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| 1 | A high-quality genome assembly of quinoa provides insights into the molecular basis of salt bladder-based salinity tolerance and the exceptional nutritional value显示文摘 | Changsong Zou Aojun Chen Lihong Xiao Heike M Muller Peter Ache Georg Haberer Meiling Zhang Wei Jia Ping Deng Ru Huang Daniel Lang Feng Li Dongliang Zhan Xiangyun Wu Hui Zhang Jennifer Bohm Renyi Liu Sergey Shabala Rainer Hedrich Jian-Kang Zhu Heng Zhang | 2017 | Cell Research2017，27，11： | 22 |
| 2 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 3 | Structural basis for termination of AIM2-mediated signaling by p202显示文摘 | Heng Ru Xiangmin Ni LixiaZhao Christopher Crowle Wei Ding Li-Wei Hung Neil Shaw Genhong Cheng Zhi-Jie Liu | 2013 | Cell Research2013，23，6： | 5 |
| 4 | Effect of thermal exposure on the stress-rupture life and microstructure of a low Re-containing single crystal alloy显示文摘In this paper, the stress-rupture tests of a low Re-containing single crystal alloy IC21 before and after thermal exposure at 1100 ℃for various periods of time were conducted under the test condition of 1100 ℃/137 MPa, and the microstructure of the tested specimens was characterized by SEM and TEM. The experimental results showed that the stress rupture life of this alloy was over 150 h after the standard heat treatment of1320 ℃, 10 h/AC t 870, 32 h/AC, however the stress rupture life decreased with the increase of exposure time due to the microstructure degradation. The TEM analysis revealed that the interface mismatch dislocation networks were well established. It was observed that these mismatch networks could form at 1100 ℃ even after thermal exposure for 1 h without the external stress, which is quite different from that in the traditional single crystal superalloys. | Heng Zhang Yunfei Liang Yi Ru Shusuo Li Jian Zhou Shengkai Gong | 2015 | Progress in Natural Science:Materials International2015，25，1： | 4 |
| 5 | Analyzing S100A6 Expression in Endoscopic Ultrasonography-guided Fine-needle Aspiration Specimens: A Promising Diagnostic Method of Pancreatic Cancer显示文摘 | Guo Zihao Zhang Jie Liang Yan Zhang Jing Chen Jing Li Xue Zhu Jing Li Wing Heng Gao Ru Hao Jianyu | 2013 | Journal of Clinical Gastroenterology2013，，1： | 2 |
| 6 | The research on the result of Parturient, s Free birth Posture during the Second Birth Process 显示文摘 | Ling Heng li Pan Ru | 2007 | Chinese Journal Of Practical Nursing2007，23，6： | 1 |
| 7 | Influence of withdrawal rate on last stage solidification path of a Mo-rich Ni 3 Al based single crystal superalloy显示文摘 | Cheng Ai Xinbao Zhao Lei Liu Heng Zhang Yi Ru Yanling Pei Jian Zhou Shusuo Li Shengkai Gong | 2015 | Journal of Alloys and Compounds2015，，： | 1 |
| 8 | Design and development of the deep-rock in-situ condition-preserved coring calibration platform显示文摘To systematically validate and calibrate the theory and technology of the deep in-situ conditionpreserved coring, the in-situ conditions at different depths should be simulated, and the full-size coring tests should be carried out in this simulated environment. Therefore, a deep-rock in-situ conditionpreserved coring calibration platform was designed and developed. The self-tightening sealing structure and the quick-disassembly structure were designed on the basis of an innovative segmented nonuniformdiameter structure, which was a breakthrough from the traditional high-pressure vessel frame and was verified by finite element simulation and actual testing under extreme working conditions, respectively.To simulate the actual deep in-situ environment with a temperature of 150℃ and pressure of 140 MPa for a large Φ450 mm×H1400 mm core, temperature and pressure control systems were designed by coupling, and a pre-embedded high-pressure-resistant temperature sensor was designed. Finally, highprecision assembly automation, complex movement coordination of the coring device with the platform,and rotary dynamic sealing were achieved by utilizing the combination of adaptive cabin body servo control and an adaptive mechanical structure in a limited space, laying a solid foundation for the calibration of in-situ condition-preserved coring. | Yihang Li Heping Xie Ru Zhang Zetian Zhang Zhilong Zhang Heng Gao Wei Huang Jixun Zhang Jiming Gao Xin Ma Ruibing Xu | 2023 | International Journal of Mining Science and Technology2023，33，11： | 1 |
