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| 1 | Semaglutide降低2型糖尿病患者的心脑血管事件风险显示文摘心血管疾病是2型糖尿病患者发生并发症和死亡的主要原因。最近的一些临床试验报告,一种钠-葡萄糖协同转运蛋白-2抑制剂(依帕列净)和一种胰高血糖素样肽-1(GLP-1)类似物(利拉鲁肽),能够改善心血管高风险的2型糖尿病患者的心血管结局。Semaglutide是GLP-1的一种类似物,半衰期长达约1周,可以一周一次皮下注射,但是尚不清楚其对2型糖尿病患者的心血管效应;由于Semaglutide目前处于开发阶段,尚未被批准用于治疗2型糖尿病。 | Marso SP Bain SC Consoli A 王建中 | 2016 | 中华肾病研究电子杂志2016，5，5： | 141 |
| 2 | Sphincter of Oddi dysfunction: Managing the patient with chronic biliary pain显示文摘Oddi 机能障碍(草皮) 的括约肌由于在 Oddi 的括约肌的水平的 pancreaticobiliary 流动的功能的阻塞是长期的胆汁的疼痛或周期性的胰腺炎的症候群。Milwaukee 分类成层病人根据他们的临床的图画基于腹的疼痛的提高的肝酶,扩大胆总管和存在。类型我病人们象反常的肝酶和扩大胆总管一样有疼痛。类型 II 草皮由疼痛和仅仅发现的一个目的组成,并且类型 III 仅仅由胆汁的疼痛组成。这个分类是有用的指导 Oddi 机能障碍的括约肌的诊断和管理。为诊断的当前的标准答案是测压法检测提高的括约肌压力,它与结果相关到括约肌切开术。然而,测压法不是广泛地可得到的并且是有胰腺炎的风险的一个侵略过程。包括丰满的饭 ultrasonography 和 scintigraphy,非侵略的测试方法与压力计的调查结果显示出有限关联,但是可能在预言结果到括约肌切开术有用。波特淋毒素的内视镜的注射嗯毒素出现到预言随后的结果到括约肌切开术,并且能在为治疗的病人的选择有用,特别在测压法是无法获得的背景。 | Lana Bistritz Vincent G Bain | 2006 | World Journal of Gastroenterology2006，12，24： | 19 |
| 3 | Model for end-stage liver disease score versus Child score in predicting the outcome of surgical procedures in patients with cirrhosis显示文摘AIM:To determine factors affecting the outcome of patients with cirrhosis undergoing surgery and to compare the capacities of the Child-Turcotte-Pugh(CTP) and model for end-stage liver disease(MELD)score to predict that outcome. METHODS:We reviewed the charts of 195 patients with cirrhosis who underwent surgery at two teaching hospitals over a five-year period.The combined endpoint of death or hepatic decompensation was considered to be the primary endpoint. RESULTS:Patients who reached the endpoint had a higher MELD score,a higher CTP score and were more likely to have undergone an urgent procedure.Among patients undergoing elective surgical procedures,no statistically significant difference was noted in the mean MELD(12.8±3.9 vs 12.6±4.7,P=0.9)or in the mean CTP(7.6±1.2 vs 7.7±1.7,P=0.8)between patients who reached the endpoint and those who did not.Both mean scores were higher in the patients reaching the endpoint in the case of urgent procedures(MELD:22.4± 8.7 vs 15.2±6.4,P=0.0007;CTP:9.9±1.8 vs 8.5±1.8, P=0.008).The performances of the MELD and CTP scores in predicting the outcome of urgent surgery were only fair,without a significant difference between them (AUC=0.755±0.066 for MELD vs AUC=0.696±0.070 for CTP,P=0.3). CONCLUSION:The CTP and MELD scores performedequally,but only fairly in predicting the outcome of urgent surgical procedures.Larger studies are needed to better define the factors capable of predicting the outcome of elective surgical procedures in patients with cirrhosis. | Maarouf A Hoteit Amaar H Ghazale Andrew J Bain Eli S Rosenberg Kirk A Easley Frank A Anania Robin E Rutherford | 2008 | World Journal of Gastroenterology2008，14，11： | 16 |
| 4 | Comprehensive and innovative techniques for livertransplantation in rats: A surgical guide显示文摘AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries.RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynamic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. | Tomohide Hori Justin H Nguyen Yasuhiro Ogura Toshiyuki Hata Shintaro Yagi Ann-Marie T Baine Norifumi Ohashi Christopher B Eckman Aimee R Herdt Hiroto Egawa Yasutsugu Takada Fumitaka Oike Seisuke Saka-moto Mureo Kasahara Kohei Ogawa Koichiro Hata Taku Iida Yukihide Yonekawa Lena Sibulesky Kagemasa Kuribayashi Takuma Kato Kanako Saito Mie Torii Naruhiko Sahara Naoko Kamo Tomoko Sahara Motohiko Yasutomi Shinji Uemoto | 2010 | World Journal of Gastroenterology2010，16，25： | 14 |
