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| 1 | AME证据系列001--转化医学协会:脓毒症诊断和早期识别的临床实践指南显示文摘脓毒症是一种由感染引起的异质性疾病,感染触发了一系列复杂的局部或者全身的免疫炎症反应,引起多器官功能衰竭,发病率和病死率显著升高。由于至今仍然没有诊断脓毒症的金标准,所以脓毒症的临床诊断仍是一个难题。因此,脓毒症的临床诊断需要不断改变来满足临床和研究的要求。然而,尽管有许多新型的生物标记和筛选工具去预测脓毒症发生的风险,但是这些措施的诊断价值和有效性不足以让人满意,并且没有充分的证据去建议临床使用这些新技术。因此,脓毒症的临床诊断标准需要定期更新去适应不断产生的新证据。这篇综述旨在呈现当前脓毒症的诊断和早期识别方面的最新研究证据。临床运用不同的诊断方法的推荐意见依赖于推荐、评价、发展和评估分级体系(Grades of Recommendation Assessment,Development and Evaluation,GRADE),因为大部分的研究是观察性研究,并没有对这些方法进行可靠评估,采用的是两步推理方法。未来需要更多研究来确认或者反驳某一特殊的指标检测,同时应该直接采用相关病人的结果数据。 | Zhongheng Zhang Nathan J.Smischney Haibo Zhang Sven Van Poucke Panagiotis Tsirigotis Jordi Rello Patrick M.Honore Win Sen Kuan Juliet June Ray Jiancang Zhou You Shang Yuetian Yu Christian Jung Chiara Robba Fabio Silvio Taccone Pietro Caironi David Grimaldi Stefan Hofer George Dimopoulos Marc Leone Sang-Bum Hong Mabrouk Bahloul Laurent Argaud Won Young Kim Herbert D.Spapen Jose Rodolfo Rocco 张建成(译) 尚游(译) 钟鸣(校) | 2016 | 临床与病理杂志2016，36，10： | 5 |
| 2 | Managing project risks using a cross risk breakdown matrix显示文摘 | David Hillson Sabrina Grimaldi Carlo Rafele | 2006 | Risk Management2006，，8： | 1 |
| 3 | Pharmacogenomics of neurodegenerative diseases 显示文摘 | Davide M Roberto D Grimaldi L | 2001 | Eur J Pharmacol2001，413，1： | 1 |
| 4 | Specific MAIT cell behaviour among innate-like T lymphocytes in critically ill patients with severe infections显示文摘 | David Grimaldi Lionel Bourhis Bertrand Sauneuf Agnès Dechartres Christophe Rousseau Fatah Ouaaz Maud Milder Delphine Louis Jean-Daniel Chiche Jean-Paul Mira Olivier Lantz Frédéric Pène | 2014 | Intensive Care Medicine2014，，2： | 1 |
| 5 | 小胶质细胞控制成年小鼠海马中的谷氨酸能突触显示文摘小胶质细胞是调节大脑突触发育和可塑性的重要细胞类型,但其影响突触的正常功能的机制尚不清楚。在本研究中,我们通过PLX5622造成小胶质细胞耗竭,并观察其对成年野生型小鼠海马CA3-CA1突触的影响。在小胶质细胞耗竭后,与树突棘密度降低相关的自发和诱发谷氨酸能活动的减少,出现未成熟突触特征以及突触的可塑性提高。小胶质细胞耗竭的小鼠在新物体识别任务的获取方面表现出缺陷。海马星形胶质细胞出现增生,但并没有神经炎症反应。在Cx3cr1-/-小鼠中,PLX不能导致海马出现上述改变。这说明CX3CL1/CX3CR1轴在小胶质细胞对突触功能的控制中有重要作用。PLX5622停用后,小胶质细胞的重新增殖,海马突触恢复,小鼠的学习功能也出现恢复。综上所述,小胶质细胞对维持成人大脑的突触的正常功能用重要的作用,去除小胶质细胞会导致谷氨酸能突触组织和活动的可逆变化。 | Bernadette Basilico Laura Ferrucci Patrizia Ratano Maria T Golia Alfonso Grimaldi Maria Rosito Valentina Ferretti Ingrid Reverte Caterina Sanchini Maria C Marrone Maria Giubettini Valeria De Turris Debora Salerno Stefano Garofalo Marie-Kim St-Pierre Micael Carrier Massimiliano Renzi Francesca Pagani Brijesh Modi Marcello Raspa Ferdinando Scavizzi Cornelius T Gross Silvia Marinelli Marie-Ève Tremblay Daniele Caprioli Laura Maggi Cristina Limatola Silvia Di Angelantonio Davide Ragozzino | 2021 | 神经损伤与功能重建2021，16，10： | 0 |
| 6 | Separating arbitrary free-space beams with an integrated photonic processor显示文摘Free-space optics naturally offers multiple-channel communications and sensing exploitable in many applications. The different optical beams will, however, generally be overlapping at the receiver, and, especially with atmospheric turbulence or other scattering or aberrations, the arriving beam shapes may not even be known in advance. We show that such beams can be still separated in the optical domain, and simultaneously detected with negligible cross-talk, even if they share the same wavelength and polarization, and even with unknown arriving beam shapes. The kernel of the adaptive multibeam receiver presented in this work is a programmable integrated photonic processor that is coupled to free-space beams through a two-dimensional array of optical antennas. We demonstrate separation of beam pairs arriving from different directions, with overlapping spatial modes in the same direction, and even with mixing between the beams deliberately added in the path. With the circuit’s optical bandwidth of more than 40 nm, this approach offers an enabling technology for the evolution of FSO from single-beam to multibeam space-division multiplexed systems in a perturbed environment, which has been a game-changing transition in fiber-optic systems. | Maziyar Milanizadeh SeyedMohammad SeyedinNavadeh Francesco Zanetto Vittorio Grimaldi Christian De Vita Charalambos Klitis Marc Sorel Giorgio Ferrari David A.B.Miller Andrea Melloni Francesco Morichetti | 2022 | Light(Science & Applications)2022，11，8： | 0 |
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