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| 1 | Central hepatectomy for centrally located malignant liver tumors: A systematic review显示文摘AIM: To study whether central hepatectomy(CH) canachieve similar overall patient survival and disease-freesurvival rates as conventional major hepatectomies ornot.METHODS: A systematic literature search was per-formed in MEDLINE for articles published from January1983 to June 2013 to evaluate the evidence for andagainst CH in the management of central hepatic malig-nancies and to compare the perioperative variables andoutcomes of CH to lobar/extended hemihepatectomy. RESULTS: A total of 895 patients were included from21 relevant studies. Most of these patients who un-derwent CH were a sub-cohort of larger liver resectionstudies. Only 4 studies directly compared Central vshemi-/extended hepatectomies. The range of opera-tive time for CH was reported to be 115 to 627 min andPringle's maneuver was used for vascular control in themajority of studies. The mean intraoperative blood lossduring CH ranged from 380 to 2450 mL. The reportedmorbidity rates ranged from 5.1% to 61.1%, the most common surgical complication was bile leakage and the most common cause of mortality was liver failure. Mor-tality ranged from 0.0% to 7.1% with an overall mor-tality of 2.3% following CH. The 1-year overall survival(OS) for patients underwent CH for hepatocellular car-cinoma ranged from 67% to 94%; with the 3-year and 5-year OS having a reported range of 44% to 66.8%, and 31.7% to 66.8% respectively. CONCLUSION: Based on current literature, CH is a promising option for anatomical parenchymal-preserv-ing procedure in patients with centrally located liver malignancies; it appears to be safe and comparable in both perioperative, early and long term outcomes when compared to patients undergoing hemi-/extended hepatectomy. More prospective studies are awaited to further define its role. | Ser Yee Lee | 2014 | World Journal of Hepatology2014，6，5： | 15 |
| 2 | Recurrent giant fibrovascular polyp of the esophagus显示文摘Giant fibrovascular polyps of the esophagus and hypopharynx are rare benign esophageal tumors. They arise most commonly in the upper esophagus and may, rarely, originate in the hypopharynx. They can vary significantly in size. Even though they are benign, they may be lethal due to either bleeding or, rarely, asphyxiation if a large polyp is regurgitated. Patients commonly present with dysphagia or hematemesis. The polyps may not be well visualized on endoscopy and imaging plays a vital role in aiding diagnosis as well as providing important information for preoperative planning, such as the location of the pedicle, the vascularity of the polyp and the tissue elements of the mass. They can also be recurrent in rare cases, especially if the resection margins of the base are involved. We review the recent literature and report a case of a 61-year-old man with a recurrent giant esophageal fibrovascular polyp with illustrative contrast barium swallow, CT and intra-operative images, who required several surgeries via a combination of endoscopic, trans-oral, trans-cervical, trans-thoracic and trans-abdominal approaches. | Ser Yee Lee Weng Hoong Chan Ranjiv Sivanandan Dennis Teck Hock Lim Wai Keong Wong | 2009 | World Journal of Gastroenterology2009，15，29： | 7 |
| 3 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 4 | A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform显示文摘 | Bence Sipos Simone M?ser Holger Kalthoff Virag T?r?k Matthias L?hr Günter Kl?ppel | 2003 | Virchows Archiv2003，，5： | 4 |
| 5 | ESPEN Guidelines on Enteral Nutrition: Pancreas显示文摘 | R. Meier J. Ockenga M. Pertkiewicz A. Pap N. Milinic J. MacFie C. L?ser V. Keim | 2006 | Clinical Nutrition2006，，2： | 3 |
| 6 | MULTIGRID METHODS FOR OBSTACLE PROBLEMS显示文摘In this review,we intend to clarify the underlying ideas and the relations betweenvarious multigrid methods ranging from subset decomposition,to projected subspace decompositionand truncated multigrid.In addition,we present a novel globally convergentinexact active set method which is closely related to truncated multigrid.The numericalproperties of algorithms are carefully assessed by means of a degenerate problem and aproblem with a complicated coincidence set. | Carsten Grser Ralf Kornhuber | 2009 | Journal of Computational Mathematics2009，27，1： | 3 |
