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| 1 | Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer显示文摘Gastric cancer remains one of the leading causes of cancer-related death worldwide,and most of the cases are associated with Helicobacter pylori infection.This bacterium promotes the production of reactive oxygen species(ROS),which cause DNA damage in gastric epithelial cells.In this study,we evaluated the expression of important genes involved in the recognition of DNA damage(ATM,ATR,and H2AX)and ROS-induced damage repair(APE1)and the expression of some miRNAs(miR-15a,miR-21,miR-24,miR-421 and miR-605)that target genes involved in the DNA damage response(DDR)in 31 fresh tissues of gastric cancer.Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.Analysis performed by real-time quantitative PCR exhibited significantly increased levels of the APE1(RQ=2.55,p<0.0001)and H2AX(RQ=2.88,p=0.0002)genes beyond the miR-421 and miR-605 in the gastric cancer samples.In addition,significantly elevated levels of miR-21,miR-24 and miR-421 were observed in diffuse-type gastric cancer.Correlation analysis reinforced some of the gene:gene(ATM/ATR/H2AX)and miRNA:mRNA relationships obtained also with the interaction network.Thus,our findings show that tumor cells from gastric cancer presents deregulation of genes and miRNAs that participate in the recognition and repair of DNA damage,which could confer an advantage to cell survival and proliferation in the tumor microenvironment. | Fernanda S.Manoel-Caetano Ana Flávia T.Rossi Gabriela Calvet de Morais Fábio Eduardo Severino Ana Elizabete Silva | 2019 | Genes & Diseases2019，6，2： | 5 |
| 2 | Diagnosis and Epidemiology of H elicobacter pylori Infection显示文摘 | Xavier Calvet María‐José Ramírez Lázaro Philippe Lehours Francis Mégraud | 2013 | Helicobacter2013，，： | 5 |
| 3 | Bile duct injury during laparoscopic cholecystectomyrid=''显示文摘 | J. Calvete L. Sabater B. Camps A. Verdú A. Gomez-Portilla J. Martín M. A. Torrico B. Flor N. Cassinello S. Lledó | 2000 | Surgical Endoscopy2000，，7： | 2 |
| 4 | Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori显示文摘 | Javier Gisbert Calvet | 2012 | Clinical and Experimental Gastroenterology (default)2012，，： | 2 |
| 5 | Panda X-III: Searching for neutrinoless double beta decay with high pressure ^(136)Xe gas time projection chambers显示文摘Searching for the neutrinoless double beta decay(NLDBD)is now regarded as the topmost promising technique to explore the nature of neutrinos after the discovery of neutrino masses in oscillation experiments.Panda X-III(particle and astrophysical xenon experiment III)will search for the NLDBD of136Xe at the China Jin Ping Underground Laboratory(CJPL).In the first phase of the experiment,a high pressure gas Time Projection Chamber(TPC)will contain 200 kg,90%136Xe enriched gas operated at10 bar.Fine pitch micro-pattern gas detector(Microbulk Micromegas)will be used at both ends of the TPC for the charge readout with a cathode in the middle.Charge signals can be used to reconstruct the electron tracks of the NLDBD events and provide good energy and spatial resolution.The detector will be immersed in a large water tank to ensure~5 m of water shielding in all directions.The second phase,a ton-scale experiment,will consist of five TPCs in the same water tank,with improved energy resolution and better control over backgrounds. | Xun Chen Chang Bo Fu Javier Galan Karl Giboni Franco Giuliani Ling Hui Gu Ke Han Xiang Dong Ji Heng Lin Jiang Lai Liu Kai Xiang Ni Hiroki Kusano Xiang Xiang Ren Shao Bo Wang Yong Yang Dan Zhang Tao Zhang Li Zhao Xiang Ming Sun Shou Yang Hu Si Yu