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| 1 | 羟乙基淀粉溶液在复苏肠缺血-再灌注休克中的作用显示文摘目的 比较不同剂量羟乙基淀粉溶液 ( HES)对兔肠缺血再灌注损伤所致休克的复苏作用。方法 32只新西兰白兔随机分为 4组 :模型对照、乳酸林格液复苏组 ( L RS,2 0 m l· kg- 1 · h- 1 ) ,小剂量 HES复苏组 ( HES2 ml· kg- 1· h- 1 + L RS18m l· kg- 1· h- 1 ) ,大剂量 HES复苏组 ( HES2 0 ml· kg- 1· h- 1 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠缺血再灌注休克模型 ,松夹再灌注时同步进行液体复苏。观测各时间点的血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 ) ,并通过测定肠黏膜CO2 分压和动脉血 CO2 分压的差值 (动脉二氧化碳间隙 )、肠黏膜 p H值、动脉血乳酸浓度和氧输送等指标间接评估组织氧合情况。实验结束后累计动物死亡数。结果 HES能明显提高肠缺血再灌注休克时的血流动力学参数 ,与对照组和 L RS组比较差异均有显著性 ( P均 <0 .0 5 ) ;小剂量 HES比大剂量 HES改善血流动力学参数的作用更平稳 ( P均 <0 .0 5 ) ,且较其他 3组能明显降低血乳酸浓度和动脉二氧化碳间隙 ,减轻 p Hi的降低 ( P均 <0 .0 5 ) ;而大剂量 HES对上述参数的影响不明显 ,并可见动物口鼻出血及死亡 ;小剂量或大剂量HES与其他两组比较均能使氧输送回升 ( P均 <0 .0 5 )。 | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo Daniel de Backer 肖献忠 Jean-Louis Vincent | 2004 | 中国危重病急救医学2004，16，8： | 6 |
| 2 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 3 | 不同液体复苏条件下多巴酚丁胺对肠缺血-再灌注休克的疗效比较显示文摘目的 比较多巴酚丁胺在不同液体复苏条件下对兔肠缺血再灌注损伤 (I/ R)所致休克的治疗效果。方法 32只新西兰白兔随机分为乳酸林格液 (L RS)复苏组、L RS+羟乙基淀粉溶液 (HES)复苏组、L RS复苏 +多巴酚丁胺治疗组 (L RS+DOB组 )和 L RS+HES复苏 +多巴酚丁胺治疗组 (L RS+HES+DOB组 )。采用肠系膜上动脉夹闭 6 0 m in后松夹行再灌注制备肠 I/ R休克模型 ,松夹再灌注时同步进行液体复苏和多巴酚丁胺治疗。观察各时间点血流动力学参数 (平均动脉压、心率、心排血量、肠系膜上动脉血流 )的变化 ,并通过测定动脉二氧化碳间隙〔 Pt a CO2 间隙 =肠黏膜 CO2 分压 (Pt CO2 ) -动脉血 CO2 分压 (Pa CO2 )〕、肠黏膜 p H值 (p Hi)、动脉血乳酸浓度和氧输送 (DO2 )等指标间接评价组织氧合情况。结果 多巴酚丁胺能显著减轻兔肠I/ R休克后平均动脉压、心率、心排血量和肠系膜上动脉血流的下降 ,两多巴酚丁胺治疗组与两复苏组比较 ,差异均有显著性 (P均 <0 .0 5 ) ;且 L RS+HES+DOB组平均动脉压下降程度较 L RS+DOB组明显减轻 (P<0 .0 5 )。与 L RS组比较 ,两多巴酚丁胺治疗组均能明显降低血乳酸浓度和 Pt a CO2 间隙 ,升高 p Hi和 DO2 (P均<0 .0 5 ) ,尤其在 L RS+HES+DOB组效果更显著 (P均 <0 .0 5 ) ,与 L | 涂自智 孙庆华 George Dimopoulos Suzana M Lobo DanielDe Backer 肖献忠 Jean-Louis Vincent | 2005 | 中国危重病急救医学2005，17，2： | 3 |
| 4 | Immune response-related genes associated to blocking midgut dengue virus infection in Aedes aegypti strains that differ in susceptibility显示文摘Aedes (Stegomyia) aegypti, the principal global vector of dengue viruses, has difTerences in its susceptibility to dengue virus infection. We compared the global expres? sion of genes in the midguts of Colombian Ae. aegypti dengue-susceptible (Cali-S) and dengue-refractory (Cali-MIB) field derived strains after ingesting either a sugarmeal, a bloodmeal, or a bloodmeal containing dengue virus serotype 2 (DENV-2). Microarraybased transcriptome analysis among treatments indicated a total of 4725 transcripts with differential expression between the two strains. Eleven genes were selected from different functional groups based on their significant up or down expression levels as well as reports in the literature suggesting they are associated with dengue virus elimination. We measured mRNA abundance of these 11 genes at 0, 8, 24, and 36 h postinfection using quantitative real time PCR (qPCR) to confirm the microarray results and assess any temporal patterns. Four genes were selected (Gram-negative binding protein—GNBP [AAEL009176], Niemann Pick Type-C2一NPC2 [AAEL015136], Keratinocyte lectin [AAEL009842], and Cathepsin-b [AAEL007585]) for knockdown experiments using RNA interference (RNAi) methodology to determine the phenotype (DENV-2 susceptible or refractory). Silencing GNBP、Cathepsin-b and Keratinocyte lectin reduced the percentage of mosquitoes with disseminated virus in the Cali-S strain to 8%, 20%, and 12% respectively compared with 96% in the controls. Sile ncing of NPC2 increased the percentage of mosquitos with disseminated virus infections in Cali-MIB to 66% compared with 35% in the controls. This study provides in sight into genes that may contribute to the Cali-S susceptible and Cali-MIB refractory phenotypes in 昇匕 aegypti. | Paola A. Caicedo Idalba Mildred Serrato Shuzhen Sim George Dimopoulos Heather Coatsworth Carl Lowenberger Clara B. Ocampo | 2019 | Insect Science2019，26，4： | 2 |
