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| 1 | 血管性认知损害诊断的进一步规范化:血管性认知损害分类共识研究组指南显示文摘引言血管性认知损害(vascular cognitive impairment,VCI)诊断共识的缺乏(体现为多种不同评估方案的使用),妨碍了对其理解和治疗的推进.多个国家的大量临床医生和研究人员参与了2个阶段血管性认知损害分类共识研究(Vascular Impairment of Cognition Classification Consensus Study,VICCCS),旨在就VCI的诊断原则(VICCCS-1)和诊断方案(VICCCS-2)达成一致意见.本文提供了VICCCS-2的相关内容.方法使用VICCCS-1达成的原则和已发表的诊断指南作为在线德尔菲(Delphi)调查的参考基点,以期对VCI的临床诊断达成共识.结果共进行了6轮调查,每轮有65~79名专家参与,他们就VICCCS修订的轻度和重度VCI的诊断指南达成共识,并肯定了美国国立神经疾病与卒中研究所-加拿大卒中网(National Institute of Neurological Disorders and Stroke–Canadian Stroke Network,NINDS-CSN)发布的神经心理学评估方案和对影像学检查的推荐意见.讨论VICCCS-2建议规范化应用NINDS-CSN推荐的神经心理学和影像学评估方案诊断VCI,以促进研究协作. | Olivia A. Skrobot Sandra E. Black Christopher Chen Charles DeCarli Timo Erkinjuntti Gary A. Ford Rajesh N. Kalaria John O'Brien Leonardo Pantoni Florence Pasquier Gustavo C. Roman Anders Wallin Perminder Sachdev Ingmar Skoog the VICCCS group Yoav Ben-Shlomo Anthony P. Passmore Seth Love Patrick G. Kehoe 朱婷珂 徐俊 | 2018 | 国际脑血管病杂志2018,26,4: | 58 |
| 2 | Non-invasive diagnosis of liver fibrosis and cirrhosis显示文摘The evaluation and follow up of liver fibrosis and cirrhosis have been traditionally performed by liver biopsy. However, during the last 20 years, it has become evident that this 'gold-standard' is imperfect; even according to its proponents, it is only 'the best' among available methods. Attempts at uncovering non-invasive diagnostic tools have yielded multiple scores, formulae, and imaging modalities. All are better tolerated, safer, more acceptable to the patient, and can be repeated essentially as often as required. Most are much less expensive than liver biopsy. Consequently, their use is growing, and in some countries the number of biopsies performed, at least for routine evaluation of hepatitis B and C, has declined sharply. However, the accuracy and diagnostic value of most, if not all, of these methods remains controversial. In this review for the practicing physician, we analyze established and novel biomarkers and physical techniques. We may be witnessing in recent years the beginning of the end of the first phase for the development of non-invasive markers. Early evidence suggests that they might be at least as good as liver biopsy. Novel experimental markers and imaging techniques could produce a dramatic change in diagnosis in the near future. | Yoav Lurie Muriel Webb Ruth Cytter-Kuint Shimon Shteingart Gerardo Z Lederkremer | 2015 | World Journal of Gastroenterology2015,21,41: | 36 |
| 3 | 北京地区闪电活动与气溶胶浓度的关系研究显示文摘基于2015—2017年北京闪电定位网(BLNET)总闪资料与35个自动空气质量监测站PM 2.5数据,分析了北京地区(39.5°N—41.0°N,115.0°E—117.5°E)夏季(6—8月)闪电活动与PM 2.5的时空分布特征,同时针对117次雷暴天气,探讨了气溶胶浓度变化对闪电活动的可能影响.结果表明:PM 2.5浓度及总闪密度均呈现自西北向东南升高的空间分布特征.闪电峰值在污染背景下出现的时间(19∶00LT)晚于清洁背景下(15∶00LT)约4 h,且总闪百分比(~20%)可达清洁背景下(~9%)的两倍.对雷暴前1~4 h的PM 2.5浓度与时间窗(12∶00—22∶00LT)内总闪数目的中位数进行相关分析,发现PM 2.5浓度低于130μg·m-3时,PM 2.5与总闪数存在明显正相关,此时气溶胶可能通过影响云微物理过程进而影响雷暴的对流发展,增强闪电活动;PM 2.5大于150μg·m-3时,总闪数随PM 2.5浓度的增加呈减少趋势,可能的原因是高气溶胶浓度下地面太阳辐射显著下降,对流活动受到抑制,导致闪电活动减少.当PM 2.5浓度在130~150μg·m-3时,两者关系不明显. | 孙萌宇 郄秀书 刘冬霞 Yoav Yair 夏祥鳌 袁善锋 王东方 卢晶雨 Abhay Srivastava Didier Ntwali | 2020 | 地球物理学报2020,63,5: | 5 |
| 4 | Comparison of anti-vascular endothelial growth factors, laser treatments and a combination of the both for treatment of central retinal vein occlusion显示文摘AIM:To compare changes in visual acuity and macular edema in patients with central retinal vein occlusion(CRVO)treated with intravitreal injections of bevacizumab,macular grid photocoagulation combined with pan retinal photocoagulation(PRP),or both(bevacizumab+grid+PRP).