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| 1 | 应用中国商环包皮环切手术标准化方案对328例成年男性包皮环切的临床报告显示文摘目的:成年男性包皮环切手术标准化和培训可显著降低因手术引起的并发症发生率。由于目前国内外尚无可供参考的成年男性包皮环切手术标准化方案和培训制度,使得临床医生开展成年男性包皮环切手术的质量无法保证。为了建立成年男性包皮环切手术标准化和培训制度,便于临床医生和相关医护人员学习和掌握包皮环切器的临床应用技巧,以中国商环(简称'商环,ShangRing')包皮环切技术为例,根据商环的技术特点和临床实践经验,特别制订了商环包皮环切手术标准化方案,并将其标准化操作运用于临床。方法:采用商环包皮环切手术标准化方案对328例受术者(年龄18~58岁,平均27.8岁;已婚134例,未婚194例;包茎25例,包皮过长303例)进行包皮环切手术。对手术时间、疼痛评分(视觉模拟评分法,VAS)、术后并发症、包皮创口愈合时间、术后外观满意情况进行观察和随访。结果:手术时间为(4.70±1.31)min。手术时受术者疼痛(VAS)评分为(0.24±0.59)分,术后24h疼痛评分为(1.59±0.95)分,去环前24h内疼痛评分(1.72±1.11)分,去环时疼痛评分为(2.72±1.37)分。主要并发症发生率为术后感染0.6%(2/328)、出血0.6%(2/328)、伤口裂开0.6%(2/328)和水肿4.89%(16/328)。在发生出血和伤口裂开的受术者中无1例需要缝合。术后包皮创口完全愈合时间为(20.30±6.69)d。受术者对术后外观满意率99.7%(327/328)。结论:商环包皮环切术具有手术方式易于标准化、手术时间短、术中疼痛轻、术后无须特殊护理、容易完整保留系带,并完全暴露冠状沟、术后外观满意度高、受术者易于接受等优点。初步证明了中国商环包皮环切手术标准化方案的可接受性,严格按照此方案实施手术和随访护理,能最大化地实现商环包皮环切技术的诸多临床优势,将并发症发生率控制在可接受的范围内。 | 程跃 彭弋峰 刘毅东 田龙 吕年青 苏新军 严泽军 胡嘉盛 Richard LEE Howard KIM David C. SOKAL 李石华 | 2009 | 中华男科学杂志2009，15，7： | 155 |
| 2 | 中国建立男性包皮环切手术标准化和培训的重要性显示文摘尽管HIV在非洲的大流行仍然是一个严重的问题,而在其他地区,如亚洲和南美洲,HIV感染率也正在迅速上升。国际健康组织已经认识到有必要制定有效的策略来检测和控制全球HIV的传播。研究表明,男性包皮环切能显著降低HIV、人乳头状瘤病毒(HPV)、单纯疱疹病毒2型(HSV-2)和其他性传播疾病(STD)的感染率。虽然男性包皮环切技术有许多,但是没有标准化的手术方案和培训计划。研究表明,男性包皮环切技术的标准化与培训计划的实施可以大大降低并发症发生率。并发症发生率高是实施男性包皮环切服务的一个主要障碍。我们建议,在推广男性包皮环切之前应建立手术标准和培训计划。 | 李石华 吕年青 程跃 彭弋峰 田龙 刘毅东 贲昆龙 徐建春 Richard LEE Howard KIM David C.SOKAL | 2009 | 中华男科学杂志2009，15，5： | 56 |
| 3 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 4 | Histone acetyltransferase GCN5 interferes with the miRNA pathway in Arabidopsis显示文摘MicroRNAs (miRNA ) 指导在基因表示的一个重要角色在植物为到环境条件的发展进程和回答要求了的顺序特定的 posttranscriptional 基因 silencing 玩。然而,很少对 transcriptional 和 miRNA 表示的 posttranscriptional 规定被知道。Histone acetylation 在染色质改变起一个重要作用并且为基因激活被要求。由在 Arabidopsis 的异种分析 miRNAs 和相应主要 miRNAs 的子集的累积,我们显示出那 histone acetyltransferase GCN5 (一般控制非镇压的 protein5 )在 miRNA 上有一般压抑的效果生产,当它为一个子集的表示被要求时(例如压力可诱导) MIRNA 基因。在 miRNA 生产的 GCN5 的一般否定功能多半通过象 DICER LIKE1 (DCL1 ) 那样的 miRNA 机械基因的间接压抑被完成,有锯齿(SE ) ,偏下性的 LEAVES1 (HYL1 ) 和 ARGONAUTE1 (AGO1 ) 。染色质 immunoprecipitation 试金表明 GCN5 指向到 MIRNA 基因的一个子集并且为在这些 loci 的 histone H3 离氨酸 14 的 acetylation 被要求。而且,由 trichostatin 的 histone deacetylation 的抑制一个处理或在 histone deacetylase,基因异种损害了某些 miRNAs 的累积。这些数据一起建议 Arabidopsis GCN5 在 transcriptional 和 posttranscriptional 层次防碍 miRNA 小径, histone acetylation/deacetylation 是涉及 miRNA 的规定的 epigenetic 机制生产。 | Wanhui Kim Moussa Benhamed Caroline Servet David Latrasse Wei Zhang Marianne Delarue Dao-Xiu Zhou | 2009 | Cell Research2009，19，7： | 10 |
| 5 | Effect of cavity flow control on high-speed train pantograph and roof aerodynamic noise显示文摘The pantograph and its recess on the train roof are major aerodynamic noise sources on high-speed trains.Reducing this noise is particularly important because conventional noise barriers usually do not shield the pantograph.However,less attention has been paid to the pantograph recess compared with the pantograph.In this paper,the flow features and noise contribution of two types of noise reduction treatments rounded and chamfered edges are studied for a simplified high-speed train pantograph recess,which is