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| 1 | NF-KB in immunobiology显示文摘 | Matthew S Hayden Sankar Ghosh | 2011 | Cell Research2011，21，2： | 101 |
| 2 | Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells显示文摘基础切除修理(BER ) 是为由消除损坏的几打维持 genomic 完整的 evolutionarily 保存的进程(氧化或烷基 ated ) 或内长地被产生或由 genotoxicants 导致了的不恰当的库,主要反应的氧种类(ROS ) 。BER 包含由脱氧核糖核酸 glycosylase 以基础切除开始的 4-5 步骤,由通常包含 AP-endonuclease (无尾猿) 产生 3' 的一条普通小径列在后面哦在损坏地点的终点,与由脱氧核糖核酸连接酶封上的 DNA 和刻痕由修复合成列在后面。这条小径也负责修理脱氧核糖核酸单个海滨与 ROS 直接产生的堵住的终点决裂。将近所有 glycosylases,比他们特别地为氧化的底的底层损害少得多,宽广、重叠的底层变化,并且能用作备份酶体内。相反,哺乳动物的房间编码仅仅一无尾猿, APE1,不同于在更低的有机体的二无尾猿。尽管有全面类似,有在哺乳动物的不同潜水艇小径的 BER 比在 E 更复杂。关口 i。glycosylases 与下游的蛋白质形成建筑群经由不同潜水艇小径执行有效修理哪个之一,负责因为海滨的修理与 NEIL 家庭 glycosylases 或由 ROS 产生的 3' 磷酸盐终点决裂,要求多核苷酸 kinase 的磷酸酶活动而不是 APE1。不同建筑群可以利用不同 DNA 和 ligases。哺乳动物的 glycosylases 非在终点之一保存了延期、为酶的活动非必需却为和另外的 BER 并且非的相互作用需要 -- 为指向的复杂形成和细胞器的 BER 蛋白质。哺乳动物的酶 covalently 有时被修改它可以影响活动和复杂形成。这评论的焦点在在为氧化损坏的哺乳动物的 BER 的早步上。 | Muralidhar L Hegde Tapas K Hazra Sankar Mitra | 2008 | Cell Research2008，18，1： | 15 |
| 3 | 球孢白僵菌对油桐尺蛾的生物效力(英文)显示文摘分别在2005年和2006年的5、6月份,在Kamalpur和Hunterpara茶园、孟加拉西部以及印度地区对一种昆虫致病真菌球孢白僵菌对油桐尺蛾Buzura(=Biston)suppressaria Guen.的生物效力进行了评估。以农场主常用的化学杀虫剂40%SP灭多虫和25%EC氯氰菊酯作为标准检测物。试验中球孢白僵菌浓度为1.50 g,2.00 g和2.5 g/lit.of water;灭多虫和氯氰菊酯浓度分别为0.75 mL,1.00 mL和1.50 mL,和0.50 mL,1.00 mL和1.50 mL/lit.of water。在喷洒2.5 g/lit.of water球孢白僵菌3天后,Kamalpur和Hunterpara茶园中油桐尺蛾种群个体数分别降低了88.00%和84.00%。死的毛虫变成黑色,垂悬在叶片上。并且发现球孢白僵菌的杀虫活性与高剂量的灭多虫和氯氰菊酯的相当。 | Sibani Sankar GHATAK Md. Wasim REZA | 2007 | 昆虫学报2007，50，9： | 9 |
| 4 | Absorbable magnesium-based stent: physiological factors to consider for in vitro degradation assessments显示文摘Absorbable metals have been widely tested in various in vitro settings using cells to evaluate their possible suitability as an implant material.However,there exists a gap between in vivo and in vitro test results for absorbable materials.A lot of traditional in vitro assessments for permanent materials are no longer applicable to absorbable metallic implants.A key step is to identify and test the relevant microenvironment and parameters in test systems,which should be adapted according to the specific application.New test methods are necessary to reduce the difference between in vivo and in vitro test results and provide more accurate information to better understand absorbable metallic implants.In this investigative review,we strive to summarize the latest test methods for characterizing absorbable magnesium-based stent for bioabsorption/biodegradation behavior in the mimicking vascular environments.Also,this article comprehensively discusses the direction of test standardization for absorbable stents to paint a more accurate picture of the in vivo condition around implants to determine the most important parameters and their dynamic interactions. | JuanWang Christopher E.Smith Jagannathan Sankar Yeoheung Yun Nan Huang | 2015 | Regenerative Biomaterials2015，2，1： | 9 |
| 5 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 6 | Curcumin reverses T cell-mediated adaptive immune dysfunctions in tumor-bearing hosts显示文摘Immune dysfunction is well documented during tumor progression and likely contributes to tumor immune evasion.CD81 cytotoxic T lymphocytes(CTLs)are involved in antigen-specific tumor destruction and CD41 T cells are essential for helping this CD81 T cell-dependent tumor eradication.Tumors often target and inhibit T-cell function to escape from immune surveillance.This dysfunction includes loss of effector and memory T cells,bias towards type 2 cytokines and expansion of T regulatory(Treg)cells.Curcumin has previously been shown to have antitumor activity and some research has addressed the immunoprotective potential of this plant-derived polyphenol in tumor-bearing hosts.Here we examined the role of curcumin in the prevention of tumor-induced dysfunction of T cell-based immune responses.We observed severe loss of both effector and memory T-cell populations,downregulation of type 1 and upregulation of type 2 immune responses and decreased proliferation of effector T cells in the presence of tumors.Curcumin,in turn,prevented this loss of T cells,expanded central memory T cell(TCM)/effector memory T cell(TEM)populations,reversed