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| 1 | Clinical impact of occult hepatitis B virus infection in immunosuppressed patients显示文摘Occult hepatitis B infection(OBI), is characterized by low level hepatitis B virus(HBV) DNA in circulating blood and/or liver tissue. In clinical practice the presence of antibody to hepatitis B core antigen in hepatitis B surface antigen(HBsAg)-/anti-HBs-negative subjects is considered indicative of OBI. OBI is mostly observed in the window period of acute HBV infection in blood donors and in recipients of blood and blood products, in hepatitis C virus chronic carriers, in patients under pharmacological immunosuppression, and in those with immunodepression due to HIV infection or cancer. Reactivation of OBI mostly occurs in anti-HIV-positive subjects, in patients treated with immunosuppressive therapy in onco-hematological settings, in patients who undergo hematopoietic stem cell transplantation, in those treated with anti-CD20 or anti-CD52 monoclonal antibody, or anti-tumor necrosis factors antibody for rheumatological diseases, or chemotherapy for solid tumors. Under these conditions the mortality rate for hepatic failure or progression of the underlying disease due to discontinuation of specific treatment can reach 20%. For patients with OBI, prophylaxis with nucleot(s)ide analogues should be based on the HBV serological markers, the underlying diseases and the type of immunosuppressive treatment. Lamivudine prophylaxis is indicated in hemopoietic stem cell transplantation and in onco-hematological diseases when high dose corticosteroids and rituximab are used; monitoring may be indicated when rituximab-sparing schedules are used, but early treatment should be applied as soon as HBsAg becomes detectable. This review article presents an up-to-date evaluation of the current knowledge on OBI. | Evangelista Sagnelli Mariantonietta Pisaturo Salvatore Martini Pietro Filippini Caterina Sagnelli Nicola Coppola | 2014 | World Journal of Hepatology2014，6，6： | 4 |
| 2 | Treatment of chronic hepatitis C in patients with HIV/HCV coinfection显示文摘Hepatitis C virus(HCV) infection is one of the mostfrequent causes of comorbidity and mortality in the human immunodeficiency virus(HIV) population, and liver-related mortality is now the second highest cause of death in HIV-positive patients, so HCV infection should be countered with adequate antiviral therapy. In 2011 began the era of directly acting antivirals(DAAs) and the HCV NS3/4A protease inhibitors telaprevir and boceprevir were approved to treat HCV-genotype-1 infection, each one in combination with pegylated interferon alfa(Peg-IFN) + ribavirin(RBV). The addition of the first generation DAAs, strongly improved the efficacy of antiviral therapy in patients with HCVgenotype 1, both for the HCV-monoinfected and HIV/HCV coinfected, and the poor response to Peg-IFN + RBV in HCV/HIV coinfection was enhanced. These treatments showed higher rates of sustained virological response than Peg-IFN + RBV but reduced tolerability and adherence due to the high pill burden and the several pharmacokinetic interactions between HCV NS3/4A protease inhibitors and antiretroviral drugs. Then in 2013 a new wave of DAAs arrived, characterized by high efficacy, good tolerability, a low pill burden and shortened treatment duration. The second and third generation DAAs also comprised IFN-free regimens, which in small recent trials on HIV-positive patients have shown comforting preliminary results in terms of efficacy, tolerability and adherence. | Nicola Coppola Salvatore Martini Mariantonietta Pisaturo Caterina Sagnelli Pietro Filippini Evangelista Sagnelli | 2015 | World Journal of Virology2015，4，1： | 3 |
| 3 | New insights into the brain involvement in patients with Crohn’s disease: a voxel‐based morphometry study显示文摘 | A. Agostini F. Benuzzi N. Filippini A. Bertani A. Scarcelli V. Farinelli C. Marchetta C. Calabrese F. Rizzello P. Gionchetti M. Ercolani M. Campieri P. Nichelli | 2012 | Neurogastroenterology & Motility2012，，2： | 2 |
