5篇
您的检索式：作者名="Carlo Colosimo"
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| 1 | Diabetes mellitus and Parkinson's disease:dangerous liaisons between insulin and dopamine显示文摘The relationship between diabetes mellitus and Parkinson's disease has been described in several epidemiological studies over the 1960 s to date.Molecular studies have shown the possible functional link between insulin and dopamine,as there is strong evidence demonstrating the action of dopamine in pancreatic islets,as well as the insulin effects on feeding and cognition through central nervous system mechanism,largely independent of glucose utilization.Therapies used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson's disease,while an old dopamine agonist,bromocriptine,has been repositioned for the type 2 diabetes mellitus treatment.This review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson's disease. | Angela De Iuliis Ennio Montinaro Giuseppe Fatati Mario Plebani Carlo Colosimo | 2022 | Neural Regeneration Research2022，17，3： | 3 |
| 2 | Hypofractionated and Low Dose Radiotherapy Combined with Temozolomide in Naive Unresectable Glioblastoma:A Pilot Study显示文摘Background/Aim: To assess safety of hypo-fractionated radiotherapy( HyRT) followed by low dose radiation therapy( LD-FRT) plus Temozolomide( TMZ) in naive unresectable Glioblastoma. Methods: Patients( ECOG < 2,age > 18) undergone to biopsy or with gross residual tumor after surgery were enrolled. HyRT( 30 Gy in ten fraction) plus TMZ was administered. From the second adjuvant cycle of TMZ,patients received LD-FRT( 0. 40 Gy twice daily over 5 days,every 28 days) for two cycles. The primary endpoints were safety and toxicity. Moreover we analyzed response,overall survival( OS) and progression-free survival( PFS). Results: Twenty patients were enrolled. Median dose of LD-FRT was 12 Gy. All toxicities were reversible. Four out of 20 patients had Partial Response( PR)and 6 experienced a stable disease( SD). Median OS and PFS were 14 and 11 months,respectively.Conclusions: HyRT followed by LD-FRT plus TMZ is safe and shows good clinical outcomes. A new study is ongoing. | Silvia Chiesa Milena Ferro Stefano Luzi Barbara Diletto Francesco Beghella Bartoli Nicola Dinapoli Gian Carlo Mattiucci Vincenzo Frascino Francesco Miccichè Cesare Colosimo Carmelo Anile Alessandro Olivi Vincenzo Valentini Mario Balducci | 2017 | 肿瘤预防与治疗2017，30，1： | 2 |
| 3 | Statistics of extremes through component distribution 显示文摘 | Giuseppe Mendicino Guo Rendong | 1993 | Hydrologic continetntale (france)1993，8，2： | 1 |
| 4 | Multiple system atrophy显示文摘 | Gregor K Wenning Carlo Colosimo Felix Geser Werner Poewe | 2004 | Lancet Neurology2004，，： | 1 |
| 5 | Prevalence and clinical features of hedonistic homeostatic dysregulation in Parkinson's disease显示文摘 | Francesca Romana Pezzella Carlo Colosimo Nicola Vanacore | 2005 | Mov Disord2005，20，1： | 1 |
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