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| 1 | Efficacy of a therapeutic strategy for eradication of Helicobacter pylori infection显示文摘AIM: To determine the efficacy of our therapeutic strategy for Helicobacter pylori (H. pylori) eradication and to identify predictive factors for successful eradication. METHODS: From April 2006 to June 2010, we retrospectively assessed 2428 consecutive patients (1025 men, 1403 women; mean age 55 years, age range 18-92 years) with gastric histology positive for H. pylori infection referred to our unit for 13-C urea breath test(UBT), after first-line therapy with proton pump inhibitor (PPI) b.i.d. + amoxicillin 1 g b.i.d. + clarithromycin 500 mg b.i.d. for 7 d. Patients who were still positive to UBT were recommended a second-line therapy (PPI b.i.d. + amoxicillin 1 g b.i.d. + tinidazole 500 mg b.i.d. for 14 d). Third choice treatment was empirical with PPI b.i.d. + amoxicillin 1 g b.i.d. + levofloxacin 250 mg b.i.d. for 14 d. RESULTS: Out of 614 patients, still H. pylori-positive after first-line therapy, only 326 and 19 patients respectively rechecked their H. pylori status by UBT after the suggested second and third-line regimens. 'Per protocol' eradication rates for first, second and thirdline therapy were 74.7% (95% CI: 72.7%-76.4%), 85.3% (95% CI: 81.1%-89.1%) and 89.5% (95% CI: 74.9%-103%) respectively. The overall percentage of patients with H. pylori eradicated after two treatments was 97.8% (95% CI: 97.1%-98.4%), vs 99.9% (95% CI: 99.8%-100%) after three treatments. The study found that eradication therapy was most effective in patients with ulcer disease (P < 0.05, P = 0.028), especially in those with duodenal ulcer. Smoking habits did not significantly affect the eradication rate. CONCLUSION: First-line therapy with amoxicillin and clarithromycin produces an H. pylori eradication rate comparable or superior to other studies and secondline treatment can still be triple therapy with amoxicillin and tinidazole. | Giuliana Sereni Francesco Azzolini Lorenzo Camellini Debora Formisano Francesco Decembrino Veronica Iori Cristiana Tioli Maurizio Cavina Francesco Di Mario Giuliano Bedogni Romano Sassatelli | 2012 | World Journal of Gastroenterology2012，18，33： | 4 |
| 2 | Randomized-comparison of loops for transurethral resection of the prostate:preliminary result显示文摘 | FERRETTI S AZZOLINI N BARBIERI A | 2004 | J Endourol2004，18，9： | 1 |
| 3 | A systematic review on levosimendan in paediatric patients显示文摘 | Silvetti S Silvani P Azzolini ML | 2015 | Curr Vasc Pharmacol2015，13，1： | 1 |
| 4 | Long-term histopathologic evaluation of human expanded skin显示文摘 | Matturri L Azzolini A Riberti C | 1992 | Plast Reconstr Surg1992，90，： | 1 |
| 5 | CRI on erythrocytes of Brazilian systemic lupus erythematosus patients: The influence of disease activity on expression and ability of this receptor to bind immune complexes opsonized with complement from normal human serum 显示文摘 | MARZOCCHI-MACHADO C M ALVES C M AZZOLINI A E | 2005 | J Autoimmun2005，25，4： | 1 |
| 6 | Optical coherence tomography in idiopathic epiretinal macular membrane surgery显示文摘 | Azzolini C Patelli F Codenotti M | 1999 | Eur J Ophthalmology1999，9，3： | 1 |
| 7 | Proposal of a new clinical index predictive of endoscopic severity in ulcerative colitis显示文摘 | Azzolini F Pagnini C Camellini L | 2005 | Dig Dis Sci2005，50，2： | 1 |
| 8 | Environmental Contaminants in Hospital Settings and Progress in Disinfecting Techniques显示文摘 | Gabriele Messina Emma Ceriale Daniele Lenzi Sandra Burgassi Elena Azzolini Pietro Manzi Marc Léone | 2013 | BioMed Research International2013，，： | 1 |
| 9 | Effect of the period of treatment with a single dose of propyhhiouracil on the antibody response in rats 显示文摘 | Duarte CG Azzolini AECS Assis-Pandochi A1 | 2003 | International lmmunopharmacology2003，3，： | 1 |
| 10 | Modulation of human neutrophil oxidative metabolism and degranulation by extract of Tamarindus indica L. fruit pulp显示文摘 | Fabiana S. Paula Luciana M. Kabeya Alexandre Kanashiro Andréa S.G. de Figueiredo Ana Elisa C.S. Azzolini Sérgio A. Uyemura Yara Maria Lucisano-Valim | 2008 | Food and Chemical Toxicology2008，，1： | 1 |
