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| 1 | Obese diet-induced mouse models of nonalcoholic steatohepatitis-tracking disease by liver biopsy显示文摘AIM:To characterize development of diet-induced nonalcoholic steatohepatitis(NASH)by performing live biopsy in wild-type and genetically obese mice.METHODS:Male wild-type C57BL/6J(C57)mice(DIO NASH)and male Lep ob/Lep ob(ob/ob)mice(ob/ob-NASH were maintained on a diet high in trans-fat(40%)fructose(22%)and cholesterol(2%)for 26 and 12 wk respectively.A normal chow diet served as control in C57 mice(lean chow)and ob/ob mice(ob/ob chow)After the diet-induction period,mice were liver biopsied and a blinded histological assessment of steatosis and fibrosis was conducted.Mice were then stratified into groups counterbalanced for steatosis score and fibrosi stage and continued on diet and to receive daily PO dosing of vehicle for 8 wk.Global gene expression in liver tissue was assessed by RNA sequencing and bioin formatics.Metabolic parameters,plasma liver enzyme and lipids(total cholesterol,triglycerides)as well a hepatic lipids and collagen content were measured b biochemical analysis.Non-alcoholic fatty liver disease activity score(NAS)(steatosis/inflammation/ballooningdegeneration)and fibrosis were scored.Steatosis and fibrosis were also quantified using percent fractional area.RESULTS:Diet-induction for 26 and 12 wk in DIONASH and ob/ob-NASH mice,respectively,elicited progressive metabolic perturbations characterized by increased adiposity,total cholesterol and elevated plasma liver enzymes.The diet also induced clear histological features of NASH including hepatosteatosis and fibrosis.Overall,the metabolic NASH phenotype was more pronounced in ob/ob-NASH vs DIO-NASH mice.During the eight week repeated vehicle dosing period,the metabolic phenotype was sustained in DIO-NASH and ob/ob-NASH mice in conjunction with hepatomegaly and increased hepatic lipids and collagen accumulation.Histopathological scoring demonstrated significantly increased NAS of DIO-NASH mice(0 vs4.7±0.4,P<0.001 compared to lean chow)and ob/ob-NASH mice(2.4±0.3 vs 6.3±0.2,P<0.001compared to ob/ob chow),respectively.Furthermore,fibrosis stage was significantly elevated for DIO-NASH mice(0 vs 1.2±0.2,P<0.05 compared to lean chow)and ob/ob NASH(0.1±0.1 vs 3.0±0.2,P<0.001compared to ob/ob chow).Notably,fibrosis stage was significantly(P<0.001)increased in ob/ob-NASH mice,when compared to DIO-NASH mice.CONCLUSION:These data introduce the obese dietinduced DIO-NASH and ob/ob-NASH mouse models with biopsy-confirmed individual disease staging as a preclinical platform for evaluation of novel NASH therapeutics. | Maria Nicoline Baandrup Kristiansen Sanne Skovgard Veidal Kristoffer Tobias Gustav Rigbolt Kirstine Sloth Tolbol Jonathan David Roth Jacob Jelsing Niels Vrang Michael Feigh | 2016 | World Journal of Hepatology2016，8，16： | 10 |
| 2 | 腹腔镜腹壁疝修补术SAGES指南显示文摘腹壁疝修补的目标是解除病人的症状和(或)治愈疝本身。近年来,越来越多的医生开展腹腔镜腹壁疝修补术,但是选择开放手术还是腹腔镜手术治疗腹壁疝仍有争议。该指南旨在为外科医生开展腹腔镜腹壁疝修补术时,在病人的选择、手术技术以及术后处理方面提供帮助。1方法用疝、腹壁、外科、腔镜、英语、人类等主题词,在Medline上进行文献检索。 | David Earle J.Scott Roth Alan Saber 陈大伟 | 2017 | 中国微创外科杂志2017，17，11： | 7 |
| 3 | Hepatocellular carcinoma after Iocoregional therapy:Magnetic resonance imaging findings in falsely negative exams显示文摘AIM:To elucidate causes for false negative magnetic resonance imaging(MRI)exams by identifying imaging characteristics that predict viable hepatocellular carcinoma(HCC)in lesions previously treated with locoregional therapy when obvious findings of recurrence are absent.METHODS:This retrospective institutional review board-approved and Health Insurance Portability and Accountability Act-compliant study included patients who underwent liver transplantation at our center between 1/1/2000 and 12/31/2012 after being treated for HCC with locoregional therapy.All selected patients had a contrast-enhanced MRI after locoregional therapy within 90 d of transplant that was prospectively interpreted as without evidence of residual or recurrenttumor.Retrospectively,2 radiologists,blinded to clinica and pathological data,independently reviewed the pre transplant