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| 1 | Expert consensus on the use of human serum albumin in critically ill patients显示文摘Introduction Human serum albumin(HSA)is a non-glycosylated,negatively charged,single-chain polypeptide composed of 585 amino acid residues with a relative molecular mass of 66.438 kD.It is synthesized by the liver at a rate of approximately 200 mg·kg^(-1)·day^(-1),with a half-life of 21 days,and subjected to catabolism in the muscles,liver,and kidneys at a rate of 4%per day.[1]Albumin,accounting for 60%of the total plasma protein,has various physiological functions,[2]such as maintaining 70%to 80%of effective plasma colloid osmotic pressure,coordinating vascular endothelial integrity,anti-oxidant and anti-inflammatory activities,maintaining the acidbase balance,and participating in the transport,distribution,and metabolism of a variety of endogenous and exogenous substances. | Yue-Tian Yu Jiao Liu Bo Hu Rui-Lan Wang Xiang-Hong Yang Xiu-Ling Shang Gang Wang Chang-Song Wang Bai-Ling Li Ye Gong Sheng Zhang Xin Li Lu Wang Min Shao Mei Meng Feng Zhu You Shang Qiang-Hong Xu Zhi-Xiong Wu De-Chang Chen | 2021 | Chinese Medical Journal2021，，14： | 22 |
| 2 | Genetic diversity in Chinese modern wheat varieties revealed by microsatellite markers显示文摘Genetic diversity of 1680 modern varieties in Chinese candidate core collections was analyzed at 78 SSR loci by fluorescence detection system. A total of 1336 alleles were detected, of which 1253 alleles could be annotated into 71 loci. For these 71 loci, the alleles ranged from 4 to 44 with an average of 17.6, and the PIC values changed from 0.19 to 0.89 with an average of 0.69. (1) In the three genomes of wheat, the average genetic richness was B>A>D, and the genetic diversity indexes were B>D>A. (2) Among the seven homoeologous groups, the average genetic richness was 2=7>3>4>6>5>1, and the genetic diversity indexes were 7>3>2>4>6>5>1. As a whole, group 7 possessed the highest genetic diversity, while groups 1 and 5 were the lowest. (3) In the 21 wheat chromosomes, 7A, 3B and 2D possessed much higher genetic diversity, while 2A, 1B, 4D, 5D and 1D were the lowest. (4) The highest average genetic diversity index existed in varieties bred in the 1950s, and then it declined continually. However, the change tendency of genetic diversity among decades was not greatly sharp. This was further illustrated by changes of the average genetic distance between varieties. In the 1950s it was the largest (0.731). Since the 1960s, it has decreased gradually (0.711, 0.706, 0.696, 0.695). The genetic base of modern varieties is becoming narrower and narrower. This should be given enough attention by breeders and policy makers. | HAO Chenyang, WANG Lanfen, ZHANG Xueyong, YOU Guangxia, DONG Yushen, JIA Jizeng, LIU Xu, SHANG Xunwu, LIU Sancai & CAO Yongsheng Key Laboratory of Crop Germplasm & Biotechnology, MOA, Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China Agronomy College, Gansu Agricultural University, Lanzhou 730070, China | 2006 | Science China(Life Sciences)2006，49，3： | 19 |
