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| 1 | Assessment of hemostatic profile in patients with mild to advanced liver cirrhosis显示文摘BACKGROUND Hemostasis of patients suffering from liver cirrhosis is challenging due to both,pro-and anticoagulatory disorders leading to hemostatic alterations with distinct abnormalities of coagulation.Pathological changes in conventional coagulation analysis and platelet count are common manifestations of decreased liver synthesis of coagulation factors and reduced platelet count in these patients.However,conventional coagulation analysis and platelet count do not reflect invivo coagulation status or platelet function.The purpose of this present observational study was therefore to assess the haemostatic profile including plasmatic coagulation using thrombelastometry and impedance aggregometry for platelet function in patients suffering from liver cirrhosis.AIM To assess the hemostatic profile of cirrhotic patients according to model for endstage liver disease(MELD)score.METHODS Our study included both in-and outpatients suffering from liver cirrhosis attending the out-and inpatient care of the department of hepatology.Demographic and biochemical data as well as medical history including cause of liver cirrhosis,end stage kidney failure and medication with anticoagulants were recorded.To assess the hemostatic profile,platelet function was analyzed by multiple electrode aggregometry(MEA)using Multiplate^■(ADP-,ASPI-and TRAP-test)and thrombelastometry using ROTEM^■(EXTEM,INTEM,FIBTEM).Data were compared using Mann-Whitney U-or χ^2-test.Spearman correlation was performed to analyze the association between MELD Score and results of thrombelastometry and MEA.RESULTS A total of 68 patients attending the out-and inpatient care suffering from liver cirrhosis were screened.Of these,50 patients were included and assigned to groups according to MELD score 6 to 11(n=25)or≥17(n=25).Baseline patient characteristics revealed significant differences for MELD score(8 vs 22,P<0.0001)and underlying laboratory parameters(international normalized ratio,bilirubine,creatinine)as well as fibrinogen level(275 mg/dL vs 209 mg/dL,P=0.006)and aPTT(30 s vs 35 s,P=0.047).MEA showed a moderately impaired platelet function(medians:AUCADP=43U,AUCASPI=71U,AUCTRAP=92U)but no significant differences between both groups.Thrombelastometry using ROTEM?(EXTEM,INTEM,FIBTEM)revealed values within normal range in both groups.No significant correlation was observed between MELD score and results of MEA/thrombelastometry.CONCLUSION Our data demonstrate a partially impaired hemostatic profile in liver cirrhosis patients unrelated to MELD score.An individual assessment of a potential coagulopathy should therefore be considered. | Elisabeth Hannah Adam Madara Mohlmann Eva Herrmann Sonia Schneider Kai Zacharowski Stefan Zeuzem Christian Friedrich Weber Nina Weiler | 2020 | World Journal of Gastroenterology2020，26，17： | 5 |
| 2 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 3 | Diffusion Tensor Imaging (DTI) of the Kidney at 3 Tesla–Feasibility, Protocol Evaluation and Comparison to 1.5 Tesla显示文摘 | Mike Notohamiprodjo Olaf Dietrich Wihelm Horger Annie Horng Andreas D. Helck Karin A. Herrmann Maximilian F. Reiser Christian Glaser | 2010 | Investigative Radiology2010，，： | 2 |
| 4 | Identification of Residues in the Human Guanylate-binding Protein 1 Critical for Nucleotide Binding and Cooperative GTP Hydrolysis显示文摘 | Gerrit J.K. Praefcke Stephan Kloep Utz Benscheid Hauke Lilie Balaji Prakash Christian Herrmann | 2004 | Journal of Molecular Biology2004，，1： | 1 |
| 5 | The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis显示文摘Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010. | Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth | 2019 | Neural Regeneration Research2019，14，11： | 1 |
| 6 | Diffusion Tensor Imaging of the Kidney With Parallel Imaging: Initial Clinical Experience显示文摘 | Mike Notohamiprodjo Christian Glaser Karin A. Herrmann Olaf Dietrich Ulrike I. Attenberger Maximilian F. Reiser Stefan O. Schoenberg Henrik J. Michaely | 2008 | Investigative Radiology2008，，： | 1 |
| 7 | Myelodysplastic Cells in Patients Reprogram Mesenchymal Stromal Cells to Establish a Transplantable Stem Cell Niche Disease Unit显示文摘 | Hind Medyouf Maximilian Mossner Johann-Christoph Jann Florian Nolte Simon Raffel Carl Herrmann Amelie Lier Christian Eisen Verena Nowak Bettina Zens Katja Müdder Corinna Klein Julia Obl?nder Stephanie Fey Jovita Vogler Alice Fabarius Eva Riedl Henning Roe | 2014 | Cell Stem Cell2014，，6： | 1 |
