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| 1 | 新生儿重症监护室医院感染预防策略显示文摘新生儿是医院感染的易感人群,医院感染能增加新生儿重症监护室(NICU)患儿的患病率、死亡率,延长住院时间,增加医疗费用,本文阐述了关于新生儿医院感染的预防和管理策略。
一、手卫生
手卫生是医务人员洗手、卫生手消毒、外科手消毒的总称。手卫生是降低医院感染最有效的方法。以下情况应遵守手卫生:接触患儿前后;从患儿污染的部位到清洁部位;进行侵袭性操作之前;接触患儿体液、排泄物、破损的皮肤、伤口敷料之后;直接接触患儿周围环镜后;摘除无菌或被污染的手套后。 | 卜祥芳 张欣 Polin RA Denson S Brady MT | 2014 | 中国新生儿科杂志2014，29，6： | 7 |
| 2 | Impaired granulocyte-macrophage colony-stimulating factor bioactivity accelerates surgical recurrence in ileal crohn's disease显示文摘AIM To examine the relationship between elevated granulocyte-macrophage colony-stimulating factor(GMCSF) auto-antibodies(Ab) level and time to surgical recurrence after initial surgery for Crohn's disease(CD). METHODS We reviewed 412 charts from a clinical database at tertiary academic hospital. Patients included in the study had ileal or ileocolonic CD and surgical resection of small bowel or ileocecal region for management of disease. Serum samples were analyzed for serological assays including GM-CSF cytokine, GM-CSF Ab, ASCA Ig G and Ig A, and genetic markers including SNPs rs2066843, rs2066844, rs2066845, rs2076756 and rs2066847 in NOD2, rs2241880 in ATG16 L1, and rs13361189 in IRGM. Cox proportional-hazards models were used to assess the predictors of surgical recurrence.RESULTS Ninety six percent of patients underwent initial ileocecal resection(ICR) or ileal resection(IR) and subsequently 40% of patients required a second ICR/IR for CD. GMCSF Ab level was elevated at a median of 3.81 mcg/mL. Factors predicting faster time to a second surgery included elevated GM-CSF Ab [hazard ratio(HR) 3.52, 95%CI: 1.45-8.53, P = 0.005] and elevated GM-CSF cytokine(HR = 2.48, 95%CI: 1.31-4.70, P = 0.005). Factors predicting longer duration between first and second surgery included use of Immunomodulators(HR = 0.49, 95%CI: 0.31-0.77, P = 0.002), the interaction effect of low GM-CSF Ab levels and smoking(HR = 0.60, 95%CI: 0.45-0.81, P = 0.001) and the interaction effect of low GM-CSF cytokine levels and ATG16 L1(HR = 0.65, 95%CI: 0.49-0.88, P = 0.006).CONCLUSION GM-CSF bioavailability plays a critical role in maintaining intestinal homeostasis. Decreased bioavailability coupled with the genetic risk markers and/or smoking results in aggressive CD behavior. | Grace Gathungu Yuanhao Zhang Xinyu Tian Erin Bonkowski Leahana Rowehl Julia Krumsiek Billy Nix Claudia Chalk Bruce Trapnell Wei Zhu Rodney Newberry Lee Denson Ellen Li | 2018 | World Journal of Gastroenterology2018，24，5： | 5 |
| 3 | The importance of depression and alcohol use in coronary artery bypass graft surgery patients:risk factors for delirium and poorer quality of life显示文摘ObjectiveTo 调查消沉,焦虑和压力是否增加风险因为谵妄和在冠的动脉以后的生活(QOL ) 的差的质量绕过(CABG ) 180 个 CABG 病人的 surgery.MethodsA 总数(63.5 ± 的吝啬的年龄;10.1 年, 82.2% 男性) 完成了基线和手术后的自我报告问询表估计悲痛和 QOL。事件谵妄与结构化的临床的会见手术后地被诊断,病人们在在 63 个人(35% 样品) 开发的 consciousness.ResultsDelirium 为混乱和骚乱 post-operatively 每天被监视。在为 covariates 的调整以后,谵妄显著地与消沉被联系[机会比率(或) :1.08;95% 信心间隔(CI ) :1.03-1.13, P = 0.003 ] ,焦虑(或:1.07;95% CI:1.02-1.13, P = 0.01 ) 并且应力(或:1.05;95% CI:1.00-1.09, P = 0.03 ) 。外科手术前的消沉分数与更差的 QOL 包括被联系身体疼痛(β=− 0.39, P = 0.013 ) ,活力(β=− 0.32, P = 0.020 ) ,社会工作(β=− 0.51, P ≤0.001 ) ,感情的角色功能(β=− 0.44, P = 0.003 ) 并且一般健康(β=− 0.33, P = 0.038 ) 。在 covariates 之中,白酒使用的有害层次一致地与更差的 QOL.ConclusionsDepression 被联系,而消沉,焦虑和压力与谵妄风险被联系,白酒使用的有害层次一致地与更差的 QOL 被联系。这些调查结果点将推进在经历冠的 revascularization 的冠的心疾病人口检验消沉和白酒使用的有害层次的研究。 | Joanne M Humphreys Linley A Denson Robert A Baker Phillip J Tully | 2016 | Journal of Geriatric Cardiology2016，13，1： | 5 |
| 4 | The Treatment-Naive Microbiome in New-Onset Crohn’s Disease显示文摘 | Dirk Gevers Subra Kugathasan Lee A. Denson Yoshiki Vázquez-Baeza Will Van Treuren Boyu Ren Emma Schwager Dan Knights Se Jin Song Moran Yassour Xochitl C. Morgan Aleksandar D. Kostic Chengwei Luo Antonio González Daniel McDonald Yael Haberman Thomas Walter | 2014 | Cell Host & Microbe2014，，： | 3 |
