|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Epigenetic regulation in alcoholic liver disease显示文摘Alcoholic liver disease(ALD)is characterized by steatosis or fat deposition in the liver and inflammation,which leads to cirrhosis and hepatocellular carcinoma.Induction of target genes without involving changes in DNA sequence seems to contribute greatly to liver injury. Chromatin modifications including alterations in histones and DNA,as well as post-transcriptional changes collectively referred to as epigenetic effects are altered by alcohol.Recent studies have pointed to a significant role for epigenetic mechanisms at the nucleosomal level influencing gene expression and disease outcome in ALD. Specifically,epigenetic alterations by alcohol include histone modifications such as changes in acetylation and phosphorylation,hypomethylation of DNA,and alterations in miRNAs.These modifications can be induced by alcoholinduced oxidative stress that results in altered recruitment of transcriptional machinery and abnormal gene expression.Delineating these mechanisms in initiation and progression of ALD is becoming a major area of interest.This review summarizes key epigenetic mechanisms that are dysregulated by alcohol in the liver.Alterations by alcohol in histone and DNA modifications,enzymes related to histone acetylation suchas histone acetyltransferases,histone deacetylases and sirtuins,and methylation enzymes such as DNA methyltransferases are discussed.Chromatin modifications and miRNA alterations that result in immune cell dysfunction contributing to inflammatory cytokine production in ALD is reviewed.Finally,the role of alcohol-mediated oxidative stress in epigenetic regulation in ALD is described. A better understanding of these mechanisms is crucial for designing novel epigenetic based therapies to ameliorate ALD. | Pranoti Mandrekar | 2011 | World Journal of Gastroenterology2011，17，20： | 10 |
| 2 | Signaling mechanisms in alcoholic liver injury: Role of transcription factors, kinases and heat shock proteins显示文摘Alcoholic liver injury comprises of interactions of various intracellular signaling events in the liver. Innate immune responses in the resident Kupffer cells of the liver, oxidative stress-induced activation of hepatocytes, fibrotic events in liver stellate cells and activation of liver sinusoidal endothelial cells all contribute to alcoholic liver injury. The signaling mechanisms associated with alcoholic liver injury vary based on the cell type involved and the extent of alcohol consumption. In this review we will elucidate the oxidative stress and signaling pathways affected by alcohol in hepatocytes and Kupffer cells in the liver by alcohol. The toll-like receptors and their down-stream signaling events that play an important role in alcohol-induced inflammation will be discussed. Alcohol-induced alterations of various intracellular transcription factors such as NFκB, PPARs and AP-1, as well as MAPK kinases in hepatocytes and macrophages leading to induction of target genes that contribute to liver injury will be reviewed. Finally, we will discuss the significance of heat shock proteins as chaperones and their functional regulation in the liver that could provide new mechanistic insights into the contributions of stress-induced signaling mechanisms in alcoholic liver injury. | Pranoti Mandrekar | 2007 | World Journal of Gastroenterology2007，13，37： | 3 |
| 3 | Signalling pathways in alcohol-induced liver inflammation<.--'Review' -->显示文摘 | Pranoti Mandrekar Gyongyi Szabo | 2009 | Journal of Hepatology2009，，6： | 2 |
| 4 | Signalling pathways in alcohol-induced liver inflammation<!--'Review' -->显示文摘 | Pranoti Mandrekar Gyongyi Szabo | 2009 | Journal of Hepatology2009，，6： | 2 |
| 5 | PPARγ agonists as therapeutics for the treatment of Alzheimer's disease 显示文摘 | Landreth G Jiang Q Mandrekar S | 2008 | Neurotherapeuties2008，5，3： | 1 |
| 6 | The Unfolding Web of Innate Immune Dysregulation in Alcoholic Liver Injury显示文摘 | Szabo G Mandrekar P Petrasek J | | 0，，： | 1 |
| 7 | Incidence and outcome of cervical artery dissection: a population-based study 显示文摘 | Lee VH Brown RD Jr Mandrekar JN | 2006 | Neurology2006，67，10： | 1 |
| 8 | Existence of mild solutions for stochastic differential equations and semilinear equations with non-Gaussian Lrvy noise 显示文摘 | ALBEVERIO S MANDREKAR V RUDIGER B | 2009 | Stochastic Processes and their Applications2009，119，3： | 1 |
| 9 | Complications of diagnostic cerebral angiography:evaluation of 19,826consecutive patients显示文摘 | KAUFMANN T J HUSTON J 3rd MANDREKAR J N | 2007 | Radiology2007，243，： | 1 |
| 10 | Phase trial of peme trexedplusbevacizumab for second-line therapy of patients with advanced non small cell lungcancer:NCCTG and SWOG study N0426显示文摘 | Adjei AA Mandrekar SJ Dy GK | 2010 | J Clin 0ncol2010，28，4： | 1 |
| 11 | Incidence and outcome of cervical artery dissection:a population-based study显示文摘 | Lee VH Brown RD Mandrekar JN | 2006 | Neurology2006，67，10： | 1 |
| 12 | Predictors of recording an event during prolonged inpatient video electroencephalogram monitoring in children显示文摘 | Wyatt KD Mandrekar J Wong-Kisiel L | 2014 | Pediatr Neurol2014，50，5： | 1 |
| 13 | Receiver Operating Characteristic Curve in Diag- nostic Test Assessment 显示文摘 | Mandrekar JN | 2010 | J Thoracic Oncnlogy2010，5，9： | 1 |
| 14 | Thirty- andninety-day outcomes after sublobar resection with and withoutbrachytherapy for non-small cell lung cancer : results from amulticenter phase M study显示文摘 | Fernando HC Landreneau RJ Mandrekar SJ | 2011 | J Thorac Cardiovasc Surg2011，142，5： | 1 |
| 15 | A phase Ⅱ NC-CTG/CALGB trial of imatinib (ST1571) in patients with c-kit-expressing relapsed small cell lung cancer (SCLC)显示文摘 | Dy GK Miller AA Mandrekar S | 2005 | Proc Am Clin Soc Oncol2005，，： | 1 |
| 16 | Prognostic factors dif- fer by tumor stage for small cell lung cancer:a pooled analysis of North Central Cancer Treatment Group trials显示文摘 | Foster NR Mandrekar SJ Schild SE | 2009 | Cancer2009，115，12： | 1 |
| 17 | High serum cholesterol levels are associated with herpes zoster infection after heart transplantation 显示文摘 | Del Pozo J van de Beek D Mandrekar J | 2010 | Clin Infect Dis2010，50，1： | 1 |
| 18 | Signaling pathways in alco- hol-induced liver inflammation 显示文摘 | Mandrekar P Szabo G | 2009 | J Hepatol2009，50，6： | 1 |
| 19 | Alcohol exposure regu-lates heat shock transcription factor binding and heat shock proteins 70 and 90 in monocytes and macrophages:implication for TNF-alpha reg-ulation显示文摘 | Mandrekar P Catalano D Jeliazkova V | | 0，，5： | 1 |
| 20 | Signalling pathways in alcohol-induced liver inflammation显示文摘 | Mandrekar P Szabo G | 2009 | J Hepato12009，50，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员