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| 1 | Differences in neuroplasticity after spinal cord injury in varying animal models and humans显示文摘Rats have been the primary model to study the process and underlying mechanisms of recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can regain weight-bearing abilities without therapeutic interventions, as assessed by the Basso, Beattie and Bresnahan locomotor scale. However, many human patients suffer from permanent loss of motor function following spinal cord injury. While rats are the most understood animal model, major differences in sensorimotor pathways between quadrupeds and bipeds need to be considered. Understanding the major differences between the sensorimotor pathways of rats, non-human primates, and humans is a start to improving targets for treatments of human spinal cord injury. This review will discuss the neuroplasticity of the brain and spinal cord after spinal cord injury in rats, non-human primates, and humans. A brief overview of emerging interventions to induce plasticity in humans with spinal cord injury will also be discussed. | Mallory E.Filipp Benjamin J.Travis Stefanie S.Henry Emma C.Idzikowski Sarah A.Magnuson Megan YF Loh Daniel J.Hellenbrand Amgad S.Hanna | 2019 | Neural Regeneration Research2019，14，1： | 8 |
| 2 | Peroxisome proliferator-activated receptor γ agonist reduces the severity of post-ERCP pancreatitis in rats显示文摘AIM: To determine the effects of prophylactic peroxi-some proliferator-activated receptor (PPARγ) agonist administration in an experimental model of post-endoscopic retrograde cholangiopancreatography (post-ERCP) acute pancreatitis.METHODS: Post-ERCP pancreatitis was induced in male Wistar rats by infusion of contrast medium into the pancreatic duct. In additional group, rosiglitazone, a PPARγ agonist, was administered 1 h before infusion of contrast medium. Plasma and pancreas samples were obtained 6 h after the infusion.RESULTS: Infusion of contrast medium into the pan-creatic duct resulted in an inflammatory process characterized by increased lipase levels in plasma, and edema and myeloperoxidase activity (MPO) in pancreas. This result correlated with the activation of nuclear factor κB (NFκB) and the inducible NO synthase (iNOS) expression in pancreatic cells. Rosiglitazone reduced the increase in lipase and the level of edema and the increase in myeloperoxidase as well as the activation of NFκB and iNOS expression.CONCLUSION: A single oral dose of rosiglitazone, given 1 h before post-ERCP pancreatitis induction is effective in reducing the severity of the subsequent inflammatory process. The protective effect of rosiglitazone was associated with NFκB inhibition and the blockage of leukocyte infiltration in pancreas. | Emma Folch-Puy Susana Granell Juan L Iovanna Marc Barthet Daniel Closa | 2006 | World Journal of Gastroenterology2006，12，40： | 6 |
| 3 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘 | Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter | 2014 | Cell Host & Microbe2014，，： | 3 |
| 4 | Infrared fluorescence imaging of infarcted hearts with A@S nanodots显示文摘Ag2S nano dots have already bee n dem onstrated as promisi ng n ear-i nfrared (NIR-II, 1.0-1.45 pm) emitting nan oprobes with low toxicity, high penetration and high resolution for in vivo imaging of, for example, tumors and vasculature. In this work, we have systematically investigated the pote ntial applicati on of function alized Ag2S nano dots for accurate imaging of damaged myocardium tissues after a myocardial in farction in duced by either partial or global ischemia. Ag2S nano dots surface-function alized with the an giote nsin II peptide (ATI I) have show n over 10-fold enhanced binding efficiency to damaged tissues than non-specifically (PEG) functionalized Ag2S nanodots due to their interaction with the upregulated angiotensin II receptor type I (AT1R). It is demonstrated how the NIR-II images generated by ATII-functionalized Ag2S nanodots contain valuable information about the location and extension of damaged tissue in the myocardium allowing for a proper identification of the occluded artery as well as an in direct evaluati on of the damage level. The pote ntial applicati on of Ag2S nano dots in the n ear future for in vivo imaging of myocardial infarction was also corroborated by performing proof of concept whole body imaging experiments. | Dirk H. Ortgies Angel Luis Garcia-Villalon Miriam Granado Sara Amor Emma Martin Rodriguez Harrisson DA Santos Jingke Yao Jorge Rubio-Retama Daniel Jaque | 2019 | Nano Research2019，12，4： | 2 |
