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| 1 | Microbiota modification by probiotic supplementation reduces colitis associated colon cancer in mice显示文摘AIM To investigate the effect of probiotic supplementation during the development of an experimental model of colitis associated colon cancer(CAC). METHODS C57 BL/6 mice received an intraperitoneal injection of azoxymethane(10 mg/kg), followed by three cycles of sodium dextran sulphate diluted in water(5% w/v). Probiotic group received daily a mixture of Lactobacillus acidophilus, Lactobacil us rhamnosus and Bifidobacterium bifidum. Microbiota composition was assessed by 16 Sr RNA Illumina Hi Seq sequencing. Colon samples were collected for histological analysis. Tumor cytokines was assessed by Real Time-PCR(Polymerase Chain Reaction); and serum cytokines by Multiplex assay. All tests were two-sided. The level of significance was set at P < 0.05. Graphs were generated and statistical analysis performed using the software Graph Pad Prism 5.0. The project was approved by the institutional review board committee. RESULTS At day 60 after azoxymethane injection, the mean number of tumours in the probiotic group was 40% lower than that in the control group, and the probiotic group exhibited tumours of smaller size(< 2 mm)(P < 0.05). There was no difference in richness and diversity between groups. However, there was a significant difference in beta diversity in the multidimensional scaling analysis. The abundance of the genera Lactobacillus, Bifidobacterium, Allobaculum, Clostridium XI and Clostridium XVⅢ increased in the probiotic group(P < 0.05). The microbial change was accompanied by reduced colitis, demonstrated by a 46% reduction in the colon inflammatory index; reduced expression of the serum chemokines RANTES and Eotaxin; decreased p-IKK and TNF-α and increased IL-10 expression in the colon. CONCLUSION Our results suggest a potential chemopreventive effect of probiotic on CAC. Probiotic supplementation changes microbiota structure and regulates the inflammatory response, reducing colitis and preventing CAC. | Maria Carolina S Mendes Daiane SM Paulino Sandra R Brambilla Juliana A Camargo Gabriela F Persinoti José Barreto C Carvalheira | 2018 | World Journal of Gastroenterology2018，24，18： | 17 |
| 2 | Transcranial direct current stimulation enhances theory of mind in Parkinson’s disease patients with mild cognitive impairment:a randomized,double-blind,sham-controlled study显示文摘Background:Parkinson’s Disease(PD)with mild cognitive impairment(MCI)(PD-MCI)represents one of the most dreaded complications for patients with PD and is associated with a higher risk of developing dementia.Although transcranial direct current stimulation(tDCS)has been demonstrated to improve motor and non-motor symptoms in PD,to date,no study has investigated the effects of tDCS on Theory of Mind(ToM),i.e.,the ability to understand and predict other people’s behaviours,in PD-MCI.Methods:In this randomized,double-blind,sham-controlled study,we applied active tDCS over the medial frontal cortex(MFC)to modulate ToM performance in twenty patients with PD-MCI.Twenty matched healthy controls(HC)were also enrolled and were asked to perform the ToM task without receiving tDCS.Results:In the patients with PD-MCI,i)ToM performance was worse than that in the HC,ii)ToM abilities were poorer in those with fronto-executive difficulties,and iii)tDCS over the MFC led to significant shortening of latency for ToM tasks.Conclusions:We show for the first time that active tDCS over the MFC enhances ToM in patients with PD-MCI,and suggest that non-invasive brain stimulation could be used to ameliorate ToM deficits observed in these patients. | Mauro Adenzato Rosa Manenti Ivan Enrici Elena Gobbi Michela Brambilla Antonella Alberici Maria Sofia Cotelli Alessandro Padovani Barbara Borroni Maria Cotelli | 2019 | Translational Neurodegeneration2019，8，1： | 9 |
