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| 1 | Intraductal endoscopic radiofrequency ablation for the treatment of hilar non-resectable malignant bile duct obstruction显示文摘AIM: To evaluate the safety and technical success of endoscopic radiofrequency ablation(RFA) for palliative treatment of malignant hilar bile duct obstruction. METHODS: In this study, a recently CE and FDA-approved endoscopic RFA catheter was first tested in an ex vivo pig liver model to study the effect of electrosurgical variables on the extent of the area of induced necrosis. Subsequently, a retrospective analysis was conducted of all patients treated with endoscopic RFA for malignant biliary obstruction at our center between February 2012 and April 2013. All patients received an additional plastic stent implantation into the biliary tree following RFA. RESULTS: In the pig model, ablation time of 60-90 seconds using the bipolar soft coagulation mode at 8-10 watts with an effect of 8 was found to be the most feasible setting. Twelve patients(5 females, 7 males; mean age, 70 years) underwent 19 endoscopic RFA(range, 1-5) sessions. Deployment of RFA was successful in all patients. Systemic chemotherapy was administered in four patients. We observed biliary bleeding 4-6 wk after the intervention in three cases and two of these patients died: in one patient, spontaneous hemobilia occurred, whereas bleeding started during stent extraction in the other. In the third patient, bleeding was stopped by insertion of a non-covered self-expanding metal stent. Another three patients developed cholangitis during follow-up. Seven patients died during follow-up and median survival was 6.4 mo(95%CI: 0.05-12.7) from the time of the first RFA. CONCLUSION: Endoscopic RFA is an easy to perform and technically highly successful procedure. However, hemobilia possibly associated with RFA occurred in three of our patients. Therefore, larger prospective studies are needed to further evaluate the safety and efficacy of this promising new method. | Andrea Oliver Tal Johannes Vermehren Mireen FriedrichRust Jrg Bojunga Christoph Sarrazin Stefan Zeuzem Jrg Trojan Jrg Gerhard Albert | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，1： | 18 |
| 2 | Performance of Transient Elastography for the Staging of Liver Fibrosis: A Meta-Analysis显示文摘 | Mireen Friedrich–Rust Mei–Fang Ong Swantje Martens Christoph Sarrazin Joerg Bojunga Stefan Zeuzem Eva Herrmann | 2008 | Gastroenterology2008，，4： | 6 |
| 3 | Influence of antibiotic-regimens on intensive-care unit-mortality and liver-cirrhosis as risk factor显示文摘AIM: To assess the rate of infection, appropriateness of antimicrobial-therapy and mortality on intensive care unit(ICU). Special focus was drawn on patients with liver cirrhosis.METHODS: The study was approved by the local ethical committee. All patients admitted to the Internal Medicine-ICU between April 1, 2007 and December 31, 2009 were included. Data were extracted retrospectively from all patients using patient charts and electronic documentations on infection, microbiological laboratory reports, diagnosis and therapy. Due to the large hepatology department and liver transplantation center, special interest was on the subgroup of patients with liver cirrhosis. The primary statistical-endpoint was the evaluation of the influence of appropriate versusinappropriate antimicrobial-therapy on in-hospitalmortality.RESULTS: Charts of 1979 patients were available. The overall infection-rate was 53%. Multiresistantbacteria were present in 23% of patients with infection and were associated with increased mortality(p < 0.000001). patients with infection had significantly increased in-hospital-mortality(34% vs 17%, p < 0.000001). Only 9% of patients with infection received inappropriate initial antimicrobial-therapy, no influence on mortality was observed. Independent risk-factors for in-hospital-mortality were the presence of septicshock, prior chemotherapy for malignoma and infection with pseudomonas spp. Infection and mortality-rate among 175 patients with liver-cirrhosis was significantly higher than in patients without liver-cirrhosis. Infection increased mortality 2.24-fold in patients with cirrhosis. patients with liver cirrhosis were at an increased risk to receive inappropriate initial antimicrobial therapy.CONCLUSION: The results of the present study report the successful implementation of early-goal-directed therapy. Liver cirrhosis patients are at increased risk of infection, mortality and to receive inappropriate therapy. Increasing burden are multiresistant-bacteria. | Mireen Friedrich-Rust Beate Wanger Florian Heupel Natalie Filmann Reinhard Brodt Volkhard AJ Kempf Johanna Kessel Thomas A Wichelhaus Eva Herrmann Stefan Zeuzem Joerg Bojunga | 2016 | World Journal of Gastroenterology2016，22，16： | 6 |