| 7 | Dense Trajectories and Motion Boundary Descriptors for Action Recognition显示文摘 | Heng Wang Alexander Kl?ser Cordelia Schmid Cheng-Lin Liu | 2013 | International Journal of Computer Vision2013，，： | 2 |
| 8 | R_2PdSi_3(R=Pr,Tb和Gd)单晶生长沉淀(英文)显示文摘利用具有无坩埚、高稳定性等特性的光辐射悬浮区熔法,制备R2PdSi3(R=Pr,Tb和Gd)单晶。从原材料和试样制备过程、单晶生长过程、熔体内部以及单晶基体4个方面研究单晶制备过程中一个很重要的现象,第二相沉淀。采用退火热处理方法以及给料棒成分微调法可以有效减少凝固后期冷却过程中由于Si溶解度降低析出的条纹状RSi(R=Pr,Tb和Gd)沉淀。 | 徐义库 刘林 Wolfgang LSER 葛丙明 | 2011 | Transactions of Nonferrous Metals Society of China2011，21，11： | 2 |
| 9 | Improvement of Insulin Resistance After Obesity Surgery: A Comparison of Gastric Banding and Bypass Procedures显示文摘 | Wei-Jei Lee Yi-Chih Lee Kong-Han Ser Jung-Chien Chen Shu Chung Chen | 2008 | Obesity Surgery2008，，9： | 2 |
| 10 | Heparin-induced thrombocytopenia in solid organ transplant recipients: The current scientific knowledge显示文摘Exposure to heparin is associated with a high incidence of immunization against platelet factor 4(PF4)/heparin complexes. A subgroup of immunized patients is at risk of developing heparin-induced thrombocytopenia(HIT), an immune mediated prothrombotic adverse drug effect. Transplant recipients are frequently exposed to heparin either due to the underlying end-stage disease, which leads to listing and transplantation or during the transplant procedure and the perioperative period. To review the current scientific knowledge on antiheparin/PF4 antibodies and HIT in transplant recipients a systematic Pub Med literature search on articles in English language was performed. The definition of HIT is inconsistent amongst the publications. Overall, six studies and 15 case reports have been published on HIT before or after heart, liver, kidney, and lung transplantation, respectively. The frequency of seroconversion for anti-PF4/heparin antibodies ranged between 1.9% and 57.9%. However, different methods to detect anti-PF4/heparin antibodies were applied. In none of the studies HIT-associated thromboembolic events or fatalities were observed. More importantly, in patients with a history of HIT, reexposure to heparin during transplantation was not associated with thrombotic complications. Taken together, the overall incidence of HIT after solid organ transplantation seems to be very low. However, according to the current knowledge, cardiac transplant recipients may have the highest risk to develop HIT. Different alternative suggestions for heparin-free anticoagulation have been reported for recipients with suspected HIT albeit no official recommendations on management have been published for this special collective so far. | Volker Assfalg Norbert Hüser | 2016 | World Journal of Transplantation2016，6，1： | 2 |
| 11 | On the friction and adhesion hysteresis between polymer brushes attached to curved surfaces: Rate and solvation effects显示文摘Computer simulations of friction between polymer brushes are usually simplified compared to real systems in terms of solvents and geometry.In most simulations,the solvent is only implicit with infinite compressibility and zero inertia.In addition,the model geometries are parallel walls rather than curved or rough as in reality.In this work,we study the effects of these approximations and more generally the relevance of solvation on dissipation in polymer-brush systems by comparing simulations based on different solvation schemes.We find that the rate dependence of the energy loss during the collision of brush-bearing asperities can be different for explicit and implicit solvent.Moreover,the non-Newtonian rate dependences differ noticeably between normal and transverse motion,i.e.,between head-on and off-center asperity collisions.Lastly,when the two opposing brushes are made immiscible,the friction is dramatically reduced compared to an undersaturated miscible polymer-brush system,irrespective of the sliding direction. | Sissi de BEER G.DjuidjéKENMOÉ Martin H.MÜSER | 2015 | Friction2015，3，2： | 2 |