| 8 | Effects of ensil ing,silage additives and storage period on methane formation of biogas crops显示文摘 | Christiane Herrmann Monika Heiermann Christine Idler | 2011 | Bioresource Technology2011，，51： | 1 |
| 9 | Impact of fibronectin on surface properties of intraocular lenses显示文摘 | Andreas C. Schroeder Christian Lingenfelder Berthold Seitz Udo Grabowy Christoph W. Spraul Zisis Gatzioufas Mathias Herrmann | 2009 | Graefe’s Archive for Clinical and Experimental Ophthalmology2009，，9： | 1 |
| 10 | Zur Analytik der Tocopherole und Tocotrienole in Lebensmitteln显示文摘 | Christian Gertz Karl Herrmann | 1982 | Zeitschrift für Lebensmittel - Untersuchung und - Forschung1982，，5： | 1 |
| 11 | MDR1 expression correlates with mutantp53 expression in colorectal cancer metastases显示文摘 | Eric Kant Immo Heide Christian Thiede Richard Herrmann Christoph F. Rochlitz | 1996 | Journal of Cancer Research and Clinical Oncology1996，，11： | 1 |
| 12 | Diffusion‐weighted imaging of the healthy pancreas: ADC values are age and gender dependent显示文摘 | Jochen Herrmann Bjoern P. Schoennagel Magdalena Roesch Jasmin D. Busch Thorsten Derlin Laura K. Doh Kay U. Petersen Joachim Graessner Gerhard Adam Christian R. Habermann | 2012 | J. Magn. Reson. Imaging2012，，： | 1 |
| 13 | Functional consequences of frizzled-7 receptor overexpression in human hepatocellular carcinoma显示文摘 | Philippe Merle Suzanne de la Monte Miran Kim Marc Herrmann Shinji Tanaka Annette Von Dem Bussche Michael C. Kew Christian Trepo Jack R. Wands | 2004 | Gastroenterology2004，，4： | 1 |
| 14 | Construct and correlates of basic motor competencies in primary school-aged children显示文摘Background: A central aim of physical education is the promotion of basic motor competencies(in German: Motorische Basiskompetenzen;MOBAK), which are prerequisites for children's active participation in sports culture. This article introduces the MOBAK-1 test instrument for 6-to 8-year-old children and determines the construct validity of this test instrument. In addition, the relationship between MOBAK and motor ability(i.e., strength) as well as body mass index(BMI), sex, and age is investigated.Methods: We analyzed data of 923 first and second graders(422 girls, 501 boys, age = 6.80 ±0.44 years). The children's basic motor competencies were assessed by the MOBAK-1 test instrument. Besides analyses of frequency, correlation, and variance, 3 confirmatory factor analyses with covariates were performed.Results: We found 2 MOBAK factors consisting of 4 items each. The first factor, locomotion, included the items balancing, rolling, jumping, and side stepping; the second factor, object control, included the items throwing, catching, bouncing, and dribbling. The motor ability strength had a significant influence on the factors locomotion(b = 0.60) and object control(b = 0.50). Older pupils achieved better results than younger pupils on object control(b = 0.29). Boys performed better on object control(b = -0.44), whereas girls achieved better results in locomotion(b = 0.07).Pupils with a high BMI achieved lower performance only on the factor locomotion(b =-0.28).Conclusion: The MOBAK-1 test instrument developed for this study meets psychometric validity demands and is suitable to evaluate effects of sports and physical education. | Christian Herrmann Christopher Heim Harald Seelig | 2019 | Journal of Sport and Health Science2019，8，1： | 1 |
| 15 | Wnt3a Plays a Major Role in the Segmentation Clock Controlling Somitogenesis显示文摘 | Alexander Aulehla Christian Wehrle Beate Brand-Saberi Rolf Kemler Achim Gossler Benoit Kanzler Bernhard G Herrmann | 2003 | Developmental Cell2003，，3： | 1 |
| 16 | Bladder neck incision using a 70?W 2 micron continuous wave laser (RevoLix)显示文摘 | Thorsten Bach Thomas R. W. Herrmann Christian Cellarius Andreas J. Gross | 2007 | World Journal of Urology2007，，3： | 1 |
| 17 | Antisocial Punishment Across Societies显示文摘 | Herrmann Benedikt Christian Thoni Simon Gaehter | 2008 | Science2008，319，5868： | 1 |
| 18 | Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy显示文摘 | Christian Markus Lange J?rg Bojunga Elizabeth Ramos-Lopez Michael von Wagner Angela Hassler Johannes Vermehren Eva Herrmann Klaus Badenhoop Stefan Zeuzem Christoph Sarrazin | 2010 | Journal of Hepatology2010，，5： | 1 |
| 19 | Trust,Volun-tary Cooperation,and Socio-economic Background:Survey andExperimental Evidence显示文摘 | Simon Gchter Benedikt Herrmann Christian Thni | 2004 | Original Research Article Journal of E-conomic Behavior&Organization2004，55，50： | 1 |
| 20 | Preparation and luminescence properties of Eu 2+ -doped BaSi 2 O 5 glass-ceramics显示文摘 | Andreas Herrmann Adrian Simon Christian Rüssel | 2011 | Journal of Luminescence2011，，： | 1 |
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