| 9 | New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16显示文摘Interferon gamma-inducible protein 16(IFI16)senses DNA in the cytoplasm and the nucleus by using two tandem hematopoietic interferon-inducible nuclear(HIN)domains,HINa and HINb,through the cooperative assembly of IFI16 filaments on double-stranded DNA(dsDNA).The role of HINa in sensing DNA is not clearly understood.Here,we describe the crystal structure of the HINa domain in complex with DNA at 2.55A°resolution and provide the first insight into the mode of DNA binding by the HINa domain.The structure reveals the presence of two oligosaccharide/nucleotide-binding(OB)folds with a unique DNA-binding surface.HINa uses loop L45 of the canonical OB2 fold to bind to the DNA backbone.The dsDNA is recognized as two single strands of DNA.Interestingly,deletion of HINb compromises the ability of IFI16 to induce IFN-b,while HINa mutants impaired in DNAbinding enhance the production of IFN-b.These results shed light on the roles of IFI16 HIN domains in DNA recognition and innate immune responses. | Xiangmin Ni Heng Ru Feng Ma Lixia Zhao Neil Shaw Yingang Feng Wei Ding Weibin Gong Qiaofeng Wang Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2016 | Journal of Molecular Cell Biology2016，8，1： | 1 |
| 10 | The Improved Lipid Accumulation Product is an Accurate Index for Predicting Metabolic Syndrome in the Xinjiang Population显示文摘The metabolic syndrome(MetS),which comprises of a variety of metabolic disorders,including obesity,hyperglycemia,hypertension,dyslipidemia,hyperviscosity,hyper uric acid,fatty liver,and hyperinsulinemia[1],has impacted all nations and races,becoming a significant challenge for public health institutions worldwide.MetS is associated with cardiovascular disease。 | DING Yu Song LI Yang ZHANG Xiang Hui MA Ru Lin GUO Heng MA Long LIU Tao YAO Ping | 2021 | Biomedical and Environmental Sciences2021，34，6： | 1 |
| 11 | Removal of phosphate from polluted water by lanthanum doped vesuvianite 显示文摘 | Li Heng Ru Jingyu Yin Wen | 2009 | Journal of Hazar- dous Materials2009，168，1： | 1 |
| 12 | Structural biology study of human TNF receptor associated factor 4 TRAF domain显示文摘TRAF4 is a unique member of TRAF family,which is es-sential for innate immune response,nervous system and other systems.In addition to being an adaptor protein,TRAF4 was identifi ed as a regulator protein in recent studies.We have determined the crystal structure of TRAF domain of TRAF4(residues 292-466)at 2.60Åresolution by X-ray crystallography method.The trimericly assembled TRAF4 resembles a mushroom shape,containing a super helical“stalk”which is made of three right-handed intertwinedαhelixes and a C-terminal“cap”,which is divided at resi-due L302 as a boundary.Similar to other TRAFs,both intermolecular hydrophobic interaction in super helical“stalk”and hydrogen bonds in“cap”regions contribute directly to the formation of TRAF4 trimer.However,differ-ing from other TRAFs,there is an additional fl exible loop(residues 421-426),which contains a previously identifi ed phosphorylated site S426 exposing on the surface.This S426 was reported to be phosphorylated by IKKαwhich is the pre-requisite for TRAF4-NOD2 complex formation and thus to inhibit NOD2-induced NF-κB activation.Therefore,the crystal structure of TRAF4-TRAF is valuable for under-standing its molecular basis for its special function and provides structural information for further studies. | Fengfeng Niu Heng Ru Wei Ding Songying Ouyang Zhi-Jie Liu | 2013 | Protein & Cell2013，4，9： | 1 |
