietary changes and these did not correlate with HRI change.CONCLUSION:Three months RT improves hepatic fat content accompanied by favorable changes in body composition and ferritin.RT may serve as a complement to treatment of NAFLD. | Shira Zelber-Sagi Assaf Buch Hanny Yeshua Nahum Vaisman Muriel Webb Gil Harari Ofer Kis Naomi Fliss-Isakov Elena Izkhakov Zamir Halpern Erwin Santo Ran Oren Oren Shibolet | 2014 | World Journal of Gastroenterology2014，20，15： | 17 |
| 3 | 公元前1920年溃决洪水为中国大洪水传说和夏王朝的存在提供依据显示文摘中国传统史学讲述了一个在治理洪水成功后建立夏朝并开启文明史的故事。然而,洪水和夏朝的历史真实性一直存在争议。本文重建了约公元前1920年黄河上游地震引发的滑坡坝体的溃决洪水,为一万年以来地球上发生的最大的内陆洪水之一,可以解释中国传说的大洪水。本文将夏朝的开端确定为约公元前1900年,比传统的认识晚了2~3个世纪。测定结果表明,此年代的黄河流域状态与新石器向青铜器时代大变迁时的状态相吻合,这同时也佐证了初级国家形态——二里头文化是夏朝存在的考古证据的假说。 | 吴庆龙 赵志军 刘莉 Darryl E.Granger 王辉 David J.Cohen 吴小红 叶茂林 Ofer Bar-Yosef 陆斌 张进 张培震 袁道阳 齐乌云 蔡林海 白世彪 陈菁(编译) 李荣富(编译) 刘志(编译) 肖晨光(编译) 周程婷(编译) 毕博(编译) | 2017 | 中国水利2017，，3： | 11 |
| 4 | 整体移动和倾斜移动技术内收尖牙治疗时间及支抗控制的比较研究显示文摘 | Nir Shpack Moshe Davidovitch Ofer Sarne Narchos Panayi Alexander D.Vardimon 王瑞端 | 2008 | 中国实用口腔科杂志2008，1，1： | 10 |
| 5 | Targeting PVR(CD155)and its receptors in anti-tumor therapy显示文摘Poliovirus receptor(PVR,CD155)has recently been gaining scientific interest as a therapeutic target in the field of tumor immunology due to its prominent endogenous and immune functions.In contrast to healthy tissues,PVR is expressed at high levels in several human malignancies and seems to have protumorigenic and therapeutically attractive properties that are currently being investigated in the field of recombinant oncolytic virotherapy.More intriguingly,PVR participates in a considerable number of immunoregulatory functions through its interactions with activating and inhibitory immune cell receptors.These functions are often modified in the tumor microenvironment,contributing to tumor immunosuppression.Indeed,increasing evidence supports the rationale for developing strategies targeting these interactions,either in terms of checkpoint therapy(i.e.,targeting inhibitory receptors)or in adoptive cell therapy,which targets PVR as a tumor marker. | Paola Kučan Brlić Tihana Lenac Roviš Guy Cinamon Pini Tsukerman Ofer Mandelboim Stipan Jonjić | 2019 | Cellular & Molecular Immunology2019，16，1： | 10 |
| 6 | Present indications and techniques of percutaneous nephrolithotomy:What the future holds?显示文摘The purpose of the review was to present the latest updates on percutaneous nephrolithotomy(PCNL)procedure in terms of indications and evolving techniques,and to identify the advantages and disadvantages of each modality.The data for this review were collected after a thorough PubMed search in core clinical journals in English language.The key words included“PCNL”and“PNL”in combination with“indications”,“techniques”,“review”and“miniaturized PCNL”.Publications relevant to the subject were retrieved and critically reviewed.Current European and American Urology Association Nephrolithiasis Guidelines were included as well.The indications for standard PCNL have been changed through the past decade.Despite evolution of the procedure,innovations and the development of new technical approaches,the indications for miniaturized PCNL have not been standardized yet.There is a need for well-constructed randomized trials to explore the indications,complications and results for each evolving approach.A continuous reduction of tract size is not the only revolution of the last years.There is constant ongoing interest in developing new efficient miniature instruments,intracorporeal lithotripters and sophisticated tract creation methods.We can summarize that,PCNL represents a valuable well-known tool in the field of endourology.We should be open minded to future changes in surgical approaches and technological improvements. | Itay M.Sabler Ioannis Katafigiotis Ofer N.Gofrit Mordechai Duvdevani | 2018 | Asian Journal of Urology2018，5，4： | 7 |
