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| 1 | Does progesterone show neuroprotective effects on traumatic brain injury through increasing phosphorylation of Akt in the hippocampus?显示文摘There are currently no federally approved neuroprotective agents to treat traumatic brain injury. Progesterone, a hydrophobic steroid hormone, has been shown in recent studies to exhibit neuroprotective effects in controlled cortical impact rat models. Akt is a protein kinase known to play a role in cell signaling pathways that reduce edema, inflammation, apoptosis, and promote cell growth in the brain. This study aims to determine if progesterone modulates the phosphorylation of Akt via its threonine 308 phosphorylation site. Phosphorylation at the threonine 308 site is one of several sites responsible for activating Akt and enabling the protein kinase to carry out its neuroprotective effects. To assess the effects of progesterone on Akt phosphorylation, C57BL/6 mice were treated with progesterone(8 mg/kg) at 1(intraperitonally), 6, 24, and 48 hours(subcutaneously) post closed-skull traumatic brain injury. The hippocampus was harvested at 72 hours post injury and prepared for western blot analysis. Traumatic brain injury caused a significant decrease in Akt phosphorylation compared to sham operation. However, mice treated with progesterone following traumatic brain injury had an increase in phosphorylation of Akt compared to traumatic brain injury vehicle. Our findings suggest that progesterone is a viable treatment option for activating neuroprotective pathways after traumatic brain injury. | Richard Justin Garling Lora Talley Watts Shane Sprague Lauren Fletcher David F.Jimenez Murat Digicaylioglu | 2014 | Neural Regeneration Research2014，9，21： | 6 |
| 2 | Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidence显示文摘 | Sidney Winawer Robert Fletcher Douglas Rex John Bond Randall Burt Joseph Ferrucci Theodore Ganiats Theodore Levin Steven Woolf David Johnson Lynne Kirk Scott Litin Clifford Simmang | 2003 | Gastroenterology2003，，2： | 4 |
| 3 | Lineage-specific distribution of high levels of genomic 5-hydroxymethylcytosine in mammalian development显示文摘cytosine 的 Methylation 是与基因压抑联系的 DNA 修正。最近,新奇 cytosine 修正, 5-hydroxymethylcytosine (5-hmC ) 被发现了。这里,我们在哺乳动物的开发期间并且在细胞的系统检验 5-hmC 分发,并且证明 5-hmC 的发展动力学与 5-methylcytosine (5-mC ) 的那些不同;特别地 5-hmC 与成年纸巾相比在胚胎的上下文被充实。一个可检测的 5-hmC 信号在在父亲的染色体受到 5-mC 的染色体宽的 hydroxylation 的地方,在接合子阶段开始的培植前开发出现,它精确在父亲的前核与 5-mC 信号的损失与一致。5-hmC 的层次与在老鼠的表示 nestin 房间人口在在胚囊,和修正 colocalises 的内部房间团的房间高培植以后的胚胎。比作另外的成年哺乳动物的机关, 5-hmC 强烈在骨头髓和大脑被充实, 5-hmC 内容在那里高是 neuronal 祖先和 mitotic 以后神经原的一个特征。我们证明 5-hmC 的那高水平是在老鼠和人的胚胎的干细胞(转换字符) 的不仅现在并且,在区别期间输以前被报导了,而且在导致的 pluripotent 干细胞的产生期间重现;因此, 5-hmC 丰富与一个 pluripotent 房间状态相关。我们的调查结果建议除了 neuronal 系的房间, genomic 5-hmC 的高水平是胚胎的房间人口和细胞的 pluri 系和多系力量的一个 epigenetic 特征。到我们的知识, 5-hmC 那么代表其丰富是的发现的 DNA 的第一 epigenetic 修正房间类型特定。 | Alexey Ruzov Yanina Tsenkina Andrea Serio Tatiana Dudnakova Judy Fletcher Yu Bai Tatiana Chebotareva Steve Pells Zara Hannoun Gareth Sullivan Siddharthan Chandran David C Hay Mark Bradley Ian Wilmut Paul De Sousa | 2011 | Cell Research2011，21，9： | 4 |
| 4 | Remifentanil, Fentanyl, and Cardiac Surgery: A Double-Blinded, Randomized, Controlled Trial of Costs and Outcomes显示文摘 | Paul S. Myles Jennifer O. Hunt Helen Fletcher Jennifer Watts David Bain Andrew Silvers Mark R. Buckland | 2002 | Anesthesia & Analgesia2002，，4： | 2 |
| 5 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
| 6 | Differential Targeting of Prosurvival Bcl-2 Proteins by Their BH3-Only Ligands Allows Complementary Apoptotic Function显示文摘 | Lin Chen Simon N. Willis Andrew Wei Brian J. Smith Jamie I. Fletcher Mark G. Hinds Peter M. Colman Catherine L. Day Jerry M. Adams David C.S. Huang | 2005 | Molecular Cell2005，，3： | 2 |
