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| 1 | Avian hepatitis B viruses: Molecular and cellular biology, phylogenesis, and host tropism显示文摘人的肝炎 B (HBV ) 和鸭肝炎 B (DHBV ) 分享几个基本特征。两个病毒有一部分,经由 RNA 中介和编码开的读物被复制的双 stranded DNA 染色体装裱(ORF ) 广泛地重叠。另外, genomic 和生物特征,在两个病毒是很类似的。大多数 hepadnaviral 感染的特色首先在 DHBV 模型系统被发现并且随后为 HBV 证实了。然而,人的 HBV 和 DHBV 之间有几差别。这评论将作为一个模型系统在 DHBV 上与特别强调集中于鸟的肝炎 B 的分子、细胞的生物学,进化,和主人改编。 | Anneke Funk Mouna Mhamdi Hans Will Hüseyin Sirma | 2007 | World Journal of Gastroenterology2007，13，1： | 15 |
| 2 | Collections-based systematics: Opportunities and outlook for 2050显示文摘系统的生物学是在集合生根的一个学科。这些集合在研究和保存起重要作用并且对我们关于生物多样性和保存教育社会的努力不可分。集合在全世界并且整个最近、地质的时间提供有机体的分发的一个无价的记录,并且他们是行星的生物、物理、文化的差异的唯一的直接文档:过去,现在,和未来。在生物信息学和 cyberinfrastructure 的最近的开发由开创新机会正在转变 systematics,作为一个结果学生, digitization 努力逐渐地使大量生物多样性数据可得到。训练的基于收集的 systematics 社区需要有综合技巧的组织主义者下一代,在不同规模关于生物多样性探讨宏大问题,开发社区宽的 cyberinfrastructure ,有效地传播系统的数据到生物学家和公众,并且积极地在 Anthropocene 的生物多样性危机在 systematics 和集合的重要性上教育公众和政策制造者。明确地,我们要求新全球生物多样性 CyberBank,比得上为基因数据的 GenBank,主修是所有生物多样性数据,以及系统的生物学的一个世界组织的仓库带这域的行动。我们也为分类的书构画出新工作流,它两个都利用综合的传统的力量多样的基于收集的分类数据和联机资源和生物信息学工具的能力。 | Jun Wen Stefanie M. Ickert-Bond Marc S. Appelhans Laurence J. Dorr Vicki A. Funk | 2015 | Journal of Systematics and Evolution2015，53，6： | 15 |
| 3 | The RNA component of human telomerase显示文摘 | Feng J Funk WD Wang SS | | 0，，： | 13 |
| 4 | Using phylogenomics to resolve mega-families: An example from Compositae显示文摘为阐明的下一代的定序和 phylogenomics 抓住伟人诺言在大植物家庭之中的复杂关系。这里,我们执行了在大、多样的被子植物家庭 Compositae (Asteraceae ) 的在 Illumina 站台上的下一代的定序跟随的低拷贝序列的指向的俘获。家庭是 monophyletic 基于形态学和分子的数据,然而,发展史的许多区域有未解决的 polytomies 和解释种系发生的模式是历史上困难的。以便构画出一个方法并且提供一个框架并且为未来在 Compositae 的种系发生的研究,我们从越过关系很好象姐妹家庭 Calyceraceae 的一个成员一样在被建立的家庭定序 23 taxa。我们从 795 产生了原子数据从离开目标俘获的 loci 和装配叶绿体染色体读启用比较原子并且为种系发生的分析的叶绿体染色体。我们也分析了在我们的数据的原子基因在 orthology 察觉期间用一个聚类的方法设置了的多拷贝,并且我们把一条网络途径用于所有相关地点拷贝的这些 clusters—analyzing。用这些数据,我们生产了两个都雇用一个保守人士的种系发生的关系的假设(每指向的地点与一个拷贝限制了为仅仅 loci ) 并且一条 multigene 途径(每指向的地点包括所有拷贝) 。这里介绍的方法和生物信息学工作流为针对象在另外的工厂为 phylogenomic 分析提供一个模型一样在 Compositae 理解基因家庭进化的未来工作提供一个稳固的基础大家庭。 | Jennifer R. Mandel Rebecca B. Dikow Vicki A. Funk | 2015 | Journal of Systematics and Evolution2015，53，5： | 11 |
| 5 | Collections-based science in the 21st Century显示文摘 | Vicki A. Funk | 2018 | Journal of Systematics and Evolution2018，56，3： | 9 |
| 6 | 基于FRN技术的我国不同地区典型土壤保持措施的有效性评价显示文摘选择中国西南-东北样带4个典型土壤侵蚀区,包括位于长江上游的西昌,黄土高原延安,北方风蚀区的丰宁和东北黑土区的拜泉,应用环境放射性核素(FRN)技术研究了不同土壤保持措施在减少土壤侵蚀、改善土壤质量方面的作用。在西昌,137Cs和210Pbex的测定结果表明,不同植被覆盖结构减少土壤侵蚀的作用为:灌木>有地被物的乔木>草类>无地被物的乔木;在延安,利用137Cs示踪技术对坡地景观的产沙量估算结果表明,梯田和林草地相对于坡耕地产沙量分别减少了49%和80%,林草地的土壤有机质、碱解氮和速效磷含量相对于坡耕地分别增加了255%、198%和18%,梯田土壤有机质、碱解氮和速效磷含量分别增加了121%、103%和162%,而土壤容重分别降低了1.6%和6.4%;在丰宁,对7Be的测定结果表明,与传统耕作方式相比,4年免耕+作物高留茬(50~56cm)和免耕+作物低留茬(25cm)分别使土壤侵蚀速率下降44%和33%;在拜泉,通过137Cs测定结果发现,坡改梯使土壤流侵蚀降低14%,等高耕作使土壤侵蚀量减少了34%。研究结果说明,灌木林覆盖、林草复合结构是控制西南侵蚀山地土壤侵蚀的优选生物配置措施,梯田和林草复合结构在控制黄土高原土壤侵蚀和改善土壤质量方面有重要作用,免耕+高留茬措施是我国北方风蚀区防治土壤侵蚀退化的有效措施,等高耕作应当成为防治东北黑土区土壤侵蚀的关键措施。 | 于寒青 李勇 Nguyen M L Funk R 刘国强 李俊杰 无 | 2012 | 核农学报2012，26，2： | 6 |