| 5 | P-Selectin Expression and Kupffer Cell Activation in Rat Acute Pancreatitis显示文摘 | Emma Folch Neus Prats Georgina Hotter Santiago López Emilio Gelpi Joan Roselló-Catafau Daniel Closa | 2000 | Digestive Diseases and Sciences2000，，8： | 2 |
| 6 | Vedolizumab for ulcerative colitis: Real world outcomes from a multicenter observational cohort of Australia and Oxford显示文摘BACKGROUND Vedolizumab(VDZ),a humanised monoclonal antibody that selectively inhibits alpha4-beta7 integrins is approved for use in adult moderate to severe ulcerative colitis(UC)patients.AIM To assess the efficacy and safety of VDZ in the real-world management of UC in a large multicenter cohort involving two countries and to identify predictors of achieving remission.METHODS A retrospective review of Australian and Oxford,United Kingdom data for UC patients.Clinical response at 3 mo,endoscopic remission at 6 mo and clinical remission at 3,6 and 12 mo were assessed.Cox regression models and Kaplan Meier curves were performed to assess the time to remission,time to failure and the covariates influencing them.Safety outcomes were recorded.RESULTS Three hundred and three UC patients from 14 centres in Australia and United Kingdom,[60%n=182,anti-TNF naïve]were included.The clinical response was 79%at 3 mo with more Australian patients achieving clinical response compared to Oxford(83%vs 70%P=0.01).Clinical remission for all patients was 56%,62%and 60%at 3,6 and 12 mo respectively.Anti-TNF naive patients were more likely to achieve remission than exposed patients at all the time points(3 mo 66%vs 40%P<0.001,6 mo 73%vs 46%P<0.001,12 mo 66%vs 51%P=0.03).More Australian patients achieved endoscopic remission at 6 mo compared to Oxford(69%vs 43%P=0.01).On multi-variate analysis,anti-TNF naïve patients were 1.8(95%CI:1.3-2.3)times more likely to achieve remission than anti-TNF exposed(P<0.001).32 patients(11%)had colectomy by 12 mo.CONCLUSION VDZ was safe and effective with 60%of UC patients achieving clinical remission at 12 mo and prior anti-TNF exposure influenced this outcome. | Samba Siva Reddy Pulusu Ashish Srinivasan Krupa Krishnaprasad Daniel Cheng Jakob Begun CharlotteKeung Daniel Van Langenberg Lena Thin Tamara Mogilevski Peter De Cruz Graham Radford-Smith Emma Flanagan Sally Bell Soleiman Kashkooli Miles Sparrow Simon Ghaly Peter Bampton Elise Sawyer Susan Connor Quart-ul-ain Rizvi Jane M Andrews Gillian Mahy Paola Chivers Simon Travis Ian Craig Lawrance | 2020 | World Journal of Gastroenterology2020，26，30： | 2 |
| 7 | Social interactivity in pigeon courtship behavior显示文摘A closed-loop teleprompter system was used to isolate and manipulate social interactivity in thenatural courtship interactions of pigeons Columbia livia. In Experiment 1, a live face-to-face real-time interaction between 2 courting pigeons (Live) was compared to a played back version of thevideo stimulus recorded during the pairs Live interaction. We found that pigeons were behavinginteractively; their behavior depended on the relationships between their own signals and those oftheir partner. In Experiment 2, we tested whether social interactivity relies on spatial cues presentin the facing direction of a partner's display. By moving the teleprompter camera 90~ away from itsoriginal location, the partner's display was manipulated to appear as if it is directed 90~ away fromthe subject. We found no effect of spatial offset on the pigeon's behavioral response. In Experiment3, 3 time delays, 1 s, 3s, and 9s, a Live condition, and a playback condition were chosen to investi-gate the importance of temporal contiguity in social interactivity. Furthermore, both opposite-sex(courtship) and same-sex (rivalry) pairs were studied to investigate whether social-context affectssocial interactivity sensitivity. Our results showed that pigeon courtship behavior is sensitive totemporal contiguity. Behavior declined in the 9 s and Playback conditions as compared to Live con-dition and the shorter time delays. For males only, courtship behavior also increased in the 3-sdelay condition. The effect of social interactivity and time delay was not observed in rivalry inter-actions, suggesting that social interactivity may be specific to courtship. | Emma L.R. WARE Daniel R. SAUNDERS Nikolaus F, TROJE | 2017 | Current Zoology2017，63，1： | 2 |