Jian Xing Long Li Xiao Mei Li Hao Liang Huan Qiao Zhang Ming Rui Zhao Jing Zhou Ya Jun Mao Hao Qiao Si Guang Wang Ying Yuan Meng Wang Amir N.Khan Neill Raper Jian Tang Wei Wang Jia Ning Dong Chang Qing Feng Cheng Li Jian Bei Liu Shu Bin Liu Xiao Lian Wang Dan Yang Zhu Juan F.Castel Susana Cebri'an Theopisti Dafni Javier G.Garza Igor G.Irastorza Francisco J.Iguaz Gloria Luz ′on Hector Mirallas Stephan Aune Eric Berthoumieux Yann Bedfer Denis Calvet Nicole d'Hose Alain Delbart Maria Diakaki Esther Ferrer-Ribas Andrea Ferrero Fabienne Kunne Damien Neyret Thomas Papaevangelou Franck Sabatie Maxence Vanderbroucke AnDi Tan Wick Haxton Yuan Mei Chinorat Kobdaj Yu-Peng Yan | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，6： | 2 |
| 6 | Update on non-bismuth quadruple (concomitant) therapy for eradication of Helicobacter pylori显示文摘 | Javier Gisbert Calvet | 2012 | Clinical and Experimental Gastroenterology (default)2012，，： | 2 |
| 7 | Some Experiments on Extraction of Heavy Metals Present in Soil显示文摘 | R. Calvet S. Bourgeois J. J. Msaky | 1990 | International Journal of Environmental Analytical Chemistry1990，，1： | 2 |
| 8 | Bile duct injury during laparoscopic cholecystectomy Myth or reality of the learning curve显示文摘 | Calvete J Sabater L Camps B | 2000 | Surg Endosc2000，14，： | 1 |
| 9 | The genetics and physiology of polycystic kidney disease显示文摘 | Calvet CP Grantharn JJ | 2001 | Semin Nephrol2001，21，： | 1 |
| 10 | A note onbilevel linear fraction programming problem 显示文摘 | Calvete H I Gale C | 2004 | European Journal of Operational Research2004，1，152： | 1 |
| 11 | Some experiments on extraction of heavy metals present in soil 显示文摘 | CALVET R | 1990 | Intern J Environ Anal Chem1990，39，： | 1 |
| 12 | Effect of acid treatment on surface properties evolution of attapulgite clay:Anapplication of inverse gas chromatography显示文摘 | BOUDRICHEA L CALVET R HAMDI B | 2011 | Colloids and Surfaces A:Physicochemical and Engineering Aspects2011，392，： | 1 |
| 13 | On the quasiconcave bilevel programming problem显示文摘 | Calvete H I Gale C | 1998 | Journal of Optimization Theroy and Applications1998，98，3： | 1 |
| 14 | A meta-analysis of short versus long therapy with a proton pump inhibitor,clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection显示文摘 | Calvet X Garcia N Lopez T | 2000 | Aliment Pharmacol Ther2000，14，： | 1 |
| 15 | Helicobacter pylori is a risk factor for peptic ulcer disease in cirrhotic patients. A meta-analysis显示文摘 | Mercedes Vergara Xavier Calvet Marta Roqué | 2002 | European Journal of Gastroenterology & Hepatology2002，，： | 1 |
| 16 | Development of the Teacher Self-concept Evaluation Scale and its Relation to Burnout 显示文摘 | VILLA A CALVETE E | 2001 | Studies in Educational Evaluation2001，27，： | 1 |
| 17 | Bile duct injury during laparoscopic cholecystectomy: myth or reality of the learning curve 显示文摘 | Calvete J Sabater L Camps B | 2000 | ? Surg Endosc2000，14，7： | 1 |
| 18 | Effect of sucralfate on gastric intramucosal pH in critically ill patients显示文摘 | Calvet X Baigorri F Duarte M | 1997 | Intensive Care Med1997，23，7： | 1 |
| 19 | Feedforward and feedback linearization of nonlinear systems and its implementation using internal model control (IMC) 显示文摘 | CALVET J ARKUN Y | 1988 | Industrial Engineering Chemistry Research1988，27，10： | 1 |
| 20 | A meta‐analysis of short versus long therapy with a proton pump inhibitor, clarithromycin and either metronidazole or amoxycillin for treating Helicobacter pylori infection显示文摘 | Calvet García López Gisbert Gené Roque | 2001 | Alimentary Pharmacology & Therapeutics2001，，5： | 1 |
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