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| 1 | Physiology of bile secretion显示文摘The formation of bile depends on the structural and functional integrity of the bile-secretory apparatus and its impairment, in different situations, results in the syndrome of cholestasis. The structural bases that permit bile secretion as well as various aspects related with its composition and flow rate in physiological conditions will first be reviewed. Canalicular bile is produced by polarized hepatocytes that hold transporters in their basolateral (sinusoidal) and apical (canalicular) plasma membrane. This review summarizes recent data on the molecular determinants of this primary bile formation. The major function of the biliary tree is modification of canalicular bile by secretory and reabsorptive processes in bileduct epithelial cells (cholangiocytes) as bile passes through bile ducts. The mechanisms of fluid and solute transport in cholangiocytes will also be discussed. In contrast to hepatocytes where secretion is constant and poorly controlled, cholangiocyte secretion is regulated by hormones and nerves. A short section dedicated to these regulatory mechanisms of bile secretion has been included. The aim of this revision was to set the bases for other reviews in this series that will be devoted to specific issues related with biliary physiology and pathology. | Alejandro Esteller | 2008 | World Journal of Gastroenterology2008，14，37： | 17 |
| 2 | Review:DNA-damage response network at the crossroads of cell-cycle checkpoints, cellular senescence and apoptosis显示文摘Tissue homeostasis requires a carefully-orchestrated balance between cell proliferation, cellular senescence and cell death. Cells proliferate through a cell cycle that is tightly regulated by cyclin-dependent kinase activities. Cellular senescence is a safeguard program limiting the proliferative competence of cells in living organisms. Apoptosis eliminates unwanted cells by the coordinated activity of gene products that regulate and effect cell death. The intimate link between the cell cycle, cellular senes- cence, apoptosis regulation, cancer development and tumor responses to cancer treatment has become eminently apparent. Extensive research on tumor suppressor genes, oncogenes, the cell cycle and apoptosis regulatory genes has revealed how the DNA damage-sensing and -signaling pathways, referred to as the DNA-damage response network, are tied to cell proliferation, cell-cycle arrest, cellular senescence and apoptosis. DNA-damage responses are complex, involving “sensor” proteins that sense the damage, and transmit signals to “transducer” proteins, which, in turn, convey the signals to numerous “effector” proteins implicated in specific cellular pathways, including DNA repair mechanisms, cell-cycle checkpoints, cellular senescence and apoptosis. The Bcl-2 family of proteins stands among the most crucial regulators of apoptosis and performs vital functions in deciding whether a cell will live or die after cancer chemotherapy and irradiation. In addition, several studies have now revealed that members of the Bcl-2 family also interface with the cell cycle, DNA repair/recombination and cellular senescence, effects that are generally distinct from their function in apoptosis. In this review, we report progress in understanding the molecular networks that regulate cell-cycle checkpoints, cellular senescence and apoptosis after DNA damage, and discuss the influence of some Bcl-2 family members on cell-cycle checkpoint regulation. | SCHMITT Estelle PAQUET Claudie BEAUCHEMIN Myriam BERTRAND Richard | 2007 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2007，8，6： | 17 |
