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| 1 | Pharmacologic therapy for acute pancreatitis显示文摘While conservative management such as fluid,bowel rest,and antibiotics is the mainstay of current acute pancreatitis management,there is a lot of promise in pharmacologic therapies that target various aspects of the pathogenesis of pancreatitis.Extensive review of preclinical studies,which include assessment of therapies such as anti-secretory agents,protease inhibitors,anti-inflammatory agents,and anti-oxidants are discussed.Many of these studies have shown therapeutic benefit and improved survival in experimental models.Based on available preclinical studies,we discuss potential novel targeted pharmacologic approaches that may offer promise in the treatment of acute pancreatitis.To date a variety of clinical studies have assessed the translational potential of animal model effective experimental therapies and have shown either failure or mixed results in human studies.Despite these discouraging clinical studies,there is a great clinical need and there exist several preclinical effective therapies that await investigation in patients.Better understanding of acute pancreatitis pathophysiology and lessons learnedfrom past clinical studies are likely to offer a great foundation upon which to expand future therapies in acute pancreatitis. | Swetha Kambhampati Walter Park Aida Habtezion | 2014 | World Journal of Gastroenterology2014，20，45： | 22 |
| 2 | Endocytosis unplugged: multiple ways to enter the cell显示文摘Endocytosis 在房间表面发生并且与它的成分膜蛋白质和类脂化合物一起包含血浆膜(下午) 的成为主观。Endocytosis 涉及细胞外的周围的采样并且也服务调整在房间表面开始的各种各样的过程。这些包括滋养的举起,从房间表面受体,和为在 metazoans 工作的房间和织物的许多另外的过程必需品发信号。它对下午类脂化合物和蛋白质动态平衡的维护也中央。有成为主观的多重工具并发地操作,在房间表面。与在高分辨率的可视化技术的前进,同时追踪多重 endocytic 货物现在是可能的,揭示在一个单个房间的 endocytic 进程的显著差异。实时房间成像和有效基因操作的联合也帮助了在成为主观的这些机制理解分子的播放器的功能的层次。这里,我们提供各种各样的 endocytic 线路的一篇报道,他们越过数的操作和出现的机制。 | Sudha Kumari Swetha MG Satyajit Mayor | 2010 | Cell Research2010，20，3： | 19 |
| 3 | Bioactive polymeric scaffolds for tissue engineering显示文摘A variety of engineered scaffolds have been created for tissue engineering using polymers,ceramics and their composites.Biomimicry has been adopted for majority of the three-dimensional(3D)scaffold design both in terms of physicochemical properties,as well as bioactivity for superior tissue regeneration.Scaffolds fabricated via salt leaching,particle sintering,hydrogels and lithography have been successful in promoting cell growth in vitro and tissue regeneration in vivo.Scaffold systems derived from decellularization of whole organs or tissues has been popular due to their assured biocompatibility and bioactivity.Traditional scaffold fabrication techniques often failed to create intricate structures with greater resolution,not reproducible and involved multiple steps.The 3D printing technology overcome several limitations of the traditional techniques and made it easier to adopt several thermoplastics and hydrogels to create micro-nanostructured scaffolds and devices for tissue engineering and drug delivery.This review highlights scaffold fabrication methodologies with a focus on optimizing scaffold performance through the matrix pores,bioactivity and degradation rate to enable tissue regeneration.Review highlights few examples of bioactive scaffold mediated nerve,muscle,tendon/ligament and bone regeneration.Regardless of the efforts required for optimization,a shift in 3D scaffold uses from the laboratory into everyday life is expected in the near future as some of the methods discussed in this review become more streamlined. | Scott Stratton Namdev B.Shelke Kazunori Hoshino Swetha Rudraiah Sangamesh G.Kumbar | 2016 | Bioactive Materials2016，1，2： | 14 |