MRIs for 7 imaging features.Liver explan histopathology provided the reference standard,with clinically significant tumor defined as viable tumor≥1.0cm in maximum dimension.Fisher’s exact test was firs performed to identify significant imaging features.RESULTS:Inclusion criteria selected for 42 patients with 65 treated lesions.Fourteen of 42 patients(33%and 16 of 65 treated lesions(25%)had clinically significant viable tumor on explant histology.None o the 7 imaging findings examined could reliably and reproducibly determine which treated lesion had viable tumor when the exam had been prospectively read as without evidence of viable HCC.CONCLUSION:After locoregional therapy some treated lesions that do not demonstrate any MRI evidence o HCC will contain viable tumor.As such even patients with a negative MRI following treatment should receive regular short-term imaging surveillance because some have occult viable tumor.The possibility of occult tumo should be a consideration when contemplating any action which might delay liver transplant. | David Becker-Weidman Jesse M Civan Sandeep P Deshmukh Christopher G Roth Steven K Herrine Laurence Parker Donald G Mitchell | 2016 | World Journal of Hepatology2016，8，16： | 2 |
| 4 | An assessment of the efficacy and safety of eszopiclone in the treatment of transient insomnia in healthy adults显示文摘 | Russell Rosenberg Judy Caron Thomas Roth David Amato | 2004 | Sleep Medicine2004，，1： | 2 |
| 5 | Opportunities for treatment of the hepatitis C virus-infected patient with chronic kidney disease显示文摘The prevalence of hepatitis C virus(HCV) infection amongst patients with chronic kidney disease(CKD) and end-stage renal disease exceeds that of the general population. In addition to predisposing to the development of cirrhosis and hepatocellular carcinoma, infection with HCV has been associated with extra-hepatic complications including CKD, proteinuria, glomerulonephritis, cryoglobulinemia, increased cardiovascular risk, insulin resistance, and lymphoma. With these associated morbidities, infection with HCV is not unexpectedly accompanied by an increase in mortality in the general population as well as in patients with kidney disease. Advances in the understanding of the HCV genome have resulted in the development of direct-acting antiviral agents that can achieve much higher sustained virologic response rates than previous interferon-based protocols. The direct acting antivirals have either primarily hepatic or renal metabolism and excretion pathways. This information is particularly relevant when considering treatment in patients with reduced kidney function. In this context, some of these agents are not recommended for use in patients with a glomerular filtration rate < 30 m L/min per 1.73 m^2. There are now Food and Drug Administration approved direct acting antiviral agents for the treatment of patients with kidney disease and reduced function. These agents have been demonstrated to be effective with sustained viral response rates comparable to the general population with good safety profiles. A disease that was only recently considered to be very challenging to treat in patients with kidney dysfunction is now curable with these medications. | Marco Ladino Fernando Pedraza David Roth | 2017 | World Journal of Hepatology2017，9，19： | 2 |
| 6 | Single Event Testing of DC/DC Conwerters for Space Flight显示文摘 | Kevin Warren David Roth Jim Kinnison | 2002 | IEEE2002，10，02： | 1 |
| 7 | Randomized trial of hematocrit 25% versus 35% during hypothermic cardiopulmonary bypass in infant heart surgery显示文摘 | Jane W. Newburger Richard A. Jonas Janet Soul Barry D. Kussman David C. Bellinger Peter C. Laussen Richard Robertson John E. Mayer Pedro J. del Nido Emile A. Bacha Joseph M. Forbess Frank Pigula Stephen J. Roth Karen J. Visconti Adre J. du Plessis David M | 2007 | The Journal of Thoracic and Cardiovascular Surger2007，，2： | 1 |
| 8 | Lasting Epigenetic Influence of Early-Life Adversity on the BDNF Gene显示文摘 | Tania L. Roth Farah D. Lubin Adam J. Funk J. David Sweatt | 2009 | Biological Psychiatry2009，，9： | 1 |
