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| 1 | 家庭收入变化、夫妻间时间利用与性别平等显示文摘基于'收入-闲暇'模型和非一致同意假设,本文利用201.0年12 066位城镇和农村劳动年龄男女(6033对在婚夫妻)信息详细考察了家庭非劳动收入变化对夫妻全天时间利用模式及其性别差异的影响。研究表明,在中国的家庭中,夫妻间时间利用依然呈现'男主外、女主内'的传统模式,家庭非劳动收入相对提升对夫妻间时间配置的影响亦存在遵从社会性别角色规范的明显差异,且农村地区影响更甚。此外,家庭非劳动收入的相对增加显著拉大了夫妻家务时间利用性别距(time use gender gap),但工作时间利用性别距却显著收敛了。家庭非劳动收入相对提升并未显著改善中国夫妻间时间利用上的性别不平等,居民福利的性别差异亟待重视。 | 刘娜 Anne de Bruin | 2015 | 世界经济2015，38，11： | 30 |
| 2 | m TOR signaling in liver regeneration: Rapamycin combined with growth factor treatment显示文摘AIM: To investigate the effects of mammalian target of rapamycin(mT OR) inhibition on liver regeneration and autophagy in a surgical resection model.METHODS: C57BL/6 mice were subjected to a 70% partial hepatectomy(PH) and treated intraperitoneally every 24 h with a combination of the m TOR inhibitor rapamycin(2.5 mg/kg per day) and the steroid dexamethasone(2.0 mg/kg per day) in phosphate bufferedsaline(PBS) or with PBS alone as vehicle control. In the immunosuppressant group, part of the group was treated subcutaneously 4 h prior to and 24 h after PH with a combination of human recombinant interleukin 6(IL-6; 500 μg/kg per day) and hepatocyte growth factor(HGF; 100 μg/kg per day) in PBS. Animals were sacrificed 2, 3 or 5 d after PH and liver tissue and blood were collected for further analysis. Immunohistochemical staining for 5-Bromo-2'-deoxyuridine(Brd U) was used to quantify hepatocyte proliferation. Western blotting was used to detect hepatic microtubule-associated protein 1 light chain 3(LC3)-Ⅱ protein expression as a marker for autophagy. Hepatic gene expression levels of proliferation-, inflammation- and angiogenesisrelated genes were examined by real-time reverse transcription-polymerase chain reaction and serum bilirubin and transaminase levels were analyzed at the clinical chemical core facility of the Erasmus MC-University Medical Center.RESULTS: m TOR inhibition significantly suppressed regeneration, shown by decreased hepatocyte proliferation(2% vs 12% Brd U positive hepatocyte nuclei at day 2, P < 0.01; 0.8% vs 1.4% at day 5, P = 0.02) and liver weight reconstitution(63% vs 76% of initial total liver weight at day 3, P = 0.04), and furthermore increased serum transaminase levels(aspartate aminotransferase 641 U/L vs 185 U/L at day 2, P = 0.02). Expression of the autophagy marker LC3-Ⅱ, which was reduced during normal liver regeneration, increased after mT OR inhibition(46% increase at day 2, P = 0.04). Hepatic gene expression showed an increased inflammation-related response [tumor necrosis factor(TNF)-α 3.2-fold upregulation at day 2, P = 0.03; IL-1Ra 6.0-fold upregulation at day 2 and 42.3-fold upregulation at day 5, P < 0.01] and a reduced expression of cell cycle progression and angiogenesis-related factors(HGF 40% reduction at day 2; vascular endothelial growth factor receptor 2 50% reduction at days 2 and 5; angiopoietin 1 60% reduction at day 2, all P ≤ 0.01). Treatmentwith the regeneration stimulating cytokine IL-6 and growth factor HGF could overcome the inhibitory effect on liver weight(75% of initial total liver weight at day 3, P = 0.02 vs immunosuppression alone and P = 0.90 vs controls) and partially reversed gene expression changes caused by rapamycin(TNF-α and IL-1Ra levels at day 2 were restored to control levels). However, no significant changes in hepatocyte proliferation, serum injury markers or autophagy were found.CONCLUSION: mT OR inhibition severely impairs liver regeneration and increases autophagy after PH. These effects are partly reversed by stimulation of the IL-6 and HGF pathways. | Suomi MG Fouraschen Petra E de Ruiter Jaap Kwekkeboom Ron WF de Bruin Geert Kazemier Herold J Metselaar Hugo W Tilanus Luc JW van der Laan Jeroen de Jonge | 2013 | World Journal of Transplantation2013，3，3： | 6 |
| 3 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 4 | Prolonged QTc Interval and Risk of Sudden Cardiac Death in a Population of Older Adults显示文摘 | Sabine M.J.M. Straus Jan A. Kors Marie L. De Bruin Cornelis S. van der Hooft Albert Hofman Jan Heeringa Jaap W. Deckers J. Herre Kingma Miriam C.J.M. Sturkenboom Bruno H. Ch. Stricker Jacqueline C.M. Witteman | 2006 | Journal of the American College of Cardiology2006，，2： | 4 |