| 7 | Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort显示文摘 | Ian Jacobs Aleksandra Gentry-Maharaj Matthew Burnell Ranjit Manchanda Naveena Singh Aarti Sharma Andy Ryan Mourad W Seif Nazar N Amso Gillian Turner Carol Brunell Gwendolen Fletcher Rani Rangar Kathy Ford Keith Godfrey Alberto Lopes David Oram Jonathan He | 2011 | Lancet Oncology2011，，1： | 2 |
| 8 | On the CFD modelling of Taylor flow in microchannels显示文摘 | Raghvendra Gupta David F. Fletcher Brian S. Haynes | 2009 | Chemical Engineering Science2009，，12： | 2 |
| 9 | New Concepts in Intestinal Imaging for Inflammatory Bowel Diseases显示文摘 | Joel G. Fletcher Jeff L. Fidler David H. Bruining James E. Huprich | 2011 | Gastroenterology2011，，6： | 1 |
| 10 | Intronic miR-211 Assumes the Tumor Suppressive Function of Its Host Gene in Melanoma显示文摘 | Carmit Levy Mehdi Khaled Dimitrios Iliopoulos Maja M. Janas Steffen Schubert Sophie Pinner Po-Hao Chen Shuqiang Li Anne L. Fletcher Satoru Yokoyama Kenneth L. Scott Levi A. Garraway Jun S. Song Scott R. Granter Shannon J. Turley David E. Fisher Carl D. No | 2010 | Molecular Cell2010，，5： | 1 |
| 11 | The influence of queen age and quality during queen replacement in honeybee colonies显示文摘 | David R Tarpy Shanti Hatch David J C Fletcher | 2000 | Animal Behaviour2000，59，1： | 1 |
| 12 | Computational fluid dynamics modelling of cerebrospinal fluid pressure in Chiari malformation and syringomyelia显示文摘 | Elizabeth C. Clarke David F. Fletcher Marcus A. Stoodley Lynne E. Bilston | 2013 | Journal of Biomechanics2013，，11： | 1 |
| 13 | Determinants of Medical System Delay in the Diagnosis of Colorectal Cancer Within the Veteran Affairs Health System显示文摘 | Deborah A. Fisher Leah L. Zullig Steven C. Grambow David H. Abbott Robert S. Sandler Robert H. Fletcher Hashem B. El-Serag Dawn Provenzale | 2010 | Digestive Diseases and Sciences2010，，5： | 1 |
| 14 | Steatosis Is a Cofactor in Liver Injury in Hemochromatosis显示文摘 | Elizabeth E. Powell Azmat Ali Andrew D. Clouston Jeannette L. Dixon Douglas J. Lincoln David M. Purdie Linda M. Fletcher Lawrie W. Powell Julie R. Jonsson | 2005 | Gastroenterology2005，，6： | 1 |
| 15 | Computed Tomography Enterography Detects Intestinal Wall Changes and Effects of Treatment in Patients With Crohn’s Disease显示文摘 | David H. Bruining Edward V. Loftus Eric C. Ehman Hassan A. Siddiki Douglas L. Nguyen Jeff L. Fidler James E. Huprich Jayawant N. Mandrekar William S. Harmsen William J. Sandborn Joel G. Fletcher | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 16 | Colorectal cancer screening and surveillance: Clinical guidelines and rationale—Update based on new evidence显示文摘 | Sidney Winawer Robert Fletcher Douglas Rex John Bond Randall Burt Joseph Ferrucci Theodore Ganiats Theodore Levin Steven Woolf David Johnson Lynne Kirk Scott Litin Clifford Simmang | 2003 | Gastroenterology2003，，2： | 1 |
| 17 | Taylor flow heat transfer in microchannels—Unification of liquid–liquid and gas–liquid results显示文摘 | Zhenhui Dai Zhenyi Guo David F. Fletcher Brian S. Haynes | 2015 | Chemical Engineering Science2015，，： | 1 |
| 18 | Defining and characterizing team resilience in elite sport显示文摘 | Paul B.C. Morgan David Fletcher Mustafa Sarkar | 2013 | Psychology of Sport & Exercise2013，，4： | 1 |
| 19 | CFD approaches for the simulation of hydrodynamics and heat transfer in Taylor flow显示文摘 | Azadeh N. Asadolahi Raghvendra Gupta David F. Fletcher Brian S. Haynes | 2011 | Chemical Engineering Science2011，，22： | 1 |
| 20 | A grounded theory of psychological resilience in Olympic champions显示文摘 | David Fletcher Mustafa Sarkar | 2012 | Psychology of Sport & Exercise2012，，5： | 1 |
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