| 4 | Bioactive polymeric materials and electrical stimulation strategies for musculoskeletal tissue repair and regeneration显示文摘Electrical stimulation(ES)is predominantly used as a physical therapy modality to promote tissue healing and functional recovery.Research efforts in both laboratory and clinical settings have shown the beneficial effects of this technique for the repair and regeneration of damaged tissues,which include muscle,bone,skin,nerve,tendons,and ligaments.The collective findings of these studies suggest ES enhances cell proliferation,extracellular matrix(ECM)production,secretion of several cytokines,and vasculature development leading to better tissue regeneration in multiple tissues.However,there is still a gap in the clinical relevance for ES to better repair tissue interfaces,as ES applied clinically is ineffective on deeper tissue.The use of a conducting material can transmit the stimulation applied from skin electrodes to the desired tissue and lead to an increased function on the repair of that tissue.Ionically conductive(IC)polymeric scaffolds in conjunction with ES may provide solutions to utilize this approach effectively.Injectable IC formulations and their scaffolds may provide solutions for applying ES into difficult to reach tissue types to enable tissue repair and regeneration.A better understanding of ES-mediated cell differentiation and associated molecular mechanisms including the immune response will allow standardization of procedures applicable for the next generation of regenerative medicine.ES,along with the use of IC scaffolds is more than sufficient for use as a treatment option for single tissue healing and may fulfill a role in interfacing multiple tissue types during the repair process. | Bryan Ferrigno Rosalie Bordett Nithyadevi Duraisamy Joshua Moskow Michael R.Arul Swetha Rudraiah Syam P.Nukavarapu Anthony T.Vella Sangamesh G.Kumbar | 2020 | Bioactive Materials2020，5，3： | 8 |
| 5 | Influence of heat treatment on the machinability and corrosion behavior of AZ91 Mg alloy显示文摘In the present study,AZ91 Mg alloy was heat treated at 410℃ for 6,12 and 24 h to investigate the influence of heat treatment on machinability and corrosion behavior.The effect of soaking time on the amount and distribution of Mg 17 Al 12(β-phase)was analyzed under the optical microscope.Microhardness measurements demonstrated the increased hardness with increased heat treatment soaking time,which can be attributed to the solid solution strengthening.The influence of super saturatedα-grains on reducing the cutting force(F z)with respect to increased cutting speed was observed as prominent.The corrosion behavior of the heat treated specimens was studied by conducting electrochemical tests.Surprisingly,corrosion rate of heat treated samples was observed as increased compared with the base material.From the results,it is evident that the machinability of AZ91 Mg alloy can be improved by producing super saturatedα-grains through heat treatment but at the cost of losing corrosion resistance. | Swetha Chowdary V Ravikumar Dumpala Anand Kumar S Kondaiah VV Ratna Sunil B | 2018 | Journal of Magnesium and Alloys2018，6，1： | 7 |
| 6 | 硝基咪唑杂环药物化学研究进展显示文摘硝基咪唑是一类特殊结构的杂环,五元芳香杂环咪唑与硝基的共缀使其衍生物呈现广泛的应用潜力,在药物、人工诊断剂与人工探针等相关领域研究异常活跃,尤其是在医药方面作为人工合成的化学药物已在临床中广泛用于抗癌、抗菌、抗寄生虫等,备受关注.本文结合本课题组相关研究,参考国内外近期文献,系统地综述了硝基咪唑类化合物在药物化学领域的研究与应用,包括抗肿瘤、抗细菌、抗真菌、抗寄生虫、抗结核、抗高血压以及作为人工诊断剂与病理探针、超分子基体等领域的当前现状,展望了其未来可能的发展趋势.希望该评述能为硝基咪唑类杂环化合物的多用途开发提供有益的指导. | 李珍珍 Maddili Swetha Kameswari TangadanchuVijai Kumar Reddy Bheemanaboina Rammohan R.Yadav 林健梅 杨仁国 蔡桂鑫 周成合 | 2019 | 中国科学:化学2019，49，2： | 6 |
| 7 | Review: Bioengineering approach for the repair and regeneration of peripheral nerve显示文摘Complex craniofacial surgeries of damaged tissues have several limitations,which present complications and challenges when trying to replicate facial function and structure.Traditional treatment techniques have shown suitable nerve function regeneration with various drawbacks.As technology continues to advance,new methods have been explored in order to regenerate damaged nerves in an effort to more efficiently and effectively regain original function and structure.This article will summarize recent bioengineering strategies involving biodegradable composite scaffolds,bioactive factors,and external stimuli alone or in combination to support peripheral nerve regeneration.Particular emphasis is made on the contributions of growth factors and electrical stimulation on the regenerative process. | Joshua Moskow Bryan Ferrigno Nikhil Mistry Devina Jaiswal Ketan Bulsara Swetha Rudraiah Sangamesh G.Kumbar | 2019 | Bioactive Materials2019，4，1： | 6 |
