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| 1 | Accuracy of magnetic resonance cholangiography compared to operative endoscopy in detecting biliary stones, a single center experience and review of literature显示文摘AIM: To compare diagnostic sensitivity, specificity and accuracy of magnetic resonance cholangiopancreatography(MRCP) without contrast medium and endoscopic ultrasound(EUS)/endoscopic retrograde cholangiopancreatography(ERCP) for biliary calculi. METHODS: From January 2012 to December 2013, two-hundred-sixty-three patients underwent MRCP at our institution, all MRCP procedure were performed with the same machinery. In two-hundred MRCP was done for pure hepatobiliary symptoms and these patients are the subjects of this study. Among these two-hundred patients, one-hundred-eleven(55.5%) underwent ERCP after MRCP. The retrospective study design consisted in the systematic revision of all images from MRCP and EUS/ERCP performed by two radiologist with a long experience in biliary imaging, an experienced endoscopist and a senior consultant in Hepatobiliopancreatic surgery. A false positive was defined an MRCP showing calculi with no findings at EUS/ERCP; a true positive was defined as a concordance between MRCP and EUS/ERCP findings; a false negative was defined as the absence of images suggesting calculi at MRCP with calculi localization/extraction at EUS/ERCP and a true negative was defined as a patient with nocalculi at MRCP ad at least 6 mo of asymptomatic followup. Biliary tree dilatation was defined as a common bile duct diameter larger than 6 mm in a patient who had an in situ gallbladder. A third blinded radiologist who examined the MRCP and ERCP data reviewed misdiagnosed cases. Once obtained overall data on sensitivity, specificity, accuracy, positive predictive value(PPV) and negative predictive value(NPV) we divided patients in two groups composed of those having concordant MRCP and EUS/ERCP(Group A, 72 patients) and those having discordant MRCP and EUS/ERCP(Group B, 20 patients). Dataset comparisons had been made by the Student's t-test and χ2 when appropriate.RESULTS: Two-hundred patients(91 men, 109 women, mean age 67.6 years, and range 25-98 years) underwent MRCP. All patients attended regular follow-up for at least 6 mo. Morbidity and mortality related to MRCP were null. MRCP was the only exam performed in 89 patients because it did show only calculi into the gallbladder with no signs of the presence of calculi into the bile duct and symptoms resolved within a few days or after colecistectomy. The patients remained asymptomatic for at least 6 mo, and we assumed they were true negatives. One hundred eleven(53 men, 58 women, mean age 69 years, range 25-98 years) underwent ERCP following MRCP. We did not find any difference between the two groups in terms of race, age, and sex. The overall median interval between MRCP and ERCP was 9 d. In detecting biliary stones MRCP Sensitivity was 77.4%, Specificity 100% and Accuracy 80.5% with a PPV of 100% and NPV of 85%; EUS showed 95% sensitivity, 100% specificity, 95.5% accuracy with 100% PPV and 57.1% NPV. The association of EUS with ERCP performed at 100% in all the evaluated parameters. When comparing the two groups, we did not find any statistically significant difference regarding age, sex, and race. Similarly, we did not find any differences regarding the number of extracted stones: 116 stones in Group A(median 2, range 1 to 9) and 27 in Group B(median 2, range 1 to 4). When we compared the size of the extracted stones