the type 2 immune bias and attenuated the tumor-induced inhibition of T-cell proliferation in tumor-bearing hosts.Further investigation revealed that tumor burden upregulated Treg cell populations and stimulated the production of the immunosuppressive cytokines transforming growth factor(TGF)-b and IL-10 in these cells.Curcumin,however,inhibited the suppressive activity of Treg cells by downregulating the production of TGF-b and IL-10 in these cells.More importantly,curcumin treatment enhanced the ability of effector T cells to kill cancer cells.Overall,our observations suggest that the unique properties of curcumin may be exploited for successful attenuation of tumor-induced suppression of cell-mediated immune responses. | Sankar Bhattacharyya Dewan Md Sakib Hossain Suchismita Mohanty Gouri Sankar Sen Sreya Chattopadhyay Shuvomoy Banerjee Juni Chakraborty Kaushik Das Diptendra Sarkar Tanya Das Gaurisankar Sa | 2010 | Cellular & Molecular Immunology2010，7，4： | 7 |
| 7 | 标准·方案·指南--全科医疗对下肢静脉溃疡的管理指南显示文摘背景慢性下肢静脉溃疡是全科医疗中最常见的伤口,其管理既具有挑战性,又十分耗时。目的介绍包含TIME概念和A2BC2D方法的简短实用指南,帮助全科医生和护士对慢性下肢静脉溃疡患者开展基于循证医学的照护。讨论慢性溃疡的有效管理涉及对溃疡和患者的评估。管理的基本要求是采取适当的措施清除溃疡,选择合适的敷料以保持恰当的水分平衡,在对动脉循环进行评估后,应用渐进压力绷带以及解决患者关心的问题,例如疼痛和令人讨厌的伤口分泌物。结论遵循本文提出的简单、基于循证的方法,大多数慢性下肢静脉溃疡患者可以在全科诊所得到有效管理。 | Sankar Sinha Sadhishaan Sreedharan 本刊编辑部 | 2014 | 中国全科医学2014，17，33： | 7 |
| 8 | 印度小圆胸小蠹的一种新寄主植物(英文)显示文摘自然条件下印度小圆胸小蠹Euwallacea fornicatus(Eichhoff,1868)在茶树枝条虫瘿内取食,是茶的重要害虫之一,以茶蛀虫著称。2010年5-8月,在印度MugaEri研究中心3号农场(Lahdoigarh,Jorhat-Assam)的黄心树Persea bombycina Kost.(樟科)种植园中发现该虫有自然分布,且已对黄心树造成了明显的危害。黄心树为小圆胸小蠹一种新纪录的寄主植物。本文对小圆胸小蠹的寄主范围、分布、生物学和生活史等进行了讨论。 | Rajesh KUMAR Girin RAJKHOWA Mattipalli SANKAR Rama Krishnan RAJAN | 2011 | 昆虫学报2011，54，6： | 7 |
| 9 | Environmental life cycle assessment of Indian coal-fired power plants显示文摘 | Udayan Singh Naushita Sharma Siba Sankar Mahapatra | 2016 | International Journal of Coal Science & Technology2016，3，2： | 5 |
| 10 | Shared Principles in NF-κB Signaling显示文摘 | Matthew S. Hayden Sankar Ghosh | 2008 | Cell2008，，3： | 4 |
| 11 | Alpha-tocopherol supplementation on chromium toxicity: a study on rat liver and kidney cell membrane显示文摘Membrane damage is one of the important consequence of chromium, an environmental toxicant, to produce cytotoxicity. α-tocopherol, a membrane protectant can be used to reduce the chromium-induced membrane damage. In the present study, the impact of chromium in presence and absence of α-tocopherol was studied on plasma membrane of liver and kidney in male Wistar rats (80—100 g body weight). Significant increase in membrane cholesterol level as well as significant decrease in membrane phospholipid level in chromium exposed ( 0.8 mg /100 g body weight/d, i.p., for 4 weeks) animals suggest structural alteration of both liver and kidney plasma memebrane. The alkaline phosphatase, total ATPase and Na +-K +-ATPase activities of plasma membrane were significantly decreased in both liver and kidney after chromium treatment. However, α-tocopherol (30 mg/100 g diet) supplementation can restrict the changes in these membrane-bound enzyme activities. Thus, the usefulness of dietary supplementation of α-tocopherol to restrain the chromium-induced membrane damage is suggested. | Sankar Kumar Dey Prasunpriya Nayak Somenath Roy | 2003 | Journal of Environmental Sciences2003，15，3： | 4 |
| 12 | MADCR:Mobility Aware Dynamic Clustering-Based Routing Protocol in Internet of Vehicles显示文摘Internet of Vehicles(IoV)is an evolution of the Internet of Things(IoT)to improve the capabilities of vehicular ad-hoc networks(VANETs)in intelligence transport systems.The network topology in IoV paradigm is highly dynamic.Clustering is one of the promising solutions to maintain the route stability in the dynamic network.However,existing algorithms consume a considerable amount of time in the cluster head(CH)selection process.Thus,this study proposes a mobility aware dynamic clustering-based routing(MADCR)protocol in IoV to maximize the lifespan of networks and reduce the end-to-end delay of vehicles.The MADCR protocol consists of cluster formation and CH selection processes.A cluster is formed on the basis of Euclidean distance.The CH is then chosen using the mayfly optimization algorithm(MOA).The CH subsequently receives vehicle data and forwards such data to the Road Side Unit(RSU).The performance of the MADCR protocol is compared with that ofAnt Colony Optimization(ACO),Comprehensive Learning Particle Swarm Optimization(CLPSO),and Clustering Algorithm for Internet of Vehicles based on Dragonfly Optimizer(CAVDO).The proposed MADCR protocol decreases the end-toend delay by 5–80 ms and increases the packet delivery ratio by 5%–15%. | Sankar Sennan Somula Ramasubbareddy Sathiyabhama Balasubramaniyam Anand Nayyar Chaker Abdelaziz Kerrache Muhammad Bilal | 2021 | China Communications2021，18，7： | 4 |