· METHODS:Our study is a retrospective cohort clinical study that examined patients that suffered from ischemic CRVO with macular edema.Study inclusion criteria were ischemic CRVO with macula edema and the availability of complete medical records for at least 12 mo after treatment.Excluded were patients with diabetes or any other retinal disease.We reviewed the medical records of patients treated in one ophthalmology departmentcomparing changes in visual acuity and macular edema in patients treated with intravitreal injections of bevacizumab vs those that were treated with macular grid photocoagulation and PRP or both.The main outcome measures were the differences in best corrected visual acuity(BCVA) and in macular thickness,as assessed by optical coherence tomography,between the enrollment and the final follow up visits.· RESULTS:Sixty-five patients met inclusion criteria.There were no statistically significant differences among the three groups in the mean changes in macular thickness as measured by ocular coherence tomography(131.5±41.2,108.6±29.2,and 121.1±121.1,P=0.110),or in visual acuity(0.128±0.077,0.088±0.057,and 0.095±0.065),for intravitreal injections,macular grid photocoagulation+PRP and a combination of the treatments,respectively,P =0.111.The proportions of patients with macular edema after treatment were:26.1%,28.6%,and 14.3%,respectively,P=0.499.· CONCLUSION:Similar benefit was observed for intravitreal injections,laser photocoagulation,or a combined regimen in the treatment of CRVO.A nonstatistically significant trend for reduction in macular edema was observed following combined treatment. | Yoav Y.Pikkel Adi Sharabi-Nov Itzchak Beiran Joseph Pikkel | 2016 | International Journal of Ophthalmology(English edition)2016,9,3: | 5 |
| 5 | Natural orifice surgery: initial clinical experience显示文摘 | Santiago Horgan John P. Cullen Mark A. Talamini Yoav Mintz Alberto Ferreres Garth R. Jacobsen Bryan Sandler Julie Bosia Thomas Savides David W. Easter Michelle K. Savu Sonia L. Ramamoorthy Emily Whitcomb Sanjay Agarwal Emily Lukacz Guillermo Dominguez Ped | 2009 | Surgical Endoscopy2009,,7: | 5 |
| 6 | FibroSURE^(TM) and FibroScan~ in relation to treatment response in chronic hepatitis C virus显示文摘AIM:To compare histological endpoint assessment using noninvasive alternatives to biopsy during treatment in a chronic hepatitis C virus(HCV)cohort.METHODS:Patients with chronic HCV were randomized to receive interferon-based therapy for 24(genotypes 2/3)or 48(genotype 1)wk.FibroSURE~TM(FS)was assessed at baseline and at week-12 post-treatment follow-up.Baseline biopsy for METAVIR was assessed by a single pathologist.FibroScan~ transient elastogra-phy(TE)was performed during treatment in a patient subset.RESULTS:Two thousand and sixty patients(n = 253 in Asia)were classif ied as METAVIR F0-1(n = 1682)or F2-4(n = 378).For F2-4,FS(n = 2055)had sensitiv-ity and specif icity of 0.87 and 0.61,respectively,with area under the receiver-operating curve of 0.82;corre-sponding values for TE(n = 214)and combined FS/TE(n = 209)were 0.77,0.88 and 0.88,and 0.93,0.68 and 0.88.Overall FS/TE agreement for F2-4 was 71%(κ = 0.41)and higher in Asians vs non-Asians(κ = 0.86 vs 0.35;P < 0.001).Combined FS/TE had 97% accuracy in Asians(n = 33).Baseline FS(0.38 vs 0.51,P < 0.001)and TE(8.0 kPa vs 11.9 kPa,P = 0.006)scores were lower in patients with sustained virological response than in nonresponders,and were maintained through follow-up.CONCLUSION:FS and TE may reliably differentiate mild from moderate-advanced disease,with a potential for high diagnostic accuracy in Asians with chronic HCV. | Keyur Patel Mireen Friedrich-Rust Yoav Lurie Mircea Grigorescu Carol Stanciu Chuan-Mo Lee Eugene R Schiff Dieter Hussinger Michael P Manns Guido Gerken Isabelle Colle Michael Torbenson Erik Pulkstenis G Mani Subramanian John G McHutchison Stefan Zeuzem | 2011 | World Journal of Gastroenterology2011,17,41: | 4 |