| 3 | Molecular Control of Flowering in Response to Day Length in Rice显示文摘Flowering at the most appropriate times of the year requires careful monitoring of environmental conditions and correct integration of such information with an endogenous molecular network. Rice (Oryza sativa) is a facultative short day plant, and flowers quickly under short day lengths, as opposed to Arabidopsis thaliana whose flowering is accelerated by longer days. Despite these physiological differences, several genes controlling flowering in response to day length (or photoperiod) are conserved between rice and Arabidopsis, and the molecular mechanisms involved are similar. Inductive day lengths trigger expression of florigenic proteins in leaves that can move to the shoot apical meristem to induce reproductivedevelopment. As compared to Arabidopsis, rice also possesses unique factors that regulate expression of florigenic genes. Here, we discuss recent advances in understanding the molecular mechanisms involved in day length perception, production of florigenic signals, and molecular responses of the shoot apical meristem to florigenic proteins. | Vittoria Brambilla Fabio Fornara | 2013 | Journal of Integrative Plant Biology2013，55，5： | 5 |
| 4 | International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma显示文摘 | William D. Travis Elisabeth Brambilla Masayuki Noguchi Andrew G. Nicholson Kim R. Geisinger Yasushi Yatabe David G. Beer Charles A. Powell Gregory J. Riely Paul E. Van Schil Kavita Garg John H. M. Austin Hisao Asamura Valerie W. Rusch Fred R. Hirsch Giorg | 2011 | Journal of Thoracic Oncology2011，，2： | 4 |
| 5 | Innovative Metallized Formulations for Solid Rocket Propulsion显示文摘Several metallized solid rocket propellants,AP/Metal/HTPB in the ratio 68/18/14,were experimentally analyzed at the Space Propulsion Laboratory of Politecnico di Milano.Effects of the metals(micrometric and nanometric Al,B,Mg,and a variety of dual metals) on the performance of the propellant were studied and contrasted to a conventional micrometric aluminum(30 μm average grain size) taken as reference.It is shown that the propellant microstructure plays a fundamental role in controlling the critical aggregation/agglomeration phenomena occurring below and near the burning surface.Two specific effects of microstructure in terms of steady burning rate and average agglomerate size are illustrated. | Luigi T DeLUCA Luciano GALFETTI Filippo MAGGI Giovanni COLOMBO Alice REINA Stefano DOSSI Daniele CONSONNI Melissa BRAMBILLA | 2012 | 含能材料2012，20，4： | 3 |
| 6 | Hollow-core antiresonant terahertz fiber-based TOPAS extruded from a 3D printer using a metal 3D printed nozzle显示文摘We report the use of a terahertz(THz)transparent material,cyclic olefin copolymer(COC or TOPAS),for fabricating a hollow-core antiresonant fiber that provides an electromagnetic wave guidance in the THz regime.A novel fabrication technique to realize a hollow-core antiresonant polymer optical fiber(HC-ARPF)for THz guidance is proposed and demonstrated.The fiber is directly extruded in a single-step procedure using a conventional fused deposition modeling 3 D printer.The fiber geometry is defined by a structured nozzle manufactured with a metal 3 D printer,which allows tailoring of the nozzle design to the various geometries of microstructured optical fibers.The possibility to use the HC-ARPF made from TOPAS for guiding in the THz region is theoretically and experimentally assessed through the profile of mode simulation and time-frequency diagram(spectrogram)analysis. | WANVISA TALATAISONG JON GORECKI LIEKE D.VAN PUTTEN RAND ISMAEEL JAMES WILLIAMSON KATIE ADDINALL DANIEL SCHWENDEMANN MARTYNAS BERESNA VASILIS APOSTOLOPOULOS GILBERTO BRAMBILLA | 2021 | Photonics Research2021，9，8： | 2 |