| 13 | Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees显示文摘Objective:To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris(G.vulgarix) Nees.Methods:G.vulgarix Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala. Various parts of this plant have been used in the treatment of ulcers,sores,inflammation, dyspepsia,healing of wounds,etc.The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation(HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.Results:Both the methods showed significant anti-inflammatory property of the different extracts tested. Conclusions:The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium. | TK Mohamed Saleem AK Azeem C Dilip C Sankar NV Prasanth R Duraisami | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 3 |
| 14 | Missing Pieces in the NF-κB Puzzle显示文摘 | Sankar Ghosh Michael Karin | 2002 | Cell2002，，2： | 3 |
| 15 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 16 | Factors associated with coverage of praziquantel for schistosomiasis control in the communitydirect intervention (CDI) approach in Mali (West Africa)显示文摘Background:Despite the progress made in the control of Neglected Tropical Diseases(NTD),schistosome and soil-transmitted helminth infections are far from being effectively managed in many parts of the world.Chemotherapy,the key element of all control strategies,is faced with some difficulties in terms of access to treatment.Our study aims to describe the factors involved in the success or failure of the community-directed intervention(CDI)approach through control programmes,which aims to achieve consistent high coverage at affordable and sustainable costs in endemic areas.Methods:The CDI approach was carried out from December 2007 to October 2008 in ten villages of the district of Diéma,Mali.At inclusion,each child part of the study’s sample was interviewed and submitted for a physical examination.The study focused on:data collection,treatment of the eligible population,evaluation of the treatment coverage,performance of community drug distributors(CDDs),and the involvement and perception of populations.Results:A total of 8,022 eligible people were studied with a mean coverage rate of 76.7%.Using multiple regression,it was determined that receiving praziquantel as treatment was associated with five factors:belonging to the Fulani or Moorish ethnic minority versus the Bambara/Soninke,use of the central versus the house-to-house drug distribution mode,the ratio of the population to the number of CDDs,the lack of supervision and belonging to the age group of 15 years or above(p<0.05).As well as that,it was found that the presence of parallel community-based programmes(HIV,tuberculosis)that provide financial incentives for community members discouraged many CDDs(who in most cases are volunteers)to participate in the CDI approach due to a lack of incentives.Conclusions:The findings indicate that the success of the CDI approach depends on,amongst other things,the personal characteristics of the respondents,as well as on community factors. | Abdoulaye Dabo Boubacar Bary Bourema Kouriba Oumar Sankaré Ogobara Doumbo | 2013 | Infectious Diseases of Poverty2013，2，1： | 3 |
| 17 | 负载型Pd基双金属催化剂的设计及其在环境领域的应用(英文)显示文摘负载型双金属催化剂在很多催化反应中都有着十分重要的意义,包括选择性氧化、加氢/氢解、重整、生物质转化等反应。这一类催化剂的活性、选择性和稳定性取决于颗粒尺寸、组成和形貌等结构特性。针对Pd基负载型双金属催化剂体系,本文讨论了其结构特性,并探讨了不同合成方法对结构性质的调控机制。同时,本文阐述了Pd基催化剂在环境催化反应中的应用,包括CO氧化、烃类氧化、加氢脱氯和NO_x分解等反应。尽管在这些领域的研究取得了一定的进展,然而还需要更先进的催化技术来应对一些重大的挑战,如环境修复等。最近,在材料、光谱、显微、催化化学以及工程领域的研究人员的共同努力下,通过先进表征方法、机理研究手段的采用以及构效关系的研究,针对双金属催化剂设计的研究取得了一些新的进展。本篇综述旨在激励相关领域科学家设计合理的新型催化剂体系,以用于未来的绿色及可持续发展。 | Ewa NOWICKA Meenakshisundaram SANKAR | 2018 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2018，19，1： | 3 |