| 5 | Effect of surface roughness on the aerodynamic performance of turbine blade cascade显示文摘The effect of surface roughness on the boundary development and loss behavior of turbine blades is investigated with different Reynolds numbers in this paper.The result shows that the velocity profile in boundary layer is plumper on rough surface than on smooth blade.The aerodynamic loss is lowered at low Reynolds number,but becomes significantly large at high Reynolds number.The total pressure loss coefficient of cascade can reach a top increase of 129%for rougher blades comparing with smooth blades at Re=300000. | Tao Bain Jingyuan Liu Weihao Zhang Zhengping Zou | 2014 | Propulsion and Power Research2014，3，2： | 9 |
| 6 | Oxidative stress and extracellular matrices after hepatectomy and liver transplantation in rats显示文摘AIM:To investigate oxidative stress(OS)-mediated damage and the behavior of extracellular matrices in various rat models because shear stress with portal hypertension and cold ischemia/warm reperfusion injury trigger the liver regeneration cascade after surgery. These injuries also cause fatal liver damage.METHODS: Rats were divided into four groups according to the surgery performed: control; hepatectomy with 40% liver remnant(60% hepatectomy); orthotopic liver transplantation(OLT) with whole liver graft(100% OLT); and split OLT(SOLT) with 40% graft(40% SOLT). Survival was evaluated. Blood and liver samples were collected at 6 h after surgery. Biochemical and histopathological examinations were performed. OSinduced damage, 4-hydroxynonenal, ataxia-telangiectasia mutated kinase, histone H2AX, phosphatidylinositol 3-kinase(PI3K) and Akt were evaluated by western blotting. Behavior of extracellular matrices, matrix metalloproteinase(MMP)-9, MMP-2, tissue inhibitor of metalloproteinase(TIMP)-1 and TIMP-2 were also evaluated by western blotting and zymography. RESULTS: Although 100% OLT survived, 60% hepatectomy and 40% SOLT showed poor survival. Histopathological, immunohistological, biochemical and protein assays revealed that 60% hepatectomy, 100% OLT and 40% SOLT showed liver damage. PI3K and Akt were decreased in 60% hepatectomy and 40% SOLT. For protein expression, 40% SOLT showed differences in MMP-9, MMP-2 and TIMP-2. TIMP-1 showed differences in 60% hepatectomy and 40% SOLT. For protein activity, MMP-9 demonstrated significant differences in 60% hepatectomy, 100% OLT and 40% SOLT. CONCLUSION: Under conditions with an insufficient liver remnant, prevention of OS-induced damage via the Akt/PI3K pathway may be key to improve the postoperative course. MMP-9 may be also a therapeutic target after surgery. | Tomohide Hori Shinji Uemoto Feng Chen Lindsay B Gardner Ann-Marie T Baine Toshiyuki Hata Takayuki Kogure Justin H Nguyen | 2014 | World Journal of Hepatology2014，6，2： | 7 |
| 7 | 抗炎介质表达缺陷参与中性粒细胞型支气管哮喘发病机制:半乳糖凝集素-3和白细胞介素-1RA/白细胞介素-1beta比例显著下降显示文摘支气管哮喘(哮喘)是具有异质性的气道炎症性疾病,其主要特点表现为气道高反应和可变的气流受限。在哮喘的发病机制中,过敏原诱导的TH2淋巴细胞激活以及IL-5介导的嗜酸粒细胞渗出起到重要的作用。近年来发现超过50%的哮喘患者气道的嗜酸粒细胞水平并不增高,并将这种亚型定义为非嗜酸粒细胞型哮喘。其中部分患者表现为气道中性粒细胞明显增高,称为中性粒细胞型哮喘。 | 高鹏 Peter G Gibson Katherine J Baines Ian A Yang John W Upham Paul N Reynolds Sandra Hodge Alan L James Christine Jenkins Matthew J Peters 张捷 Jodie L Simpson | 2016 | 中华结核和呼吸杂志2016，39，11： | 5 |
| 8 | Cr^(4+):YAG被动调Q激光器中受激粒子上转换效应对脉冲的影响研究显示文摘分析和报道了受激粒子能量上转换 (ETU)效应对Cr:YAG被动调QNd :YAG Nd :YVO4激光器的输出脉冲影响研究 .结合ETU理论分析和被动调Q速率方程组 ,得到了初始反转粒子密度 ,末态反转粒子密度和光强最大时反转粒子密度的比值变化对激光输出脉冲宽度和脉冲能量的影响 ,和实验结果相一致 .同时讨论了降低ETU效应的方法 。 | 杨林 黄维玲 丘军林 冯宝华 张治国 Volker Gaebler Baining Liu Hans J.Eichler | 2003 | 物理学报2003，52，10： | 5 |