represented as a rectangular cavity and numerically investigated at 1/10 scale.Improved delayed detached-eddy simulations are performed for the near-field turbulent flow simulation,and the Ffowcs Williams and Hawkings aeroacoustic analogy is used for far-field noise prediction.The highly unsteady flow over the cavity is significantly reduced by the cavity edge modifications,and consequently,the noise radiated from the cavity is reduced.Furthermore,effects of the rounded cavity edges on the flow and noise of the pantographs(one raised and one folded)are investigated by comparing the flow features and noise contributions from the cases with and without rounding of the cavity edges.Different train running directions are also considered.Flow analysis shows that the highly unsteady flow within the cavity is reduced by rounding the cavity edges and a slightly lower flow speed occurs around the upper parts of the raised pantograph,whereas the flow velocity in the cavity is slightly increased by the rounding.Higher pressure fluctuations occur on the folded pantograph and the lower parts of the raised pantograph,whereas weaker fluctuations are found on the panhead of the raised pantograph.This study shows that by rounding the cavity edges,a reduction in radiated noise at the side and the top receiver positions can be achieved.Noise reductions in the other directions can also be found. | Hogun Kim Zhiwei Hu David Thompson | 2020 | Railway Engineering Science2020，28，1： | 10 |
| 6 | 丰田汽车公司实施精益管理对医疗行业的启示显示文摘介绍了丰田汽车公司实施精益管理的基本概念、实际运用方法及当前状态价值流图的作用,举例说明了医疗行业引入精益管理的必要性及良好效果,阐述了精益管理从企业文化、流程优化、经营效率等方面带给医疗行业的启示。 | Christopher S. Kim David A. Spahlinger Jeanne M. Kin John E. Billi 袁进 | 2009 | 中华医院管理杂志2009，25，2： | 9 |
| 7 | GIGANTEA and EARLY FLOWERING 4 in Arabidopsis Exhibit Differential Phase-Specific Genetic Influences over a Diurnal Cycle显示文摘内长的生理节奏的钟调整与工厂幸存和适应性有关的许多生理的过程。GIGANTEA (官方补给) ,联系钟的蛋白质,贡献生理节奏的时期长度和振幅的维护,并且也响应白天调整 flowering 时间和胚轴生长长度。同样,早 FLOWERING 4 (ELF4 ) ,另一个钟管理者,也贡献这些过程。然而,很少对也被知道在之间的基因或分子的相互作用官方补给并且在 Arabidopsis 的 ELF4。在这研究,我们调查了在之间的基因相互作用官方补给并且在生理节奏的控制钟的产量的规定的 ELF4。我们的变异的分析显示出那官方补给是到在 flowering 时间决心的 ELF4 的 epistatic,当 ELF4 是 epistatic 到时在胚轴生长官方补给规定。而且,官方补给并且 ELF4 在内长的钟规定上有 synergistic 或添加剂效果。介绍的基因表示官方补给, elf4,和官方补给的 elf4 异种进一步建立了那官方补给并且 ELF4 有差别对在黄昏和黎明的生理节奏的生理的产量的主导的影响分别地。这分阶段执行官方补给并且 ELF4 影响提供一个潜在的工具在生理节奏的生理的产量的规定完成差异,包括 flowering 时间和胚轴生长。 | Yumi Kim Miji Yeom Hyunmin Kim Junhyun Lim Hee Jung Koo Daehee Hwang David Somers Hong Gil Nam | 2012 | Molecular Plant2012，5，3： | 7 |
| 8 | Hepatobiliary scintigraphy for detecting biliary strictures after living donor liver transplantation显示文摘AIM:To investigate the diagnostic accuracy of hepatobiliary scintigraphy(HBS) in detecting biliary strictures in living donor liver transplantation(LDLT) patients.METHODS:We retrospectively reviewed 104 adult LDLT recipients of the right hepatic lobe with duct-toduct anastomosis,who underwent HBS and cholangiography.The HBS results were categorized as normal,parenchymal dysfunction,biliary obstruction,or bile leakage without re-interpretation.The presence of biliary strictures was determined by percutaneous cholangiography