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| 1 | Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms显示文摘协调的子宫胚胎的轴形成并且蜕膜的改变是哺乳动物的培植以后的胚胎开发的特点。胚胎子宫的取向在起始的培植被决定并且与蜕膜的开发同步。然而,控制这些事件的分子的机制留下尽管有它的发现逃犯很长时间以前。在现在的学习,我们发现了 Rbpj 的那子宫特定的删除,槽口发信号的原子变换器,在培植以后的阶段导致了反常胚胎子宫的取向和蜕膜的 patterning,导致实质的胚胎损失。我们进一步表明在胚胎附件以前, Rbpj 授与在时间上经由身体上与子宫的雌激素受体交往的子宫的腔形状转变(ERα) 以一种槽口小径无关的方式,它为在有子宫的轴的排列的胚胎取向的起始的建立是必要的。当时在培植以后的阶段, Rbpj 直接以一种槽口小径依赖者方式调整子宫的矩阵 metalloproteinase 的表示,它为正常被要求培植以后的蜕膜的改变。这些结果证明子宫的 Rbpj 为经由指示起始的胚胎子宫的取向并且以一种阶段特定的方式保证正常蜕膜的 patterning 的正常胚胎开发是必要的。我们的数据也证实正常哺乳动物的胚胎子宫的取向要求的概念合适的指导从发展地控制了子宫的发信号。 | Shuang Zhang Shuangbo Kong Bingyan Wang Xiaohong Cheng Yongjie Chen Weiwei Wu Qiang Wang Junchao Shi Ying Zhang Shumin Wang Jinhua Lu John P Lydon Francesco DeMayo Warren S Pear Hua Han Haiyan Lin Lei Li Hongmei Wang Yan-ling Wang Bing Li Qi Chen Enkui Duan Haibin Wang | 2014 | Cell Research2014，24，8： | 12 |
| 2 | Senescence and p130/Rb12: a new beginning to the end显示文摘 | Francesco P Fiorentinot Catherine E Symonds Marcella Macaluso Antonio Giordano | 2009 | Cell Research2009，19，9： | 3 |
| 3 | Impact of sodium glucose cotransporter-2 inhibitors on liver steatosis/fibrosis/inflammation and redox balance in non-alcoholic fatty liver disease显示文摘BACKGROUND Sodium glucose cotransporter-2 inhibitors(SGLT2-I)are the most recently approved drugs for type 2 diabetes(T2D).Recent clinical trials of these compounds reported beneficial cardiovascular(CV)and renal outcomes.A major cause of vascular dysfunction and CV disease in diabetes is hyperglycemia associated with inflammation and oxidative stress.Pre-clinical studies demonstrated that SGLT2-I reduce glucotoxicity and promote anti-inflammatory effects by lowering oxidative stress.AIM To investigate the effects of SGLT2-I on markers of oxidative stress,inflammation,liver steatosis,and fibrosis in patients of T2D with non-alcoholic fatty liver disease(NAFLD).METHODS We referred fifty-two consecutive outpatients treated with metformin monotherapy and exhibiting poor glycemic control to our centre.We introduced the outpatients to an SGLT2-I(dapagliflozin,empagliflozin,or canagliflozin;n=26)or a different hypoglycemic drug[other glucose-lowering drugs(OTHER),n=26].We evaluated circulating interleukins and serum hydroxynonenal(HNE)-or malondialdehyde(MDA)-protein adducts,fatty liver index(FLI),NAFLD fibrosis score,aspartate aminotransferase(AST)/alanine aminotransferase(ALT)ratio,AST-to-platelet-ratio index(APRI),and fibrosis-4 on the day before(T0)and following treatment for six months(T1).We also performed transient elastography at T0 and T1.RESULTS Add-on therapy resulted in improved glycemic control and reduced fasting blood glucose in both groups.Of note,following treatment for six months,a reduction of FLI and APRI,as well as of the FibroScan result,was reported in patients treated with SGLT2-I,but not in the OTHER group;furthermore,in the SGLT2-I group,we reported lower circulating levels of interleukin(IL)-1β,IL-6,tumor necrosis factor,vascular endothelial growth factor,and monocyte chemoattractant protein-1,and higher levels of IL-4 and IL-10.We did not observe any modification in circulating interleukins in the OTHER group.Finally,serum HNE-and MDA-protein adducts decreased significantly in SGLT2-I rather than OTHER patients and correlated with liver steatosis and fibrosis scores.CONCLUSION The present data indicate that treatment with SGLT2-I in patients with T2D and NAFLD is associated with improvement of liver steatosis and fibrosis markers and circulating pro-inflammatory and redox status,more than optimizing glycemic control. | Francesco Bellanti Aurelio Lo Buglio MichałDobrakowski Aleksandra Kasperczyk Sławomir Kasperczyk Palok Aich Shivaram P Singh Gaetano Serviddio Gianluigi Vendemiale | 2022 | World Journal of Gastroenterology2022，28，26： | 3 |
| 4 | Age at diagnosis of type 2 diabetes and cardiovascular risk factor profile:A pooled analysis显示文摘BACKGROUND The diagnosis of type 2 diabetes(T2D)in younger adults,an increasingly common public health issue,is associated with a higher risk of cardiovascular complications and mortality,which may be due to a more adverse cardiovascular risk profile in individuals diagnosed at a younger age.AIM To investigate the association between age at diagnosis and the cardiovascular risk profile in adults with T2D.METHODS A pooled dataset was used,comprised of data from five previous studies of adults with T2D,including 1409 participants of whom 196 were diagnosed with T2D under the age of 40 years.Anthropometric and blood biomarker measurements included body weight,body mass index(BMI),waist