| 5 | 8-Year Follow-up of Randomized Trial: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Patients with Peritoneal Carcinomatosis of Colorectal Cancer显示文摘 | Vic J. Verwaal MD PhD Sjoerd Bruin MD Henk Boot MD PhD Gooike Slooten MD Harm Tinteren ScM | 2008 | Annals of Surgical Oncology2008，，9： | 3 |
| 6 | 8-Year Follow-up of Randomized Trial: Cytoreduction and Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy in Patients with Peritoneal Carcinomatosis of Colorectal Cancer显示文摘 | Vic J. Verwaal Sjoerd Bruin Henk Boot Gooike Slooten Harm Tinteren | 2008 | Annals of Surgical Oncology2008，，： | 3 |
| 7 | 老年人群中QTc间期延长与心脏性猝死风险之间的关系显示文摘OBJECTIVES: This study sought to investigate whether prolongation of the heart rate-corrected QT(QTc) interval is a risk factor for sudden cardiac death in the general population. BACKGROUND: In developed countries, sudden cardiac death is a major cause of cardiovascular mortality. Prolongation of the QTc interval has been associated with ventricular arrhythmias, but in most population-based studies no consistent association was found between QTc prolongation and total or cardiovascular mortality. Only very few of these studies specifically addressed sudden cardiac death. METHODS: This study was conducted as part of the Rotterdam Study, a prospective population- based cohort study that comprises 3,105 men and 4,878 women aged 55 years and older. The QTc interval on the electrocardiogram was determined during the baseline visit(1990 to 1993) and the first follow-up examination(1993 to 1995). The association between a prolonged QTc interval and sudden cardiac death was estimated using Cox proportional hazards analysis. RESULTS: During an average follow-up period of 6.7 years(standard deviation, 2.3 years) 125 patients died of sudden cardiac death. An abnormally prolonged QTc interval(>450 ms in men, >470 ms in women) was associated with a threefold increased risk of sudden cardiac death(hazard ratio, 2.5; 95% confidence interval, 1.3 to 4.7), after adjustment for age, gender, body mass index, hypertension, cholesterol/high-density lipoprotein ratio, diabetes mellitus, myocardial infarction, heart failure, and heart rate. In patients with an age below the median of 68 years, the corresponding relative risk was 8.0(95% confidence interval 2.1 to 31.3). CONCLUSIONS: Abnormal QTc prolongation on the electrocardiogram should be viewed as an independent risk factor for sudden cardiac death. | Straus S.M.J.M Kors J.A De Bruin M.L. B.H.Ch. Stricker 王亭忠 | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，5： | 3 |
| 8 | Evapotranspiration components determined by stable isotope, sap flow and eddy covariance techniques显示文摘 | D.G. Williams W. Cable K. Hultine J.C.B. Hoedjes E.A. Yepez V. Simonneaux S. Er-Raki G. Boulet H.A.R. de Bruin A. Chehbouni O.K. Hartogensis F. Timouk | 2004 | Agricultural and Forest Meteorology2004，，3： | 2 |
| 9 | Development of a Rapid Risk and Impact Assessment Tool to Enhance Response to Environmental Emergencies in the Early Stages of a Disaster: A Tool Developed by the European Multiple Environmental Threats Emergency NETwork (EMETNET) Project显示文摘Every year,numerous environmental disasters and emergencies occur across the globe with far-reaching impacts on human health and the environment.The ability to rapidly assess an environmental emergency to mitigate potential risks and impacts is paramount.However,collating the necessary evidence in the early stages of an emergency to conduct a robust risk assessment is a major challenge.This article presents a methodology developed to help assess the risks and impacts during the early stages of such incidents,primarily to support the European Union Civil Protection Mechanism but also the wider global community in the response to environmental emergencies.An online rapid risk and impact assessment tool has also been developed to promote enhanced collaboration between experts who are working remotely,considering the impact of a disaster on the environment and public health in the short,medium,and long terms.The methodology developed can support the appropriate selection of experts and assets to be deployed to affected regions to ensure that potential public health and environmental risks and impacts are mitigated whenever possible.This methodology will aid defensible decision making,communication,planning,and risk management,and presents a harmonized understanding of the associated impacts of an environmental emergency. | Emma-Jane Goode Eirian Thomas Owen Landeg Raquel Duarte-Davidson Lisbeth Hall Jolanda Roelofs Sjors Schulpen Arnout De Bruin Elisabeth Wigenstam Birgitta Liljedahl Annica Waleij Louise Simonsson Ann Göransson Nyberg | 2021 | International Journal of Disaster Risk Science2021，12，4： | 2 |