| 9 | Acousto-optical modulation of thin film lithium niobate waveguide devices显示文摘Due to its strong piezoelectric effect and photo-elastic property, lithium niobate is widely used for acousto-optical applications. However, conventional bulk lithium niobate waveguide devices exhibit a large footprint and limited light–sound interaction resulting from the weak guiding of light. Here, we report the first acousto-optical modulators with surface acoustic wave generation, phononic cavity, and low-loss photonic waveguide devices monolithically integrated on a 500 nm thick film of lithium niobate on an insulator. Modulation efficiency was optimized by properly arranging the propagation directions of surface acoustic waves and optical guided modes.The effective photo-elastic coefficient extracted by comparing the first and third harmonic modulation signals from an on-chip Mach–Zehnder interferometer indicates the excellent acousto-optical properties of lithium niobate are preserved in the thin film implementation. Such material property finding is of crucial importance in designing various types of acousto-optical devices. Much stronger amplitude modulation was achieved in a high Q(>300,000) optical resonator due to the higher optical sensitivity. Our results pave the path for developing novel acousto-optical devices using thin film lithium niobate. | LUTONG CAI ASHRAF MAHMOUD MSI KHAN MOHAMED MAHMOUD TAMAL MUKHERJEE JAMES BAIN GIANLUCA PIAZZA | 2019 | Photonics Research2019，7，9： | 5 |
| 10 | 循证综述:慢性腰痛和软组织综合征存在神经病理性疼痛的证据显示文摘目的:本综述旨在提供慢性腰痛和软组织综合征与神经病理性疼痛是否相关的证据,以及两者中神经病理性疼痛的患病率。方法:研究的816例患者中,11例慢性腰痛患者存在神经病理性疼痛诊断,5例软组织综合征患者存在神经病理性疼痛诊断。研究分组依据神经病理性疼痛的诊断方法,如体格检查、神经病理性疼痛量表类型等。神经病理性疼痛的患病率为各组研究中所有患者的合计。慢性腰痛和软组织综合征中神经病理性疼痛的患病率为两者各自研究中所有患者的总和。两名评价者独立根据11项质量标准对每个研究做出质量评分,依据卫生保健政策和研究机构(AHCPR)指南评估各分组证据的强度和一致性。结果:各分组中所有研究报道均存在神经病理性疼痛。慢性腰痛中神经病理性疼痛的患病率是36.6%,软组织综合征中神经病理性疼痛的患病率是41.1%。不同的神经病理性疼痛诊断方法间患病率存在显著差异。结论:所有的方法一致证实,慢性腰痛和软组织综合征患者中存在神经病理性疼痛,且合并患病率显著。这对慢性腰痛和软组织综合征的治疗有重要意义。 | David A.Fish bain 韩奇 王晓雷 陈萌蕾 朱玫娟 郑拥军 王祥瑞 | 2015 | 中国疼痛医学杂志2015，21，10： | 5 |
| 11 | 激光二极管端面泵浦的多晶Nd:YAG1.32μm连续激光器显示文摘本文报道了激光二极管端面泵浦的多晶Nd:YAG(polycrystalline Nd:YAG ceramic)1.32μm连续激光器的实验研究。在泵浦功率为2.1W时,激光达到阈值开始输出;在泵浦功率为9W时,输出功率达到690mW,斜率效率为11%。据我们所知,这是目前报道的功率最大的多晶Nd:YAG 1.32μm连续激光器。 | 杨林 黄维玲 丘军林 Volker Gaebler Liu Baining Hans J.Eichler | 2003 | 量子电子学报2003，20，3： | 5 |
| 12 | Muscle Wasting Is Associated With Mortality in Patients With Cirrhosis显示文摘 | Aldo J. Montano–Loza Judith Meza–Junco Carla M.M. Prado Jessica R. Lieffers Vickie E. Baracos Vincent G. Bain Michael B. Sawyer | 2012 | Clinical Gastroenterology and Hepatology2012，，2： | 5 |
| 13 | Engine-Out Takeoff Path Optimization for Large Civil Aircraft显示文摘 | Bertrand Masson Michael Bain John Page | 2013 | Journal of Mechanics Engineering and Automation2013，3，6： | 4 |
| 14 | Simple and reproducible hepatectomy in the mouse using the clip technique显示文摘AIM: To investigate the reliability of massive hepatectomy models by using clip techniques. METHODS: We analyzed anatomical findings in 100 mice following massive hepatectomy induced by liver reduction > 70%. The impact of various factors in the different models was also analyzed, including learning curves, operative time, survival curves, and histopathological findings.RESULTS: According to anatomical results, models with 75%, 80%, and 90% hepatectomy produced massive hepatectomy. Learning curves and operative times were most optimal with the clip technique. Each hepatectomy performed using the clip technique produced a reasonable survival curve, and there were no differences in histopathological findings between the suture and clip techniques. CONCLUSION: Massive hepatectomy by the clip technique is simple and can provide reliable and relevant data. | Tomohide Hori Norifumi Ohashi Feng Chen Ann-Marie T Baine Lindsay B Gardner Toshiyuki Hata Shinji Uemoto Justin H Nguyen | 2012 | World Journal of Gastroenterology2012，18，22： | 4 |