| 3 | 表观遗传学如何诠释人肿瘤转移microRNA的新作用显示文摘转移过程的特征是肿瘤细胞可通过血液系统播散到远端组织,然后这些变异的细胞在那里增殖,并形成继发性肿瘤,这也是肿瘤患者死亡最主要的原因。近年来,一系列重要的肿瘤相关基因陆续被报道,如钙粘素、层粘连蛋白、乙酰肝素硫酸盐、蛋白水解酶、血管生成抑制剂等。但是,这些基因在肿瘤转移中发生改变的机制尚不明了,因为尽管它们的表达普遍下调, | Amaia Lujambio Manel Esteller 南娟(翻译) 丁燕(翻译) 孙丹(校对) | 2009 | 中国肺癌杂志2009，12，8： | 11 |
| 4 | Multi-scale phylogenetic structure in coastal dune plant communities across the globe显示文摘Aims Studies integrating phylogenetic history and large-scale community assembly are few,and many questions remain unanswered.Here,we use a global coastal dune plant data set to uncover the important factors in community assembly across scales from the local filtering processes to the global long-term diversification and dispersal dynamics.Coastal dune plant communities occur worldwide under a wide range of climatic and geologic conditions as well as in all biogeographic regions.However,global patterns in the phylogenetic composition of coastal dune plant communities have not previously been studied.Methods The data set comprised vegetation data from 18463 plots in New Zealand,South Africa,South America,North America and Europe.The phylogenetic tree comprised 2241 plant species from 149 families.We calculated phylogenetic clustering(Net Relatedness Index,NRI,and Nearest Taxon Index,NTI)of regional dune floras to estimate the amount of in situ diversification relative to the global dune species pool and evaluated the relative importance of land and climate barriers for these diversification patterns by geographic analyses of phylogenetic similarity.We then tested whether dune plant communities exhibit similar patterns of phylogenetic structure within regions.Finally,we calculated NRI for local communities relative to the regional species pool and tested for an association with functional traits(plant height and seed mass)thought to vary along sea–inland gradients.Important Findings Regional species pools were phylogenetically clustered relative to the global pool,indicating regional diversification.NTI showed stronger clustering than NRI pointing to the importance of especially recent diversifications within regions.The species pools grouped phylogenetically into two clusters on either side of the tropics suggesting greater dispersal rates within hemispheres than between hemispheres.Local NRI plot values confirmed that most communities were also phylogenetically clustered within regions.NRI values decreased with increasing plant height and seed mass,indicating greater phylogenetic clustering in communities with short maximum height and good dispersers prone to wind and tidal disturbance as well as salt spray,consistent with environmental filtering along sea–inland gradients.Height and seed mass both showed significant phylogenetic signal,and NRI tended to correlate negatively with both at the plot level.Low NRI plots tended to represent coastal scrub and forest,whereas high NRI plots tended to represent herb-dominated vegetation.We conclude that regional diversification processes play a role in dune plant community assembly,with convergence in local phylogenetic community structure and local variation in community structure probably reflecting consistent coastal-inland gradients.Our study contributes to a better understanding of the globally distributed dynamic coastal ecosystems and the structuring factors working on dune plant communities across spatial scales and regions. | Ane Kirstine Brunbjerg Jeannine Cavender-Bares Wolf L.Eiserhardt Rasmus Ejrnæs Lonnie W.Aarssen Hannah L.Buckley Estelle Forey Florian Jansen Jens Kattge Cynthia Lane Roy A.Lubke Angela T.Moles Ana Laura Monserrat Robert K.Peet Julissa Roncal Louise Wootton Jens-Christian Svenning | 2014 | Journal of Plant Ecology2014，7，2： | 9 |
