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| 1 | Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features显示文摘Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome (ZES). ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal re?ux disease and occasional diarrhea. Genetically, nonhereditary (sporadic) gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 (MEN1) syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors (NETs) includes 18 patients (23.4%) with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients (4.5%) suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished fromtumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functionally inactive NETs expressing gastrin, but not as gastrinomas. | Martin Anlauf Nele Garbrecht Tobias Henopp Anja Schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel | 2006 | World Journal of Gastroenterology2006，12，34： | 7 |
| 2 | Evolving role of FDG-PET/CT in prognostic evaluation of resectable gastric cancer显示文摘Gastric cancer(GC) remains a leading cause of cancer death worldwide. Radical gastrectomy is the only potentially curative treatment, and perioperative adjuvant therapies may improve the prognosis after curative resection. Prognosis largely depends on the tumour stage and histology, but the host systemic inflammatory response(SIR) to GC may contribute as well, as has been determined for other malignancies. In GC patients, the potential utility of positron emission tomography/computed tomography(PET/CT) with the imaging radiopharmaceutical 18F-fluorodeoxyglucose(FDG) is still debated, due to its lower sensitivity in diagnosing and staging GC compared to other imaging modalities. There is, however, growing evidence that FDG uptake in the primary tumour and regional lymph nodes may be efficient for predicting prognosis of resected patients and for monitoring tumour response to perioperative treatments, having prognostic value in that it can change therapeutic strategies. Moreover, FDG uptake in bone marrow seems to be significantly associated with SIR to GC and to represent an efficient prognostic factor after curative surgery. In conclusion, PET/CT technology is efficient in GC patients, since it is useful to integrate other imaging modalities in staging tumours and may have prognostic value that can change therapeutic strategies. With ongoing improvements, PET/CT imaging may gain further importance in the management of GC patients. | Emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Bruno Cola | 2017 | World Journal of Gastroenterology2017，23，38： | 5 |
| 3 | Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes显示文摘In neonates, persistent hyperinsulinemic hypoglycemia (PHH) is associated with nesidioblastosis. In adults, PHH is usually caused by solitary benign insulinomas. We report on an adult patient who suffered from insulin-de- pendent diabetes mellitus, and subsequently developed PHH caused by diffuse nesidioblastosis. Mutations of the MEN1 and Mody 2/3 genes were ruled out. Preoperative diagnostic procedures, the histopathological criteria and the surgical treatment options of adult nesidioblastosis are discussed. So far only one similar case of adult nesidioblastosis subsequent to diabetes mellitus Ⅱ has been reported in the literature. In case of conversion of diabetes into hyperinsulinemic hypoglycemia syndrome, nesidioblastosis in addition to insulinoma should be con- sidered. | A Raffel M Anlauf SB Hosch M Krausch T Henopp J Bauersfeld R Klofat D Bach CF Eisenberger G Klppel WT Knoefel | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 4 | Complications and treatment of migrated biliary endoprostheses:A review of the literature显示文摘内视镜的胆汁的斯滕特氏印模膏插入是一个生长得很好的过程。它在对待手术后的胆汁的漏缝是特别成功的,并且可以阻止外科的干预。在 3 瞬间以后的 endoprostheses 的一个平淡的变化是一个普通惯例,但是这能被延长到 6 瞬间。我们向书籍的右页 sigmoid 冒号由于胆汁的斯滕特氏印模膏脱臼和移植汇报了一个结肠的穿孔,并且考察了文学。 | Thomas Namdar Andreas Martin Raffel Stefan Andreas Topp Lisa Namdar Ingo Alldinger Marcus Schmitt Wolfram Trudo Knoefel Claus Ferdinand Eisenberger | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 5 | Simultaneous curative resection of double colorectal carcinoma with synchronous bilobar liver metastases显示文摘Synchronous colorectal carcinoma(SCRC) indicates more than one primary colorectal carcinoma(CRC) discovered at the time of initial presentation, accounts for 3.1%-3.9% of CRC, and may occur either in the same or in different colorectal segments. The accurate preoperative diagnosis of SCRC is difficult and diagnostic failures may lead to inappropriate treatment and poorer prognosis. SCRC requires colorectal resections tailored to individual patients, based on the number, location, and stage of the tumours, from conventional or extended hemicolectomies to total colectomy or proctocolectomy, when established predisposing conditions