| 3 | Angiographic prevalence of myocardial bridging in a defined very large number of Chinese patients with chest pain显示文摘背景:心肌内冠的动脉被称为的 epicardial 分割的肌纤维 overlying 心肌的衔接(MB ) 。MB 的可变流行与小、大的样品尺寸研究在尸体和 angiographic 系列被描述了。另外,没有类似的学习在中国人口被报导。这研究的目的是调查 MB 的 angiographic 流行在连续有从我们的中心的胸痛的 37,106 个中国病人。方法:我们进行了观察研究在经历的病人之中与 MB 评估连续案例选择冠的血管造影术,并且在很大的样品尺寸的这研究分析了 angiograhic 流行和 MB 的临床的特征。结果:在有胸痛的 37 105 个病人之中,我们以一种回顾的方式与 1011 MB 发现了 1002 个案例,并且全面流行是 2.70% 。尽管(991/1002 ) 超过 99% 病人有单个桥牌, 8 个案例被发现有超过二 MB (七与二,和一与三) 。没有动脉粥样硬化患者损害,总的来说 54.39% 案例(545/1002 ) 有 MB,并且(973/1011 )96.24% 在左前面的下降冠的动脉(男孩) 衔接定位了,主要在男孩的中间(792/1011, 78.33%) 。根据诺贝尔分类,单个桥(n=991 ) ,阻塞的 <50% 是占优势的(471/991, 47.52%) 。完全, 50%-69% 占了 34.81%(345/991 ) ,阻塞的 >70% 是 17.65%(175/991 ) 。结论:这些数据证明在有胸痛的中国病人的 angiographically 可检测的 MB 的流行类似于以前的研究的那些,与在这种很大的样品尺寸的 2.7% 流行。 | LI Jian-jun SHANG Zheng-lu YAO Min LI Jie YANG Yue-jin CHEN Ji-lin QIAO Shu-bin MA Wei-hua QIN Xue-wen LIU Hai-bo WU Yong-jian YUAN Jin-qing CHEN Jue YOU Shi-jie DAI Jun XU Bo XIA Ran GAO Run-lin | 2008 | Chinese Medical Journal2008，，5： | 17 |
| 4 | Data Analytics and Machine Learning for Smart Process Manufacturing: Recent Advances and Perspectives in the Big Data Era显示文摘Safe, ef cient, and sustainable operations and control are primary objectives in industrial manufacturing processes. State-of-the-art technologies heavily rely on human intervention, thereby showing apparent limitations in practice. The burgeoning era of big data is in uencing the process industries tremendously, providing unprecedented opportunities to achieve smart manufacturing. This kind of manufacturing requires machines to not only be capable of relieving humans from intensive physical work, but also be effective in taking on intellectual labor and even producing innovations on their own. To attain this goal, data analytics and machine learning are indispensable. In this paper, we review recent advances in data analytics and machine learning applied to the monitoring, control, and optimization of industrial processes, paying particular attention to the interpretability and functionality of machine learning mod- els. By analyzing the gap between practical requirements and the current research status, promising future research directions are identi ed. | Chao Shang Fengqi You | 2019 | Engineering2019，5，6： | 15 |
| 5 | Molecular Mechanisms of Ventilator-Induced Lung Injury显示文摘 | Lin Chen Hai-Fa Xia You Shang Shang-Long Yao | 2018 | Chinese Medical Journal2018，，10： | 12 |
| 6 | Melatonin reduces acute lung injury in endotoxemic rats显示文摘有 melatonin 的背景治疗显著地减少 bleomycin, paraquat 和局部缺血灌注导致的肺损害。在现在的学习,我们在 32 只男 Sprague-Dawley 老鼠随机被分到四个组的尖锐 endotoxemia.Methods 期间在肺的发炎和肺损害调查了 melatonin 的可能的保护的角色:车辆 + 盐的组, melatonin + 盐的组,车辆 + lipopolysaccharide 组, melatonin + lipopolysaccharide 组。老鼠与 melatonin 被对待(10 mg/kg, intraperitoneal 注射(I.p )) 或车辆(1% 乙醇盐) ,在 lipopolysaccharide 管理以前的 30 分钟(6 mg/kg,静脉内的注射) 。在 lipopolysaccharide 注射以后的四个小时,肺的织物的样品被收集。血煤气的分析被执行。光显微镜学被执行在肺检验病理学的变化,肺损害 20 被估计。湿 / 干燥的比率(W/D ) , myeloperoxidase 活动, malondialdehyde 集中和肿瘤坏死 factor-alpha (TNF -- 一) 并且在肺的 interleukin-10 (IL-10 ) 层次被测量。原子 factor-kappa B (NF-KB ) p65 的肺的表达式被西方的弄污计算。在车辆 + lipopolysaccharide 组的结果 PaO2 在车辆 + 与那相比减少了盐的组。这减少显著地在 melatonin + lipopolysaccharide 组被减少。从盐的 + lipopolysaccharide 组的肺纸巾显著地被损坏,它是在 melatonin + lipopolysaccharide 组读的更少。 W/D 比率在车辆+ lipopolysaccharide 组显著地增加了( 6.1 晩捩湡?楤晦牥湥散漠?卅?贞舄棏绗彿鬁u瑡敩瑮?楷桴畯?剓??华?愠摮眠瑩?剓??华?獶传????敨敭戠湩楤杮猠瑩?吠楨?瑳摵?楡敭?潴椠癮獥楴慧整琠敨爠汥瑡潩獮楨?敢睴敥??偄?硯摩獡??畢楮??瀲潨?敧敮瀠汯浹牯桰獩?湡?协???瑥潨獤吠敨朠湥瑯灹獥漠??瀲潨?潰祬潭灲楨浳眠牥?敤整浲湩摥戠?潰祬敭慲敳挠慨湩爠慥瑣潩?敲瑳楲瑣潩?牦条敭瑮氠湥瑧?潰祬潭灲楨浳?倨剃刭??愠獳祡椠???湵敲慬整??橢捥獴漠?桴?慈?潰異慬楴湯椠?潳瑵敨湲爠来潩?景?楨慮?湩汣摵湩???协?? ? | SHANG You XU San-peng WU Yan JIANG Yuan-xu WU Zhou-yang YUAN Shi-ying YAO Shang-long | 2009 | Chinese Medical Journal2009，，12： | 11 |
