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| 1 | From the Gla domain to a novel small-molecule detector of apoptosis显示文摘Apoptosis 在众多的医药混乱的病原学或致病起一个枢轴的作用,并且这样, apoptotic 房间指向可以实质地推进耐心的照顾。在我们为为 apoptosis 的新奇 low-molecular-weight 探针的探索,我们集中了于不平常的氨基酸纬 - carboxyglutamic 酸(Gla ) ,它在 clotting 因素的绑定起一个重要作用到否定地控告的 phospholipid 表面。基于 Gla 的 alkyl-malonic 酸主题,我们开发了并且现在介绍 ML-10 (2-(5-fluoro-pentyl )-2-methyl-malonic 酸, MW=206 Da ) , apoptosis 的小分子的察觉者的一个新奇家庭的原型的成员。ML-10 被发现在 apoptotic 房间执行选择举起和累积,当从可行或坏死的房间被排除时。有 caspase 激活, Annexin-V 绑定和 mitochondrial 膜潜力的混乱的 apoptotic 特点的 ML-10 举起相互关联。malonate 一半被发现为在 apoptosis 察觉的 ML-10 功能关键。ML-10 在早 apoptosis 对房间的特征的唯一的建筑群作出回应,包括膜潜力,房间膜和细胞质的永久使发酸,和膜正直的保藏的不可逆的损失。ML-10 因此是迄今为止知道的最紧缩的 apoptosis 探查。由于它的氟的符号原子, ML-10 对顺从与 18F 同位素标记收音机,向它为 apoptosis 的临床的正电子排放断层摄影术成像的潜在的未来使用。 | Avi Cohen Anat Shirvan Galit Levin Hagit Grimberg Ayelet Reshef Ilan Ziv | 2009 | Cell Research2009，19，5： | 12 |
| 2 | Additive manufacturing of metallic and polymeric load-bearing biomaterials using laser powder bed fusion:A review显示文摘Surgical prostheses and implants used in hard-tissue engineering should satisfy all the clinical,mechanical,manufacturing,and economic requirements in order to be used for load-bearing applications.Metals,and to a lesser extent,polymers are promising materials that have long been used as load-bearing biomaterials.With the rapid development of additive manufacturing(AM)technology,metallic and polymeric implants with complex structures that were once impractical to manufacture using traditional processing methods can now easily be made by AM.This technology has emerged over the past four decades as a rapid and cost-effective fabrication method for geometrically complex implants with high levels of accuracy and precision.The ability to design and fabricate patient-specific,customized structural biomaterials has made AM a subject of great interest in both research and clinical settings.Among different AM methods,laser powder bed fusion(L-PBF)is emerging as the most popular and reliable AM method for producing load-bearing biomaterials.This layer-by-layer process uses a high-energy laser beam to sinter or melt powders into a part patterned by a computer-aided design(CAD)model.The most important load-bearing applications of L-PBF-manufactured biomaterials include orthopedic,traumatological,craniofacial,maxillofacial,and dental applications.The unequalled design freedom of AM technology,and L-PBF in particular,also allows fabrication of complex and customized metallic and polymeric scaffolds by altering the topology and controlling the macro-porosity of the implant.This article gives an overview of the L-PBF method for the fabrication of load-bearing metallic and polymeric biomaterials. | Alireza Nouri Anahita Rohani Shirvan Yuncang Li Cuie Wen | 2021 | Journal of Materials Science & Technology2021，，35： | 9 |
| 3 | Evaluation of the efficacy of blood glucose home monitoring device 显示文摘 | Bastanhagh MH Shirvan AR Heshmat R | 2007 | Med Sci Mouit2007，13，3： | 1 |
| 4 | Copper recovery in a spoutedvessel electrolytic reactor(SBER)显示文摘 | Shirvan PA Calo JM | 2005 | Journal ofApplied Electrochemistry2005，35，1： | 1 |