| 5 | Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer显示文摘 | Potter R Dimopoulos J Georg P | 2007 | Radiother Oncol2007，83，2： | 1 |
| 6 | Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer 显示文摘 | Potter R Georg P Dimopoulos JC | 2011 | RadiotherOneol2011，100，1： | 1 |
| 7 | Dose-volume histogram parameters and late side effects in magnetic resonance image-guided adaptive cervical cancer brachytherapy显示文摘 | Georg P Lang S Dimopoulos J C A | 2011 | International Journal of Radiation Oncology*Biology*Physics2011，79，2： | 1 |
| 8 | Uncertainties in as sessment of the vaginal dose for intracavitary brachytherapy of cervical cancer using a tandem-ring applicator显示文摘 | Berger D Dimopoulos J Georg P | 2007 | Int J Radiat Oncol Biol Phys2007，67，5： | 1 |
| 9 | Clinical outcome of protocol based image (MRI) guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patiens with locally advanced cervical cancer显示文摘 | Potter R Georg P Dimopoulos JC | 2011 | Radiother Oncol2011，100，1： | 1 |
| 10 | Uncertainties in assessment of the vaginal dose for intracavitary brachytherapy of cervical cancer using a tandem-ring applicator显示文摘 | Berger D Dimopoulos J Georg P | 2007 | Int J Radiat Oncol Biol Phys2007，67，： | 1 |
| 11 | Exergy analysis and optimization of a steam methane pre-reforming system显示文摘 | George G Dimopoulos Lason C Stefanatos Nikolaos M P Kakalis | 2012 | Energy2012，58，： | 1 |
| 12 | The predictive value of dose volume paranmters on local tumour control in MRI assisted brachytherapy of cervix cancer显示文摘 | Dimopoulos J Georg P Kirisits K | 2006 | Radiother Oncol2006，81，： | 1 |
| 13 | Clinical impact of MRl assisted dose volume adaptation and dose escalation in brachytherapy of locally advanced cervix cancer显示文摘 | Potter R Dimopoulos J Georg P | 2007 | Radiothe Oncol2007，83，2： | 1 |
| 14 | An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients显示文摘 | Dimitrios Matthaiou Georgia Ntani Marina Kontogiorgi Garyfallia Poulakou Apostolos Armaganidis George Dimopoulos | 2012 | Intensive Care Medicine2012，，6： | 1 |
| 15 | Dose-volume histogramparameters and late side effects in magnetic resonance image-guided adaptive cervical cancer brachytherapy 显示文摘 | Georg P Lang S Dimopoulos JC | 2011 | Int J RadiatOncol Biol Phys2011，79，2： | 1 |
| 16 | Clinical outcome ofprotocol based image ( MRI) guided adaptive brachytherapy com-bined with 3D conformal radiotherapy with or without chemothera-py in patients with locally advanced cervical cancer显示文摘 | Potter R Georg P Dimopoulos JCA | 2011 | RadiotherOncol2011，100，1： | 1 |
| 17 | Effect of reliabilityconsiderations on the optimal synthesis,design and operation of acogeneration system 显示文摘 | Frangopoulos Christos A George G Dimopoulos | 2004 | Energy2004，29，3： | 1 |
| 18 | Clinical impact of MRI assisted dose volume adaptation and dose escalation in brachythera- py of locally advanced cervix cancer 显示文摘 | Potter R Dimopoulos J Georg P | 2007 | Radiother Oncol2007，83，2： | 1 |
| 19 | An ESICM systematic review and meta-analysis of procalcitonin-guided antibiotic therapy algorithms in adult critically ill patients显示文摘 | Dimitrios Matthaiou Georgia Ntani Marina Kontogiorgi Garyfallia Poulakou Apostolos Armaganidis George Dimopoulos | 2012 | Intensive Care Medicine2012，，6： | 1 |
| 20 | Clinical outcome of protocol based image(MRI)guided adaptive brachytherapy combined with 3D conformal radiotherapy with or without chemotherapy in patients with locally advanced cervical cancer显示文摘 | Potter R Georg P Dimopoulos JC | 2011 | Radiother Oncol2011，100，1： | 1 |
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