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| 1 | H pylori infection and systemic antibodies to CagA and heat shock protein 60 in patients with coronary heart disease显示文摘AIM: To determine the overall prevalence of H pylori and CagA positive H pylori infection and the prevalence of other bacterial and viral causes of chronic infection in patients with coronary heart disease (CHD), and the potential role of anti-heat-shock protein 60 (Hsp60) anti- body response to these proteins in increasing the risk of CHD development. METHODS: Eighty patients with CHD and 160 controls were employed. We also compared the levels of anti- heat-shock protein 60 (Hsp60) antibodies in the two groups. The H pylori infection and the CagA status were determined serologically, using commercially available enzyme-linked immunosorbent assays (ELISA), and a Western blotting method developed in our laboratory. Systemic antibodies to Hsp60 were determined by a sandwich ELISA, using a polyclonal antibody to Hsp60 to sensitise polystyrene plates and a commercially available human Hsp60 as an antigen. RESULTS: The overall prevalence of H pylori infec- tion was 78.7% (n = 63) in patients and 76.2% (n = 122) in controls (P = 0.07). Patients infected by CagA- positive (CagA+) H pylori strains were 71.4% (n = 45) vs 52.4% of infected controls (P = 0.030, OR = 2.27). Sys-temic levels of IgG to Hsp60 were increased in H pylori- negative patients compared with uninfected controls (P < 0.001) and CagA-positive infected patients compared with CagA-positive infected controls (P = 0.007). CONCLUSION: CagA positive H pylori infection may concur to the development of CHD; high levels of anti- Hsp60 antibodies may constitute a marker and/or a con- comitant pathogenic factor of the disease. | Cristina Lenzi Alberto Palazzuoli Nicola Giordano Giuliano Alegente Catia Gonnelli Maria Stella Campagna Annalisa Santucci Michele Sozzi Panagiotis Papakostas Fabio Rollo Ranuccio Nuti Natale Figura | 2006 | World Journal of Gastroenterology2006，12，48： | 23 |
| 2 | Hepatocellular carcinoma in viral and autoimmune liver diseases:Role of CD4+CD25+Foxp3+regulatory T cells in the immune microenvironment显示文摘More than 90%of cases of hepatocellular carcinoma(HCC)occurs in patients with cirrhosis,of which hepatitis B virus and hepatitis C virus are the leading causes,while the tumor less frequently arises in autoimmune liver diseases.Advances in understanding tumor immunity have led to a major shift in the treatment of HCC,with the emergence of immunotherapy where therapeutic agents are used to target immune cells rather than cancer cells.Regulatory T cells(Tregs)are the most abundant suppressive cells in the tumor microenvironment and their presence has been correlated with tumor progression,invasiveness,as well as metastasis.Tregs are characterized by the expression of the transcription factor Foxp3 and various mechanisms ranging from cell-to-cell contact to secretion of inhibitory molecules have been implicated in their function.Notably,Tregs amply express checkpoint molecules such as cytotoxic T lymphocyte-associated antigen 4 and programmed cell-death 1 receptor and therefore represent a direct target of immune checkpoint inhibitor(ICI)immunotherapy.Taking into consideration the critical role of Tregs in maintenance of immune homeostasis as well as avoidance of autoimmunity,it is plausible that targeting of Tregs by ICI immunotherapy results in the development of immune-related adverse events(irAEs).Since the use of ICI becomes common in oncology,with an increasing number of new ICI currently under clinical trials for cancer treatment,the occurrence of irAEs is expected to dramatically rise.Herein,we review the current literature focusing on the role of Tregs in HCC evolution taking into account their opposite etiological function in viral and autoimmune chronic liver disease,and we discuss their involvement in irAEs due to the new immunotherapies. | Alessandro Granito Luigi Muratori Claudine Lalanne Chiara Quarneti Silvia Ferri Marcello Guidi Marco Lenzi Paolo Muratori | 2021 | World Journal of Gastroenterology2021，27，22： | 11 |