or endoscopic retrograde cholangiopancreatography(ERCP).RESULTS:In 89 patients with biliary strictures,HBS showed biliary obstruction in 50 and no obstruction in 39,for a sensitivity of 56.2%.Of 15 patients with no biliary strictures,HBS showed no obstruction in 11,for a specificity of 73.3%.The positive predictive value(PPV) was 92.6%(50/54) and the negative predictive value(NPV) was 22%(11/50).We also analyzed the diagnostic accuracy of the change in bile duct size.The sensitivity,NPV,specificity,and PPV were 65.2%,27.9%,80% and 95%,respectively.CONCLUSION:The absence of biliary obstruction on HBS is not reliable.Thus,when post-LDLT biliary strictures are suspected,early ERCP may be considered. | Yu Jin Kim Kyu Taek Lee Young Cheol Jo Kwang Hyuck Lee Jong Kyun Lee Jae-Won Joh Choon Hyuck David Kwon | 2011 | World Journal of Gastroenterology2011，17，21： | 6 |
| 9 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 10 | Single hepatocellular carcinoma ≤ 3 cm in left lateral segment:Liver resection or radiofrequency ablation?显示文摘AIM:To evaluate the long-term results of radiofrequency ablation(RFA)compared to left lateral sectionectomy(LLS)in patients with Child-Pugh class A disease for the treatment of single and small hepatocellular carcinoma(HCC)in the left lateral segments.METHODS:We retrospectively reviewed the data of133 patients with single HCC(≤3 cm)in their left lateral segments who underwent curative LLS(n=66)or RFA(n=67)between 2006 and 2010.RESULTS:The median follow-up period was 33.5mo in the LLS group and 29 mo in the RFA group(P=0.060).Most patients had hepatitis B virus-related HCC.The hospital stay was longer in the LLS group than in the RFA group(8 d vs 2 d,P<0.001).The 1-,2-,and 3-year disease-free survival and overall survival rates were 80.0%,68.2%,and 60.0%,and 95.4%,92.3%,and 92.3%,respectively,for the LLS group;and 80.8%,59.9%,and 39.6%,and 98.2%,92.0%,and 74.4%,respectively,for the RFA group.The disease-free survival curve and overall survival curve were higher in the LLS group than in the RFA group(P=0.012 and P=0.013,respectively).Increased PIVKA-Ⅱlevels and small tumor size were associated with HCC recurrence in multivariate analysis.CONCLUSION:Liver resection is suitable for single HCC≤3 cm in the left lateral segments. | Jong Man Kim Tae Wook Kang Choon Hyuck David Kwon Jae-Won Joh Justin Sangwook Ko Jae Berm Park Hyunchul Rhim Joon Hyeok Lee Sung Joo Kim Seung Woon Paik | 2014 | World Journal of Gastroenterology2014，20，14： | 4 |
| 11 | Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial显示文摘 | Hansjochen Wilke Kei Muro Eric Van Cutsem Sang-Cheul Oh Gy?rgy Bodoky Yasuhiro Shimada Shuichi Hironaka Naotoshi Sugimoto Oleg Lipatov Tae-You Kim David Cunningham Philippe Rougier Yoshito Komatsu Jaffer Ajani Michael Emig Roberto Carlesi David Ferry Kuma | 2014 | Lancet Oncology2014，，11： | 4 |
