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| 1 | 丁酰胆碱酯酶传感器用于有机磷农药测定显示文摘近年来,随着生命科学和环境科学诸领域的迅速发展,以生物材料为基础的各种生物传感器的开发应用愈来愈受到关注。酶传感器便是其中之一。本文以丁酰胆碱酯酶(BuchE)为例,对该酶的固定化以及酶传感器的研制与应用进行了一系列的探索性研究。利用BuchE传感器测定某些有机磷农药,具有相当高的灵敏度,且传感器敏感部分即固定化BuchE膜随时间的稳定性良好,因此大大方便了其保存与更换。 | 李发生 H.K.布特尼科夫 E.P.梅江采娃 | 1994 | 化学传感器1994，14，2： | 7 |
| 2 | Evaluation and SAR analysis of the cytotoxicity of tanshinones in colon cancer cells显示文摘AIM:This study was designed to evaluate the anti-cancer actions of tanshinone I and tanshinone IIA,and six derivatives of tanshinone IIA on normal and cancerous colon cells.Structure activity relationship(SAR) analysis was conducted to delineate the significance of the structural modifications of tanshinones for improved anti-cancer action.METHOD:Tanshinone derivatives were designed and synthesized according to the literature.The cytotoxicity of different compounds on colon cancer cells was determined by the MTT assay.Apoptotic activity of the tanshinones was measured by flow cytometry(FCM).RESULTS:Tanshinone I and tanshinone IIA both exhibited significant cytotoxicity on colon cancer cells.They are more effective in p53+/+ colon cancer cell line.It was also noted that the anti-cancer activity of tanshinone I was more potent and selective.Two of the derivatives of tanshinone IIA(N1 and N2) also exhibited cytotoxicity on colon cancer cells.CONCLUSIONS:The anti-colon cancer activity of tanshinone I was more potent and selective than tanshinone IIA,and is p53 dependent.The derivatives obtained by structural modifications of tanshinone IIA exhibited lower cytotoxicity on both normal and colon cancer cells.From steric and electronic characteristics point of view,it was concluded that structural modifications of ring A and furan or dihydrofuran ring D on the basic structure of tanshinones influences the activity.An increase of the delocalization of the A and B rings could enhance the cytotoxicity of such compounds,while a non-planar and small sized D ring region would provide improved anti-cancer activity. | WANG Lin LIU An ZHANG Fei-Long Yeung John H.K. LI Xu-Qin CHO Chi-Hin | 2014 | Chinese Journal of Natural Medicines2014，12，3： | 6 |
| 3 | 浮选含金矿石的新药剂显示文摘介绍了一些浮选含金矿石的新型捕收剂。研究结果表明,与单独用丁基黄药相比,用丁基黄药与TAA或R-404组合用,泡沫产品中的金回收率提高0.63%~3.33%,其中的金品位提高2~3倍。 | H.K.阿尔盖布拉依斯多娃 汪镜亮 雨田 | 2006 | 国外金属矿选矿2006，43，1： | 5 |
| 4 | Identification of the metabolites of biologically active xanthones isolated from Halenia elliptica D.Don by high performance liquid chromatography coupled to ion trap time-of-flight mass spectrometry显示文摘新陈代谢学习在 1-hydroxy-2,3,5-trimethoxyxanthone (HM-1 ) 和 1-hydroxy-2,3,4,7-tetramethoxyxanthone (HM-2 ) 上被执行了,它是从西藏的植物孤立的二生物学上活跃的成分, Halenia elliptica D. 唐,在在 vitro 的老鼠肝微体。联合到离子陷井 time-of-flight 团 spectrometry ( LCMSn-ESI-IT-TOF )的高效液体层析的一个方法被使用在线上分析 HM-1 和 HM-2 的代谢物,并且五代谢物被识别包含 1,5-dihydroxy-2,3-dimethoxyxanthone ( HM-5 ), 1,7-dihydroxy-2,3,4-trimethoxyxanthone ( HM-9 ), 1,4 , 7-trihydroxy-2,3-dimethoxyxanthone ( HM-10 ), 1,4-dihydroxy-2,3,7-trimethoxyxanthone ( HM-11 )和 1,2-dihydroxy-3,4,7-trimethoxyxanthone ( HM-12 )。在这些代谢物之中, HM-9, HM-11,和 HM-12 互相是异构体。结果显示了那 HM-1, HM-2 发生了阶段我在在 vitro 的老鼠微体的 demethylation 的新陈代谢的反应。 | Ru Feng Jian Gong Shi Xiao Wei Liu Chun Tao Che John H.K. Yeung Yan Wang | 2011 | Chinese Chemical Letters2011，22，7： | 4 |
