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| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Diabetes mellitus and Parkinson's disease:dangerous liaisons between insulin and dopamine显示文摘The relationship between diabetes mellitus and Parkinson's disease has been described in several epidemiological studies over the 1960 s to date.Molecular studies have shown the possible functional link between insulin and dopamine,as there is strong evidence demonstrating the action of dopamine in pancreatic islets,as well as the insulin effects on feeding and cognition through central nervous system mechanism,largely independent of glucose utilization.Therapies used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson's disease,while an old dopamine agonist,bromocriptine,has been repositioned for the type 2 diabetes mellitus treatment.This review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson's disease. | Angela De Iuliis Ennio Montinaro Giuseppe Fatati Mario Plebani Carlo Colosimo | 2022 | Neural Regeneration Research2022，17，3： | 3 |
| 3 | Histomorhological and clinical evaluation of maxillary alveolar ridge reconstruction after craniofacial trauma by applying combination of allogeneic and autogenous bone graft显示文摘 | Francesco Saverio De Ponte Roberto Falzea Michele Runci Enrico Nastro Siniscalchi Floriana Lauritano Ennio Bramanti Gabriele Cervino Marco Cicciu | 2017 | Chinese Journal of Traumatology2017，20，1： | 2 |
| 4 | Proton Pump Inhibitors Exacerbate NSAID-Induced Small Intestinal Injury by Inducing Dysbiosis显示文摘 | John L. Wallace Stephanie Syer Emmanuel Denou Giada de Palma Linda Vong Webb McKnight Jennifer Jury Manlio Bolla Premysl Bercik Stephen M. Collins Elena Verdu Ennio Ongini | 2011 | Gastroenterology2011，，： | 2 |
| 5 | Beyond the joint: Subclinical atherosclerosis in rheumatoid arthritis显示文摘Rheumatoid arthritis is a chronic autoimmune inflammatory disease associated with increased cardiovascular risk and higher mortality in respect to general population.Beyond joint disease,inflammation is the major determinant of accelerated atherosclerosis observed in rheumatoid arthritis.We review the relationship between inflammation,atherosclerosis and cardiovascular risk in rheumatoid arthritis,focusing on the assessment of subclinical atherosclerosis by functional and morphological methods.These tools include flow mediated dilatation,carotid intima-media thickness,ankle/brachial index,coronary calcium content,pulse wave analysis and serum biomarker of subclinical atherosclerosis. | Antongiulio Scarno Fabio Massimo Perrotta Francesca Cardini Alessia Carboni Gianmarco Annibali Ennio Lubrano Antonio Spadaro | 2014 | World Journal of Orthopedics2014，5，3： | 2 |
| 6 | Estimation of Trip Matrices From Traffic Counts and Survey Data: a Generalized Least Squares Estimator 显示文摘 | CASCETrA Ennio | 1984 | Transportation Research1984，18，4： | 1 |
| 7 | Principles on cryopreservation of human platelets显示文摘 | Ennio C | 1999 | Cryobilogy1999，138，3： | 1 |
| 8 | Efficacy and Safety of Anti-Tumour Necrosis Factor in Elderly Patients with Rheumatoid Arthritis: An Observational Study显示文摘 | Matteo Filippini Chiara Bazzani Ennio Giulio Favalli Antonio Marchesoni Fabiola Atzeni Piercarlo Sarzi-Puttini Francesca Bobbio Pallavicini Roberto Caporali Roberto Gorla | 2010 | Clinical Reviews in Allergy & Immunology2010，，： | 1 |
| 9 | Soil-geosynthetic interaction: Modelling and analysis显示文摘 | Ennio M P | 2009 | Geotextiles and Geomembranes2009，27，5： | 1 |
| 10 | Soil-geosynthetic interaction:Modelling and analysis显示文摘 | Ennio Marques Palmeira | 2009 | Geotextiles and Geomembranes2009，27，： | 1 |
| 11 | Inflammatory Myofibroblastic Tumor of the Orbit显示文摘 | Ennio Politoa Patrizia Pichierria Antonio Loffredoa | 2007 | Ophthalmologica2007，221，5： | 1 |
| 12 | Dynamic Estimators of Origin-Destination Matrices Using Traffic Counts显示文摘 | CASCETTA Ennio INAUDI Domenico MARQUIS Gerald | 1993 | Transportation Science1993，27，4： | 1 |
| 13 | How Drosophila combats microbial infection: a model to study innate immunity and host-pathogen interactions 显示文摘 | Phoebe T Ennio DG Bruno L | 2002 | Curt Opin Microbiol2002，5，1： | 1 |
| 14 | Multiple Effects of Berberine Derivatives on Colon Cancer Cells显示文摘 | Luis Miguel Guamán Ortiz Micol Tillhon Michael Parks Ilaria Dutto Ennio Prosperi Monica Savio Andrea G. Arcamone Franco Buzzetti Paolo Lombardi Anna Ivana Scovassi Steve Winder | 2014 | BioMed Research International2014，，： | 1 |
| 15 | Activity of Flurbiprofen and Chemically Related Anti-inflammatory Drugs in Models of Alzheimer's Disease显示文摘 | Laura G Ennio O Donna W | | 0，，02： | 1 |
| 16 | Cubane-like water clusters in a 3D supramolecular network of zinc with pyridine-2,6-dicarboxylic acid and 5-aminotetrazole显示文摘 | Sudipta Dalai Abhinandan Rana Durga Sankar Chowdhuri Madhusudan Bera Ennio Zangrando | 2009 | Inorganica Chimica Acta2009，，5： | 1 |
| 17 | Mobility and location impacts analysis of the HS line Roma-Napoli显示文摘 | Ennio C Andrea P Francesco P | 2009 | Ingegneria Ferroviaria2009，64，78： | 1 |
| 18 | Reduction of Cr(Ⅵ)to Cr(Ⅲ)in Artificial,Contaminated Soil Using Ferrous Sulfate Heptahydrate and Sodium Thiostlfate显示文摘 | KOSTARELOS KOSTARELOS ENNIO RAO DANIELA REALE | 2009 | Practice Periodical of Hazardous Toxic and Radioactive Waste Management2009，2，13： | 1 |
| 19 | MRI appearance of the low transverse incision after caesarean section in a symptomatic woman显示文摘 | Davide Lijoi Ennio Biscaldi Emanuela Mistrangelo Stefano Bogliolo Nicola Ragni | 2006 | European Journal of Radiology Extra2006，，3： | 1 |
| 20 | Bowel endometriosis: CT-enteroclysis显示文摘 | Ennio Biscadi Simone Ferrero | 2007 | Abdom Imaging2007，32，： | 1 |
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