| 12 | Laparoscopic Single-Anastomosis Duodenal–Jejunal Bypass with Sleeve Gastrectomy (SADJB-SG): Short-term Result and Comparison with Gastric Bypass显示文摘 | Wei-Jei Lee Kuo-Ting Lee Kazunori Kasama Yosuke Seiki Kong-Han Ser Shu-Chun Chun Jung-Chien Chen Yi-Chih Lee | 2014 | Obesity Surgery2014，，1： | 2 |
| 13 | Characterization of different plasma-treated cobalt oxide catalysts for oxygen reduction reaction in alkaline media显示文摘Plasma-synthesized cobalt oxide supported on carbon has been analyzed for its use for electrocatalytic oxygen reduction reaction(ORR) in alkaline anion exchange membrane fuel cells(AEMFC). This work presents the ORR activity in 0.1 mol L^(-1) KOH and 0.1 mol L^(-1) K_2CO_3at25 °C. Cyclic voltammetry(CV) was used to determine the potentials at which the ORR occurs and to evaluate the stability of catalyst. Moreover, a rotating ring-disk electrode(RRDE) was used to investigate the activity of the catalysts and the formation of the by-product hydroperoxide anion(HO2-) as well as to identify the preferred pathway of the ORR. Calculated kinetic parameters for the ORR for the cobalt catalysts are shown in this work together with a comparison to a commercial platinum catalyst. However, the cobalt oxide produced more by-products which could lead to damage of the membrane in a fuel cell through a radical attack of the polymer backbone. | Lisa M.Uhlig Gustav Sievers Volker Brüser Alexander Dyck Gunther Wittstock | 2016 | Science Bulletin2016，61，8： | 2 |
| 14 | Solid pseudopapillary neoplasms of the pancreas: Is there a pathologic basis for the observed gender differences in incidence?显示文摘 | Yu-Wen Tien Kong-Han Ser Rey-Heng Hu Chih-Yuan Lee Yung-Ming Jeng Po-Huang Lee | 2005 | Surgery2005，，6： | 2 |
| 15 | Hepatic adenoma mimicking a metastatic lesion on computed tomography-positron emission tomography scan显示文摘Positron emission tomography (PET) using 18F-fluorodeoxyglucose ( 18F-FDG) is an imaging modality which reflects cellular glucose metabolism. Most malignant cells accumulate and trap 18F-FDG, allowing the visualisation of increased uptake. It is hence widely used to differentiate malignant from benign lesions. 'False positive' findings of hepatic lesions have been described in certain instances such as hepatic abscesses, but are rare in cases involving hepatocellular adenomas. To our knowledge, there have been only 7 reports in the English literature documenting PET-avid hepatocellular adenomas; 6 of the 7 reports were published in the last 3 years with the first report by Patel et al. We report the case of a 44-year-old Chinese female patient with a history of cervical adenocarcinoma, referred for a hepatic lesion noted on a surveillance computed tomography (CT) scan. A subsequent CT-PET performed showed a hypermetabolic lesion (standardized uptake value 7.9) in segment Ⅳb of the liver. After discussion at a multidisciplinary hepato-pancreato-biliary conference, the consensus was that of a metastatic lesion from her previous cervical adenocarcinoma, and a resection of the hepatic lesion was performed. Histology revealed features consistent with a hepatocyte nuclear factor-1 α inactivated steatotic hepatocellular adenoma. | Darryl Lim Ser Yee Lee Kiat Hon Lim Chung Yip Chan | 2013 | World Journal of Gastroenterology2013，19，27： | 2 |
| 16 | Poststroke Dementia: Clinical Features and Risk Factors显示文摘 | Raquel Barba Susana Martínez-Espinosa Elena Rodríguez-García Margarita Pondal José Vivancos Teodoro Del Ser | 2000 | Stroke: Journal of the American Heart Association2000，，7： | 2 |
| 17 | Mutants of GABA transaminase(POP2)suppress the severe phenotype of succinic semialdehyde dehydrogenase(ssadh)mutants in Arabidopsis显示文摘 | Ludewig F Hüser A Fromm H | 2008 | Plo S ONE2008，3，10： | 1 |
| 18 | Efficacy and safety of nimodipine in modipine in subcortical vascular dementia: a randomized placebo-controlled trial显示文摘 | Pantoni L del Ser T Soglian AG | 2005 | Stroke2005，36，3： | 1 |
| 19 | Putting energy back in control显示文摘 | Ortega R van ser Scharf A J Mareels I | 2001 | IEEEControl System Magazine2001，21，2： | 1 |
| 20 | Control of the growth of zinc-iron phases in the hot-dip galvanizing process 显示文摘 | CULCASI J D SER P R ELSNER C I DI SARLI A R | 1999 | Surf Coat Technol1999，122，1： | 1 |
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