| 3 | The role of antioxidant therapy in the treatment of male infertility: an overview显示文摘在最近的年里,许多研究在男 eproductive 系统上集中了于氧化应力,反应的氧种类(ROS ) 和抗氧化剂的效果。在生理的条件下面,精子生产 ROS 的小数量,它为使肥沃, acrosome 反应和 capacitation 被需要。不管多么如果 ROS 的增加的生产没与清除的类似的增加被联系系统,精子血浆膜的 peroxidative 损坏和 DNA 完整的损失典型地发生,它导致房间死亡和减少的富饶。而且,自从在精子质量和怀孕率之间没有线性关联,在精液参数的改进不应该是在抗氧化剂治疗的研究考虑的唯一的结果。当大多数以前的研究缺乏控制组,关于这些治疗的利益的一个权威的结论是困难的获得,在不同联合和剂量的考虑不同抗氧化剂,或没在以前不肥沃的夫妇评估怀孕率。就算有益的效果在男不孕的一些情况中被报导,更多的 multicentre,与一样的标准执行的双窗帘研究为富饶上的各种各样的抗氧化剂的效果的增加的理解是必要的。 | Francesco Lombardo Andrea Sansone Francesco Romanelli DonateUa Paoli Loredana Gandiniand Andrea Lenzi | 2011 | Asian Journal of Andrology2011，13，5： | 10 |
| 4 | Effects of percutaneous varicocele repair on testicular volume:results from a 12-month follow-up显示文摘Varicocele is a comm on fin ding in men. Varicocele correcti on has bee n advocated for young patients with testicular hypotrophy, but there is a lack of morphofunctional follow-up data. We assessed whether percutaneous treatment of left varicocele is associated with testicular 'catch-up growth' in the following 12 months by retrospectively reviewing data from an electronic database of 10 656 patients followed up in our clinic between 2006 and 2016. We selected all young adults (<35 years) with left varicocele who un derwe nt percuta neous treatment, had a minimum of 12 mon ths' ultraso und imagi ng follow-up, and had no other con ditions affecting testicular volume. One hundred and fourteen men (mean±standard deviation [s.d.] of age: 22.8 ± 5.4 years) met the inclusion and exclusion criteria. Left testicular hypotrophy (LTH), defined as a >20% difference between left and right testicular volume at baseline, was observed in 26 (22.8%) men. Participants with LTH (mean±s.d.: 14.5 ± 2.7 ml) had lower baseline testicular volume compared to those without LTH (mean±s.d.: 15.7 ± 3.8 ml;P= 0.032). Repeated measures mixed models showed a sign ifica nt in teraction betwee n LTH and time posttreatme nt when correcting for baseli ne left testicular volume (β= 0.114, 95% confidence interval [Cl]: 0.018-0.210, P=0.020), resulting in a catch-up growth of up to 1.37 ml per year (95% Cl: 0.221- 2.516). Age at intervention was also associated with reduced testicular volume (-0.072 ml per year, 95% Cl:-0.135--0.009;P = 0.024). Percutaneous treatment of left varicocele in young adults with LTH can result in catch-up growth over 1 year of follow-up. The reproductive and psychological implicati ons of these findings n eed to be confirmed in Ion ger and larger prospective studies. | Andrea Sansone Danilo Alunni Fegatelli Carlotta Pozza Giorgio Fattorini Rosa Lauretta Marianna Minnetti Francesco Romanelli Pierleone Lucatelli Mario Corona Mario Bezzi Francesco Lombardo Andrea Lenzi Daniele Gianfrilli | 2019 | Asian Journal of Andrology2019，21，4： | 8 |
| 5 | Non-alcoholic fatty liver disease connections with fat-free tissues: A focus on bone and skeletal muscle显示文摘The estimates of global incidence and prevalence of non-alcoholic fatty liver disease(NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis. Bone and the skeletal muscle are fat- free tissues which appeared to be independently associated with NAFLD in several cross-sectional studies. The deterioration of bone mineral density and lean body mass, leading to osteoporosis and sarcopenia, respectively, are age-related processes. The prevalence of NAFLD also increases with age. Beyond physiological aging, the three conditions share some common underlying mechanisms, and their elucidations could be of paramount importance to design more effective treatment strategies for the management of NAFLD. In this review, we provide an overview on epidemiological data as well as on potential contributors to the connections of NAFLD with bone and skeletal muscle. | Eleonora Poggiogalle Lorenzo Maria Donini Andrea Lenzi Claudio Chiesa Lucia Pacifico | 2017 | World Journal of Gastroenterology2017，23，10： | 7 |