| 5 | Cloning and characterization of a FLORICAULA/LEAFY ortholog, PFL, in polygamous papaya显示文摘The homologous genes FLORICAULA (FLO) in Antirrhinum and LEAFY (LFY) in Arabidopsis are known to regu- late the initiation of flowering in these two distantly related plant species. These genes are necessary also for the expression of downstream genes that control floral organ identity. We used Arabidopsis LFY cDNA as a probe to clone and sequence a papaya ortholog of LFY, PFL. It encodes a protein that shares 61% identity with the Arabidopsis LFY gene and 71% identity with the LFY homologs of the two woody tree species: California sycamore (Platanus racemosa) and black cottonwood (Populus trichocarpa). Despite the high sequence similarity within two conserved regions, the N-terminal proline-rich motif in papaya PFL differs from other members in the family. This difference may not affect the gene function of papaya PFL, since an equally divergent but a functional LFY ortholog NEEDLY of Pinus radiata has been reported. Genomic and BAC Southern analyses indicated that there is only one copy of PFL in the papaya genome. In situ hybridization experiments demonstrated that PFL is expressed at a relatively low level in leaf primordia, but it is expressed at a high level in the floral meristem. Quantitative PCR analyses revealed that PFL was expressed in flower buds of all three sex types - male, female, and hermaphrodite with marginal difference between hermaphrodite and unisexual flowers. These data suggest that PFL may play a similar role as LFY in flower development and has limited effect on sex differentiation in papaya. | Qingyi YU Paul H. MOORE Henrik H. ALBERT Adrienne H.K. ROADER Ray MING | 2005 | Cell Research2005，15，8： | 4 |
| 6 | 印度炎症性肠病患者的IL-1受体拮抗剂的基因多态性 | Mittal R.D. Bid H.K. Ghoshal U.C. 郝筱倩 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，12： | 4 |
| 7 | LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2显示文摘(HP1 ) Heterochromatin 蛋白质 1 是染色质结构和功能的一个主要管理者。在动物,与 HP1 交往的蛋白质的网络主要与组成的 heterochromatin 由 H3K9me3 标记被联系。HP1 身体上与 SNF2 染色质 remodeler ATRX 的通常认为的 ortholog ?交往,它在哺乳动物控制 histone 变体 H3.3 的免职。在这研究,我们证明 ATRX 的 Arabidopsis thaliana ortholog ?参予 H3.3 免职并且在植物拥有特定的保存领域。我们发现象 HP1 (LHP1 ) 蛋白质一样的那植物通过在陆地植物明确地演变的领域与 ATRX 交往 ? 祖先。在 Arabidopsis 的 ATRX 功能的损失影响 PRC2 (POLYCOMB 压抑的建筑群 2 ) 控制的基因的一个有限子集的表示,包括 flowering 时间管理者 FLC。在 flowering 时间的规定的 ATRX 的函数要求新奇交往 LHP1 领域和 ATRX SNF2 helicase 域的 ATPase 活动。一起拿,这些结果建议不同进化小径在植物在哺乳动物和它的对应物 LHP1 导致了在 ATRX 和 HP1 之间的相互作用,导致 transcriptional 的不同模式规定。 | Haifeng Wang Danhua Jiang Elin Axelsson Zdravko J. Lorkovic Sean Montgomery Sarah Holec Bas J.G.E. Pieters Abbas H.K. AI Temimi Jasmin Mecinovic Frederic Berger | 2018 | Molecular Plant2018，11，8： | 3 |
| 8 | Metal removal studied by a laboratory scale immobilized microalgal reactor显示文摘1IntroductionIndustrialwastewaters,particularlythosedischargedfrommanufacturingofprintedcircuitboard(PCB)andelectroplatingcon... | Arthur Lau, Yuk Shan Wong Research Center/Biology Department, Hong Kong University of Science and Technology, Clearwater Road, Kowloon, H.K. Zhang Tong ** CEDRC, Beijing 100028, China Nora F.Y.Tam Department of Biology and Chemistry, City University of Hong Kong, Kowloon, H.K. | 1998 | Journal of Environmental Sciences1998，10，4： | 3 |