| 7 | Effects of biological soil crusts and drought on emergence and survival of a Patagonian perennial grass in the Monte of Argentina显示文摘Biological soil crusts are widely distributed in arid and semiarid regions. They have an important ecological role, especially by modifying physical and chemical properties of soils. Biological crusts may also modify seed germination and seedling establishment. The effects vary widely according to the type of crust and the vascular plant species. The objective of this study was to determine the effect of moss-dominated biological soil crusts on the emergence, biomass and survival of Poa ligularis Nees ex Steud. under different irrigation regimes. We collected seeds of P. ligularis and biological soil crusts composed of two species of mosses: Syntrichia princeps(De Not.) Mitt and Ceratodon purpureus(Hedw.) Brid. from an area in the Monte of Argentina. The result showed that seedling emergence of P. ligularis was higher in treatments with bare soil than in soil covered by crusts, and also in those with watering to field capacity. Mean emergence time was higher in treatments with bare soil and watering to field capacity. Seedling biomass also showed significant differences between treatments. These results suggest that biological soil crusts dominated by mosses do not promote P. ligularis emergence, although they would not affect its survival. | Flavia Alejra FUNK Alejro LOYDI Guadalupe PETER | 2014 | Journal of Arid Land2014，6，6： | 5 |
| 8 | The Compositae Tree of Life in the age of phylogenomics显示文摘包括超过 25000 种类,葵花家庭(Compositae 或 Asteraceae ) 是 flowering 植物的最大的家庭。许多它的系经历了最近、快速的放射,和家庭有大规模基因复制和 polyploidy 的深、普遍的历史。许多由于对发展史的主要节点的支持的差的分辨率和缺乏关于家庭差异的最重要的进化问题仍然保持未答复。我们的组用包括定序 1000 低拷贝的数字的 Hyb-Seq 采用了一条 phylogenomics 途径原子标记,为大量种类的正部分 plastomes。这里,我们讨论我们的进步标明日期并且介绍包括九个亚科和 25 个部落用的二发展史并置并且基于结合的分析。我们为合并高质量的参考染色体和 transcriptomes 在 Compositae 推进系统、进化的研究讨论未来计划。当我们向为采用 phylogenomics 并且在 Compositae 以内解决关系开发工具做了大迈进时,许多工作留下。最近形成的全球合伙将工作 megafamily 为这解决未答复的进化问题。 | Jennifer R. Mandel Michael S. Barker Randall J. Bayer Rebecca B. Dikow Tian-Gang Gao Katy E. Jones Sterling Keeley Norbert Kilian Hong Ma Carolina M. Siniscalchi Alfonso Susanna Ramhari Thapa Linda Watson Vicki A. Funk | 2017 | Journal of Systematics and Evolution2017，55，4： | 4 |
| 9 | 与GNA11体细胞突变相关的先天性血管瘤和先天性血管瘤病显示文摘先天性血管瘤是一种罕见的良性血管性肿瘤,出生时即被发现,常呈孤立型。该文作者报高1例男性患儿,出生时即发现巨大血管性肿物,并伴发贫血、血小板减少及广泛的凝血障碍,皮肤见大量散在的小血管丘疹。手术切除后,标本进行免疫组织化学及基因检测。 | Funk T Lim Y Kulungowski AM | 2016 | 中国口腔颌面外科杂志2016，14，5： | 3 |
| 10 | Definitive management of severe facial trauma utilizing free tissue transfer显示文摘 | Neal D. Futran D. Gregory Farwell Russell B. Smith Paul E. Johnson Gerry F. Funk | 2005 | Otolaryngology - Head and Neck Surgery2005，，1： | 3 |