| 4 | Does kidney transplantation onto the external iliac artery affect the haemodynamic parameters of the cavernosal arteries?显示文摘减少的 cavernosal 在肾通过端对端的吻合在接受者移植 revascularized 到内部肠骨的动脉以后,动脉的流入被假设了是可勃起的机能障碍的可能的原因,在外部肠骨的动脉建议那 end-to-side 吻合更好。学习是有希望地由评估在可勃起的功能,荷尔蒙侧面和阴茎血流动上评估外部肠骨的动脉的使用的效果的这的目的在 end-to-side 前后在 22 个接受者的一个连续系列在阴茎颜色 Doppler 超声参数变化外部肠骨的动脉移植。可勃起的功能可勃起的函数(IIEF-EF ) 领域 20 的吝啬的国际索引显著地减少了 3 个月在以后移植(18.09 ± 6.33 对 22.50 ± 7.09, P=0.01 ) 。在山峰的减小收缩速度(PSV ) 为到方面的多孔的动脉 homolateral 是重要的移植(42.60 ± 18.77 对 52.01 ± 19.91, P=0.01 ) 。吝啬的手术后的目的心脏舒张的速度(EDV ) 没与外科手术前的价值(P=0.74 ) 显著地不同。没有统计差别在睾丸激素或催乳激素的浆液层次被发现。在外部肠骨的动脉吻合的肾接枝生产了重要(P=0.01 ) 在在在正常阀值上面留下了的 homolateral cavernosal 动脉的动脉的流入的减小。这些 haemodynamic 是否变化,能解释要证明的手术后的可勃起的功能遗体变得更坏。 | Paolo Gontero Marco Oderda Claudia Filippini Francesco Fontana Elisa Lazzarich Piero Stratta Ernesto Turello Alessandro Tizzani Bruno Frea | 2012 | Asian Journal of Andrology2012，14，4： | 2 |
| 5 | The effect of water treeing on the electric field distribution of XLPE显示文摘 | Radu I Acedo M Filippini J C | 2000 | IEEE Trans on Dielectrics and Electrical Insulation2000，7，6： | 1 |
| 6 | Identification of novel RP2 mutations in a subset of X-linked retilfitis pigmentosa families and prediction of new domains 显示文摘 | Miano MG Testa F Filippini F Trujifio M Conte I Lanzara C | 2001 | Hum Murat2001，18，2： | 1 |
| 7 | Influence of polymer morphology on water treeing显示文摘 | Raharimalala V Poggi Y Filippini J C | 1994 | IEEE Trans on Dielectrics and Electrical Insulation1994，1，6： | 1 |
| 8 | ,Licensing Contract in a Stackelberg Model显示文摘 | L | 2005 | The Manchester School2005，73，5： | 1 |
| 9 | European attempts for the standardization of antiphospholipid antibodies显示文摘 | Ticani A Filippini M Scarsi M | 2009 | Lupus2009，18，： | 1 |
| 10 | Influence of water trees on the electric field distribution and breakdown in the pointpoint geometry显示文摘 | Radu I Notingher P V Filippini J C | 2000 | Journal of Electrostatics2000，48，： | 1 |
| 11 | Neuropsycho- logical development in children belonging to BECTS spec- trum: long-term effect of epileptiform activity 显示文摘 | Filippini M Boni A Giannotta M | 2013 | Epilepsy Behav2013，28，3： | 1 |
| 12 | Dress syndrome and fulminant hepatic failure induced by lamotrigine 显示文摘 | AMANTE M F FILIPPINI A V CEJAS N | 2009 | Ann Hepatol2009，8，1： | 1 |
| 13 | Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma显示文摘 | Filippini G Falcone C Boiardi A | 2008 | Neuro Oncol2008，10，1： | 1 |
| 14 | Antimicrobial Properties of N-carboxybutyl chitosan,Antimicro显示文摘 | Muzzarelli R A A Tarsi R Filippini O | 1990 | Agents Chemother1990，34，10： | 1 |
| 15 | Interferons in relapsing remitting multiple sclerosis: a systematic review显示文摘 | Filippini G Munari L Incorvaia B | 2003 | Lancet2003，361，9357： | 1 |
| 16 | Water Treeing Test Using the Wa-ter Needle Method: the Influence of the Magnitude of theElectric Field at the Needle Tip显示文摘 | Filippini J C Meyer C T | 1988 | IEEE Transactions onDielectrics and Electrical Insulation1988，23，2： | 1 |
| 17 | The different modes for absorbing knowledge: an analytic lens on absorptive capacity from a process perspective 显示文摘 | FILIPPINI R G1]TTEL W H NEIROTTI P NOSELLA A | 2012 | Interna- tional Journal of Knowledge Management Studies2012，5，1： | 1 |
| 18 | Intraoperative ultrasound in spinal tumor surgery显示文摘 | Prada F Vetrano IG Filippini A | 2014 | J Ultrasound2014，17，3： | 1 |
| 19 | Efficacy and Safety of Anti-Tumour Necrosis Factor in Elderly Patients with Rheumatoid Arthritis: An Observational Study显示文摘 | Matteo Filippini Chiara Bazzani Ennio Giulio Favalli Antonio Marchesoni Fabiola Atzeni Piercarlo Sarzi-Puttini Francesca Bobbio Pallavicini Roberto Caporali Roberto Gorla | 2010 | Clinical Reviews in Allergy & Immunology2010，，： | 1 |
| 20 | Toll‐like receptors in prostate infection and cancer between bench and bedside显示文摘 | Guido Gambara Paola Cesaris Cosimo Nunzio Elio Ziparo Andrea Tubaro Antonio Filippini Anna Riccioli | 2013 | J Cell Mol Med2013，，6： | 1 |
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