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| 1 | Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage显示文摘Asparaginyl endopeptidase (AEP ) 是有为在 P1 地点的天门冬素残余的偏爱的 endo/lysosomal 半胱氨酸 endopeptidase 并且在像使用费的受体 3/7/9 的成熟起一个重要作用。AEP 被知道为催化激活在酸的 pH 经历 autoproteolytic 成熟。这里,我们描述 AEP 酶原的水晶结构和 AEP 的成熟形式。在 AEP 和 caspases 之间的结构的比较在关键残余的作文并且在催化机制揭示了类似。Mutagenesis 研究作为为肽底层的劈开是必要的残余识别了 N44, R46, H150, E189, C191, S217/S218 和 D233。在成熟期间, AEP 的帽子领域的 autoproteolytic 劈开在核心领域上开创存取到活跃地点。出人意料地,一个中间的 autoproteolytic 成熟阶段被发现在近似 pH 4.5 在哪个部分激活的 AEP 能被颠倒回到它的酶原形式。这个唯一的特征被 AEP pH4.5 (AEP 在 pH 被成熟 4.5 并且在 pH 结晶 8.5 ) ,在哪个破肽契约被重新绑扎,结构被转变回到它的酶原形式。另外, AEP 禁止者 cystatin C 能被充分激活的 AEP 消化,但是不能被激活的组织蛋白酶消化。因此,我们第一次证明 cystatins 可以为活跃地点通过底层竞争调整 AEP 的活动。 | Lixia Zhao Tian Hua Christopher Crowley Heng Ru Xiangmin Ni Neil Shaw Lianying Jiao Wei Ding Lu Qu Li-Wei Hung Wei Huang Lei Liu Keqiang Ye Songying Ouyang Genhong Cheng Zhi-Jie Liu | 2014 | Cell Research2014，24，3： | 6 |
| 2 | Crystal structure and nucleotide selectivity of human IFIT5/ISG58显示文摘 | Feng Feng LingminYuan Yao E Wang Christopher Crowley Zongyang Lv Jingjing Li Yingfang Liu Genhong Cheng Su Zeng Huanhuan Liang | 2013 | Cell Research2013，23，8： | 4 |
| 3 | Evolution of endovascular mechanical thrombectomy for acute ischemic stroke显示文摘Acute ischemic stroke(AIS) is a common medical problem associated with significant morbidity and mortality worldwide. A small proportion of AIS patients meet eligibility criteria for intravenous thrombolysis(IVT) with recombinant tissue plasminogen activator, and its efficacy for large vessel occlusion is poor. Therefore, an increasing number of patients with AIS are being treated with endovascular mechanical thrombectomy when IVT is ineffective or contraindicated. Rapid advancement in catheter-based and endovascular device technology has led to significant improvements in rates of cerebral reperfusion with these devices. Stentrievers and modern aspiration catheters have now surpassed earlier generation devices in the degree and rapidity of revascularization. This progress has been achieved with no concurrent increase in risk of major complications or mortality, both when used alone or in combination with IVT. The initial randomized controlled trials comparing endovascular therapy to IVT for AIS failed to show superior outcomes with endovascular treatment, butkey limitations of each trial may limit the significance of these results to current practice. While endovascular devices and operator experience continue to evolve, we are optimistic that this will be accompanied by improvements in patient outcomes. This review highlights the major endovascular devices used in current practice and the trials which have investigated their efficacy. | Colin J Przybylowski Dale Ding Robert M Starke Christopher R Durst R Webster Crowley Kenneth C Liu | 2014 | World Journal of Clinical Cases2014，2，11： | 2 |
| 4 | Lithogeochemistry, geochronology and geodynamic setting of the Lupa Terrane, Tanzania: Implications for the extent of the Archean Tanzanian Craton显示文摘 | Christopher J.M. Lawley David Selby Daniel J. Condon Matthew Horstwood Ian Millar Quentin Crowley Jonathan Imber | 2013 | Precambrian Research2013，，： | 1 |
| 5 | Stem-cell-based, tissue engineered tracheal replacement in a child: a 2-year follow-up study显示文摘 | Martin J Elliott Paolo De Coppi Simone Speggiorin Derek Roebuck Colin R Butler Edward Samuel Claire Crowley Clare McLaren Anja Fierens David Vondrys Lesley Cochrane Christopher Jephson Samuel Janes Nicholas J Beaumont Tristan Cogan Augustinus Bader Alexan | 2012 | The Lancet2012，，9846： | 1 |
| 6 | Blunted heart rate recovery is improved following exercise training in overweight adults with obstructivesleep apnea显示文摘 | Christopher EK Crowley EP Gary BE | 2013 | Int J Cardiol2013，167，4： | 1 |
| 7 | 学会喜欢自己的暗面显示文摘[参考译文]暗面是指我们自己内在的消极因素。我们把自己一切消极的思想感情,也就是我们甚至不想让自己的伴侣和好友知道的东西,全都压抑下去并使其进入无意识之中,其中既有我们已知的,也有未知的。这是我们自己的影子。影子会起妨碍作用,使我们难以充分享受生活。 | Christopher Crowley 成之 | 2001 | 英语文摘2001，0，4： | 0 |
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