| 11 | 环境放射性核素^(137)Cs和^(210)Pb_(ex)的田间原位测定研究显示文摘原位现场γ谱仪具有快速准确监测土壤中环境放射性核素137Cs和210Pbex的潜力,可以解决传统环境放射性核素示踪土壤侵蚀在选择参考点和测定时间过长问题。本研究应用现场γ谱仪(ISOCS,In-situObject Counting System),对内蒙古锡林浩特草原土壤中137Cs和210Pbex的含量进行了田间原位(不采样)测定,并与室内γ谱仪测定结果进行了比对。结果显示:现场γ谱仪的探头离地面1m,采用90度准直器,测量时间保证3600s以上时,测定的土壤中137Cs面积浓度与室内测定结果一致,二者的平均偏差为8%,表明现场γ谱仪测定具有较高精度,是快速评价土壤侵蚀速率的有效技术;210Pbex的原位测定结果显著高于室内测定结果,可能由于测定时间较短所致。初步研究结果表明:原位测定具有时间短、精度高的优点,可以克服传统采样造成的空间变异误差。 | 李勇 李俊杰 Roger Funk 李璐 张晴雯 | 2007 | 核农学报2007，21，6： | 2 |
| 12 | CETP新突变点Ala373Pro和Arg451Gln及其座位关系显示文摘收集在脂质专科门诊就诊者中血清高密度脂蛋白-胆固醇(HDL-C)高于1.8mmol/L者的全血标本,通过聚合酶链反应(PCR)技术扩增胆固醇酯转运蛋白(CETP)基因,继而采用荧光直读法进行CETP基因组DNA序列分析,首次发现一女性先驱者同时携带CETP基因两个新的突变点,即CETP第373位丙氨酸为脯氨酸取代(Ala373Pro)和第451位精氨酸突变为谷氨酰胺(Arg451Gln).采用等位基因特异性长片段PCR技术进一步研究表明该先驱者所携带的两个CETP基因新突变点Ala373Pro和Arg451Cln位于同一染色体. | 陆付耳 黄光英 李鸣真 叶望云 Heiko Wiebusch Harald Funke Gerd Assmann | 1998 | 中国心血管杂志1998，3，6： | 2 |
| 13 | Development of an event-specific Real-time PCR detection method for the transgenic Bt rice line KMD1显示文摘 | Ruzha Babekova Tristan Funk Sven Pecoraro Karl-Heinz Engel Ulrich Busch | 2009 | European Food Research and Technology2009，，5： | 2 |
| 14 | Complete loss of RNA editing from the plastid genome and most highly expressed mitochondrial genes of Welwitschia mirabilis显示文摘Comparative genomics among gymnosperms suggested extensive loss of mitochondrial RNA editing sites from Welwitschia mirabilis based on predictive analysis. However, empirical or transcriptome data to confirm this massive loss event are lacking,and the potential mechanisms of RNA site loss are unclear. By comparing genomic sequences with transcriptomic and reversetranscription PCR sequencing data, we performed a comprehensive analysis of the pattern of RNA editing in the mitochondrial and plastid genomes(mitogenome and plastome, respectively) of W. mirabilis and a second gymnosperm, Ginkgo biloba. For W.mirabilis, we found only 99 editing sites located in 13 protein-coding genes in the mitogenome and a complete loss of RNA editing from the plastome. The few genes having high editing frequency in the Welwitschia mitogenome showed a strong negative correlation with gene expression level. Comparative analyses with G. biloba, containing 1,405 mitochondrial and 345 plastid editing sites, revealed that the editing loss from W. mirabilis is mainly due to the substitution of editable cytidines to thymidines at the genomic level, which could be caused by retroprocessing. Our result is the first study to uncover massive editing loss from both the mitogenome and plastome in a single genus. Furthermore, our results suggest that gene expression level and retroprocessing both contributed to the evolution of RNA editing in plant organellar genomes. | Weishu Fan Wenhu Guo Lexis Funk Jeffrey P.Mower Andan Zhu | 2019 | Science China(Life Sciences)2019，62，4： | 2 |