| 7 | Preservation of sperm of cancer patients: extent of use and pregnancy outcome in a tertiary infertility center显示文摘精子 cryopreservation 是最好的形式为与癌症诊断的男性保证未来生育力。cryopreserved 精子实际上为受精,可得到的富饶治疗选择和这些治疗的成功率被使用到的程度没深入地被调查。谁的 682 个病人的医药记录 cryopreserved 精子房间由于癌症,治疗被分析。七十个这些病人在 20 年的经期(在在 cryopreservation 以后的开始的 4 年以内的大多数) 上为生育力治疗撤退了他们的冻结的精子。不同恶意的精子质量和为在与治疗的类型和恶意的类型的关系的怀孕成就的帮助繁殖治疗(艺术) 的结果被评估。结果证明在我们的单位为富饶治疗从癌症病人使用融化 cryo 的精子的率是 10.3 %。精子优秀索引在恶意的不同类型之间不同,与在阴囊的癌症测量的最差的质量。概念在 184 个艺术周期中的 46 个被完成(25 %) ,并且导致了 36 交货。注射(ICSI ) 方法论产出的 intracytoplasmic 精子的使用显著地更高的怀孕率(37.4 %) 比子宫内的授精(IUI;11.5 %) 并且类似于用这些形式的其它组不肥沃的夫妇。在 vitro,授精(IVF ) 没能生产怀孕。在结论,在癌症病人的 cryopresseved 精子的使用的率是相对低的(10.3 %) 。由 ICSI 的怀孕的成就介绍最好的选择但是当有足够的存储精子样品和足够的质量时, IUI 能被采用。Cryopreservation 是但为癌症病人保存未来生育力潜力和希望的最好的选择。 | Amnon Botchan Shiri Karpol Ofer Lehavi Gedalia Paz Sandra E Kleiman LeahYogev Haim Yavetz Ron Hauser | 2013 | Asian Journal of Andrology2013，15，3： | 4 |
| 8 | Abnormalities of uterine cervix in women with inflammatory bowel disease显示文摘AIM: To evaluate the prevalence of abnormalities of the uterine cervix in women with inflammatory bowel disease (IBD) when compared to healthy controls. METHODS: One hundred and sixteen patients with IBD [64 with Crohn’s disease (CD) and 52 with ulcerative colitis (UC)] were matched to 116 healthy controls by age (+/- 2 years) at the time of most recent papanicolaou (Pap) smear. Data collected consisted of age, race, marital status, number of pregnancies, abortions/miscarriages, duration and severity of IBD, Pap smear results within five years of enrollment, and treatment with immunosuppressive drugs. Pap smear results were categorized as normal or abnormal including atypical squamous cells of undetermined significance (ASCUS), low-grade squamous intraepithelial lesion (LGSIL), and high-grade squamous intraepithelial lesion (HGSIL). RESULTS: The median age at the time of Pap smear was 46 (range: 17-74) years for the IBD group and matched controls (range: 19-72 years). There were more Caucasian subjects than other ethnicities in the IBD patient group (P = 0.025), as well as fewer abortions (P = 0.008), but there was no significant difference regarding marital status. Eighteen percent of IBD patients had abnormal Pap smears compared to 5% of controls (P = 0.004). Subgroup analysis of the IBD patients revealed no significant differences between CD and UC patients in age, ethnicity, marital status, number of abortions, disease severity, family history of IBD, or disease duration. No significant difference was observedin the number of abnormal Pap smears or the use of immunosuppressive medications between CD and UC patients (P = 0.793). No definitive observation could be made regarding HPV status, as this was not routinely investigated during the timeframe of our study. CONCLUSION: Diagnosis of IBD in women is related to an increased risk of abnormal Pap smear, while type of IBD and exposure to immunosuppressive medications are not. This has significant implications for women with IBD in that Pap smear screening protocols should be conscientiously followed, with appropriate investigation of abnormal results. | Jyoti Bhatia Jason Bratcher Burton Korelitz Katherine Vakher Shlomo Mannor Maria Shevchuk Gworgia Panagopoulos Adam Ofer Ecaterina Tamas Panayota Kotsali Oana Vele | 2006 | World Journal of Gastroenterology2006，12，38： | 3 |
| 9 | Posterior shoulder fracture-dislocation:A systematic review of the literature and current aspects of management显示文摘Purpose Posterior fracture-dislocation of shoulder is an infrequent traumatic event;however,most orthopaedic surgeons may face the challenge of treating it.The aim of this study is to review and summarise systematically the current principles of the management of this complex injury,and create a treatment algorithm.Methods Both PubMed and Scopus Databases were systematically searched for the terms“posterior shoulder fracture-dislocation”or“posterior glenohumeral fracture-dislocation”or“posterior glenoid fracture-dislocation”for articles written in English and published in the last decade.Results A total of 900 articles were identified,of which 13 were retained for analysis.A total of 153 patients(161 shoulders)were identified.These patients