| 18 | Chinese Grand Strategies in Central Asia:The Role of Shanghai Cooperation Organization and Belt and Road Initiative显示文摘Central Asia has long emerged as a hotspot for both the regional and extra-regional powers for two main reasons:its geopolitical location in the middle of Eurasia between Europe,South Asia,the Middle East,Russia and China,and their abundant and mostly unexplored natural resources.Sitting on huge untapped hydrocarbon potentials the Central Asian geographical entity in recent years has offered enormous opportunity and appeal for global countries and emerged as a grand chessboard for regional and extra-regional players.China is one such new pole in the new great game without which any geopolitical and geo-economic debate on Central Asia would be incomplete.With this prelude,this article attempts to analyse China's rise in Central Asia and its strategies to strengthen its position in the heartland region by discarding the much-hyped great game thesis and argues that China’s rise is unparallel and unmatched as testified by the recent Belt and Road Initiative of Beijing. | Ramakrushna Pradhan Siba Sankar Mohanty | 2021 | Fudan Journal of the Humanities and Social Sciences2021，14，2： | 3 |
| 19 | Gasification kinetic modelling of Victorian brown coal chars and validity for entrained flow gasification in CO_(2)显示文摘The gasification kinetic modelling of two Victorian brown coal(Yallourn and Maddingley)chars and the validity for entrained flow gasification were investigated in this study.The study was conducted in a thermogravimetric analyzer(TGA)at 750–1100℃,30%–90%CO_(2)concentration using different char particle sizes within 20–106 mm.It was found that random pore model and modified volumetric model are applicable for TGA results,but volumetric model and grain model are not.The effect of particle size under106 mm on gasification rate is very limited.Activation energies of Maddingley char and Yallourn char in CO_(2)gasification are 219–220 and 197–208 k J/mol,respectively.The pre-exponential factors are in the same order of magnitude,and they increased as particle size decreased.A mathematical model was developed to predict carbon conversion over time for entrained flow gasification of Victorian brown coal chars at 1000–1400℃. | Tao Xu Yongping Wu Sankar Bhattacharya | 2021 | International Journal of Mining Science and Technology2021，31，3： | 2 |
| 20 | Development and validation of a high throughput UPLC–MS/MS method for simultaneous quantification of esomeprazole,rabeprazole and levosulpiride in human plasma显示文摘A high throughput ultra pressure liquid chromatography–mass spectrometry(UPLC–MS/MS) method with good sensitivity and selectivity has been developed and validated for simultaneous quantification of esomeprazole,rabeprazole and levosulpiride in human plasma using lansoprazole as internal standard(IS).The extraction method based on liquid–liquid extraction technique was used to extract the analytes and IS from of 50 mL of human plasma using methyl tert-butyl ether:ethyl acetate(80:20,v/v),which offers a high recovery.Chromatographic separation of analytes and IS was achieved on a Hypersil gold C_(18) column using gradient mobile phase consisting of 2 mM ammonium formate/acetonitrile.The flow rate was set at 0.5 mL/min to elute all the analytes and IS within 1.00 min runtime.Detection of target compounds was performed on a triple quadruple mass spectrometer by multiple reaction monitoring(MRM) mode via positive electrospray ionization(ESI).Method validation results demonstrated that the developed method has good precision and accuracy over the concentration ranges of 0.1–2000 ng/mL for each analyte.Stability of compounds was established in a battery of stability studies,i.e.,bench top,autosampler,dry extract and long-term storage stability as well as freeze-thaw cycles.The validated method has been successfully applied to analyze human plasma samples for application in pharmacokinetic studies. | Raja Haranadha Babu Chunduri Gowri Sankar Dannana | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 2 |
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