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| 1 | Fecal microbiota transplantation as novel therapy in gastroenterology:A systematic review显示文摘AIM:To study the clinical efficacy and safety of Fecal microbiota transplantation(FMT).We systematically reviewed FMT used as clinical therapy.METHODS:We searched MEDLINE,EMBASE,the Cochrane Library and Conference proceedings from inception to July,2013.Treatment effect of FMT was calculated as the percentage of patients who achieved clinical improvement per patient category,on an intention-to-treat basis.RESULTS:We included 45 studies;34 on Clostridium difficile-infection(CDI),7 on inflammatory bowel disease,1 on metabolic syndrome,1 on constipation,1 on pouchitis and 1 on irritable bowel syndrome(IBS).In CDI 90% resolution of diarrhea in 33 case series(n = 867) was reported,and 94% resolution of diarrhea after repeated FMT in a randomized controlled trial(RCT)(n = 16).In ulcerative colitis(UC) remission rates of 0% to 68% were found(n = 106).In Crohn's disease(CD)(n = 6),no benefit was observed.In IBS,70% improvement of symptoms was found(n = 13).100% Reversal of symptoms was observed in constipation(n = 3).In pouchitis,none of the patients(n = 8) achieved remission.One RCT showed significant improvement of insulin sensitivity in metabolic syndrome(n = 10).Serious adverse events were rare.CONCLUSION:FMT is highly effective in CDI,and holds promise in UC.As for CD,chronic constipation,pouchitis and IBS data are too limited to draw conclusions.FMT increases insulin sensitivity in metabolic syndrome. | Noortje G Rossen John K Mac Donald Elisabeth M de Vries Geert R D'Haens Willem M de Vos Erwin G Zoetendal Cyriel Y Ponsioen | 2015 | World Journal of Gastroenterology2015，21，17： | 41 |
| 2 | Analysis of monocyte chemotactic protein-1 gene polymorphism in patients with spontaneous bacterial peritonitis显示文摘AIM:To investigate a genetic polymorphism of the monocyte chemotactic protein-1 (MCP-1 ) gene in patients with spontaneous bacterial peritonitis (SBP).METHODS:MCP-1 genotyping was performed in 23 patients with SBP and 83 cirrhotic control patients with non-infected ascites.RESULTS:The frequency of carriers of the G-allele was lower in SBP patients but this difference did not reach statistical significance. However,in the subgroup of patients with alcoholic cirrhosis (n=80),carriers of the G-allele were significantly less frequent in SBP-patients (38.1%) than in cirrhotic controls (67.8%,P=0.021). CONCLUSION:In patients with alcoholic liver cirrhosis,the-2518 MCP-1 genotype AA is a risk factor for the development of SBP. | Erwin Gbele Marcus Mhlbauer Hartwig Paulo Monika Johann Christin Meltzer Franz Leidl Norbert Wodarz Reiner Wiest Jrgen Schlmerich Claus Hellerbrand | 2009 | World Journal of Gastroenterology2009，15，44： | 7 |
| 3 | Standard forward-viewing colonoscopy versus full-spectrum endoscopy: an international, multicentre, randomised, tandem colonoscopy trial显示文摘 | Ian M Gralnek Peter D Siersema Zamir Halpern Ori Segol Alaa Melhem Alain Suissa Erwin Santo Alan Sloyer Jay Fenster Leon M G Moons Vincent K Dik Ralph B D’Agostino Douglas K Rex | 2014 | Lancet Oncology2014，，3： | 6 |