| 9 | Are dysplasia and colorectal cancer endoscopically visible in patients with ulcerative colitis?显示文摘 | David T. Rubin Jami A. Rothe Jeremy T. Hetzel Russell D. Cohen Stephen B. Hanauer | 2007 | Gastrointestinal Endoscopy2007，，7： | 1 |
| 10 | Coronary Calcification, Coronary Disease Risk Factors, C-Reactive Protein, and Atherosclerotic Cardiovascular Disease Events显示文摘 | Yadon Arad Kenneth J. Goodman Marguerite Roth David Newstein Alan D. Guerci | 2005 | Journal of the American College of Cardiology2005，，1： | 1 |
| 11 | Relationships among self-monitoring processes,memory,and depression显示文摘 | David Roth Lynn P Rehm | | 0，，02： | 1 |
| 12 | Follicular dynamics and concentrations of steroids and gonadotropins in lactating cows and nulliparous heifers显示文摘 | David Wolfenson Gil Inbar Zvi Roth | 2004 | Theriogenology2004，62，： | 1 |
| 13 | Exercise, APOE, and working memory: MEG and behavioral evidence for benefit of exercise in epsilon4 carriers显示文摘 | Sean P. Deeny David Poeppel Jo B. Zimmerman Stephen M. Roth Josef Brandauer Sarah Witkowski Joseph W. Hearn Andrew T. Ludlow José L. Contreras-Vidal Jason Brandt Bradley D. Hatfield | 2008 | Biological Psychology2008，，2： | 1 |
| 14 | Follicular dynamics and concentrations of steroids and gonadotropins in lactating cows and nulliparous heifers 显示文摘 | David Wolfenson Gil Inbar Zvi Roth | 2004 | Theriogenology2004，，62： | 1 |
| 15 | Does Prenatal WIC Participation Improve Birth Outcomes? New Evidence from Florida 显示文摘 | David Figlio Sarah Hamersma and Jeffrey Roth | 2009 | Journal of Public Economics2009，93，： | 1 |
| 16 | In Praise of Cultural Imperialism 显示文摘 | Roth Kopf David | 1997 | Foreign Policy1997，，107： | 1 |
| 17 | Quality Indicators for the Management of Medical Conditions in Nursing Home Residents显示文摘 | Debra Saliba David Solomon Laurence Rubenstein Roy Young John Schnelle Carol Roth Neil Wenger | 2004 | Journal of the American Medical Directors Association2004，，3： | 1 |
| 18 | Fixation of hand fractures with bicortical screws显示文摘 | Jeffrey J. Roth David M. Auerbach | 2005 | Journal of Hand Surgery2005，，1： | 1 |
| 19 | Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks显示文摘The systemic processes involved in the manifestation of life・threatening COVID-19 and in disease recovery are still incompletely understood,despite investigations focusing on the dysregulation of immune responses after SARS-CoV-2 infection.To define hallmarks of severe COVID-19 in acute disease(n=58)and in disease recovery in con valesce nt patie nts(n=28)from Han nover Medical School,we used flow cytometry and proteomics data with unsupervised clustering analyses.In our observational study,we combined analyses of immune cells and cytokine/chemokine networks with endothelial activation and injury.ICU patients displayed an altered immune signature with prolonged lymphopenia but the expansion of granulocytes and plasmablasts along with activated and terminally differentiated T and NK cells and high levels of SARS-CoV-2-specific antibodies.The core signature of seven plasma proteins revealed a highly inflammatory microenvironment in addition to endothelial injury in severe COVID-19.Changes within this sign ature were associated with either disease progression or recovery.In summary,our data suggest that besides a strong inflammatory response,severe COVID-19 is driven by endothelial activation and barrier disruption,whereby recovery depends on the regeneration of the endothelial integrity. | Louisa Ruhl Isabell Pink Jenny F.Kiihne Kerstin Beushausen Jana Keil Stella Christoph Andrea Sauer Lennart Boblitz Julius Schmidt Sascha David Hans-Martin Jack Edith Roth Markus Cornberg Thomas F.Schulz Tobias Welte Marius M.Hoper Christine S.Falk | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 20 | Does the Timing of Esophagectomy After Chemoradiation Affect Outcome?显示文摘 | Jae Y. Kim Arlene M. Correa Ara A. Vaporciyan Jack A. Roth Reza J. Mehran Garrett L. Walsh David C. Rice Jaffer A. Ajani Dipen M. Maru Manoop S. Bhutani James Welsh Edith M. Marom Stephen G. Swisher Wayne L. Hofstetter | 2012 | The Annals of Thoracic Surgery2012，，1： | 1 |
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