| 13 | 基于个体化机器学习的原发性免疫性血小板减少症危重出血预测模型:一项全国前瞻性队列研究显示文摘原发性免疫性血小板减少症(ITP)中少见但至关重要的危重出血事件,给患者的预后、生活质量和治疗决策带来严重影响。尽管有一些研究探讨了ITP中与危重出血相关的风险因素,但目前尚缺乏大样本数据、大规模多中心研究结果以及针对ITP患者致命出血事件的预测模型。本研究首次采用国际血栓与止血学会新提出的ITP致命出血标准,利用大样本数据开发了首个基于机器学习的在线应用,用于预测ITP患者的致命出血.研究中,我们使用中国各地大型多中心数据进行开发,并对全国39家医疗中心进行为期一年的外部测试,得到了较好的训练、验证和测试数据集预测能力该基于新算法的便捷网络工具能够快速识别ITP患者的出血风险,辅助临床决策,有望未来降低不良事件的发生。 | Zhuo-Yu An Ye-Jun Wu Yu Hou Heng Mei Wei-Xia Nong Wen-Qian Li Hu Zhou Ru Feng Jian-Ping Shen Jun Peng Hai Zhou Yi Liu Yong-Ping Song Lin-Hua Yang Mei-Yun Fang Jian-Yong Li Yun-Feng Cheng Peng Liu Ya-Jing Xu Zhao Wang Yi Luo Zhen Cai Hui Liu Jing-Wen Wang Juan Li Xi Zhang Zi-Min Sun Xiao-Yu Zhu Xin Wang Rong Fu Liang Huang Shao-Yuan Wang Tong-Hua Yang Li-Ping Su Liang-Ming Ma Xie-Qun Chen Dai-Hong Liu Hong-Xia Yao Jia Feng Hong-Yu Zhang Ming Jiang Ze-Ping Zhou Wen-Sheng Wang Xu-Liang Shen Yangjin Baima Yue-Ying Li Qian-Fei Wang Qiu-Sha Huang Hai-Xia Fu Xiao-Lu Zhu Yun He Qian Jiang Hao Jiang Jin Lu Xiang-Yu Zhao Ying-Jun Chang Tao Wu Yao-Zhu Pan Lin Qiu Da Gao A-Rong Jin Wei Li Su-Jun Gao Lei Zhang Ming Hou Xiao-Jun Huang Xiao-Hui Zhang on behalf of the National Cooperative ITP Working Group | 2023 | Science Bulletin2023，68，18： | 0 |
| 14 | Eco-engineering for wastes treatment in process of alcohol production显示文摘1IntroductionIthasbeenforalongtimeadisturbedproblemforhumanbeingstofindatradeofbetweeneconomicdevelopmentandenvironmentalpro... | Lu Bing you, Wang Ru song DSE, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Zhang Ren wu Agro Environmental Protection Institute, Tianjin 300191, China Sui Zhi heng Jilin Agro Environ | 1998 | Journal of Environmental Sciences1998，10，4： | 0 |
| 15 | 群落时间稳定性对刈割和养分富集的响应随时间的变化显示文摘土地利用和养分富集能对生物多样性和生态系统功能产生巨大的影响。然而,群落时间稳定性对土地利用和养分富集的响应是如何随时间变化的尚不清楚。作为历经15年(2005-2019)野外实验的一部分,本研究旨在探索在蒙古高原温带草原上,刈割、氮添加和磷添加对群落时间稳定性的效应。经过15年的实验,氮添加和磷添加均降低了群落时间稳定性,尤其是灌木和半灌木功能群的时间稳定性。刈割仅在实验早期(2005-2009)增加群落时间稳定性。氮添加在实验早期和末期(2015-2019)降低了群落时间稳定性,但在实验中期(2010-2014)反而提高了群落时间稳定性。磷添加在实验早期只轻微降低群落时间稳定性,但在实验末期显著降低群落时间稳定性。氮添加引起的群落时间稳定性变化的波动主要归因于其对物种异步性和种群时间稳定性的不同影响。我们的发现强调了植物功能群和物种异步性在调控群落时间稳定性方面的重要作用,以及仍然需要进行更长期的研究,以准确预测全球变化背景下的生态系统响应模式。 | Heng Li Jiajia Zhang Jingyi Ru Jian Song Zhensheng Chi Yujin Zheng Lin Jiang Shiqiang Wan | 2023 | Journal of Plant Ecology2023，16，4： | 0 |
| 16 | Preliminary research and scheme design of deep underground in situ geo-information detection experiment for Geology in Time显示文摘The deep earth,deep sea,and deep space are the main parts of the national“three deep”strategy,which is in the forefront of the strategic deployment clearly defined in China’s 14th Five-Year Plan(2021-2025)and the Long-Range Objectives Through the Year 2035.It is important to reveal the evolutionary process and mechanism of deep tectonics to understand the earth’s past,present and future.The academic con-notation of Geology in Time has been given for the first time,which refers to the multi-field evolution response process of geological bodies at different time and spatial scales caused by geological processes inside and outside the Earth.Based on the deep in situ detection space and the unique geological envi-ronment of China Jinping Underground Laboratory,the scientific issue of the correlation mechanism and law between deep internal time-varying and shallow geological response is given attention.Innovative research and frontier exploration on deep underground in situ geo-information detection experiments for Geology in Time are designed to be carried out,which will have the potential to explore the driving force of Geology in Time,reveal essential laws of deep earth science,and explore innovative technologies in deep underground engineering. | Heping Xie Ru Zhang Zetian Zhang Yinshuang Ai Jianhui Deng Yun Chen Yong Zhou Mingchuan Li Liqiang Liu Mingzhong Gao Zeqian Yang Weiqiang Ling Heng Gao Qijun Hao Kun Xiao Chendi Lou | 2024 | International Journal of Mining Science and Technology2024，34，1： | 0 |
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