| 5 | Anterograde and Retrograde Regulation of Nuclear Genes Encoding Mitochondrial Proteins during Growth, Development, and Stress显示文摘在植物的 Mitochondrial 生物的续生说和功能要求编码 mitochondrial 蛋白质(NGEMP ) 的超过 1000 原子基因的表示。这些基因的表达式被织物特定、发展、内部、外部的刺激 thatresult 在涉及的一个动态细胞器调整新陈代谢并且许多发信号的进程。尽管线粒体的新陈代谢的 andbiosynthetic 机械很好相对被理解,调整这些过程和 varioussignaling 小径的因素仅仅在分子的水平正在识别包含。anterograde 的分子的部件(对 mitochondrial 原子) 并且后退(mitochondrial 到原子) 与叶绿体调整 NGEMPsinteract 的表示的发信号的小径 -- ,生长 -- ,并且在在许多层次的房间的发信号压力的小径,与在这些信号的传播和执行的普通 componentsinvolved。这作为在 thecell,不是仅仅在 mitochondrial 功能本身的直接发信号,而且在察觉到或集成许多 otherinternal 和外部信号发信号的重要中心放线粒体。这与精力新陈代谢和压力回答集成并且优化生长,哪个在光合、非光合的 cells.Key 词的 isrequired: | Sophia Ng Inge De Clercqc Olivier Van Akena Simon R. Lawd Aneta Ivanovad Patrick Willems Estelle Giraud Frank Van Breusegem James Wheland | 2014 | Molecular Plant2014，7，7： | 8 |
| 6 | IL-17 and Th17 Cells显示文摘 | Thomas Korn Estelle Bettelli Mohamed Oukka Vijay K. Kuchroo | 2009 | Annual Review of Immunology2009，，： | 6 |
| 7 | Defining the Mitochondrial Stress Response in Arabidopsis thaliana显示文摘获得的全球概述线粒体对应力作出回应,我们试图定义工厂 mitochondrial 压力反应(MSR ) 。由联合通常认为地与压力相关的条件的 16 个 microarray 实验编码 mitochondrial 蛋白质的一套 1196 Arabidopsis thaliana 基因, 45 原子编码基因被定义为广泛地压力应答。用绿色荧光灯蛋白质(GFP ) 熔化试金,很多这些指向蛋白质的 mitochondrial 被测试,在是的总数 26 蛋白质证实 mitochondrially 指向了。几这些蛋白质被观察双指向了到线粒体和质体,包括小热吃惊蛋白质 sHSP23.5 和 sHSP23.6。除了线粒体的明确的压力部件,例如其他的 oxidases,菸碱腺嘌 dinucleotide (NAD (P) H ) 脱氢酶,和热震惊蛋白质,许多另外的蛋白质,许多与未知功能,被识别。mitochondrial 搬运人蛋白质家庭在压力应答的基因是过去代表的,建议那个压力越过 mitochondrial 为代谢物运输导致改变的需要内部膜。尽管这些蛋白质编码许多的基因包含普通行动 cis 规章的元素,很多个不同规章的过程或信号多半触发了 MSR,是明显的。因此,这些基因提供新模型系统学习 mitochondrial 后退规定,除了广泛地使用的其他的 oxidase 模型。另外,当在对应力应答的蛋白质的变化没在一个抄本与变化相关很好,铺平,它建议 post-transcriptional 机制也在定义 MSR 起一个重要作用。 | Olivier Van Aken Botao Zhang Chris Carrie Vindya Uggalla Ellen Paynter Estelle Giraud James Whelan | 2009 | Molecular Plant2009，2，6： | 4 |
| 8 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles显示文摘AIM:To evaluate the risk associated with variants of the UNC5C gene recently suspected to predispose to familial colorectal cancer(CRC).METHODS:We screened patients with familial CRC forms as well as patients with sporadic CRCs.In a first time,we analyzed exon 11 of the UNC5C gene in 120unrelated patients with suspected hereditary CRC,58patients with suspected Lynch-associated cancer or polyposis,and 132 index cases of Lynch syndrome families with a characterized mutation in a DNA mismatch repair(MMR).Next,1023 patients with sporadic CRC and1121 healthy individuals were screened for the variants identified in patients with familial cancer.RESULTS:Of 120 patients with familial CRC of unknown etiology,one carried the previously reported mis-sense mutation p.Arg603Cys(R603C)and another exhibited the unreported variant of unknown significance p.Thr617Ile(T617I).The p.Ala628Lys(A628K)mutation previously described as the main UNC5C risk variant for familial CRC was not detected in any cases of familial CRC of unknown etiology,but was present in a patient with familial gastric cancer and in two Lynch syndrome patients in co-occurrence with MMR mutations.A statistically non-significant increase in cancer risk was identified in familial CRC and/or other Lynchassociated cancers(1/178 patients vs 2/1121 healthy controls,OR=3.2,95%CI:0.29-35.05,P=0.348)and in sporadic CRCs(4/1023 patients vs 2/1121 healthy controls,OR=2.2,95%CI:0.40-12.02,P=0.364).CONCLUSION:We confirm that UNC5C mutations are very rare in familial and sporadic CRCs,but further investigations are needed to justify routine UNC5C testing for diagnostic purposes. | Sébastien Küry Céline Garrec Fabrice Airaud Flora Breheret Virginie Guibert Cécile Frenard Shuo Jiao Dominique Bonneau Pascaline Berthet Céline Bossard Olivier Ingster Estelle Cauchin Stéphane Bezieau | 2014 | World Journal of Gastroenterology2014，20，1： | 4 |
