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| 1 | Magnetic resonance elastography is accurate in detecting advanced fibrosis in autoimmune hepatitis显示文摘To assess the value of magnetic resonance elastography(MRE) in detecting advanced fibrosis/cirrhosis in autoimmune hepatitis(AIH).METHODS In this retrospective study, 36 patients(19 treated and 17 untreated) with histologically confirmed AIH and liver biopsy performed within 3 mo of MRE were identified at a tertiary care referral center. Liver stiffness(LS) with MRE was calculated by a radiologist, and inflammation grade and fibrosis stage in liver biopsy was assessed by a pathologist in a blinded fashion. Two radiologistsevaluated morphological features of cirrhosis on conventional magnetic resonance imaging(MRI). Accuracy of MRE was compared to laboratory markers and MRI for detection of advanced fibrosis/cirrhosis.RESULTS Liver fibrosis stages of 0, 1, 2, 3 and 4 were present in 4, 6, 7, 6 and 13 patients respectively. There were no significant differences in distribution of fibrosis stage and inflammation grade between treated and untreated patient groups. LS with MRE demonstrated stronger correlation with liver fibrosis stage in comparison to laboratory markers for chronic liver disease(r = 0.88 vs-0.48-0.70). A trend of decreased mean LS in treated patients compared to untreated patients was observed(3.7 k Pa vs 3.84 k Pa) but was not statistically significant. MRE had an accuracy/sensitivity/specificity/positive predictive value/negative predictive value of 0.97/90%/100%/100%/90% and 0.98/92.3%/96%/92.3%/96% for detection of advanced fibrosis and cirrhosis, respectively. The performance of MRE was significantly better than laboratory tests for detection of advanced fibrosis(0.97 vs 0.53-0.80, P < 0.01), and cirrhosis(0.98 vs 0.58-0.80, P < 0.01) and better than conventional MRI for diagnosis of cirrhosis(0.98 vs 0.78, P = 0.002).CONCLUSION MRE is a promising modality for detection of advanced fibrosis and cirrhosis in patients with AIH with superior diagnostic accuracy compared to laboratory assessment and MRI. | Jin Wang Neera Malik Meng Yin Thomas C Smyrk Albert J Czaja Richard L Ehman Sudhakar K Venkatesh | 2017 | World Journal of Gastroenterology2017，23，5： | 15 |
| 2 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 3 | Advanced Fibrosis in Nonalcoholic Fatty Liver Disease: Noninvasive Assessment with MR Elastography显示文摘 | Donghee Kim W. Ray Kim Jayant A. Talwalkar Hwa Jung Kim Richard L. Ehman | 2013 | Radiology2013，，2： | 3 |
| 4 | Measurement of muscle activity with magnetic resonance elastography显示文摘 | Guido Heers Thomas Jenkyn M. Alex Dresner Marc-Oliver Klein Jeffrey R Basford Kenton R Kaufman Richard L Ehman Kai-Nan An | 2003 | Clinical Biomechanics2003，，6： | 2 |
| 5 | Noninvasive muscle tension measurement using the novel technique of magnetic resonance elastography (MRE)显示文摘 | Thomas R. Jenkyn Richard L. Ehman Kai-Nan An | 2003 | Journal of Biomechanics2003，，12： | 2 |
| 6 | Magnetic resonance imaging with respiratory gating: techniques and advantages显示文摘 | Ehman RL McNamara MT Pallack M | 1984 | AJR1984，143，6： | 1 |
| 7 | MR elastography of the human abdominal aorta: A preliminary study显示文摘 | Lei Xu Jun Chen Kevin J. Glaser Meng Yin Phillip J. Rossman Richard L. Ehman | 2013 | J. Magn. Reson. Imaging2013，，： | 1 |
| 8 | Magnetic resonance elastogra- phy of liver: Clinical applications显示文摘 | Venkatesh SK Yin M Ehman RL | 2013 | J Comput Assist Tomogr2013，37，6： | 1 |
| 9 | Errors model and accuracyanalysis of a six - DOF stewart platform 显示文摘 | Ehman K F | 1995 | Manufacturing Science and Engineering1995，2，1： | 1 |
| 10 | Intracranial aneu rysms and vascular malformations: comparison of time of flight and phase contrast MR angiography 显示文摘 | Huston J Rufenacht DA Ehman RL | 1991 | Radiology1991，181，12： | 1 |
| 11 | Adaptive technique for high definition MR imaging of moving structures显示文摘 | Ehman RL Felmlee JP | 1989 | Radiology1989，173，： | 1 |
| 12 | Value of MR Imaging in Differentiating benign from Malignant Soft-tissue Masses:Study of 95 Lesions显示文摘 | Berquist TH Ehman RL King BF | 1990 | AJR1990，155，6： | 1 |
| 13 | In the Age of 300 mm Silicon,Technology Standards Are Even More Srueial显示文摘 | C ehman B L | 2001 | Solid State Technology2001，44，： | 1 |
| 14 | Assessment of Hepatic Fibrosis With Magnetic Resonance Elastography显示文摘 | Meng Yin Jayant A. Talwalkar Kevin J. Glaser Armando Manduca Roger C. Grimm Phillip J. Rossman Jeff L. Fidler Richard L. Ehman | 2007 | Clinical Gastroenterology and Hepatology2007，，10： | 1 |
| 15 | Review of MR elastogra- phy applications and recent developments 显示文摘 | Glaser K J Manduca A Ehman RL | 2012 | J Magn Reson Imaging2012，36，4： | 1 |
| 16 | Feasibility of using 3D MR elastography to determine pancreatic stiffness in healthy volunteers显示文摘 | Yu Shi Kevin J. Glaser Sudhakar K. Venkatesh Ephraim I. Ben‐Abraham Richard L. Ehman | 2015 | J. Magn. Reson. Imaging2015，，： | 1 |
| 17 | MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy显示文摘 | Christine U. Lee James F. Glockner Kevin J. Glaser Meng Yin Jun Chen Akira Kawashima Bohyun Kim Walter K. Kremers Richard L. Ehman James M. Gloor | 2012 | Academic Radiology2012，，7： | 1 |
| 18 | Magnetic resonance elastography in breast cancer显示文摘 | Ehman RL | 2003 | Acade Radiol2003，10，： | 1 |
| 19 | An integrated GIS and modeling approach for assessing the transient response of for-ests of the southern great lakes region to a doubled CO2 climate 显示文摘 | Ehman J E Fan W H Randolph J C | 2002 | Forest Ecology and Management2002，155，： | 1 |
| 20 | Intracranial aneurysms and vascular maifor mations:Comparison of time-of-flight and phasecontras MR angiography 显示文摘 | Huston J Rufenacht DA Ehman RL | 1991 | Radiology1991，181，3： | 1 |
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