were treated either with open reduction and internal fixation,modified McLaughlin procedure,allograft/autograft humeral head reconstruction or shoulder arthroplasty.The mean age was 40.15 years.The mean postoperative Constant score in cases treated by open reduction and internal fixation was 86.45,whereas by bone graft was 84.18.Further,the mean postoperative Constant score was between 79.6 and 67.1 in those that were managed by modified McLaughlin and arthroplasty procedure,respectively.Conclusion The management of posterior shoulder fracture-dislocation may be challenging,and the best surgical option depends on many variables such as the chronicity of the injury,the presence of a fracture at the level of the surgical neck or tuberosities and the extend of the Hill-Sachs lesion if any.A treatment algorithm is proposed,based on the current literature in an effort to create a consensus for these injuries.For the acute shoulder fracture-dislocations,an open reduction should be performed.For the chronic fracture/dislocations in the elderly low-demand patients,conservative treatment should be performed.For the rest of the patients,depending on the severity of the Hill-Sachs lesion different surgical options are available such as the McLaughlin technique,the use of an allograft,osteotomy or arthroplasty. | Georgios Paparoidamis Efthymios Iliopoulos AAli Narvani Ofer Levy Eleftherios Tsiridis loannis Polyzois | 2021 | Chinese Journal of Traumatology2021，24，1： | 3 |
| 10 | Inflammatory bowel disease patient profiles are related to specific information needs: A nationwide survey显示文摘BACKGROUND Inflammatory bowel diseases(IBD) is a heterogenous, lifelong disease, with an unpredictable and potentially progressive course, that may impose negative psychosocial impact on patients.While informed patients with chronic illness have improved adherence and outcomes, previous research showed that the majority of IBD patients receive insufficient information regarding their disease.The large heterogeneity of IBD and the wide range of information topics makes a one-size fits all knowledge resource overwhelming and cumbersome.We hypothesized that different patient profiles may have different and specific information needs, the identification of which will allow building personalized computer-based information resources in the future.AIM To evaluate the scope of disease-related knowledge among IBD patients and determine whether different patient profiles drive unique information needs.METHODS We conducted a nationwide survey addressing hospital-based IBD clinics.A Total of 571 patients completed a 28-item questionnaire, rating the amount of information received at time of diagnosis and the importance of information, as perceived by participants, for a newly diagnosed patient, and for the participants themselves, at current time.We performed an exploratory factor analysis of the crude responses aiming to create a number of representative knowledge domains(factors), and analyzed the responses of a set of 15 real-life patient profiles generated by the study team.RESULTS Participants gave low ratings for the amount of information received at disease onset(averaging 0.9/5) and high ratings for importance, both for the newly diagnosed patients(mean 4.2/5) and for the participants themselves at current time(mean 3.5/5).Factor analysis grouped responses into six informationdomains.The responses of selected profiles, compared with the rest of the participants, yielded significant associations(defined as a difference in rating of >0.5 points with a P < 0.05).Patients with active disease showed a higher interest in work-disability, stress-coping, and therapy-complications.Patients newly diagnosed at age > 50, and patients with long-standing disease(> 10 years)showed less interest in work-disability.Patients in remission with mesalamine or no therapy showed less interest in all domains except for nutrition and long-term complications.CONCLUSION We demonstrate unmet patient information needs.Analysis of various patient profiles revealed associations with specific information topics, paving the way for building patient-tailored information resources. | Saleh Daher Tawfik Khoury Ariel Benson John R Walker Oded Hammerman Ron Kedem Timna Naftali Rami Eliakim Ofer Ben-Bassat Charles N Bernstein Eran Israeli | 2019 | World Journal of Gastroenterology2019，25，30： | 3 |