| 15 | 应激诱导下星形胶质细胞的结构和功能修饰——进一步提示胶质细胞对应激的中枢反应显示文摘有机体的应激反应需要多个大脑区域的激活。这可能对突触传递和可塑性长期有益的影响。最近的证据证明,除神经元外,神经胶质细胞也参与调节应激的中枢反应。重复的或不受控制的应激与多种神经精神病症的出现密切相关。情绪和应激障碍(如严重抑郁症)状态下神经胶质细胞功能障碍在人类研究中一直被观察到,而有趣的是,应激的动物模型重现了与人类状况相当的神经胶质细胞异常,验证了啮齿动物模型在应激障碍研究中的可用性。在这篇综述中,我们将关注胶质细胞家族中的星形胶质细胞,并总结迄今为止将星形胶质细胞与可能的应激相关疾病联系起来的证据。 | Murphy-Royal C Gordon GR Bains JS 聂昊(编译) | 2019 | 神经损伤与功能重建2019，14，4： | 3 |
| 16 | Remifentanil, Fentanyl, and Cardiac Surgery: A Double-Blinded, Randomized, Controlled Trial of Costs and Outcomes显示文摘 | Paul S. Myles Jennifer O. Hunt Helen Fletcher Jennifer Watts David Bain Andrew Silvers Mark R. Buckland | 2002 | Anesthesia & Analgesia2002，，4： | 2 |
| 17 | CD 64 distinguishes macrophages from dendritic cells in the gut and reveals the T h1‐inducing role of mesenteric lymph node macrophages during colitis显示文摘 | Samira Tamoutounour Sandrine Henri Hugues Lelouard Béatrice de Bovis Colin de Haar C. Janneke van der Woude Andrea M. Woltman Yasmin Reyal Dominique Bonnet Dorine Sichien Calum C. Bain Allan McI. Mowat Caetano Reis e Sousa Lionel F. Poulin Bernard Malisse | 2012 | Eur J Immunol2012，，12： | 2 |
| 18 | Managing the post–liver transplantation anastomotic biliary stricture: multiple plastic versus metal stents: a systematic review显示文摘 | Dina Kao Sergio Zepeda-Gomez Puneeta Tandon Vince G. Bain | 2013 | Gastrointestinal Endoscopy2013，，5： | 2 |
| 19 | Highwall mining of thick,steeply dipping coal–A case study in geotechnical design and recovery optimization显示文摘Highwall mining of thick(up to 30.48 m)steeply dipping(20°or more)coal seams provides many chal lenges,both geotechnically and operationally,as seam dips near or in excess of highwall mining machine capabilities are encountered.Maximizing coal recovery while maintaining highwall stability requires innovative techniques with regard to web and barrier pillar layout,depth of penetration,and choice of mining horizon within the seam.Stability of highwall mining slopes,openings,and pillarsare typically analyzed using the ARMPS-HWM program,as well as LAMODEL,UDEC and SLOPE/W modeling.Highwall stability can be maintained,and highwall mining production optimized by applying design cri-teria in creative ways,including alternating miner penetration depths and initiating mining of thick seams toward the bottom of the seam.Highwall mining of thick,steeply dipping coal requires careful planning and execution,including close cooperation between geotechnical design engineers,the mining company,and the highwall mining contractor.This paper describes the application of creative design techniques to a specific pit arrangement at the Westmoreland Kemmerer Mine,Kemmerer,Wyoming.Highwall mining was accomplished by UGM ADDCAR Systems,LLC on a contract basis. | Chris Ross David Conover Jake Baine | 2019 | International Journal of Mining Science and Technology2019，29，5： | 2 |
| 20 | Proton Pump Inhibitors and Risk of Fractures: A Meta-Analysis of 11 International Studies显示文摘 | Elaine W. Yu Scott R. Bauer Paul A. Bain Douglas C. Bauer | 2011 | The American Journal of Medicine2011，，6： | 2 |
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