| 9 | Co-combustion of coal and municipal solid waste in a circulating fluidized bed显示文摘 | Eric Marty and Estelle Desroches-Ducarne | 1998 | Fuel1998，77，： | 3 |
| 10 | Predictive factors for compliance with transanal irrigation for the treatment of defecation disorders显示文摘AIM To investigate compliance with transanal irrigation(TAI) one year after a training session and to identify predictive factors for compliance.METHODS The compliance of one hundred eight patients [87 women and 21 men; median age 55 years(range 18-83)] suffering from constipation or fecal incontinence(FI) was retrospectively assessed. The patients were trained in TAI over a four-year period at a single institution. They were classified as adopters if they continued using TAI for at least one year after beginning the treatment or as non-adopters if they stopped. Predictive factors of compliance with TAI were based on pretreatment assessments and trainingprogress. The outcomes of the entire cohort of patients who had been recruited for the TAI treatment were expressed in terms of intention-to-treat.RESULTS Forty-six of the 108(43%) trained patients continued to use TAI one year after their training session. The patients with FI had the best results, with 54.5% remaining compliant with TAI. Only one-third of the patients who complained of slow transit constipation or obstructed defecation syndrome continued TAI. There was an overall discontinuation rate of 57%. The most common reason for discontinuing TAI was the lack of efficacy(41%). However, 36% of the patients who discontinued TAI gave reasons independent of the efficacy of the treatment such as technical problems(catheter expulsion, rectal balloon bursting, instilled water leakage or retention, pain during irrigation, anal bleeding, anal fissure) while 23% said that there were too many constraints. Of the patients who reported discontinuing TAI, the only predictive factor was the progress of the training(OR = 4.9, 1.3-18.9, P = 0.02).CONCLUSION The progress of the training session was the only factor that predicted patient compliance with TAI. | Clémence Bildstein ChloéMelchior Guillaume Gourcerol Estelle Boueyre Valérie Bridoux Eric Vérin Anne-Marie Leroi | 2017 | World Journal of Gastroenterology2017，23，11： | 3 |
| 11 | Role of lipid-lowering agents in the management of diabetic retinopathy显示文摘Diabetic retinopathy affects a substantial proportion of patients with diabetes mellitus(DM) and is the leading cause of blindness in working-aged adults. Even though the incidence of diabetic retinopathy has declined in the last decades, its prevalence increased and is expected to rise further as a result of the increasing incidence of type 2 DM(T2DM) and the longer life expectancy of patients with DM. The pathogenesis of diabetic retinopathy is multifactorial. Some observational studies suggested an association between dyslipidemia and the development and progression of retinopathy in patients with DM but others did not confirm this association. Regarding lipid-lowering agents, studies that evaluated the role of statins in the management of these patients are mostly small and yielded discrepant results. Large randomized studies with statins in patients with T2DM showed no benefit of these agents on diabetic retinopathy but were not designed to address this effect. In contrast, both preclinical data and two large randomized controlled studies, the FIELD and the ACCORD trial, showed that fenofibrate delays the progression of diabetic retinopathy. Even though the mechanisms underpinning this favorable effect are not entirely clear, these findings suggest that fenofibrate might represent a useful tool for the management of diabetic retinopathy. | Estelle Ioannidou Vasilis-Spyridon Tseriotis Konstantinos Tziomalos | 2017 | World Journal of Diabetes2017，8，1： | 3 |