| 6 | Knockdown of MLO genes reduces susceptibility to powdery mildew in grapevine显示文摘Erysiphe necator is the causal agent of powdery mildew(PM),one of the most destructive diseases of grapevine.PM is controlled by sulfur-based and synthetic fungicides,which every year are dispersed into the environment.This is why PM-resistant varieties should become a priority for sustainable grapevine and wine production.PM resistance can be achieved in other crops by knocking out susceptibility S-genes,such as those residing at genetic loci known as MLO(Mildew Locus O).All MLO S-genes of dicots belong to the phylogenetic clade V,including grapevine genes VvMLO7,11 and 13,which are upregulated during PM infection,and VvMLO6,which is not upregulated.Before adopting a gene-editing approach to knockout candidate S-genes,the evidence that loss of function of MLO genes can reduce PM susceptibility is necessary.This paper reports the knockdown through RNA interference of VvMLO6,7,11 and 13.The knockdown of VvMLO6,11 and 13 did not decrease PM severity,whereas the knockdown of VvMLO7 in combination with VvMLO6 and VvMLO11 reduced PM severity up to 77%.The knockdown of VvMLO7 and VvMLO6 seemed to be important for PM resistance,whereas a role for VvMLO11 does not seem likely.Cell wall appositions(papillae)were present in both resistant and susceptible lines in response to PM attack.Thirteen genes involved in defense were less upregulated in infected mlo plants,highlighting the early mlo-dependent disruption of PM invasion. | Stefano Pessina Luisa Lenzi Michele Perazzolli Manuela Campa Lorenza Dalla Costa Simona Urso Giampiero Valè Francesco Salamini Riccardo Velasco Mickael Malnoy | 2016 | Horticulture Research2016，3，1： | 7 |
| 7 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome显示文摘 | Giulio Marchesini Elisabetta Bugianesi Gabriele Forlani Fernanda Cerrelli Marco Lenzi Rita Manini Stefania Natale Ester Vanni Nicola Villanova Nazario Melchionda Mario Rizzetto | 2003 | Hepatology2003，，4： | 5 |
| 8 | A rheological method for selecting nano-kaolin powder as filler in SBR rubber显示文摘This paper shows that the stiffness of styrene–butadiene solid rubber with added kaolin powder is related to the yield stress of kaolin dispersion in liquid polybutadiene rubber up to the percolation threshold. For five kinds of kaolin powder, the value of τ° spans the range of 100–430 Pa, while the corresponding compressive elastic constant of SBR varies from 12 to 21 MPa. A relationship between τ° and ΔE i /*E R is proposed. Critical examination of these data infers that kaolin powder dispersed in solid rubber matrix acts as an additive which decreases the random movement of the polybutadiene chains. Consequently, dispersions of nano-particles in liquid and in solid SBR are considered to be related, thus leading to a rheological method for selecting nano-particles as fillers in solid SBR. | Alberto Lagazzo Sergio Lenzi Rodolfo Botter Paolo Cirillo Fabrizio Demicheli Dario T. Beruto | 2010 | Particuology2010，8，3： | 4 |
| 9 | ARFI elastography in patients with chronic autoimmune liver diseases: A preliminary study显示文摘 | S. Righi E. Fiorini C. De Molo V. Cipriano F. Cassani L. Muratori M. Lenzi A.M. Morselli Labate C. Serra | 2012 | Journal of Ultrasound2012，，4： | 2 |
| 10 | Nonalcoholic fatty liver, steatohepatitis, and the metabolic syndrome显示文摘 | Giulio Marchesini Elisabetta Bugianesi Gabriele Forlani Fernanda Cerrelli Marco Lenzi Rita Manini Stefania Natale Ester Vanni Nicola Villanova Nazario Melchionda Mario Rizzetto | 2003 | Hepatology2003，，4： | 2 |