| 7 | Does capsule endoscopy have an added value in patients with perianal disease and a negative work up for Crohn's disease?显示文摘AIM:To investigate the role of capsule endoscopy in patients with persistent perianal disease and negative conventional work up for Crohn's disease(CD).METHODS:Patients with perianal disease(abscesses,fistulas,recurrent fissures) were evaluated for underlying CD.Patients who had a negative work up,defined as a negative colonoscopy with a normal ileoscopy or a normal small bowel series or a normal CT/MR enterography,underwent a Pillcam study of the small bowel after signing informed consent.Patients using nonsteroidal anti-inflammatory drugs or who had a history of inflammatory bowel disease or rheumatic disease were excluded.RESULTS:We recruited 26 patients aged 21-61 years(average 35.6 years),17 males and 9 females.One case could not be evaluated since the capsule did not leave the stomach.In 6 of 25(24%) patients with a negative standard work up for Crohn's disease,capsuleendoscopy(CE) findings were consistent with Crohn's disease of the small bowel.Family history of CD,white blood cell,hemoglobin,erythrocyte sedimentation rate or C-reactive protein did not predict a diagnosis of CD.Capsule endoscopy findings led to a change in treatment.CONCLUSION:In patients with perianal disease and a negative conventional work up to exclude CD,CE leads to incremental diagnostic yield of 24%. | Samuel N Adler Metzger Yoav Scapa Eitan Chowers Yehuda Rami Eliakim | 2012 | World Journal of Gastrointestinal Endoscopy2012,4,5: | 4 |
| 8 | Fab显示文摘 | Marko Balabanovi? Yoav Shoham | 1997 | Communications of the ACM1997,,3: | 4 |
| 9 | Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis显示文摘AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages. RESULTS: The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedminimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL). CONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential. | Ron Benyair Maria Kondratyev Elena Veselkin Sandra Tol-chinsky Marina Shenkman Yoav Lurie Gerardo Z Lederkremer | 2011 | World Journal of Gastroenterology2011,17,48: | 3 |
| 10 | Web caching with consistent hashing显示文摘 | David Karger Alex Sherman Andy Berkheimer Bill Bogstad Rizwan Dhanidina Ken Iwamoto Brian Kim Luke Matkins Yoav Yerushalmi | 1999 | Computer Networks1999,,11: | 3 |
| 11 | Second-generation colon capsule endoscopy is feasible in the out-of-clinic setting显示文摘 | Samuel Nathan Adler Cesare Hassan Yoav Metzger Yishai Sompolinsky Cristiano Spada | 2014 | Surgical Endoscopy2014,,2: | 3 |
| 12 | Long-Term Treatment With Entecavir Induces Reversal of Advanced Fibrosis or Cirrhosis in Patients With Chronic Hepatitis B显示文摘 | Eugene R. Schiff Samuel S. Lee You–Chen Chao Seung Kew Yoon Fernando Bessone Shun–Sheng Wu Wieslaw Kryczka Yoav Lurie Adrian Gadano George Kitis Suzanne Beebe Dong Xu Hong Tang Uchenna Iloeje | 2011 | Clinical Gastroenterology and Hepatology2011,,3: | 3 |
| 13 | Descemet stripping automated endothelial keratoplasty in phakic eyes:incision modification reducing cataract formation显示文摘AIM: To evaluate the efficacy of a technical modification to reduce the incidence of traumatic cataract induced by Descemet stripping automated endothelial keratoplasty(DSAEK) performed in phakic eyes. METHODS: A retrospective cohort study. The records of all patients with a clear crystalline lens and endothelial failure that underwent modified DSAEK at our insitution were reviewed. In this modification, in order to avoid inadvertent touch of the insertion forceps against the exposed crystalline lens while passing across the anterior chamber, the incision sites were shifted from the standard 9 and 3 o'clock positions, superiorly to the 10 and 2 o'clock position respectively. Formation of typically traumatic, anterior subcapsular cataract in these patients was compared to that observed in a cohort including all the patients with a clear crystalline lens and endothelial failure that underwent