| 7 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 8 | Plasma metabolomic and lipidomic alterations associated with COVID-19显示文摘The pandemic of the coronavirus disease 2019(COVID-19)has become a global public health crisis.The symptoms of COVID-19 range from mild to severe,but the physiological changes associated with COVID-19 are barely understood.In this study,we performed targeted metabolomic and lipidomic analyses of plasma from a cohort of patients with COVID-19 who had experienced different symptoms.We found that metabolite and lipid alterations exhibit apparent correlation with the course of disease in these patients,indicating that the development of COVID-19 affected their whole-body metabolism.In particular,malic acid of the TCA cycle and carbamoyl phosphate of the urea cycle result in altered energy metabolism and hepatic dysfunction,respectively.It should be noted that carbamoyl phosphate is profoundly down-regulated in patients who died compared with patients with mild symptoms.And,more importantly,guanosine monophosphate(GMP),which is mediated not only by GMP synthase but also by CD39 and CD73,is significantly changed between healthy subjects and patients with COVID-19,as well as between the mild and fatal cases.In addition,dyslipidemia was observed in patients with COVID-19.Overall,the disturbed metabolic patterns have been found to align with the progress and severity of COVID-19.This work provides valuable knowledge about plasma biomarkers associated with COVID-19 and potential therapeutic targets,as well as an important resource for further studies of the pathogenesis of COVID-19. | Di Wu Ting Shu Xiaobo Yang Jian-Xin Song Mingliang Zhang Chengye Yao Wen Liu Muhan Huang Yuan Yu Qingyu Yang Tingju Zhu Jiqian Xu Jingfang Mu Yaxin Wang Hong Wang Tang Tang Yujie Ren Yongran Wu Shu-Hai Lin Yang Qiu Ding-Yu Zhang You Shang Xi Zhou | 2020 | National Science Review2020，7，7： | 9 |
| 9 | Research on 3D Target Pose Tracking and Modeling显示文摘This paper tackles pose tracking and model refinement, one of the fundamental work for 3D photogrammetry. The researches belong to the videometrics, an interdisciplinewhich combines computer vision, digital image processing, photogrammetry and optical measurement. Related works are summarized briefly in this paper. This paper studies the problem of pose tracking for target with 3D model. For the target with accurate 3D model, line model based pose tracking methods are proposed for target which is rich in line features. Experimental results indicate that the proposed methods track the target pose accurately. Normal distance iterative reweighted least squares and distance image iterative least squares methods are proposed to process more general targets. This paper adopts bundle adjustment to tackle pose tracking in image sequence for target with inaccurate 3D line model. The proposed method optimizes the model line parameters and the pose parameters simultaneously. The model line orientation, position and mean angle error, mean position error of the pose are 0.3°,3.5 mm and 0.12°,20.1 mm in simulation experiments of satellite pose tracking. Line features are used to track target pose with unknown 3D model through image sequence. The model line parameters and pose parameters are optimized under the framework of SFM. In simulation experiments, the reconstructed line orientation, position error and mean angle error, mean position error of pose are 0.4°,7.5 mm and 0.16°,23.5 mm. | Yang SHANG Xiaoliang SUN Yueqiang ZHANG You LI Qifeng YU | 2019 | Journal of Geodesy and Geoinformation Science2019，2，2： | 7 |