| 12 | The activatory long non-coding RNA DBE-T reveals the epigenetic etiology of facioscapulohumeral muscular dystrophy显示文摘 | Miguel Vizoso Manel Esteller | 2012 | Cell Research2012，22，10： | 3 |
| 13 | 评估实验室用水中新兴污染物的存在和影响显示文摘随着分析技术灵敏度的不断改进以及新的污染物的出现,提高实验室用水的纯度水平已经成为持久不变的目标。新的污染物的出现以及对水中极低浓度水平污染物的检测能力的提高对科学家和水纯化系统的研发人员提出了一个持续的挑战。科学界必须对可能影响实验室分析的这些污染物保持警惕。此外,这些污染物的浓度水平也是我们需要关注的一个方面。科学家们和供水系统的制造商必须一起合作,以确保现有的纯化技术能够有效地去除那些可能影响实验室结果的污染物,并根据需要来设计新的策略。 | Estelle RICHE Maricar TARUN | 2010 | 生命科学仪器2010，8，5： | 2 |
| 14 | Ageing affects chondroitin sulfates and their synthetic enzymes in the intervertebral disc显示文摘The depletion of chondroitin sulfates(CSs)within the intervertebral disc(IVD)during degenerative disc disease(DDD)results in a decrease in tissue hydration,a loss of fluid movement,cell apoptosis,a loss of nerve growth inhibition and ultimately,the loss of disc function.To date,little is known with regards to the structure and content of chondroitin sulfates(CSs)during IVD ageing.The behavior of glycosaminoglycans(GAGs),specifically CSs,as well as xylosyltransferase I(XT-I)and glucuronyltransferase I(GT-I),two key enzymes involved in CS synthesis as a primer of glycosaminoglycan(GAG)chain elongation and GAG synthesis in the nucleus pulposus(NP),respectively,were evaluated in a bovine ageing IVD model.Here,we showed significant changes in the composition of GAGs during the disc ageing process(6-month-old,2-year-old and 8-year-old IVDs representing the immature to mature skeleton).The CS quantity and composition of annulus fibrosus(AF)and NP were determined.The expression of both XT-I and GT-I was detected using immunohistochemistry.A significant decrease in GAGs was observed during the ageing process.CSs are affected at both the structural and quantitative levels with important changes in sulfation observed upon maturity,which correlated with a decrease in the expression of both XT-I and GT-I.A progressive switch of the sulfation profile was noted in both NP and AF tissues from 6 months to 8 years.These changes give an appreciation of the potential impact of CSs on the disc biology and the development of therapeutic approaches for disc regeneration and repair. | Estelle C Collin Oliver Carroll Michelle Kilcoyne Marianna Peroglio Eugene See Doris Hendig Mauro Alini Sibylle Grad Abhay Pandit | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 2 |
| 15 | First spaceborne demonstration of BeiDou-3 signals for GNSS reflectometry from CYGNSS constellation显示文摘The full constellation of Chinese Global Navigation Satellite System(GNSS)Bei Dou-3 has been deployed completely and started fully operational service.In addition to providing global Positioning,Navigation and Timing(PNT)services,the Bei Dou-3 satellites transmissions can also be used as the sources of illumination for Earth Observation(EO)with a bistatic radar configuration.This innovative EO concept,known as GNSS reflectometry(GNSS-R),allows to measure the Earth surface characteristics at high resolution via the reflected L-band radar signals collected by a constellation of small,low cost and low Earth orbiting satellites.For the first time in orbit,earth reflected Bei Dou-3 signal has been detected from the limited sets of raw data collected by the NASA’s Cyclone GNSS(CYGNSS)constellation.The feasibility of spaceborne Bei Dou-3 reflections on two typical applications,including sea surface wind and flooding inundation detection,has been demonstrated.The methodology and results give new strength to the prospect of new spaceborne GNSS-R instruments and missions,which can make multi-GNSS reflectometry observations available to better capture rapidly changing weather systems at better spatio-temporal scales. | Weiqiang LI Estel CARDELLACH Serni RIBO Antonio RIUS Bo ZHOU | 2021 | Chinese Journal of Aeronautics2021，34，9： | 2 |