| 4 | Contrast‐Enhanced Ultrasound for the differentiation of benign and malignant focal liver lesions: a meta‐analysis显示文摘 | Mireen Friedrich‐Rust Tom Klopffleisch Julia Nierhoff Eva Herrmann Johannes Vermehren Maximilian D. Schneider Stefan Zeuzem Joerg Bojunga | 2013 | Liver Int2013，，5： | 3 |
| 5 | EFSUMB Guidelines and Recommendations on the Clinical Use of Ultrasound Elastography. Part 1: Basic Principles and Technology显示文摘 | J. Bamber D. Cosgrove C. Dietrich J. Fromageau J. Bojunga F. Calliada V. Cantisani J.-M. Correas M. D’Onofrio E. Drakonaki M. Fink M. Friedrich-Rust O. Gilja R. Havre C. Jenssen A. Klauser R. Ohlinger A. Saftoiu F. Schaefer I. Sporea F. Piscaglia | 2013 | Ultraschall in Med2013，，02： | 2 |
| 6 | Real-time elastography for the differen- tiation of benign and malignant thyroid nodule 显示文摘 | Bojunga J Herrmann E | 2010 | Thyroid2010，20，： | 1 |
| 7 | Real-time elastography for the differentiation of benign and malignant thyroid nodules: a meta-analysis 显示文摘 | Bojunga J Herrmann E Meyer G | 2010 | Thyroid2010，20，10： | 1 |
| 8 | Severe lactic acidosis during treatment of chronic hepatitis B with entecavir in patients with impaired liver function 显示文摘 | Lange CM Bojunga J Hofmann WP | 2009 | Hepatology2009，50，6： | 1 |
| 9 | Detection of thyroid peroxidase mRNA in peripheral blood of patients with malignant and benign thyroid diseases显示文摘 | Roddiger S J Bojunga J Klee V | 2002 | Mol Endocrinol2002，29，3： | 1 |
| 10 | Urapidil in the preoperative treat-ment of pheochromocytomas: a safe and cost - effective method 显示文摘 | Habbe N Ruger F Bojunga J | 2013 | World J Surg2013，37，5： | 1 |
| 11 | Acoustic radiation forceimpulse imaging for differentiation of thyroid nodules显示文摘 | Bojunga J Dauth N Berner C | 2012 | PLoS One2012，7，42： | 1 |
| 12 | Realtime elastogra phy for the differentiation of benign and malignant thyroid nodules: ameta-analysis 显示文摘 | Bojunga J HerrmannE Meyer G | 2010 | Thyroid2010，20，10： | 1 |
| 13 | Detection of thyroid peroxidase mRNA in peripheral blood of patients with malignant and benign thyroid diseases 显示文摘 | Bojunga J Klee V | 2002 | Mol Endocrinol2002，29，3： | 1 |
| 14 | Antioxidative treatment prevents activation of death-receptor-and mitochondrion-dependent apoptosis in the hearts of diabetic rats显示文摘 | Bojunga J Nowak D Mitrou PS | 2004 | Diabetologia2004，47，12： | 1 |
| 15 | Severe 25‐hydroxyvitamin D deficiency identifies a poor prognosis in patients with hepatocellular carcinoma – a prospective cohort study显示文摘 | F. Finkelmeier B. Kronenberger V. K?berle J. Bojunga S. Zeuzem J. Trojan A. Piiper O. Waidmann | 2014 | Aliment Pharmacol Ther2014，，10： | 1 |
| 16 | Differential effects of short-term lipid lowering with Ezetimibe and statins on endothelial function in patients with CAD: Clinical evidence for pleiotropic functions of statin therapy显示文摘 | Fichtlscherer Schmidt-Lucke C Bojunga S | 2006 | Eur Heart J2006，27，10： | 1 |
| 17 | Real-time elastography for the differentiation of benign and malignant thyroid nodules : a meta-analysis显示文摘 | BOJUNGA J HERRMANN E MEYER G | 2010 | Thyroid2010，20，10： | 1 |
| 18 | Real-time elastography for the differentiation of benign and malignant thyroid nodules:ameta-analysis显示文摘 | Bojunga J Herrmann E Meyer G | 2010 | Thyroid2010，20，10： | 1 |
| 19 | Antioxidative treat- ment prevents activation of death-receptor- and mitoehondrion- dependent apoptosis in the hearts of diabetic rats 显示文摘 | Bojunga J Nowak D Mitrou P S | 2004 | Dia-betologia2004，47，12： | 1 |
| 20 | Se- vere lactic acidosis during treatment of chronic hepatitis B with enteeavir in patients with impaired liver function 显示文摘 | LANGE C M BOJUNGA J HOFMANN W P | 2009 | Hepatology2009，50，6： | 1 |
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