| 8 | Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke: The North Dublin Population Stroke Study显示文摘 | Danielle Ní Chróinín Elizabeth L. Callaly Joseph Duggan áine Merwick Niamh Hannon órla Sheehan Michael Marnane Gillian Horgan Emma B. Williams Dawn Harris Lorraine Kyne Patricia M.E. McCormack Joan Moroney Tim Grant David Williams Leslie Daly Peter J. Kel | 2011 | Stroke2011，，： | 1 |
| 9 | Challenges and opportunities in mapping land use intensity globally显示文摘 | Tobias Kuemmerle Karlheinz Erb Patrick Meyfroidt Daniel Müller Peter H Verburg Stephan Estel Helmut Haberl Patrick Hostert Martin R. Jepsen Thomas Kastner Christian Levers Marcus Lindner Christoph Plutzar Pieter Johannes Verkerk Emma H van der Zanden Anet | 2013 | Current Opinion in Environmental Sustainability2013，，： | 1 |
| 10 | Monoclonal Antibody-Mediated Targeting of CD123, IL-3 Receptor α Chain, Eliminates Human Acute Myeloid Leukemic Stem Cells显示文摘 | Liqing Jin Erwin M. Lee Hayley S. Ramshaw Samantha J. Busfield Armando G. Peoppl Lucy Wilkinson Mark A. Guthridge Daniel Thomas Emma F. Barry Andrew Boyd David P. Gearing Gino Vairo Angel F. Lopez John E. Dick Richard B. Lock | 2009 | Cell Stem Cell2009，，1： | 1 |
| 11 | Environmental Contaminants in Hospital Settings and Progress in Disinfecting Techniques显示文摘 | Gabriele Messina Emma Ceriale Daniele Lenzi Sandra Burgassi Elena Azzolini Pietro Manzi Marc Léone | 2013 | BioMed Research International2013，，： | 1 |
| 12 | Phase I dose-finding study of golvatinib ( E7050 ), a c-Met and Eph recep- tor targeted muhi-kinase inhibitor, administered orally QD to pa- tients with advanced solid tumors 显示文摘 | Gennaro Daniele MR Montserrat BC Emma JD | 2012 | Clin Oncol2012，，： | 1 |
| 13 | Laparoscopic Reoperative Bariatric Surgery: Experience from 27 Consecutive Patients显示文摘 | Michel Gagner Paolo Gentileschi John de Csepel Subhash Kini Emma Patterson William B Inabnet Daniel Herron Alfons Pomp | 2002 | Obesity Surgery2002，，2： | 1 |
| 14 | Melanoma in the gastrointestinal tract显示文摘 | Daniel Blecker Susan Abraham Emma E Furth Michael L Kochman | 1999 | The American Journal of Gastroenterology1999，，12： | 1 |
| 15 | Effect of Simultaneous Inhibition of TNF-α Production and Xanthine Oxidase in Experimental Acute Pancreatitis: The Role of Mitogen Activated Protein Kinases显示文摘 | Javier Pereda Luis Sabater Norberto Cassinello Luis Gómez-Cambronero Daniel Closa Emma Folch-Puy Luis Aparisi Julio Calvete Miguel Cerdá Salvador Lledó José Vi?a Juan Sastre | 2004 | Annals of Surgery2004，，1： | 1 |
| 16 | Gold nanoshells: Contrast agents for cell imaging by cardiovascular optical coherence tomography显示文摘光连贯断层摄影术(10 月) 在 interventional 获得了可观的注意心血管的药并且当前在临床的背景被使用估计动脉粥样硬化患者损害并且优化 stent 放置。在细胞的水平的动脉成像向心血管的分子的成像组成第一步,它在个性化的 noninvasive 治疗的发展代表主要进展。在这个工作,我们证明心血管的 10 月能被用来检测在 biocompatible 液体推迟的单个房间。重要地,有金 nanoshells (GNS ) 的这种基于导管的临床的技术的联合在单个房间生产的 backscattered 信号作为细胞内部的对比代理人导致了实质的改进。这细胞的对比改进在 OCT 激光波长(1,300 nm ) 被归因于 GNS 的大 backscattering 剖面图。推迟的房间的 10 月代表性的图象的简单紧张分析使识别成功地合并了 GNS 的生活房间的亚人口可能。这个方法的 generalizability 用二根不同房间线(HeLa 和 Jurkat 房间) 被表明。这个工作用明确地修改的 GNS 提供新奇卓见进心血管的分子的成像。 | Jie Hu Francisco Sanz-Rodríguez Fernando Rivero Emma Martín Rodríguez Río Aguilar Torres Dirk H. Ortgies José García Solé Fernando Alfonso Daniel Jaque | 2018 | Nano Research2018，11，2： | 1 |
| 17 | 简洁的背后显示文摘丹尼尔·多(DANIEL TO)和艾玛·埃斯顿(EMMA AISTON)2008年于澳大利亚阿德菜德成立了他们的工作室——STUDIO DANIEL EMMA。他们的作品都非常简洁,但像设计师所说,简洁的背后是大量的思量和谨慎的决定。 | msright DANIEL EMMA | 2014 | 设计2014，27，12： | 1 |
| 18 | Epidemiology of Skin Disorders in Ethiopian Children and Adolescents: An Analysis of Records from the Italian Dermatological Centre, Mekelle, Tigray, Ethiopia, 2005 to 2009显示文摘 | Rosalia Marrone Pascal Vignally Annalisa Rosso Daniele Didero Emma Pizzini Federica Dassoni Maria Chiara Pajno Elisa Maiani Gennaro Franco Roberta Calcaterra Aldo Morrone Concetta Mirisola | 2012 | Pediatric Dermatology2012，，4： | 1 |
| 19 | A review of cuttlefish camouflage and object recognition and evidence for depth perception显示文摘 | Emma J Kelman Daniel Osorio Roland J Baddeley | | 0，，： | 1 |
| 20 | Association Between Acute Statin Therapy, Survival, and Improved Functional Outcome After Ischemic Stroke: The North Dublin Population Stroke Study显示文摘 | Danielle Ní Chróinín Elizabeth L. Callaly Joseph Duggan áine Merwick Niamh Hannon órla Sheehan Michael Marnane Gillian Horgan Emma B. Williams Dawn Harris Lorraine Kyne Patricia M.E. McCormack Joan Moroney Tim Grant David Williams Leslie Daly Peter J. Kel | 2011 | Stroke2011，，4： | 1 |
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