| 10 | The use of Oxaliplatin or Mitomycin C in HIPEC treatment for peritoneal carcinomatosis from colorectal cancer: A comparative study显示文摘 | D. Hompes A. D’Hoore A. Wolthuis S. Fieuws B. Mirck S. Bruin V. Verwaal | 2014 | J. Surg. Oncol2014，，： | 2 |
| 11 | Antibiotic Prophylaxis for Gi Endoscopy显示文摘 | Mouen A. Kashab Ruben D. Acosta David H. Bruining Vinay Chandrasekhara Krishnavel V. Chithadi Mohamad A. Eloubeidi Robert D. Fanelli S.A.G.E.S. Representative Ashley L. Faulx Lisa Fonkalsrud Jenifer R. Lightdale V. Raman Muthusamy Shabana F. Pasha John R. | 2014 | Gastrointestinal Endoscopy2014，，： | 2 |
| 12 | Activation of the Complement System During and After Cardiopulmonary Bypass Surgery: Postsurgery Activation Involves C-Reactive Protein and Is Associated With Postoperative Arrhythmia显示文摘 | Peter Bruins Henk te Velthuis Aria P. Yazdanbakhsh Piet G.M. Jansen Fred W.J. van Hardevelt Eddy M.F.H. de Beaumont Charles R.H. Wildevuur Leon Eijsman NA Trouwborst C. Erik Hack | 1997 | Circulation1997，，10： | 2 |
| 13 | Development of an inflatable solar dryer for improved postharvest handling of paddy rice in humid climates显示文摘Rice is the staple food for more than three billion people worldwide.Although considerable progress has been made with respect to improved breeds and production practices,losses during postharvest handling remain considerable.Drying and storage of paddy are two key stages where management can be improved.For rice,grain moisture content of 14%prevents microbiological activity,while a level of about 12%minimizes quality losses over prolonged storage periods.Due to the need for simple and economical technologies,an inflatable solar dryer(ISD)was developed based on adaptations of the Hohenheim-type solar tunnel dryer.To form a drying tunnel,transparent polyethylene(PE)film attaches by zipper to a reinforced black polyvinyl chloride(PVC)film.To reduce heat loss,a flexible multilayer floor was used along the drying area.The tunnel does not need a substructure as it is stabilized adequately from pressure created by two axial flow ventilators.During experiments,paddy was spread on the floor and mixed with a special roller bar.The ISD has been evaluated for paddy in the Philippines during both rainy and dry seasons and was subsequently optimized.Sun drying and shade drying were carried out in parallel for comparison and product was evaluated for moisture content and quality in terms of milling recovery and head rice yield.Moisture content was reduced from 23%to 14%within 26-52 h of continuous operation during the rainy season and 16%to 14%within 4-26 h of drying during the dry season.In both seasons,the final moisture content of 12%was reached after prolonged drying periods.Quality was not found to be affected with respect to drying treatment.The ISD showed advantages over sun drying,despite longer drying periods. | Ana Salvatierra-Rojas Marcus Nagle Martin Gummert Tom de Bruin Joachim Müller | 2017 | International Journal of Agricultural and Biological Engineering2017，10，3： | 2 |
| 14 | Antibody phage display technology and its application 显示文摘 | Hoogenboom H R de Bruine A P Hufton S E | 1998 | Immunotechnology1998，4，： | 2 |
| 15 | QTc prolonging drugs and hospitalizations for cardiac arrhythmias显示文摘 | Hoes AW Leufkens HGM | 2003 | Am J Cardiol2003，91，1： | 1 |
| 16 | Sickness Impact Profile:the state of the art of a generic functional status measure显示文摘 | DE WITTE LP STEVENS F | 1992 | Soc Sci Med1992，35，8： | 1 |
| 17 | Ki-67 immunoquantitation in cervical intraepithelial neoplasia(CIN):a sensitive marker for grading显示文摘 | Kruse A J Baak J P De Bruin P C | 2001 | J Pathol2001，193，1： | 1 |
| 18 | Corticosteroid therapy in severe illness显示文摘 | Lamberts SW Bruining HA de Jong FH | 1997 | N Engl J Med1997，337，18： | 1 |
| 19 | Apoptosis and non-apoptotic deaths in cancer development and treatment response显示文摘 | De Bruin EC Medema JP | 2008 | Cancer Treat Rev2008，34，5： | 1 |
| 20 | Antibody phage display technology and its applications 显示文摘 | Hoogenboom HR de Bruine AP Hufton SE | 1998 | Immunotechnology1998，4，1： | 1 |
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