| 10 | A family of symmetric mixed finite elements for linear elasticity on tetrahedral grids显示文摘A family of stable mixed finite elements for the linear elasticity on tetrahedral grids are constructed,where the stress is approximated by symmetric H(div)-Pk polynomial tensors and the displacement is approximated by C-1-Pk-1polynomial vectors,for all k 4.The main ingredients for the analysis are a new basis of the space of symmetric matrices,an intrinsic H(div)bubble function space on each element,and a new technique for establishing the discrete inf-sup condition.In particular,they enable us to prove that the divergence space of the H(div)bubble function space is identical to the orthogonal complement space of the rigid motion space with respect to the vector-valued Pk-1polynomial space on each tetrahedron.The optimal error estimate is proved,verified by numerical examples. | HU Jun ZHANG Shang You | 2015 | Science China Mathematics2015，58，2： | 7 |
| 11 | Reduction of pulmonary inflammatory response by erythropoietin n a rat model of endotoxaemia显示文摘背景 Erythropoietin 在调查的 ischaemic 灌注和 hyperoxia.We 导致的肺织物损害得到保护的效果在肺的发炎和肺损害的 erythropoietin 的保护的角色 32 只男 Sprague-Dawley 老鼠在尖锐 endotoxaemia.Methods A 期间总计随机被分到四个 groups:saline 组, erythropoietin+saline 组, saline+lipopolysaccharide 组和 erythropoietin+lipopolysaccharide group.Rats 与 erythropoietin 被对待( 3000 U/kg , i.p ) | SHANG You JIANG Yuan-xu XU San-peng WU Yan WU Zhou-yang YUAN Shi-ying YAO Shang-long | 2009 | Chinese Medical Journal2009，，7： | 7 |
| 12 | Valproic acid attenuates the multiple-organ dysfunction in a rat model of septic shock显示文摘背景 Valproic 酸(VPA ) 在一处高度致命的 poly 损伤和出血性的吃惊模型或另外的严重侮辱改进早幸存和机关功能。我们估计了 VPA 是否能在一个老鼠模型改进机关功能腐败吃惊并且说明了四十只 Sprague-Dawley 老鼠随机被分到四个组(n=10 ) 的可能的 mechanisms.Methods:控制组, VPA 组, LPS 组,和 LPS+VPA 组。Lipopolysaccharide (LPS )(10 mg/kg ) 静脉内地被注射复制试验性的模型腐败吃惊。老鼠与 VPA 被对待(300 mg/kg, i.v ) 或盐。在 LPS 注射以后的六个小时,血为煤气的分析,浆液丙氨酸 aminotransferase 的测量, aspartate aminotransferase,尿氮, creatinine 和肿瘤坏死 factor-alpha 被取样。肺,肝和肾为组织病理学说的评价被收集。另外, myeloperoxidase 活动和肿瘤坏死因素 -- 在肺的织物是在肺的 histone H3 的 measured.Acetylation 被西方的 blotting.Results LPS 也评估在 PaO2 导致了重要减少,它被 VPA 管理增加跟随的 LPS 注射。另外, LPS 也在丙氨酸 aminotransferase, aspartate aminotransferase,尿氮, creatinine,和肿瘤坏死 factor-alpha 的浆液层次导致了增加。然而,这些增加在 LPS+VPA 组被稀释。从 LPS 组的肺,肝和肾显著地与控制组相比被损坏。然而,损坏在 LPS+VPA 组被稀释。在肺的织物的 Myeloperoxidase 活动和肿瘤坏死 factor-alpha 层次与控制组相比在 LPS 组显著地增加了。这些增加显著地在 LPS+VPA 组被禁止。在在 LPS 组的肺织物的 histone H3 的 Acetylation 与控制相比被禁止。然而,在 LPS+VPA 组的 histone H3 的 acetylation 的水平显著地与有 VPA 的处理能稀释的 LPS group.Conclusions 相对照被提高导致的 LPS 引起的多重机关损坏腐败吃惊。我们的数据也建议有益的效果是部分地由于在正常 acetylation 动态平衡的煽动性的 cytokines 和恢复的减少。 | SHANG You JIANG Yuan-xu Ding Ze-jun Shen Ai-ling XU San-peng YUAN Shi-ying YAO Shang-long | 2010 | Chinese Medical Journal2010，，19： | 7 |
| 13 | Halogen Inhalation-Induced Lung Injury and Acute Respiratory Distress Syndrome显示文摘 | Ting Zhou Wei-Feng Song You Shang Shang-Long Yao Sadis Matalon | 2018 | Chinese Medical Journal2018，，10： | 6 |