| 8 | Discovery of natural berberine-derived nitroimidazoles as potentially multi-targeting agents against drug-resistant Escherichia coli显示文摘A series of natural berberine-derived nitroimidazoles as novel antibacterial agents were designed, synthesized and characterized by nuclear magnetic resonance(NMR), infrared spectra(IR), and high resolution mass spectra(HRMS) spectra. The antimicrobial evaluation showed that some target molecules exhibited moderate to good inhibitory activities against the tested bacteria and fungi including clinical drug-resistant strains isolated from infected patients. Especially, 2-fluorobenzyl derivative8 f not only gave strong activity against drug-resistant E. coli with the minimal inhibitory concentration(MIC) value of0.003 m M, 33-fold more active than norfloxacin, but also exhibited low toxicity toward RAW 264.7 cells and less propensity to trigger resistance. The aqueous solubility and Clog P values of target compounds were investigated to elucidate the structureactivity relationships. Molecular docking and quantum chemical studies for compound 8 f rationally explained its antibacterial effect. The further exploration of antibacterial mechanism revealed that the highly active compound 8 f could effectively permeabilize E. coli cell membrane and intercalate into DNA isolated from resistant E. coli to form 8 f-DNA complex that might block DNA replication to exert the powerful bioactivities. Compound 8 f could also selectively address resistant E. coli from a mixture of various strains. | Guo-Biao Zhang Swetha Kameswari Maddili Vijai Kumar Reddy Tangadanchu Lavanya Gopala Wei-Wei Gao Gui-Xin Cai Cheng-He Zhou | 2018 | Science China Chemistry2018，61，5： | 5 |
| 9 | Biogenesis of antibacterial silver nanoparticles using the endophytic bacterium Bacillus cereus isolated from Garcinia xanthochymus显示文摘Objective:To synthesize the ecofriendly nanoparticles,which is viewed as an alternative to the chemical method which initiated the use of microbes like bacteria and fungi in their synthesis.Methods:The current study uses the endophytic bacterium Bacillus cereus isolated from the Garcinia xanthochymus to synthesize the silver nanoparticles(AgNPs).The AgNPs were synthesized by reduction of silver nitrate solution by the endophytic bacterium after incubation for 3-5 d at room temperature.The synthesis was initially observed by colour change from pale white to brown which was confirmed by UV-Vis spectroscopy.The AgNPs were further characterized using FTIR,SEM-EDX and TEM analyses.Results:The synthesized nanoparticles were found to he spherical with the size in the range of 20-40 nm which showed a slight aggregation.The energy-dispersive spectra of the nanoparticle dispersion confirmed the presence of elemental silver.The AgNPs were found to have antibacterial activity against a few pathogenic bacteria like Escherichia coli,Pseudomonas aeruginosa,Staphylococcus aureus,Salmonella typhi and Klebsiella pneumoniae.Conclusions:The endophytic bacteria identified as Bacillus cereus was able to synthesize silver nanoparticles with potential antibacterial activity. | Swetha Sunkar C Valli Nachiyar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，12： | 5 |
| 10 | Evaluating the effectiveness of marine actinobacterial extract and its mediated titanium dioxide nanoparticles in the degradation of azo dyes显示文摘Aim of the present study was to synthesize titanium dioxide nanoparticles(TiO2 NPs) from marine actinobacteria and to develop an eco-friendly azo-dye degradation method. A total of five actinobacterial isolates were isolated from Chennai marine sediments, Tamilnadu, India and analyzed for the synthesis of TiO2 NPs using titanium hydroxide. Among these, the isolate PSV 3 showed positive results for the synthesis of TiO2 NPs, which was confirmed by UV analysis. Further characterization of the synthesized TiO2 NPs was done using XRD, AFM and FT-IR analysis. Actinobacterial crude extract and synthesized TiO2 NPs was found efficient in degrading azo dye such as Acid Red 79(AR-79) and Acid Red 80(AR-80). Degradation percentage was found to be 81% for AR-79, 83% for AR-80 using actinobacterial crude extract and 84% for AR-79, 85% for AR-80 using TiO2 NPs. Immobilized actinobacterial cells showed 88% for AR-79 and 81% for AR-80, dye degrading capacity. Degraded components were characterized by FT-IR and GC-MS analysis. The phytotoxicity test with 500 μg/mL of untreated dye showed remarkable phenotypic as well as cellular damage to Tagetes erecta plant. Comparatively no such damage was observed on plants by degraded dye components. In biotoxicity assay, treated dyes showed less toxic effect as compared to the untreated dyes. | S Priyaragini S Veena D Swetha L Karthik G Kumar K V Bhaskara Rao | 2014 | Journal of Environmental Sciences2014，26，4： | 4 |