| 7 | Alternative splicing enhances transcriptome complexity in desiccating seeds显示文摘Before being dispersed in the environment, mature seeds need to be dehydrated. The survival of seeds after dispersal depends on their low hydration in combination with high desiccation tolerance. These characteristics are established during seed maturation. Some key seed maturation genes have been reported to be regulated by alternative splicing(AS). However, so far AS was described only for single genes and a comprehensive analysis of AS during seed maturation has been lacking. We investigated gene expression and AS during Arabidopsis thaliana seed development at a global level, before and after desiccation. Bioinformatics tools were developed to identify differentially spliced regions within genes. Our data suggest the importance and shows the peculiar features of AS during seed desiccation. We identified AS in 34% of genes that are expressed at both timepoints before and after desiccation. Most of these AStranscript variants had not been found before in other tissues.Among the AS genes some seed master regulators could be found. Interestingly, 6% of all expressed transcripts were not transcriptionally regulated during desiccation, but only modified by AS. We propose that AS should be more routinely taken into account in the analysis of transcriptomic data to prevent overlooking potentially important regulators. | Arunkumar Srinivasan Jose M. Jimenez-Gomez Fabio Fornara Wim J. J. Soppe Vittoria Brambilla | 2016 | Journal of Integrative Plant Biology2016，58，12： | 2 |
| 8 | Use molecularly imprinted polymers in the solid-phase extraction of clenbuterol from animal feeds and biological matrics 显示文摘 | Brambilla G | 2001 | J Chromatogr B2001，759，： | 2 |
| 9 | Hormetic effect(s) of tetracyclines as environmental contaminant on Zea mays显示文摘 | Luciana Migliore Feliciana Godeas Stefania Paola De Filippis Paolo Mantovi Davide Barchi Cecilia Testa Nicolino Rubattu Gianfranco Brambilla | 2009 | Environmental Pollution2009，，1： | 2 |
| 10 | CVD Diamond for Nuclear Detection Applications显示文摘 | BERGONZO P BRAMBILLA A TROMSON D | 2002 | Nuclear Instruments and Methods in Physics Research2002，476，12： | 1 |
| 11 | Development, reliability and acceptability of a new version of the DSMIV Social and Occupational Functioning Assessment Scale ( SOFAS) to assess routine social functioning 显示文摘 | MOROSINI PL MAGLIANO L BRAMBILLA L | 2000 | Acta Psychiatr Scand2000，101，4： | 1 |
| 12 | The new World Health Organization classification of lung mmours显示文摘 | Brambilla E Travis WD Colby TV | 2001 | Eur RespirJ2001，18，6： | 1 |
| 13 | Glucagon-like peptide-1 secretion in bulimia nervosa显示文摘 | Brambilla F Monteleone P Mai M | 2009 | Psychiatry Res2009，169，1： | 1 |
| 14 | Determination of monobromobimane derivatives of phenylmercapturic and benzylmercapturic acids in urine by high-performance liquid chromatography and fluorimetry显示文摘 | BURATTI M BRAMBILLA G FUSTINONI S | 2001 | J Chromatogr B2001，751，： | 1 |
| 15 | Detection of rifampin resistance by single-strand conformation polymorphism analysis of cerebrospinal fluid of patients with tuberculosis of the central nervous system 显示文摘 | Scarpellini P Braglia S Brambilla A M | 1997 | J Clin Microbiol1997，35，11： | 1 |
| 16 | Injection of adult neurospheres induces recovery in a chronic model of multiple sclero-sis显示文摘 | Pluchino S Quattrini A Elena Brambilla | 2003 | J Nature2003，422，： | 1 |
| 17 | Prognosis of idiopathic recurrent peri-carditis as determined from previously published reports显示文摘 | Imazio M Brucato A Adler Y Brambilla G Artom G Cecchi E | 2007 | Am J Cardiol2007，100，： | 1 |
| 18 | Primary chemotherapy to avoid mastectomy in tumors with diameters of three centimeters or more 显示文摘 | Bonadonna G Veronesi U Brambilla C | 1990 | J Natl Cancer Inst1990，82，19： | 1 |
| 19 | The 2004 World Health Organization classification of lung tumors 显示文摘 | Beasley MB Brambilla E Travis WD | 2005 | Semin Roentgenol2005，40，2： | 1 |
| 20 | Effects of salt-sensitivity on neural cardiovascular regulation in essential hypertension 显示文摘 | Coruzzi P Parati G Brambilla L | 2005 | Hy- pertension2005，46，： | 1 |
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