| 14 | 960 MPa Grade High Performance Weldable Structural Steel Plate Processed by Using TMCP显示文摘To develop high strength, good toughness, and weldable steel plate, a steel composition was designed. It was an ultra-low-carbon microalloyed steel. TMCP (thermal mechanical control process) and RPC (relaxation precipitation control) were employed to ensure fine lath bainite microstructure. This kind of microstructure could induce higher strength and better toughness. | NIE Yi SHANG Cheng-jia YOU Yang LI Xiu-cheng CAO Jian-ping HE Xin-lai | 2010 | Journal of Iron and Steel Research(International)2010，17，2： | 6 |
| 15 | Study of ciprofloxacin removal by biochar obtained from used tea leaves显示文摘In this study,used tea leaves(UTLs) were pyrolyzed to obtain used tea-leaf biochar(UTC),and then the UTC was used as an adsorbent to remove ciprofloxacin(CIP) from aqueous solutions.Batch experiments were conducted to investigate the CIP adsorption performance and mechanism.The results showed that the CIP-adsorbing ability first increased and then declined as the UTC pyrolysis temperature increased.The UTC obtained at 450°C presented excellent CIP-absorbing ability at p H 6 and 40°C.The maximum monolayer adsorption capacity was 238.10 mg/g based on the Langmuir isotherm model.The pseudo-second-order kinetic equation agreed well with the CIP adsorption process,which was controlled by both external boundary layer diffusion and intra-particle diffusion.The characterization analysis revealed that the \OH groups,C_C bonds of aromatic rings,C\H groups in aromatic rings and phenolic C\O bonds play vital roles in the CIP adsorption process,and that the N\C,N\O,O\C_O and C\OH groups of UTC were consumed in large quantities.π–π interactions,hydrogen bonding and electrostatic attraction are inferred as the main adsorption mechanisms.The present work provides not only a feasible and promising approach for UTLs utilization but also a potential adsorbent material for removing high concentrations of CIP from aqueous solutions. | Jie Li Guangwei Yu Lanjia Pan Chunxing Li Futian You Shengyu Xie Yin Wang Jianli Ma Xiaofu Shang | 2018 | Journal of Environmental Sciences2018，30，11： | 5 |
| 16 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 17 | Remimazolam besylate for sedation of postoperative patients in intensive care units: a phase I, open label, dose-finding study显示文摘To the Editor:Remimazolam besylate is a novel,ultrashort-acting benzodiazepine with a rapid and a predictable onset and offset profile,no accumulation and extended effect,and independence of organ elimination. | Yun Tang Xiaobo Yang Huaqing Shu Yuan Yu Jiqian Xu Shangwen Pan Xiaojing Zou Shiying Yuan You Shang | 2022 | Chinese Medical Journal2022，135，17： | 5 |
| 18 | A simple and efficient synthesis of 2-substituted benzothiazoles catalyzed by H_2O_2/HCl显示文摘A simple and efficient procedure for the synthesis of substituted benzothiazoles through condensation of 2-aminothiophenol with aromatic aldehydes in the presence of H_2O_2/HCl system in ethanol at room temperature is described.The target compounds have been characterized by ~1H NMR,^(13)C NMR,IR and MS.Short reaction time,easy and quick isolation of the products,and excellent yields are the main advantages of this procedure. | Hong Yun Guo Ji Chao Li You Le Shang | 2009 | Chinese Chemical Letters2009，20，12： | 4 |