| 16 | Core-shell particles of C-doped CdS and graphene: A noble metal-free approach for efficient photocatalytic H_(2) generation显示文摘To achieve efficient photocatalytic H_(2) generation from water using earth-abundant and cost-effective materials,a simple synthesis method for carbon-doped CdS particles wrapped with graphene(C-doped CdS@G)is reported.The doping effect and the application of graphene as cocatalyst for CdS is studied for photocatalytic H_(2) generation.The most active sample consists of CdS and graphene(CdS-0.15G)exhibits promising photocatalytic activity,producing 3.12 mmol g^-(1) h^-(1) of H_(2) under simulated solar light which is^4.6 times superior than pure CdS nanoparticles giving an apparent quantum efficiency(AQY)of 11.7%.The enhanced photocatalytic activity for H_(2) generation is associated to the narrowing of the bandgap,enhanced light absorption,fast interfacial charge transfer,and higher carrier density(N_(D))in C-doped CdS@G samples.This is achieved by C doping in CdS nanoparticles and the formation of a graphene shell over the C-doped CdS nanoparticles.After stability test,the spent catalysts sample was also characterized to investigate the nanostructure. | Muhammad Zubair Estelle Marie M.Vanhaecke Ingeborg-Helene Svenum Magnus RФnning Jia Yang | 2020 | Green Energy & Environment2020，5，4： | 2 |
| 17 | In vitro gastrointestinal digestion study of two wheat cultivars and evaluation of xylanase supplementation显示文摘Background:The filamentous fungus Talaromyces versatilis is known to improve the metabolizable energy of wheatbased poultry diets thanks to its ability to produce a pool of CAZymes and particularly endo-β(1,4)-xylanases.In order to appreciate their in vivo mode of action,the supplementation effect of two of its xylanases,XynD and XynB from families GH10 and GH11 respectively,have been evaluated on two different wheat cultivars Caphorn and Isengrain,which were chosen amongst 6 varieties for their difference in non starch polysaccharides content and arabinoxylan composition.Results:Polysaccharides digestion was followed during 6 h along the digestive tract using the TNO gastrointestinal model-1,to mimic monogastric metabolism.Polysaccharide degradation appeared to occur mainly at the jejunal level and was higher with Isengrain than with Caphorn.For both cultivars,XynD and XynB supplementation increased notably the amount of reducing end sugars into the jejuno-ileal dialysates,which has been confirmed by a valuable increase of the soluble glucose into the jejunal dialysates.Conclusions:The amounts of arabinose and xylose into the dialysates and ileal deliveries increased consequently mainly for Caphorn,suggesting that XynD and XynB supplementation in wheat-based diet could alleviate the anti-nutritional effects of arabinoxylans by limiting the physical entrapment of starch and could increase the available metabolizable energy. | Mickael Lafond Bernard Bouza Sandrine Eyrichine Friedrich Rouffineau Luc Saulnier Thierry Giardina Estelle Bonnin Aurélie Preynat | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 2 |
| 18 | IL-17 and Th17 Cells显示文摘 | Thomas Korn Estelle Bettelli Mohamed Oukka Vijay K. Kuchroo | 2009 | Annual Review of Immunology2009，，： | 2 |
| 19 | PAI-1 promotor 4G/5G genetype as an additional risk factor for venous thrombosis in subjects withgenetic thrombophilic defects显示文摘 | Swgui R Estelles A MiraY | 2000 | Br J Haematol2000，111，6： | 1 |
| 20 | Polymorphisms in the endothelial protein C receptor gene and thrombophilia显示文摘 | Medina P Navarro S Estelles A | 2007 | Thromb Haemost2007，98，： | 1 |
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