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| 1 | Comprehensive management of full-thickness luminal defects: The next frontier of gastrointestinal endoscopy显示文摘Full thickness gastrointestinal defects such as perforations, leaks, and fistulae are a relatively common result of many of the endoscopic and surgical procedures performed in modern health care. As the number of these procedures increases, so too will the number of resultant defects. Historically, these were all treated by open surgical means with the associated morbidity and mortality. With the recent advent of advanced endoscopic techniques, these defects can be treated definitively while avoiding an open surgical procedure. Here we explore the various techniques and tools that are currently available for the treatment of gastrointestinal defects including through the scope clips, endoscopic suturing devices, over the scope clips, sealants, endoluminal stents, endoscopic suction devices, and fistula plugs. As fistulae represent the most recalcitrant of defects, we focus this editorial on a multimodal approach of treatment. This includes optimization of nutrition, treatment of infection, ablation of tracts, removal of foreign bodies, and treatment of distal obstructions. We believe that by addressing all of these factors at the time of attempted closure, the patient is optimized and has the best chance at longterm closure. However, even with all of these factors addressed, failure does occur and in those cases, endoscopic therapies may still play a role in that they allow the patient to avoid a definitive surgical therapy for a time while nutrition is optimized, and infections are addressed. | Joshua S Winder Eric M Pauli | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，8： | 13 |
| 2 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 3 | 藏医学与古代及中世纪西方医学的比较显示文摘亚欧大陆在文化和技术上是一个历史的整体。在此背景下,西方古典医学和印度、藏古典医学在理论、内容上存在着广泛的联系。继承了印度古典医学知识的藏医学与西方古典医学在体液病理学说、病原学说、疾病诊疗、生理认识等方面存在很多共性。这种联系不是纯偶然性的,我们可以找到不少两种古典医学直接或间接发生联系的证据,值得继续关注。 | 玛莉安娜·温德(Marianne Winder) 刘铁程(译) 宗喀·漾正冈布(校订) | 2011 | 西北民族大学学报(哲学社会科学版)2011，，3： | 2 |
| 4 | Molecular diversity of rumen methanogens from sheep in Western Australia显示文摘 | Wright A D G Williams A J Winder B | 2004 | Appllied Environmental Microbiology2004，70，3： | 1 |
| 5 | Antimicrobial peptides melittin and cecropin in- hibit replication of human immunodeficiency virus 1 by suppressing viral gene expression 显示文摘 | WACHINGER M KLEINSCHMIDT A WINDER D | 1998 | Journal of General Virology1998，79，4： | 1 |
| 6 | The inside and out of dystroglycan post-translational modification显示文摘 | Moore CJ Winder SJ | | 0，，11： | 1 |
| 7 | DNAJB6 myopathy: a vacuolar myopathy with childhood onset显示文摘 | Suarez-Cedeno G Winder T Milone M | 2014 | Muscle Nerve2014，49，： | 1 |
| 8 | Discriminative learning of local image descriptors显示文摘 | BROWN M GANG H WINDER S | 2011 | IEEE Transactions on Pattern Anal- ysis and Machine Intelligence2011，33，1： | 1 |
| 9 | On the current status of quartz crystal microbalance studies of superconductivity-dependent sliding friction显示文摘 | MASON B L WINDER S M KRIM J | 2001 | Tribology Letters2001，10，12： | 1 |
| 10 | Monitoring the quality of life in patients with coronary artery disease显示文摘 | Winders JA Dewhurst TA etal | 1994 | Am J cardiac1994，74，12： | 1 |
| 11 | High-Quality Video View Interpolation Using a Layered Representation显示文摘 | Sing Bing Kang Matthew Uyttendaele Simon Winder Richard Szeliski | 2004 | ACM Transactions on Graphics (S0730-0301)2004，23，3： | 1 |
| 12 | Medical rapid prototyping and 3D CT in the manufacture of custom made cranial titanium plates显示文摘 | Winder J Cooke RS Gray J | 1999 | J Med Eng Technol1999，23，1： | 1 |
| 13 | Monitoring the quality of life in patients with coronary artery disease 显示文摘 | Spertus JA Winders JA Dewhurst TA | 1994 | Am J cardiac1994，74，12： | 1 |
| 14 | Role of Plasma epinephrine in fasted exercising rats 显示文摘 | Terry L Winder W W Mitchell V M | 1985 | Am J Physiol Regulatory Integrative Comp Physiol1985，248，： | 1 |
| 15 | Monitoring the quality of life in patients with coronary artery disease显示文摘 | Spertus JA Winder JA Dewhurst TA | | 0，，12： | 1 |
| 16 | The WW domain: linking cell signalling to the membrane cytoskeleton 显示文摘 | Ilsley JL Sudol M Winder SJ | 2002 | Cell Signalling2002，14，： | 1 |
| 17 | Development and evaluation of the Seattle angina questionnaire: A new functional sta- tusmeasure for coronary artery disease 显示文摘 | Spertus JA Winder JA Dewhurst TA | 1995 | J Am Col Cardiol1995，25，2： | 1 |
| 18 | Sensitization of low bandgap polymer bulk heterojunction solar cells显示文摘 | WINDER C MATT G HUMMELEN C JAMSSEN R A J SARICIFTCI N S BRABEC C J | 2002 | Thin Solid Films2002，404，： | 1 |
| 19 | Skeletal muscle respiratory capacity, endurance, and glycogen utilization 显示文摘 | Fitts R H Booth F W Winder W W | 1975 | Am J Physiol1975，228，： | 1 |
| 20 | Antimicrobial peptides melittin and cecropin inhibit replication of human immunodeficiency virus 1 by suppressing viral gene expression显示文摘 | Wachinger M kieinSchmidt A Winder D | 1998 | J Gen Virol1998，79，4： | 1 |
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