| 12 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 13 | Macrophages are the primary effector cells in IL-7-induced arthritis显示文摘Synovial macrophages are crucial in the development of joint inflammation and bone damage;however, the pathways that controlmacrophage remodeling in inflammatory M1 cells or bone-eroding osteoclasts are not fully understood. We determined thatelevated IL-7R/CD127 expression is the hallmark of rheumatoid arthritis (RA) M1 macrophages and that these cells are highlyresponsive to interleukin-7 (IL-7)-driven osteoclastogenesis. We established that lipopolysaccharide (LPS), interferon-γ (IFNγ), andtumor necrosis factor-α (TNFα), the classic M1 macrophage mediators, enhance IL-7R expression in RA and murine macrophages.The local expression of IL-7 provokes arthritis, predominantly through escalating the number of F480^(+)iNOS^(+) cells rather than CD3^(+)T cells. Ectopic LPS injection stabilizes IL-7-induced arthritis by increasing myeloid IL-7R expression, in part via IFNγ induction.Hence, in RAG−/− mice, IL-7-mediated arthritis is suppressed because of the reduction in myeloid IL-7R expression due to the lackof IFNγ. Moreover, the amelioration of IL-7-induced arthritis by anti-TNF therapy is due to a decrease in the number of cells in theunique F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) subset, with no impact on the F480^(+)Arginase^(+) cell or CD3^(+) T cell frequency. Consistent with thepreclinical findings, the findings of a phase 4 study performed with RA patients following 6 months of anti-TNF therapy revealedthat IL-7R expression was reduced without affecting the levels of IL-7. This study shifts the paradigm by discovering that IL-7-induced arthritis is dependent on F480^(+)iNOS^(+)IL-7R^(+)CCL5^(+) cell function, which activates TH-1 cells to amplify myeloid IL-7Rexpression and disease severity. | Seung-jae Kim Huan J.Chang Michael VVolin Sadiq Umar Katrien Van Raemdonck Aimee Chevalier Karol Palasiewicz John W.Christman Suncica Volkov Shiva Arami Mehrdad Maz Anjali Mehta Ryan K.Zomorrodi David A.Fox Nadera Sweiss Shiva Shahrara | 2020 | Cellular & Molecular Immunology2020，17，7： | 4 |
| 14 | An evaluation framework for energy aware buildings using statistical model checking显示文摘Cyber-physical systems are to be found in numerous applications throughout society.The principal barrier to develop trustworthy cyber-physical systems is the lack of expressive modelling and specification formalisms supported by efficient tools and methodologies.To overcome this barrier,we extend in this paper the modelling formalism of the tool UPPAAL-SMC to stochastic hybrid automata,thus providing the expressive power required for modelling complex cyber-physical systems.The application of Statistical Model Checking provides a highly scalable technique for analyzing performance properties of this formalisms.A particular kind of cyber-physical systems are Smart Grids which together with Intelligent,Energy Aware Buildings will play a major role in achieving an energy efficient society of the future.In this paper we present a framework in UPPAAL-SMC for energy aware buildings allowing to evaluate the performance of proposed control strategies in terms of their induced comfort and energy profiles under varying environmental settings(e.g.weather,user behavior etc.).To demonstrate the intended use and usefulness of our framework,we present an application to the Hybrid Systems Verification Benchmark. | DAVID Alexandre DU DeHui LARSEN Kim G. MIKUCIONIS Marius SKOU Arne | 2012 | Science China(Information Sciences)2012，55，12： | 3 |