| 11 | Comparison of Yttrium-90 Radioembolization and Transcatheter Arterial Chemoembolization for the Treatment of Unresectable Hepatocellular Carcinoma显示文摘 | David A. Kooby Vasili Egnatashvili Swetha Srinivasan Abbas Chamsuddin Keith A. Delman John Kauh Charles A. Staley Hyun S. Kim | 2010 | Journal of Vascular and Interventional Radiology2010，，2： | 3 |
| 12 | Molded fiber and pulp products as green and sustainable alternatives to plastics:A mini review显示文摘There are significant incentives/pressures on decreasing the use of plastics and their related prod-ucts in the packaging industry,correspondingly,strong demands are emerging for clean,renew-able,recyclable/biodegradable packaging products.In this context,molded fiber/pulp products have attracted increasing attention,due to their green/sustainable advantages,simply because the raw materials used are plant-based and/or recycled fibers.Many companies have switched their packing practices from plastics to more environmentally friendly products,such as molded fiber products,which already have had and will continue to have obvious effect on packaging industries.This paper initially provides an overview on the general concept of molded pulp prod-ucts,and further summarizes the different types of molded fiber products in terms of natural fiber sources,manufacturing processes,current and emerging applications as well as the environmental sustainability of molded products. | Yanling Zhang Chao Duan Swetha Kumari Bokka Zhibin He Yonghao Ni | 2022 | Journal of Bioresources and Bioproducts2022，7，1： | 2 |
| 13 | Biopolymer-nanotube nerve guidance conduit drug delivery for peripheral nerve regeneration:In vivo structural and functional assessment显示文摘Peripheral nerve injuries account for roughly 3%of all trauma patients with over 900,000 repair procedures annually in the US.Of all extremity peripheral nerve injuries,51%require nerve repair with a transected gap.The current gold-standard treatment for peripheral nerve injuries,autograft repair,has several shortcomings.Engineered constructs are currently only suitable for short gaps or small diameter nerves.Here,we investigate novel nerve guidance conduits with aligned microchannel porosity that deliver sustained-release of neurogenic 4-aminopyridine(4-AP)for peripheral nerve regeneration in a critical-size(15 mm)rat sciatic nerve transection model.The results of functional walking track analysis,morphometric evaluations of myelin development,and histological assessments of various markers confirmed the equivalency of our drug-conduit with autograft controls.Repaired nerves showed formation of thick myelin,presence of S100 and neurofilament markers,and promising functional recovery.The conduit’s aligned microchannel architecture may play a vital role in physically guiding axons for distal target reinnervation,while the sustained release of 4-AP may increase nerve conduction,and in turn synaptic neurotransmitter release and upregulation of critical Schwann cell neurotrophic factors.Overall,our nerve construct design facilitates efficient and efficacious peripheral nerve regeneration via a drug delivery system that is feasible for clinical applications. | Ohan S.Manoukian Swetha Rudraiah Michael R.Arul Jenna M.Bartley Jiana T.Baker Xiaojun Yu Sangamesh G.Kumbar | 2021 | Bioactive Materials2021，6，9： | 2 |