| 19 | High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors显示文摘A new coronavirus(SARS-CoV-2)has been identified as the etiologic agent for the COVID-19 outbreak.Currently,effective treatment options remain very limited for this disease;therefore,there is an urgent need to identify new anti-COVID-19 agents.In this study,we screened over 6,000 compounds that included approved drugs,drug candidates in clinical trials,and pharmacologically active compounds to identify leads that target the SARS-CoV-2 papain-like protease(PLpro).Together with main protease(Mpro),PLpro is responsible for processing the viral replicase polyprotein into functional units.There-fore,it is an attractive target for antiviral drug develop-ment.Here we discovered four compounds,YM155,cryptotanshinone,tanshinone I and GRL0617 that inhibit SARS-CoV-2 PLpro with IC50 values ranging from 1.39 to 5.63 pmol/L.These compounds also exhibit strong antiviral activities in cell-based assays.YM155,an anti-cancer drug candidate in clinical trials,has the most potent antiviral activity with an EC50 value of 170 nmol/L.In addition,we have determined the crystal structures of this enzyme and its complex with YM155,revealing a unique binding mode.YM155 simultaneously targets three'hot'spots on PLpro,including the substrate-binding pocket,the interferon stimulating gene product 15(ISG15)binding site and zinc finger motif.Our results demonstrate the efficacy of this screening and repur-posing strategy,which has led to the discovery of new drug leads with clinical potential for COVID-19 treatments. | Yao Zhao Xiaoyu Du Yinkai Duan Xiaoyan Pan Yifang Sun Tian You Lin Han Zhenming Jin Weijuan Shang Jing Yu Hangtian Guo Qianying Liu Yan Wu Chao Peng Jun Wang Chenghao Zhu Xiuna Yang Kailin Yang Ying Lei Luke W.Guddat Wenqing Xu Gengfu Xiao Lei Sun Leike Zhang Zihe Rao Haitao Yang | 2021 | Protein & Cell2021，12，11： | 4 |
| 20 | Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders:phase 1 trial interim results显示文摘Chimeric antigen receptor(CAR)T-cell therapy that targets B-cell maturation antigen(BCMA)have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder(NMOSD).To evaluate the safety and efficacy of the CT103A,a self-developed BCMA-targeting CAR construct against BCMA,in patients with AQP4-IgG seropositive NMOSD,an ongoing,investigator-initiated,open-label,single-arm,phase 1 clinical trial is conducted at our center.In total,12 patients were administered with a CAR-BCMA infusion.Ten of the 12 patients dosed were women(83.3%),with a median age of 49.5 years(range,30-67).were The most common events of grade 3 or higher were hematologic toxic effects.Seven patients(58%)developed infections,but no grade 4 infections occurred.Cytokine release syndrome was reported in all patients with only events of grade 1 or 2 observed.During the follow-up of a median 5.5 months,11 patients had no relapse;all patients generally reported improvement in disabilities and quality-of-life outcomes;11 patients’AQP-4 antibodies in serum showed a downward trend by the cutoff date.CAR T-cell expansion was associated with responses,and persisted more than 6 months post-infusion in 17%of the patients.In summary,CAR T-cell therapy shows a manageable safety profile and therapeutic potentials for patients with relapsed/refractory AQP4-IgG seropositive NMOSD.Another expansion phase is currently underway to determine the safety and efficacy of CAR T-BCMA infusion in patients with other neuro-inflammatory diseases. | Chuan Qin Dai-Shi Tian Luo-Qi Zhou Ke Shang Liang Huang Ming-Hao Dong Yun-Fan You Jun Xiao Ying Xiong Wen Wang Hao Pang Jing-Jing Guo Song-Bai Cai Di Wang Chun-Rui Li Min Zhang Bi-Tao Bu Wei Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 4 |
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