| 11 | 辽宁阜新地区区域性考古调查阶段性报告(2012—2013)显示文摘2012—2103年在辽宁阜新地区查海遗址东部开展了区域性田野考古调查,调查范围104.46平方公里,共在1152个采集点进行了人工遗物的采集,发现了属于小河西、兴隆洼、赵宝沟、红山、夏家店下层、高台山、凌河类型和战国—汉时期的遗存,大体上勾勒出调查区域内从新石器时代早期,经青铜时代,一直到战国—汉时期的遗址分布格局。调查中确认了一些此前没有发现的早期新石器时代时期(也许还有前新石器时代)的遗址,而部分遗址人工遗物分布密度较高表现出当时人类活动已具有一定的强度。调查中还发现并记录了大量的细石器和一般石器,这是在此前中国东北地区系统性田野考古调查中从未做过的工作,这些石器的具体年代或文化属性还有待于进一步的比较与分析。如果有些石器的年代确实属于前新石器时代,那么这些石器的分布将会提供研究这一地区采集狩猎人群活动的重要证据。 | 滕铭予 Gideon SHELACH 万雄飞 Ofer MARDER Ido WACHTEL | 2014 | 北方文物2014，，3： | 2 |
| 12 | Connecting Malfunctioning Glial Cells and Brain Degenerative Disorders显示文摘The DNA damage response(DDR) is a complex biological system activated by different types of DNA damage.Mutations in certain components of the DDR machinery can lead to genomic instability disorders that culminate in tissue degeneration,premature aging,and various types of cancers.Intriguingly,malfunctioning DDR plays a role in the etiology of late onset brain degenerative disorders such as Parkinson's,Alzheimer's,and Huntington's diseases.For many years,brain degenerative disorders were thought to result from aberrant neural death.Here we discuss the evidence that supports our novel hypothesis that brain degenerative diseases involve dysfunction of glial cells(astrocytes,microglia,and oligodendrocytes).Impairment in the functionality of glial cells results in pathological neuro-glial interactions that,in turn,generate a ‘‘hostile' environment that impairs the functionality of neuronal cells.These events can lead to systematic neural demise on a scale that appears to be proportional to the severity of the neurological deficit. | Natalie Kaminsky Ofer Bihari Sivan Kanner Ari Barzilai | 2016 | Genomics, Proteomics & Bioinformatics2016，14，3： | 2 |
| 13 | Combined Thermo-Chemotherapy for Recurrent Bladder Cancer After Bacillus Calmette-Guerin显示文摘 | Ofer Nativ J. Alfred Witjes Kees Hendricksen Michael Cohen Daniel Kedar Ami Sidi Renzo Colombo Ilan Leibovitch | 2009 | The Journal of Urology2009，，4： | 2 |
| 14 | Positive Surgical Margins After Radical Prostatectomy: A Systematic Review and Contemporary Update显示文摘 | Ofer Yossepowitch Alberto Briganti James A. Eastham Jonathan Epstein Markus Graefen Rodolfo Montironi Karim Touijer | 2014 | European Urology2014，，： | 2 |
| 15 | Tumor microRNA-29a expression and the risk of recurrence in stage IIcolon cancer显示文摘 | Alina Weissmann-Brenner Michal Kushnir Gila Lithwick Yanai Ranit Aharonov Hadas Gibori Ofer Purim Yulia Kundel Sara Morgenstern Marissa Halperin Yaron Niv Baruch Brenner | 2012 | International Journal of Oncology2012，，： | 2 |
| 16 | 系统药理学方法发现汉黄芩苷作为新型三阴性乳腺癌血管生成抑制剂靶向Hedgehog通路显示文摘文章简介三阴性乳腺癌(TNBC)是一种侵袭性和异质性疾病,由于临床上缺乏可靶向的遗传突变,因而限制了靶向治疗的应用。近年来,系统生物学和多组学技术的崛起,极大地促进了系统药理学等网络方法在药物发现中的应用。 | 黄玉杰 方坚松 卢伟强 Zihao Wang Qi Wang Yuan Hou Xingwu Jiang Ofer Reizes Justin Lathia Ruth Nussinov Charis Eng Feixiong Cheng | 2020 | 科学新闻2020，，2： | 2 |
| 17 | Precise large deviation estimates for a one-dimensional random walk in a random environment显示文摘 | Agoston Pisztora Tobias Povel Ofer Zeitouni | 1999 | Probability Theory and Related Fields1999，，2： | 1 |
| 18 | Image resolution limits resulting from mechanical vibrations ,Part Ⅳ :real-time numerical calculation of optical transfer functions and experimental verification显示文摘 | Ofer Hadar Itai Dror Norman S Kopeika | 1994 | Optical Engineering1994，33，2： | 1 |
| 19 | Effect of passive smoking in pregnancy on neonatal nucleated red blood cells显示文摘 | Shaul D Ofer F Francis B | 2000 | Pediatr2000，106，3： | 1 |
| 20 | Quenched Sub-Exponential Tail Estimates for One-Dimensional Random Walk in Random Environment显示文摘 | Nina Gantert Ofer Zeitouni | 1998 | Communications in Mathematical Physics1998，，1： | 1 |
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