| 5 | Novel molecular imaging of cell death in experimental cerebral stroke显示文摘 | Reshef A Shirvan A Grimberg H | 2007 | Brain Res2007，1144，4： | 1 |
| 6 | Molecular imaging of cell death in vivo by a novel small molecule probe 显示文摘 | Aloya R Shirvan A Grimberg H | 2006 | Apoptosis2006，11，12： | 1 |
| 7 | Molecular imaging of cell death in vivo by a novel small molecule probe 显示文摘 | Aloya R A Shirvan H Grimberg | 2006 | Apoptosis2006，11，12： | 1 |
| 8 | Molecular imaging of neurovascular cell death in experimental cerebral stroke by PET显示文摘 | A Reshef A Shirvan RN Waterhouse | 2008 | J Nucl Med2008，49，9： | 1 |
| 9 | Semaphorins as mediators of neuronal apoptosis显示文摘 | Shirvan A Ziv I Fleminger G Shina R He Z Brudo I | 1999 | J Neurochem1999，73，： | 1 |
| 10 | ^18F-ML-10, a PET tracer for apoptosis: first human study显示文摘 | Hoglund J Shirvan A Antoni G | 2011 | J Nucl Med2011，52，： | 1 |
| 11 | Anti-semaphnrin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy显示文摘 | Shirvan A Kimron M Holdengreber V | 2002 | J Biol Chem2002，277，49： | 1 |
| 12 | Evaluation of the efficacy of blood glucose horn emonito ring dev ices 显示文摘 | Bastanhagh MH Shirvan AR Heshmat R | 2007 | Med Sci- Monit2007，13，3： | 1 |
| 13 | Outcome of penetrating cardiac injuries in southern Iran, Shiraz显示文摘ObjectiveCardiac 损害是损伤外科的地里的最挑战性的损害之一。他们的管理经常要求提供优秀手术后的批评照顾给病人的立即的外科的干预,优秀外科的技术和能力。这研究的目的是与在南部的伊朗渗透心脏的损害评估结果和病人的幸存率, ShirazMethodsFrom 2001 年 1 月到 2007 年 6 月,受不了渗透心脏的损害的所有病人的医药记录被考察,他们的结果被调查。包括标准 intraoperatively 或由尸体是证实的渗透的心脏的损害的存在。有钝心脏的损害的病人从 study.ResultsThe 学习被排除由 37 个病人组成了,包括 1 处射击创伤(2.7%) , 35 刺创伤(94.6%) 并且 1 (2.7%) 猎枪创伤。全面幸存率是 76%(28 在 37 ) 并且那在里面刺创伤病人是 80% 。收集了到期的病人揭示了的 9 的数据到达, 67% 低血压患者,和 22% 正常血压的考虑生理的表示上的 11% 死亡。在表示的在死亡和 electrocardiographic 之间的显示出的重要关联变化的配对的样品测试,在心包的保留的血的数量,临床的阶段和生理的状况,象联系损害类型一样(射击多于刺创伤) .ConclusionOur 结果证明那损害机制和起始的心脏的节奏是在有渗透心脏的损害的病人的结果的重要预言者。而且,射击损害和 exsanguination 是死亡的最重要的预兆的变量。 | Mansour Janati Shahram Bolandparvaz Shirvan Salaminia Hamed Ghoddusi Johafi | 2013 | Chinese Journal of Traumatology2013，16，2： | 1 |
| 14 | Two waves of cyclinB and proliferation cell nuclear antigen expression during dopamine-triggered neuronal apotosis显示文摘 | Ziv I Machlin T | 1997 | J Neurochem1997，69，： | 1 |
| 15 | Semaphorins as media- tors of neuronal apoptosis显示文摘 | Shirvan A Ziv I Fleminger G | 1999 | J Neurochem1999，73，3： | 1 |
| 16 | Alternative splicing of human synexin mRNA in brain, cardiac, and skeletal muscle alters the unique N- terminal domain显示文摘 | Magendzo K Shirvan A Cultraro C | 1991 | J Biol Chem1991，266，5： | 1 |
| 17 | 18F-ML-10, a PET Tracer for Apoptosis: First Human Study显示文摘 | J H0glund A Shirvan G Antoni | 2011 | Journal of Nuclear Medicine2011，52，5： | 1 |
| 18 | Levodopa toxicity and apoptosis显示文摘 | Melamed E Offen D Shirvan A | 1998 | Ann Neurol1998，44，： | 1 |
| 19 | Monitoring of tumor response to chemotherapy in vivo by a novel small-molecule detector of apoptosis显示文摘 | Grimberg H Levin G Shirvan A | 2009 | Apoptosis2009，14，3： | 1 |
| 20 | Two waves of cyclin B and proliferating cell nuclear antigen expression during dopamine - triggered neuronal apoptosis显示文摘 | Shirvan A Ziv I Madilin T | 1997 | J Neurochem1997，69，2： | 1 |
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