we found that the patients in Group B had significantly smaller stones: 14.16 ± 8.11 mm in Group A and 5.15 ± 2.09 mm in Group B; 95% confidence interval = 5.89-12.13, standard error = 1.577; P < 0.05. We also found that in Group B there was a significantly higher incidence of stones smaller than 5 mm: 36 in Group A and 18 in Group B, P < 0.05.CONCLUSION: Major finding of the present study is that choledocholithiasis is still under-diagnosed in MRCP. Smaller stones(< 5 mm diameter) are hardly visualized on MRCP. | Francesco A Polistina Mauro Frego Marco Bisello Emy Manzi Antonella Vardanega Bortolo Perin | 2015 | World Journal of Radiology2015，7，4： | 14 |
| 2 | Hierarchical and selective roles of galectins in hepatocarcinogenesis, liver fibrosis and inflammation of hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)represents a global health problem.Infections with hepatitis B or C virus,non-alcoholic steatohepatitis disease,alcohol abuse,or dietary exposure to aflatoxin are the major risk factors to the development of this tumor.Regardless of the carcinogenic insult,HCC usually develops in a context of cirrhosis due to chronic inflammation and advanced fibrosis.Galectins are a family of evolutionarily-conserved proteins defined by at least one carbohydrate recognition domain with affinity forβ-galactosides and conserved sequence motifs.Here,we summarize the current literature implicating galectins in the pathogenesis of HCC.Expression of'proto-type'galectin-1,'chimera-type'galectin-3 and'tandem repeat-type'galectin-4 is up-regulated in HCC cells compared to their normal counterparts.On the other hand,the'tandemrepeat-type'lectins galectin-8 and galectin-9 are downregulated in tumor hepatocytes.The abnormal expression of these galectins correlates with tumor growth,HCC cell migration and invasion,tumor aggressiveness,metastasis,postoperative recurrence and poor prognosis.Moreover,these galectins have important roles in other pathological conditions of the liver,where chronic inflammation and/or fibrosis take place.Galectin-based therapies have been proposed to attenuate liver pathologies.Further functional studies are required to delineate the precise molecular mechanisms through which galectins contribute to HCC. | María L Bacigalupo Malena Manzi Gabriel A Rabinovich María F Troncoso | 2013 | World Journal of Gastroenterology2013，19，47： | 2 |
| 3 | Prolonged high-pressure balloon angioplasty of femoropopliteal lesions:Impact on stent implantation rate and mid-term outcome显示文摘ObjectivesTo 在 stent 培植率和回顾地注册的 femoropopliteal lesions.MethodsWe 的延长高压力 angioplasty 的中间的结果上估计影响从 2011 年 1 月的 620 个连续病人到 2011 年 12 月(75.6 ±12.3 年, 355 男性, 76.5% 在卢班 5-6 ) ,为批评手足局部缺血参考了并且提交了到 femoropopliteal 损害的延长高压的 angioplasty。延长高压的 angioplasty 的定义为至少 120 s 包括膨胀到至少 18 atm。程序的数据,和临床、仪器的后续被分析估计比较喜欢的培植率和中间的 outcomes.ResultsThe 接近的 stent 是 ipsilateral 在 433/620 病人(69.7%) 和在 164/620 (26.4%) 的 contralateral 转线路的大腿骨的 antegrade 并且腿弯部后退 +在 23/620 (3.7%)的大腿骨的 antegrade 。技术在 193/620 病人(31.2%) 在 427/620 病人(68.8%) 和 endoluminal angioplasty 包括了 subintimal angioplasty。延长高压力汽球 angioplasty 过程在 86.2% 是成功的(次要的 intra 程序的复杂并发症率 15.7 %) , stent 培植在 74 个病人(11.9%) 被执行,与脚关节臂的索引的重要改进(0.29 ±0.6 对 0.88 ±0.3, P <00.1 ) 并且卢班(5.3 ±0.8 对 0.7 ±1.9, P <0.01 ) , 86.7% 的主要明显率, Doppler 超声和在 18.1 ± 的吝啬的后续的 14.8% 的目标损害 revascularization 上的 18.6 % 的狭窄;6.4 个月(范围 1-24 月) 。第二等的明显率高是 87.7%.ConclusionsProlonged femoropopliteal 损害的压力 angioplasty 看起来安全、有效允许可接受的明显和狭窄在期中考试上评价。 | Gianluca Rigatelli Mariano Palena Paolo Cardaioli Fabio dell'Avvocata Massimo Giordan Dobrin Vassilev Marco Manzi | 2014 | Journal of Geriatric Cardiology2014，11，2： | 2 |