| 4 | p38α controls erythroblast enucleation and Rb signaling in stress erythropoiesis显示文摘成红血球细胞的 Enucleation 对哺乳动物在终端区别期间唯一。尽管 erythroid enucleation 广泛地被学习了,包括 retinoblastoma 蛋白质(Rb ) ,仅仅一些基因被识别了调整原子挤出。它由哪个仍然保持大部分未定义发信号的分子,外来的刺激例如 erythropoietin (Epo ) ,是 transduced 导致 enucleation。这里,我们显示出那 p38α,激活 mitogen 的蛋白质 kinase (MAPK ) ,为 erythroid enucleation 被要求。在包含高 Epo 层次并且模仿的一个前 vivo 区别系统强调红血球生成, p38α在 erythroid 区别期间被激活。p38α 的损失;完全堵住主要成红血球细胞的 enucleation。而且, p38α在胎儿、贫血的压力红血球生成期间在 vivo 以一种房间自治的方式调整成红血球细胞 enucleation。显著地, p38α 的损失;导致 p21 目标 Rb 的 p21,和减少的激活的 downregulation,哪个是成红血球细胞 enucleation 的重要管理者。这研究表明那 p38α在压力红血球生成期间是为成红血球细胞 enucleation 的一个关键发信号分子。 | Simon M Schultze Andreas Mairhofer Dan Li Jin Cen Hartmut Beug Erwin F Wagner Lijian Hui | 2012 | Cell Research2012，22，3： | 2 |
| 5 | On Strong Distance in Strong Oriented Graphs显示文摘 | Chartrand G Erwin D Raines M Zhang P | 1999 | Congr Numer1999，138，： | 1 |
| 6 | Neutralization-chemical reionization mass spectrometry 显示文摘 | Erwin K M Gronert S Barlow S E | 1990 | J Am Chem Soc1990，112，： | 1 |
| 7 | Intestinal adaptation is enhanced by epidermal growth factor independent of increased ileal epidermal growth factor receptor expression显示文摘 | HELMRATH M A SHIN C E ERWIN C R | 1998 | Journal of Pediatric Surgery1998，33，7： | 1 |
| 8 | Biliary decompression promotes Kupffer cell recovery in obstructive jaundice显示文摘 | Clements MD McCaigue M Erwin P | 1996 | Gut1996，38，6： | 1 |
| 9 | Cocoa extract protects against early lcohol-induced liver injury in the rat显示文摘 | Akira K Erwin G | 2002 | Archives of Biochemistry and Biophysics2002，406，： | 1 |
| 10 | Brain remodeling due to neuronal and astrocytic proliferation after controlled cortical injury in mice显示文摘 | Kernie S G Erwin T M Parada L F | 2001 | J Neurosci Res2001，66，3： | 1 |
| 11 | Genetic organization and heterogeneity of the iceA locus of Helicobacter pylori显示文摘 | Céu Figueiredo Wim G.V Quint Ricardo Sanna Erwin Sablon John P Donahue Qing Xu Geraldine G Miller Richard M Peek Martin J Blaser Leen-Jan van Doorn | 2000 | Gene2000，，1： | 1 |
| 12 | High-efficiency coupling-insensitive transcutaneous power and data transmission via an inductive link 显示文摘 | Clements M Z Erwin S H | 1990 | IEEE Transactions on Biomedical Engineering1990，37，7： | 1 |
| 13 | Autecol- ogy and the filling of ecospace: key metazoan radia- tions 显示文摘 | BAMBACH R K BUSH A M ERWIN D H | 2007 | Palaeontology2007，50，： | 1 |
| 14 | Local endoscopic therapy for intraepithelial high-grade neoplasia and early adenocarcinoma in Barrett’s oesophagus: acute-phase and intermediate results of a new treatment approach显示文摘 | Andrea May Liebwin Gossner Oliver Pech Andreas Fritz Erwin Günter Gerd Mayer Hartmut Müller Gerhard Seitz Michael Vieth Martin Stolte Christian Ell | 2002 | European Journal of Gastroenterology & Hepatology2002，，： | 1 |
| 15 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 16 | Impact of afterschool programs to increase physical activity-ameta- analysis 显示文摘 | Beets M W Beighle A Erwin H E | 2009 | Anerucan Journal of Preventive Medicine2009，36，6： | 1 |
| 17 | Volatile fatty acid analyses of blood and rumen fluid by gas chromatography显示文摘 | Erwin S Marco G J Eemery E M | 1961 | Journal of Dairy Science1961，44，9： | 1 |
| 18 | Posttransplantation diabetes:a systematic review of the literature显示文摘 | Montori V M Basu A Erwin P J | 2002 | Diabetes Care2002，25，： | 1 |
| 19 | Volatile fatty acid analyses of blood and rumen fluid by gas chromatography 显示文摘 | ERWIN E S MARCO J EMERY E M | 1961 | Journal of Dairy Science1961，44，： | 1 |
| 20 | Volatile fatty acid analysis of blood and rumen fluid by gas chromatography 显示文摘 | ERWIN E S MARCO G J EMERY E M | 1961 | Dairy Science1961，44，9： | 1 |
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