| 9 | A REACTIVE DYNAMIC CONTINUUM USER EQUILIBRIUM MODEL FOR BI-DIRECTIONAL PEDESTRIAN FLOWS显示文摘In this paper, a reactive dynamic user equilibrium model is extended to simu-late two groups of pedestrians traveling on crossing paths in a continuous walking facility. Each group makes path choices to minimize the travel cost to its destination in a reactive manner based on instantaneous information. The model consists of a conservation law equation coupled with an Eikonal-type equation for each group. The velocity-density relationship of pedestrian movement is obtained via an experimental method. The model is solved using a finite volume method for the conservation law equation and a fast-marching method for the Eikonal-type equation on unstructured grids. The numerical results verify the rationality of the model and the validity of the numerical method. Based on this continuum model, a number of results, e.g., the formation of strips or moving clusters composed of pedestrians walking to the same destination, are also observed. | Yanqun Jiang Tao Xiong S.C. Wong Chi-Wang Shu Mengping Zhang Peng Zhang William H.K. Lam | 2009 | Acta Mathematica Scientia2009，29，6： | 3 |
| 10 | Classification of epilepsy using computational intelligence techniques显示文摘 | Khurram I. Qazi H.K. Lam Bo Xiao Gaoxiang Ouyang Xunhe Yin | 2016 | CAAI Transactions on Intelligence Technology2016，1，2： | 3 |
| 11 | 《最高人民法院关于审理侵犯专利权纠纷案件应用法律若干问题的解释》解析显示文摘最高人民法院于2009年6月18日公布了《关于审理侵犯专利权纠纷案件应用法律若干问题的解释(徵求意见稿)》。该司法解释徵求意见稿参考了国内外相关理论和司法实践,涉及的问题包括:权利要求的选择行使;内部证据和外部证据对权利要求的解释作用;权利要求保护范围的确定;功能性特徵对权利要求保护范围的影响; | Patent Law Amendment Research Group China Patent Agent(H.K.) Ltd. | 2009 | 中国专利与商标2009，，4： | 2 |
| 12 | Phase transformation and bond coat oxidation behavior of plasma-sprayed zirconia thermal barrier coating显示文摘 | C.H. Lee H.K. Kim H.S. Choi H.S. Ahn | 2000 | Surface & Coatings Technology2000，，1： | 2 |
| 13 | Inhibition of intestinal and renal Na + -glucose cotransporter by naringenin显示文摘 | Jian Mei Li Chun Tao Che Clara B.S. Lau Po Sing Leung Christopher H.K. Cheng | 2005 | International Journal of Biochemistry and Cell Biology2005，，5： | 2 |
| 14 | 应用Amplatzer血管栓塞物行术前门静脉栓塞显示文摘目的是评估应用Amplatzer血管栓塞物(AVP)行术前门静脉栓塞术(PVE)的安全性和有效性。41例病人应用明胶海绵颗粒和AVP行PVE。应用5F导管以明胶海绵颗粒(1~8mm^3)栓塞门静脉右支,然后将AVP在门静脉右支的一级或二级分支内展开。评价指标包括技术操作的成功率、并发症、血管再通、肝体积总体估计值(TELV)的改变、未来肝残留(FLR)以及FLR/TELV。41例病人中PVE技术成功40例,并在治疗后6~43d(中位数16d)行CT随访观察。2例出现严重并发症, | H. Yoo G.Y. Ko D.I. Gwon J.H. Kim H.K. Yoon K.B. Sung 李靖(译) 李威(校) | 2009 | 国际医学放射学杂志2009，32，4： | 2 |
| 15 | Bufalin induces autophagy-mediated cell death in human colon cancer cells through reactive oxygen species generation and JNK activation显示文摘 | Chuan-Ming Xie Wood Yee Chan Sidney Yu Jun Zhao Christopher H.K. Cheng | 2011 | Free Radical Biology and Medicine2011，，7： | 2 |
| 16 | 飞秒激光辅助后部板层角膜移植术:眼库保存眼手术方法的初步研究 | Soong H.K. Mian S. Abbasi O. Juhasz T. 张鹏 | 2005 | 世界核心医学期刊文摘(眼科学分册)2005，0，5： | 2 |
| 17 | Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats显示文摘 | P.N. Pushparaj H.K. Low J. Manikandan B.K.H. Tan C.H. Tan | 2006 | Journal of Ethnopharmacology2006，，2： | 2 |
| 18 | US findings of xanthogranulomatous cholecystitis显示文摘 | P.N. Kim H.K. Ha Y.H. Kim M.-G. Lee M.H. Kim Y.H. Auh | 1998 | Clinical Radiology1998，，4： | 2 |
| 19 | 尼泊尔水力资源与开发显示文摘尽管尼泊尔的水力蕴藏量非常丰富 ,在水电工程建设中仍然面临着一系列的挑战。叙述了尼泊尔水资源及经鉴定的工程情况 ,并对在技术。 | H.K.戈希末雷 朱晓红 | 2002 | 水利水电快报2002，23，16： | 1 |
| 20 | Butein downregulates chemokine receptor CXCR4 expression and function through suppression of NF-κB activation in breast and pancreatic tumor cells显示文摘 | Angeline Wei Ling Chua Hui Sin Hay Peramaiyan Rajendran Muthu K. Shanmugam Feng Li Pradeep Bist Evelyn S.C. Koay Lina H.K. Lim Alan Prem Kumar Gautam Sethi | 2010 | Biochemical Pharmacology2010，，10： | 1 |
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