| 15 | Proteome alterations in aqueous humour of primary open angle glaucoma patients显示文摘AIM: To unravel the primary open angle glaucoma(POAG) related proteomic changes in aqueous humour(AH).METHODS: Totally 35 patients listed for cataract surgery(controls: n=12, age: 67.4±13.6 y) or trabeculectomy for POAG(n=23, age: 72.5±8.3 y) were included. AH samples of those patients were obtained during cataract surgery or trabeculectomy. AH samples were subsequently pooled into the experimental groups under equal contribution in terms of protein amount of each individual patient. Protein samples were analyzed by a linear trap quadrupol Orbitrap Mass Spectrometry device with an upstream liquid chromatography system. The obtained raw data were analyzed using the Maxquant proteome software and compared. Proteins with a fold-change ratio higher than a cut-off of 2 were considered as noticeably altered.RESULTS: A total number of 175 proteins could be identified out of the AH from POAG and cataract by means of quantitative mass spectrometric analysis. Apolipoprotein D(fold change, 3.16 times), complement C3(2.96), pigment epithelium-derived factor(2.86), dickkopf-related protein 3(2.18) and wingless-related integration(Wnt) inhibitory factor 1(2.35) were significantly upregulated within the AH of glaucoma compared to cataract serving as controls.CONCLUSION: AH provides a tool to analyze changes in glaucoma and shows striking changes in Wnt signaling inhibitory molecules and other proteins. | Hanhan Liu Fabian Anders Sebastian Funke Karl Mercieca Franz Grus Verena Prokosch | 2020 | International Journal of Ophthalmology(English edition)2020，13，1： | 2 |
| 16 | 中美冠心病监护病房护理工作的调查与比较显示文摘 | 刘绍辉 张琼 Jae Patton Marge Funk | 2001 | 护士进修杂志2001，16，3： | 2 |
| 17 | Regulation of Enterocyte Apoptosis by Acyl-CoA Synthetase 5 Splicing显示文摘 | Nikolaus Gassler Wilfried Roth Benjamin Funke Armin Schneider Frank Herzog Jens J.W. Tischendorf Kerstin Grund Roland Penzel Ignacio G. Bravo John Mariadason Volker Ehemann Jaromir Sykora Tobias L. Haas Henning Walczak Tom Ganten Hanswalter Zentgraf Peter | 2007 | Gastroenterology2007，，2： | 2 |
| 18 | 交互性数字公共艺术设计实践与体验评估显示文摘公共艺术设计中新材料和新技术的运用,提升了参与者的互动体验。本文呈现了Blobulous和Strijp-T-ogether两个设计案例,提出交互性数字公共艺术的设计手法和用户体验及评估方法,表明其可在社会与文化计算领域进行新的研究。 | 王峰 胡军 Mathias Funk | 2015 | 装饰2015，，9： | 2 |
| 19 | The Coming Resolution of the European Crisis显示文摘Doom and gloom about the euro abounds. An increasing number of commentators and economists, including here at the Peterson Institute, have begun to question whether the common currency can survive.The economic and financial problems in the euro area are clearly | C.Fred Bergsten Jacob Funk Kirkegaard | 2012 | China's Foreign Trade2012，，3： | 2 |
| 20 | The long-run relationship between productivity and capital显示文摘 | Funk Mark Strauss Jack | 2000 | Economic Letters2000，69，2： | 1 |
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