| 11 | Randomized comparison of loops for transurethral resection of the prostate:preliminary results显示文摘 | Ferretti S Azzolini N Barbieri A | 2004 | J Endourol2004，18，9： | 1 |
| 12 | Effect of the extract of the tamarind ( Tamarindus indica ) fruit on the complement system: Studies in vitro and in hamsters submitted to a cholesterol-enriched diet显示文摘 | Ana Paula Landi Librandi Taís Nader Chrysóstomo Ana Elisa C.S. Azzolini Carem Gledes Vargas Recchia Sérgio Akira Uyemura Ana Isabel de Assis-Pandochi | 2007 | Food and Chemical Toxicology2007，，8： | 1 |
| 13 | Gastric per-oral endoscopic myotomy:Indications,technique,results and comparison with surgical approach显示文摘Gastroparesis is a chronic disease of the stomach that causes a delayed gastric emptying,without the presence of a stenosis.For 30 years the authors identified pylorospasm as one of the most important pathophysiological mechanisms determining gastroparesis.Studies with EndoFLIP,a device that assesses pyloric distensibility,increased the knowledge about pylorospasm.Based on this data,several pyloric-targeted therapies were developed to treat refractory gastroparesis:Surgical pyloroplasty and endoscopic approach,such as pyloric injection of botulinum and pyloric stenting.Notwithstanding,the success of most of these techniques is still not complete.In 2013,the first human gastric per-oral endoscopic myotomy(GPOEM)was performed.It was inspired by the POEM technique,with a similar dissection method,that allows pyloromyotomy.Therapeutical results of GPOEM are similar to surgical approach in term of clinical success,adverse events and post-surgical pain.In the last 8 years GPOEM has gained the attention of the scientific community,as a minimally invasive technique with high rate of clinical success,quickly prevailing as a promising therapy for gastroparesis.Not surprisingly,in referral centers,its technical success rate is 100%.One of the main goals of recent studies is to identify those patients that will respond better to the therapies targeted on pylorus and to choose the better approach for each patient. | Maria Chiara Verga Stefano Mazza Francesco Azzolini Fabrizio Cereatti Clara Benedetta Conti Andrea Drago Sara Soro Biagio Elvo Roberto Grassia | 2022 | World Journal of Gastrointestinal Surgery2022，14，1： | 1 |
| 14 | CR1 on erythrocytes of Brazilian systemic lupus erythematosus patients:The influence of disease activity on expression and ability of this receptor to bind immune complexes opsonized with complement from normal human serum显示文摘 | C M Marzocchi-Machado CMOS Alves AECS Azzolini | 2005 | Journal of Autoimmunity2005，25，： | 1 |
| 15 | Evaluating the efficacy of lysozyme against lactic acid bacteria under different winemaking scenarios显示文摘 | Azzolini M Tosi E Veneri G | 2010 | Efficacy of Lysosyme in Winemaking2010，31，2： | 1 |
| 16 | Randomized comparison of loops for transurethral resection of the prostate: preliminary results 显示文摘 | Ferretti S Azzolini N Barbieri A | 2004 | J Endouml2004，18，9： | 1 |
| 17 | The use of migrating corrosion inhibitors to repair motorways' concrete structures contaminated by chlorides 显示文摘 | Fedrizzi L Azzolini F Bonora P L | 2005 | Cement Concrete Res2005，35，3： | 1 |
| 18 | Role of thymic-andgraft-dependent mechanisms in tolerance induction to rat kidneytransplant by donor PRMC infusion显示文摘 | Cavinato RA Casiraghi F Azzolini N | 2007 | Kidney Int2007，71，11： | 1 |
| 19 | Optical coherencetomography in idiopathic epiretinal macular membrane surgery显示文摘 | Azzolini C Patelli F Codenotti M | 1999 | Eur J ophthalmol1999，9，3： | 1 |
| 20 | Rhipicephalus sanguineus trypsin inhibitors present in the tick larvae: isolation, characterization, and partial primary structure deternminaton 显示文摘 | Sant' Anna Azzolini S Sasaki SD Torquato R J | 2003 | Arch Biochem Biophys2003，417，2： | 1 |
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