| 11 | Genetic distinctions between autoimmune hepatitis in Italy and North America显示文摘AIM: Our goals were to analyze the known genetic predispositions for autoimmune hepatitis (AIH) in AIH Italian population and to compare them with North American counterparts.METHODS: Human leukocyte antigens (HLA) B8, C7, DR3,DR4, DR7, DR11, DR13, DQ2 and the B8-DR3-DQ2phenotype were determined by microlymphocytotoxicity and polymerase chain reaction in 74 Italian patients (57with type 1 and 17 with type 2 AIH) and 149 North American patients with type 1 AIH, and in adequate controls.RESULTS: B8-DR3-DQ2 occurred more frequently in Italian patients with type 1 AIH than in Italian controls (30% vs 7%, P<0.0001), but less frequently than in North American counterparts (30% vs48%, P = 0.02). DR4 occurred less frequently in Italian patients with type 1 AIH (23% vs43%,P= 0.01) and in controls (16% vs34%, P= 0.0003) than in North American counterparts. No differences were found in alleles' frequency between type 1 and type 2Italian AIH patients. DR11 had a frequency lower in type 1 Italian AIH patients than controls (17% vs35%, P= 0.01).CONCLUSION: HLA DR4 is not associated with AIH in Italy. The known HLA risk factors for ATH occur similarly in Italian patients with type 1 and type 2 AIH, and they are less frequent than in North American patients. B8-DR3-DQ2 is the predominant phenotype of type 1 AIH also in Italy, and HLA DR11 may be a regionally distinctive protective factor against type 1 AIH. | Paolo Muratori Albert J.Czaja Luigi Muratori Georgios Pappas Silvana Maccariello Fabio Cassani Alessandro Granito Rodolfo Ferrari Vilma Mantovani Marco Lenzi Francesco B.Bianchi | 2005 | World Journal of Gastroenterology2005，11，12： | 2 |
| 12 | Predictive value of brain perfusion single-photon emission computed tomography in acute ischemic stroke显示文摘 | Giubilei F Lenzi G Dipiero V | 1990 | Stroke1990，21，： | 2 |
| 13 | 迟发性性腺功能减退症与骨化二醇的关系显示文摘男性迟发性性腺功能减退症是指具有血清睾酮(T)水平降低和典型临床症状的综合征。而血清睾酮浓度是否总能真实反应Leydig细胞的功能目前仍不确定。轻度睾丸改变只有通过检测额外的生化标记物如黄体生成素(LH)和25.羟维生素D才能确诊。这些标记物可以帮助诊断称之为“亚临床”型的性腺功能减退(血清睾酮正常,LH升高)。性腺功能减退患者通常由于睾丸中CYP2Rt羟化酶受损而具有较低水平的25.羟维生素D。然而,目前仍无证据阐释维生素D3亦或骨化二醇是治疗此类病人的最佳选择。因此我们分析了26位具有典型性腺功能减退患者(总T[TT]〈12nmol 1^-1,LH≥8IU 1^-1)及46位亚临床型性腺功能减退患者(TT≥12nmol 1^-1,LH≥8IU 1^-1)以及低25-羟维生素D患者(〈50nmol 1^-1)。其中20名患者接受每周5000IU的维生素D3治疗,46名患者接受每周4000IU的骨化二醇治疗。治疗3个月后,患者25-羟维生素D及甲状旁腺激素升高。在两组患者中(原发型16人,亚临床型30人)补充骨化二醇可以显著提高25-羟维生素D水平并显著降低甲状旁腺激素水平,而补充维生素D3的患者,其25-羟维生素D和甲状旁腺激素水平并无明显变化。本研究首次阐述服用骨化二醇而非维生素D3,可以提高男性迟发性性腺功能减退患者25-羟维生素D水平。 | Carlo Foresta Aldo E Calogero Francesco Lombardo Andrea Lenzi Alberto Ferlin | 2015 | Asian Journal of Andrology2015，17，2： | 2 |
| 14 | Sperm glyceraldehyde 3-phosphate dehydrogenase gene expression in asthenozoospermic spermatozoa显示文摘精力为精子要求当 glycolysis 似乎是为沿着鞭子的 ATP 传播的重要来源时,活动性被氧化 phosphorylation 生产,这被建议了。一些研究调查了酶 glyceraldehyde 3 磷酸盐脱氢酶的化学、运动的性质在 glycolysis 和精子活动性的规定识别任何变化。相反,有很少研究,分析 hypokinesis 的基因基础。为这个原因,我们在人的精子调查了 glyceraldehyde 3 磷酸盐脱氢酶基因评估 asthenozoospermia 是否在它的表示与任何变化被相关。精液检查和 glyceraldehyde 3 磷酸盐脱氢酶基因表示研究在划分成二个组的 116 件精液样品上被执行 - 组 A 由 58 件 normokinetic 样品和 58 件运动减退的样品的组 B 组成了。全部的 RNA 从精子被提取,并且 mRNA 的即时 PCR quantification 用特定的教材和探针被执行。为组 A 和 B 的表示侧面是很类似的。吝啬的三角洲 Ct 如下 - 组 A, 5. | Donatella Paoli Marianna Pelloni Mariagrazia Gallo Giulia Coltrinari Francesco Lombardo Andrea Lenzi Loredana Gandini | 2017 | Asian Journal of Andrology2017，19，4： | 2 |
| 15 | Characterization and clinical impact of antinuclear antibodies in primary biliary cirrhosis显示文摘 | Paolo Muratori Luigi Muratori Rodolfo Ferrari Fabio Cassani Giampaolo Bianchi Marco Lenzi Luis Rodrigo Antonio Linares Dolores Fuentes Francesco B Bianchi | 2003 | The American Journal of Gastroenterology2003，，2： | 2 |
| 16 | Neural mechanisms of empathy in humans:A relay from neural systems for imitation to limbic areas 显示文摘 | Carr L Iacoboni M Dubeau M-C Mazziotta JC Lenzi GL | 2003 | Proceedings of the National Academy of Sciences of USA2003，，100： | 1 |
| 17 | Polyunsaturated fatty acids of germ cell membranes,glutathione and glutathionedependent enzyme-PHGPx:from basic to clinic显示文摘 | Lenzi A Gandini L Lombardo F | 2002 | Contraception2002，65，4： | 1 |
| 18 | Ammoniavariations in phyto-treatment ponds of land-based fish farmwastewater显示文摘 | PORRELL O FERRARI G LENZI M | 2003 | Aquaculture2003，219，： | 1 |
| 19 | Disorders of ejaculation 显示文摘 | Jannini EA Simonelli C Lenzi A | 2002 | J Endocrinol Invest2002，25，11： | 1 |
| 20 | Epidemiology of premature ejaculation显示文摘 | Jannini E A Lenzi A | 2005 | Current Opinion Urol2005，15，： | 1 |
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