| 4 | Differences in subclinical cardiovascular disease between African American and Caucasian women in systemic lupus erythematosus显示文摘 | Rhew EY Manzi SM Dyer AR | 2009 | Transl Res2009，153，2： | 1 |
| 5 | Clinical results of below-the knee intervention using pedal-plantar loop technique for the revascu- larization of foot arteries显示文摘 | Manzi M Fusaro M Ceecacei T | 2009 | J Cardiovasc Surg (Torine)2009，50，3： | 1 |
| 6 | Clinical results of below the knee intervention using pedal-plantar loop tech- nique for tie revascularization of foot arteries 显示文摘 | Manzi M Fusaro M Ceccacci T | 2009 | J Cardiovasc Surg2009，50，3： | 1 |
| 7 | Effects of belimumab, a B lymphocyte stimulator-specific inhibitor, on disease activity across muhiple organ domains in patients with systemic lupus erythematosus: combined results from two phase HI triMs显示文摘 | Manzi S S6nchez-Guerrem J Merrill Jq' | 2012 | Ann Rheum Dis2012，71，11： | 1 |
| 8 | Effect of algal ration and substitution of algae by manipulated yeast on the growth of juvenile Mercenaria 显示文摘 | Coutteau P Hadley N H Manzi J J | 1994 | Aquaculture1994，120，： | 1 |
| 9 | Realized heritability of growth rate in the hard clam Mercenaria mercenaria 显示文摘 | Hadley N H Dillon Jr R T Manzi J J | 1991 | Aquacul ture1991，93，： | 1 |
| 10 | Hard clam,Mercenaria mercenaria,broodstocks:growth of selected hatchery stocks and their reciprocal crosses显示文摘 | Manzi J J Hadley N H Dillon R T | 1991 | Aquaculture1991，94，1： | 1 |
| 11 | Effects of a stress-reduction program on psy- chological {unction, pain, and physical function of systemic lupus erythemato- sus patients: A randomized controlled trial显示文摘 | Greco CM Rudy TE Manzi S | 2004 | Arthritis Rheum2004，51，4： | 1 |
| 12 | Growth of seed clams Mercenaria mercenaria, at various densities in a commercial scale nursery system 显示文摘 | Hadley N H Manzi J J | 1984 | Aquaculture1984，36，： | 1 |
| 13 | Implentation of the ISBA parametrization scheme for land surface processes in a GCM - an annual cycle experriment显示文摘 | Manzi A O Planto S | 1994 | Journal of Hydrology1994，155，34： | 1 |
| 14 | Model Predictive Control of a Fuel Injection System with a Radial Basis Fucntion Network Observer显示文摘 | Manzie C Palaniswami M Watson H | 2002 | ASME Journal of Dynamic Systems Measurement and Control2002，124，4： | 1 |
| 15 | Clinical results of below - the knee intervention using pedal - plantar loop technique for the revascu- larization of foot arteries 显示文摘 | Manzi M Fusaro M Ceccacci T | 2009 | J Cardiovasc Surg ( ( Torino )2009，50，3： | 1 |
| 16 | Culture of the northern hard clam Mercenaria in a commercial-scale,upflow, nursery system显示文摘 | John J Manzi Hadley N H Battey C | 1984 | Journal of shellfish research1984，4，2： | 1 |
| 17 | Seed clam, Mercenaria mercenaria , culture in an experimental-scale upflow nursery system 显示文摘 | Manzi J J Hardley N H Maddox M B | 1986 | Aquaculture1986，54，： | 1 |
| 18 | Adsorption of a multicomponent mixture of gases with multisite occupancy 显示文摘 | Manzi S Mas W Belardinelli R | 2004 | Langmuir2004，20，2： | 1 |
| 19 | Model predictive con- touting control for biaxial systems 显示文摘 | Lam D Manzie C Malcolm G | 2013 | IEEE Transac-tions on Control Systems Technology2013，21，2： | 1 |
| 20 | Channel access and traffic control for dynamic-spectrum networks with single-transmit, dual-receive radios显示文摘 | Marwan Krunz David Manzi | 2011 | Computer Communications2011，，8： | 1 |
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