| 15 | DNA methylation markers in colorectal cancer显示文摘 | Myoung Sook Kim Juna Lee David Sidransky | 2010 | Cancer and Metastasis Reviews2010，，1： | 3 |
| 16 | Web caching with consistent hashing显示文摘 | David Karger Alex Sherman Andy Berkheimer Bill Bogstad Rizwan Dhanidina Ken Iwamoto Brian Kim Luke Matkins Yoav Yerushalmi | 1999 | Computer Networks1999，，11： | 3 |
| 17 | Comparison of Yttrium-90 Radioembolization and Transcatheter Arterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma显示文摘 | David A. Kooby Vasili Egnatashvili Swetha Srinivasan Abbas Chamsuddin Keith A. Delman John Kauh Charles A. Staley Hyun S. Kim | 2010 | Journal of Vascular and Interventional Radiology2010，，2： | 3 |
| 18 | Uncovering material deformations via machine learning combined with four-dimensional scanning transmission electron microscopy显示文摘Understanding lattice deformations is crucial in determining the properties of nanomaterials,which can become more prominent in future applications ranging from energy harvesting to electronic devices.However,it remains challenging to reveal unexpected deformations that crucially affect material properties across a large sample area.Here,we demonstrate a rapid and semi-automated unsupervised machine learning approach to uncover lattice deformations in materials.Our method utilizes divisive hierarchical clustering to automatically unveil multi-scale deformations in the entire sample flake from the diffraction data using four-dimensional scanning transmission electron microscopy(4D-STEM).Our approach overcomes the current barriers of large 4D data analysis without a priori knowledge of the sample.Using this purely data-driven analysis,we have uncovered different types of material deformations,such as strain,lattice distortion,bending contour,etc.,which can significantly impact the band structure and subsequent performance of nanomaterials-based devices.We envision that this data-driven procedure will provide insight into materials’intrinsic structures and accelerate the discovery of materials. | Chuqiao Shi Michael C.Cao Sarah M.Rehn Sang-Hoon Bae Jeehwan Kim Matthew RJones David A.Muller Yimo Han | 2022 | npj Computational Materials2022，，1： | 3 |
| 19 | Transanal rectosigmoid resection via natural orifice translumenal endoscopic surgery (NOTES) with total mesorectal excision in a large human cadaver series显示文摘 | Dana A. Telem Kyung Su Han Min-Chan Kim Ifode Ajari Dae Kyung Sohn Kevin Woods Varun Kapur Mohammad A. Sbeih Silvana Perretta David W. Rattner Patricia Sylla | 2013 | Surgical Endoscopy2013，，1： | 3 |
| 20 | Fecal Microbiota Transplantation Induces Remission in Patients With Active Ulcerative Colitis in a Randomized Controlled Trial显示文摘 | Paul Moayyedi Michael G. Surette Peter T. Kim Josie Libertucci Melanie Wolfe Catherine Onischi David Armstrong John K. Marshall Zain Kassam Walter Reinisch Christine H. Lee | 2015 | Gastroenterology2015，，： | 3 |
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