| 5 | Delayed diagnosis of alpha-1-antitrypsin deficiency following post-hepatectomy liver failure: A case report显示文摘Post-hepatectomy liver failure(PHLF) is a leading cause of morbidity and mortality following major liver resection. The development of PHLF is dependent on the volume of the remaining liver tissue and hepatocyte function. Without effective pre-operative assessment, patients with undiagnosed liver disease could be at increased risk of PHLF. We report a case of a 60-year-old male patient with PHLF secondary to undiagnosed alpha-1-antitrypsin deficiency(AATD) following major liver resection. He initially presented with acute large bowel obstruction secondary to a colorectal adenocarcinoma, which had metastasized to the liver. There was no significant past medical history apart from mild chronic obstructive pulmonary disease. After colonic surgery and liver directed neo-adjuvant chemotherapy, he underwent a laparoscopic partially extended right hepatectomy and radio-frequency ablation. Post-operatively he developed PHLF. The cause of PHLF remained unknown, prompting reanalysis of the histology, which showed evidence of AATD. He subsequently developed progressive liver dysfunction, portal hypertension, and eventually an extensive parastomal bleed, which led to his death; this was ultimately due to a combination of AATD and chemotherapy. This case highlights that formal testing for AATD in all patients with a known history of chronic obstructive pulmonary disease, heavy smoking, or strong family history could help prevent the development of PHLF in patients undergoing major liver resection. | Benjamin Norton Jemimah Denson Christopher Briggs Matthew Bowles David Stell Somaiah Aroori | 2016 | World Journal of Gastroenterology2016，22，11： | 3 |
| 6 | Large-scale sequence analysis of avian influenza isolates显示文摘 | Obenauer J C Denson J Mehta P K | 2006 | Science2006，311，5767： | 1 |
| 7 | TNF-alpha downregulatesmurine hepatic growth hormone receptor expression by inhibitingSpl and Sp3 binding显示文摘 | Denson LA Menon RK Shaufl Ay | 2001 | J Clin Invest2001，107，11： | 1 |
| 8 | Diet and light intensity effects on survival,growth and pigmentation of southern flounder Paralich- thys lethostigma 显示文摘 | DENSON M R SM1TH T 1 J | 1997 | J World Aquacult Soc1997，28，4： | 1 |
| 9 | Organ-specificalterations in RAR alpha: RXR alpha abundance regulaterat Mrp2 (Abcc2) expression in obstructive cholestasis 显示文摘 | Denson LA Bohan A Held MA | 2002 | Gastroenterology2002，123，2： | 1 |
| 10 | Large-scale sequence analysis of avian influenza isolates 显示文摘 | Obenauer JC Denson J Mehta PK | 2006 | Sicence2006，311，5767： | 1 |
| 11 | A comparison of the Ranson,Glasgow, and APACHE Ⅱ scoring systems to a multiple organ system score in predicting patient outcome in pancreatitis 显示文摘 | Taylor SL Morgan DL Denson KD | 2005 | Am J Surg2005，189，2： | 1 |
| 12 | A randomized controlled trial of growth hormone in active pediatric Crohn disease 显示文摘 | Denson LA Kim MO Bezold R | 2010 | J Pediatr Gastroenterol Nutr2010，51，2： | 1 |
| 13 | Characterization of the explosive triacetone triperoxide and detection by ion mobility spectrometry显示文摘 | BUTTIGIEG G A KNIGHT A K DENSON S | 2003 | Forensic Science International2003，135，1： | 1 |
| 14 | Comparison of Cystoscopic and histological findings in patients with Suspected interstial Cystitis显示文摘 | Denson Tomas L Griebling | 2000 | J Urol2000，164，： | 1 |
| 15 | Large-Scale Sequence Analysis of Avian Influenza Isolates显示文摘 | Obenauer J C Denson J Mehta P K | 2006 | Science2006，311，： | 1 |
| 16 | Adjunctive quetiapine in bipolar patientspartially responsive to lithium or valproate显示文摘 | SOKOLSKI KN DENSON TF | 2003 | ProgNeuro Psychopharma-col Biol psychiatry2003，27，5： | 1 |
| 17 | Study of the dynamics foam growth: Analysis of the growth of closely spaced spherical bubbles显示文摘 | Amon M Denson C A | 1984 | Polymer Engineering and Science1984，24，13： | 1 |
| 18 | A randomized controlled trial of growth hormone in active pediatric Crohn disease显示文摘 | Denson LA Kim MO Bezold R | | 0，，02： | 1 |
| 19 | Organ-specific alterations in RARα:RXRα ahundance regulate rat Mrp2 (Abet2) expression in ob- structive cholestasis 显示文摘 | Denson LA Bohan A Held MA | 2002 | Gastroemerology2002，123，2： | 1 |
| 20 | Large-scale sequence analysis of avian influenza isolates显示文摘 | Obenauer J C Denson J Mehta P K | 2006 | Science2006，311，5767： | 1 |
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