| 14 | End-to-end computational approach to the design of RNA biosensors for detecting miRNA biomarkers of cervical cancer显示文摘Cervical cancer is a global public health subject as it affects women in the reproductive ages,and accounts for the second largest burden among cancer patients worldwide with an unforgiving 50%mortality rate.Relatively scant awareness and limited access to effective diagnosis have led to this enormous disease burden,calling for point-of-care,minimally invasive diagnosis methods.Here,an end-to-end quantitative unified pipeline for diagnosis has been developed,beginning with identification of optimal biomarkers,concurrent design of toehold switch sensors,and finally simulation of the designed diagnostic circuits to assess performance.Using miRNA expression data in the public domain,we identified miR-21-5p and miR-20a-5p as blood-based miRNA biomarkers specific to early-stage cervical cancer employing a multi-tier algorithmic screening.Synthetic riboregulators called toehold switches specific to the biomarker panel were then designed.To predict the dynamic range of toehold switches for use in genetic circuits as biosensors,we used a generic grammar of these switches,and built a neural network model of dynamic range using thermodynamic features derived from mRNA secondary structure and interaction.Second-generation toehold switches were used to overcome the design challenges associated with miRNA biomarkers.The resultant model yielded an adj.R^(2)~0.71,outperforming earlier models of toehold-switch dynamic range.Reaction kinetics modelling was performed to predict the sensitivity of the second-generation toehold switches to the miRNA biomarkers.Simulations showed a linear response between 10 nM and 100 nM before saturation.Our study demonstrates an end-to-end computational workflow for the efficient design of genetic circuits geared towards the effective detection of unique genomic/nucleic-acid signatures.The approach has the potential to replace iterative experimental trial and error,and focus time,money,and efforts.All software including the toehold grammar parser,neural network model and reaction kinetics simulation are available as open-source software(http://gffzz188fe103f8f1460asb6xbnpx5x6uo6ffc.ffgz.tsg.suse.edu.cn/SASTRA-iGEM2019)under GNU GPLv3 licence. | Priyannth Ramasami S.Baabu Shivaramakrishna Srinivasan Swetha Nagarajan Sangeetha Muthamilselvan Thamarai Selvi Raghavv R.Suresh Ashok Palaniappan | 2022 | Synthetic and Systems Biotechnology2022，7，2： | 2 |
| 15 | Hepatitis E virus infection in the liver transplant recipients:Clinical presentation and management显示文摘Hepatitis E virus(HEV) is an emerging pathogen and an increasingly recognized cause of graft hepatitis, especially in the post-orthotopic liver transplantation immunocompromised population. The exact incidence and prevalence of HEV infection in this population remains unclear but is certainly greater than historical estimates. Identifying acute HEV infection in this population is imperative for choosing the right course of management as it is very difficult to distinguish histologically from acute rejection on liver biopsy. Current suggested approach to manage acute HEV involves modifying immunosuppression, especially discontinuing calcineurin inhibitors which are the preferred immunosuppressive agents post-orthotopic liver transplantation. The addition of ribavirin monotherapy has shown promising success rates in clearing HEV infection and is used commonly in reported cases. | Avin Aggarwal Ryan B Perumpail Swetha Tummala Aijaz Ahmed | 2016 | World Journal of Hepatology2016，8，2： | 2 |
| 16 | In vitro and in vivo aldose reductase inhibitory activity of standardized extracts and the major constituent of andrographis paniculata 显示文摘 | VEERESHAM C SWETHA E RAO A R | 2013 | Phytother Res2013，27，3： | 1 |
| 17 | Automated extraction of watershed boundary and drainage network from SRTM and comparison with survey of India toposheet显示文摘 | GOPINATH Girish SWETHA T V ASHITHA M K | 2014 | Arabian Journal of Geosciences2014，7，7： | 1 |
| 18 | Sleep and Diabetes显示文摘 | Swetha Bopparaju Salim Surani Jessica A. Mong | 2010 | International Journal of Endocrinology2010，，： | 1 |
| 19 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering显示文摘 | Swetha M Sahithi K Moorthi A | 2010 | Int J Biol Macromol2010，1，： | 1 |
| 20 | Biocomposites containing natural polymers and hydroxyapatite for bone tissue engineering显示文摘 | Maddela Swetha Kolli Sahithi Ambigapathi Moorthi Narasimhan Srinivasan Kumarasamy Ramasamy Nagarajan Selvamurugan | 2010 | International Journal of Biological Macromolecules2010，，1： | 1 |
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