conventional DSAEK at our institution.RESULTS: The study group included 49 eyes following modified DSAEK and the control group included 35 eyes following DSAEK with conventional incision sites. Anterior subcapsular cataract occurring 4 mo or less postoperatively was identified in 2 of 49(4%) eyes in the study group and 7 of 35(20%) eyes in the control group. The rates of traumatic cataract were significantly higher in the control group in comparison to the study group(P=0.03, RR=4.9, 95%CI 1.08-22.1).CONCLUSION: Traumatic cataract formation following phakic DSAEK may be avoided with a simple modification to the position of the incision sites. | Jacqueline Beltz Silvana Madi Yoav Nahum Paolo Santorum Massimo Busin | 2018 | International Journal of Ophthalmology(English edition)2018,11,1: | 2 |
| 14 | A prospective study assessing the efficacy of abdominal computed tomography scan without bowel preparation in diagnosing intestinal wall and luminal lesions in patients presenting to the emergency room with abdominal complaints显示文摘AIM: To evaluate the positive predictive value of abdominal non-prepared computed tomography (CT) for diagnosing intestinal lumen or wall lesions in patients presenting to the emergency room (ER) with abdominal complaints.METHODS: For 1-year we prospectively evaluated all ER patients hospitalized after abdominal CT scan detected either intraluminal or intestinal wall lesions. These patients underwent colonoscopy serving as gold standard. Patients with prior abdominal pathology or CT findings of appendicitis or diverticulitis were excluded.RESULTS: Five hundred and sixty-eight abdominopelvic CT scans were performed in the ER, 96 had positive colonic findings. Sixty-two patients were excluded, 46 because of diverticulitis or appendicitis, 16 because of prior abdominal pathology. Of the remaining 34 patients, 14 did not undergo colonoscopy during hospitalization.Twenty eligible patients were included in the study. The positive predictive value of the CT scans performed in the ER was calculated to be 45% (95% CI 25-67).CONCLUSION: CT findings correlated with colonoscopic findings only in approximately half of the cases. Relying on non-prepared CT scan findings in planning patient management and colonoscopy may lead to unnecessary diagnostic work-ups. | Michal Mizrahi Yoav Mintz Avraham Rivkind David Kisselgoff Eugene Libson Mayer Brezis Eran Goldin Oren Shibolet | 2005 | World Journal of Gastroenterology2005,11,13: | 2 |
| 15 | 红树林湿地植物生长促进菌及其应用展望显示文摘着重介绍从红树林根系中提取的植物促生菌的种类,即固氮细菌、溶磷细菌、光合厌氧细菌及其在红树林植被恢复中的应用前景。 | 廖宝文 李玫 康丽华 郑松发 陈玉军 Yoav Bashan Gina Holguin | 2002 | 生态科学2002,21,3: | 2 |
| 16 | An Analysis of Prospective Risk Factors for Aortic Stiffness in Men: 20-Year Follow-Up From the Caerphilly Prospective Study显示文摘 | Carmel M. McEniery Michael Spratt Margaret Munnery John Yarnell Gordon D. Lowe Ann Rumley John Gallacher Yoav Ben-Shlomo John R. Cockcroft Ian B. Wilkinson | 2010 | Hypertension2010,,1: | 2 |
| 17 | A Decision-Theoretic Generalization of On-Line Learning and an Application to Boosting显示文摘 | Yoav Freund Robert E Schapire | 1997 | Journal of Computer and System Sciences1997,,1: | 2 |
| 18 | Ovarian sex cord-stromal tumors, pleuropulmonary blastoma and DICER1 mutations: A report from the International Pleuropulmonary Blastoma Registry显示文摘 | Kris Ann P. Schultz M. Cristina Pacheco Jiandong Yang Gretchen M. Williams Yoav Messinger D. Ashley Hill Louis P. Dehner John R. Priest | 2011 | Gynecologic Oncology2011,,2: | 2 |
| 19 | Recent advances in removing phosphorus from wastewater and its future use as fertilizer( 1997-2003 )显示文摘 | De-Bashan Luz E Bashan Yoav | 2004 | Water Research2004,38,19: | 1 |
| 20 | The prosthodontic concept of crown-to-root ratio: a review of the literature 显示文摘 | Yoav C Avishai S | 2005 | J Prosthetic Dent2005,93,6: | 1 |