circumference,body fat percentage,glycaemic control(HbA1c),lipid profile and blood pressure.Univariable and multivariable linear regression models,adjusted for diabetes duration,sex,ethnicity and smoking status,were used to investigate the association between age at diagnosis and each cardiovascular risk factor.RESULTS A higher proportion of participants diagnosed with T2D under the age of 40 were female,current smokers and treated with glucose-lowering medications,compared to participants diagnosed later in life.Participants diagnosed with T2D under the age of 40 also had higher body weight,BMI,waist circumference and body fat percentage,in addition to a more adverse lipid profile,compared to participants diagnosed at an older age.Modelling results showed that each one year reduction in age at diagnosis was significantly associated with 0.67 kg higher body weight[95%confidence interval(CI):0.52-0.82 kg],0.18 kg/m^(2) higher BMI(95%CI:0.10-0.25)and 0.32 cm higher waist circumference(95%CI:0.14-0.49),after adjustment for duration of diabetes and other confounders.Younger age at diagnosis was also significantly associated with higher HbA1c,total cholesterol,low-density lipoprotein cholesterol and triglycerides.CONCLUSION The diagnosis of T2D earlier in life is associated with a worse cardiovascular risk factor profile,compared to those diagnosed later in life. | Mary M Barker Francesco Zaccardi Emer M Brady Gaurav S Gulsin Andrew P Hall Joseph Henson Zin ZinHtike Kamlesh Khunti Gerald P McCann Emma L Redman David R Webb Emma G Wilmot Tom Yates Jian Yeo Melanie J Davies Jack A Sargeant | 2022 | World Journal of Diabetes2022，13，3： | 2 |
| 5 | Uncatalyzed heterogeneous oxidation of calcium bisulfite显示文摘 | Amedeo Lancia Dino Musmarra Francesco P | 1996 | Chem Eng Sci1996，51，16： | 2 |
| 6 | Noninvasive surrogate markers of atherosclerosis显示文摘 | Steven BF Paolo V Francesco P | 2002 | Am J Cardiol2002，89，5： | 1 |
| 7 | One-pot synthesis of 3- carboxyeoumarins via consecutive knoevenagel and pinner reaction in water显示文摘 | Francesco F Ferdinando P | 2003 | Synthesis2003，15，： | 1 |
| 8 | Therapeutic aspects of IgA nephropathy:an overview显示文摘 | Francesco P Giovanni C | 2002 | Nephrology2002，7，： | 1 |
| 9 | Oxidant stress and aspirininsensitive thromboxane biosynthesis in severe unstable angina 显示文摘 | Francesco C Giovanni C Paola P | 2000 | Circulation2000，102，3： | 1 |
| 10 | Start up analysis for automotive PEM fuel cell systems显示文摘 | Francesco M D Arato E Costa P | 2002 | Journal of Power Sources2002，108，： | 1 |
| 11 | Fluconazole resistance in Candida albicans:a review of mechanisms显示文摘 | CASALINUOVO I A DI FRANCESCO P Garaci E | 2004 | Eur Rev Med Pharmacol Sci2004，8，2： | 1 |
| 12 | Glutathione, glutathione - dependent and antioxidant enzymes in mussel, Mytilus galloprovincialis, exposed to metals under field and laboratory conditions: implications for the use of biochemical biomarkers 显示文摘 | FRANCESCO R GIOVANNI P | 1995 | Aquatic Toxicology1995，31，2： | 1 |
| 13 | Two-dimensionalHyCoSy with contrast tuned imaging technology and asecond-generation contrast media for the assessment of tubalpatency in an infertility program显示文摘 | Chiara L Valeria S Francesco P | 2009 | Fertil Steril2009，92，3： | 1 |
| 14 | A novel series of potent and selective ketone histone deacetylase inhibitors with antitumor activity in vivo显示文摘 | Jones P Altamura S Francesco R | 2008 | J Med Chem2008，51，： | 1 |
| 15 | In-vitro interaction of terbinafine with amphotericin B,fluconale and itraconazoleagainst clinical isolates of Candida albicans显示文摘 | Barchiesi F Francesco LFD Compsgnucei P | | 0，，01： | 1 |
| 16 | Pseudomonas aeruginosa bloodstream infections: risk factors and treatment outcome related to the expression of the PER-1 extended-spectrum beta-lactamase显示文摘 | Andrea E Francesco L Beatrice P | 2006 | BMC Infect Dis2006，6，1： | 1 |
| 17 | Synthesis and biological evaluation of an anticancer vaccine containing the C-glycoside analogue of the Tn epitope 显示文摘 | Francesco P Laura C Maria R | 2001 | Bioconjug Chem2001，12，3： | 1 |
| 18 | The effect of thymosin on sustemiccangidasis in mice immune-supressed 显示文摘 | Francesco P Cinnor J BanneijiR | 1994 | Clin Expimmunol1994，9，42： | 1 |
| 19 | Seasonal variation in biomass, morphometric parameters and production of seagrasses in the lagoon of Venice 显示文摘 | Sfriso A Francesco Ghetti P | 1998 | Aquat Bot1998，61，： | 1 |
| 20 | Comparison of contact-force models for the simulation of collisions in DEM-based granular flow codes显示文摘 | ALBERTO D R FRANCESCO P D M | 2004 | Chemical Engineering Science2004，59，13： | 1 |
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