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| 1 | Follicular dynamics and concentrations of steroids and gonadotropins in lactating cows and nulliparous heifers显示文摘 | David Wolfenson Gil Inbar Zvi Roth | 2004 | Theriogenology2004，62，： | 1 |
| 2 | Follicular dynamics and concentrations of steroids and gonadotropins in lactating cows and nulliparous heifers 显示文摘 | David Wolfenson Gil Inbar Zvi Roth | 2004 | Theriogenology2004，，62： | 1 |
| 3 | Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis:Uremic pruritus is still a major problem for patients with end-stage renal disease显示文摘 | Inbar Zucker Gil Yosipovitch Michael David | 2003 | J AM ACAD Dermatol2003，49，： | 1 |
| 4 | Effect of patient COVID-19 vaccine hesitancy on hospital care team perceptions显示文摘BACKGROUND The coronavirus disease 2019(COVID-19)pandemic posed new challenges in patient care worldwide.Vaccinations,which have proven efficacious in lowering the COVID-19 hospital burden,are still avoided by large populations.We,therefore,hypothesized that hospital care teams would have worse perceptions regarding the characteristics and care of patients with vaccine hesitancy.AIM To evaluate whether patient vaccine hesitancy affected the hospital care team(HCT)perceptions.METHODS We performed a prospective clinical study using structured questionnaires.We approached physicians and nurses with previous experience caring for COVID-19patients from 11 medical centers across Israel during the fourth COVID-19 surge(September and October 2021).The participants completed a questionnaire with the following parts:(1)Sociodemographic characteristics;(2)Assessment of anger(STAXI instrument)and chronic workplace stress(Shirom-Melamed burnout measure);and(3)Three tools to assess the effect of patient vaccine hesitancy on the HCT perceptions(the difficult doctor-patient relation questionnaire,the medical staff perception of patient’s responsibility questionnaire and the characterological derogation questionnaire).Results were evaluated according to each part of the questionnaire and the questionnaire as a whole.Associations between HCT perceptions and their baseline characteristics,anger or chronic workplace stress were assessed.RESULTS The HCT experienced their relationship with unvaccinated patients as more difficult(P<0.001,Cohen’s d=0.85),perceived unvaccinated patients as responsible for their medical condition(P<0.001,d=1.39)and perceived vaccinated patients as having a higher character value(P<0.001,d=1.03).Unvaccinated patients were considered selfish(P<0.001),less mature(P<0.001)and less satisfying to care for(P<0.001).The relationship with unvaccinated patients was more difficult among HCT with higher burnout(r=0.37,n=66,P=0.002).No correlations with baseline characteristics were found.All three study tools showed high internal consistency(αbetween 0.72 and 0.845).CONCLUSION Our results should raise awareness of the possible effects of vaccine hesitancy on HCT perceptions regarding unvaccinated patients.In order to minimize the potential negative impact on patient care,designated departments should promote specific patient-centered preparations.Further investigations should assess whether vaccine hesitancy directly affects patient quality of care. | Inbar Caspi Ophir Freund Omer Pines Odelia Elkana Jacob N Ablin Gil Bornstein | 2023 | World Journal of Clinical Cases2023，11，4： | 0 |
| 5 | Antitumoral effects of cannabis in Notch1-mutated T-cell acute lymphoblastic leukemia显示文摘Dear Editor,In T-cell acute lymphoblastic leukemia(T-ALL),an aggressive hematologic cancer with poor clinical outcomes,more than 50%of cases show NOTCH1-driven transformation[1].The NOTCH1 receptor signaling pathway is activated through a series of proteolytic cleavages,ultimately causing the release of the active intracellular domain(NICD),which translocates to the nucleus where it promotes transcription of target genes involved in cell growth.The importance of NOTCH1 mutations in T-ALL has generated great interest in the development of anti-NOTCH1 targeted therapies.A new and promising emerging field in cancer treatment is medical cannabis.Accumulating evidence suggests the direct effects of cannabis on tumor progression in cell lines and animal models[2].Cannabis,and its unique secondary metabolites,known as phytocannabinoids,directly affect the propagation of cancer cells by modulating key cellsignaling pathways[3].We have previously demonstrated that different cannabis extracts,each containing a unique composition of metabolites,selectively impaired the survival of cancer cell lines depending on amatch between the chemical composition of the extract and the characteristics of the specific cancer cell line[4].In the present work,we set out to investigate whether cannabis extracts with unique phytocannabinoid profiles can selectively facilitate antitumor effects in T-ALL cells that harbor a Notch1 mutation. | Elazar Besser Anat Gelfand Gil Moshe Lewitus Hila Novak-Kotzer Shiri Procaccia Paula Berman Igal Louria-Hayon Inbar Shreiber-Livne Yishai Ofran David Meiri | 2023 | Cancer Communications2023，43，6： | 0 |
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