exist. The overall perioperative risks of surgery for SCRC seem to be higher than for solitary CRC. Simultaneous colorectal and liver resection represents an appealing surgical strategy in selected patients with CRC and synchronous liver metastases(CRLM), even though the cumulative risks of the two procedures need to be adequately evaluated. Simultaneous resections have the noticeable advantage of avoiding a second laparotomy, give the opportunity of an earlier initiation of adjuvant therapy, and may significantly reduce the hospital costs. Because an increasing number of recent studies have shown goodresults, with morbidity, perioperative hospitalization, and mortality rates comparable to staged resections, simultaneous procedures can be selectively proposed even in case of complex colorectal resections, including those for SCRC and rectal cancer. However, in patients with multiple bilobar CRLM, major hepatectomies performed simultaneously with colorectal resection have been associated with significant perioperative risks. Conservative or parenchymal-sparing hepatectomies reduce the extent of hepatectomy while preserving oncological radicality, and may represent the best option for selected patients with multiple CRLM involving both liver lobes. Parenchymal-sparing liver resection, instead of major or two-stage hepatectomy for bilobar disease, seemingly reduces the overall operative risk of candidates to simultaneous colorectal and liver resection, and may represent the most appropriate surgical strategy whenever possible, also for patients with advanced SCRC and multiple bilobar liver metastases. | Emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Claudio Ricci Riccardo Casadei Bruno Cola Francesco Minni | 2018 | World Journal of Gastrointestinal Oncology2018，10，10： | 3 |
| 6 | Simultaneous colorectal and parenchymal-sparing liver resection for advanced colorectal carcinoma with synchronous liver metastases:Between conventional and mini-invasive approaches显示文摘The optimal timing of surgery in case of synchronous presentation of colorectal cancer and liver metastases is still under debate.Staged approach,with initial colorectal resection followed by liver resection(LR),or even the reverse,liver-first approach in specific situations,is traditionally preferred.Simultaneous resections,however,represent an appealing strategy,because may have perioperative risks comparable to staged resections in appropriately selected patients,while avoiding a second surgical procedure.In patients with larger or multiple synchronous presentation of colorectal cancer and liver metastases,simultaneous major hepatectomies may determine worse perioperative outcomes,so that parenchymal-sparing LR should represent the most appropriate option whenever feasible.Mini-invasive colorectal surgery has experienced rapid spread in the last decades,while laparoscopic LR has progressed much slower,and is usually reserved for limited tumours in favourable locations.Moreover,mini-invasive parenchymal-sparing LR is more complex,especially for larger or multiple tumours in difficult locations.It remains to be established if simultaneous resections are presently feasible with mini-invasive approaches or if we need further technological advances and surgical expertise,at least for more complex procedures.This review aims to critically analyze the current status and future perspectives of simultaneous resections,and the present role of the available miniinvasive techniques. | Emilio De Raffele Mariateresa Mirarchi Dajana Cuicchi Ferdinando Lecce Riccardo Casadei Claudio Ricci Saverio Selva Francesco Minni | 2020 | World Journal of Gastroenterology2020，26，42： | 3 |
| 7 | Relationship between a systemic inflammatory marker,plaque inflammation,and plaque characteristics determined by intravascular optical coherence tomography显示文摘 | Raffel OC Tearney GJ Gauthier DD | 2007 | Arterioscler Thromb Vasc Biol2007，27，8： | 1 |
| 8 | Pediatric traumatic intracranial aneurysms显示文摘 | Yazbak PA McComb JG Raffel C | 1995 | Pediatr Neurosurg1995，22，1： | 1 |
| 9 | Dependence of cardiac ^11C- meta-hydroxyephedrine retention on norepinephrine transporter density显示文摘 | Raffel DM Chen W Sherman PS | 2006 | J Nucl Med2006，47，9： | 1 |
| 10 | Investigation of aerodynamic effects of coolant ejection at the T railing edge of a turbine blade model by PIV and pressure measurements显示文摘 | RAFFEL M KOST F | 1998 | Experiments in Fluids1998，24，56： | 1 |
| 11 | Subarachnoid hemor- rhage from a peripheral intracranial aneurysm associated with malignant glioma: report of a case 显示文摘 | Andrews BT Raffel C Rosegay H | 1985 | Neurosurgery1985，17，4： | 1 |
| 12 | Cardiac sympathetic dysinnervation in diabetes: implications for enhanced cardiovascular risk显示文摘 | Stevens MJ Raffel DM Allman KC | 1998 | Circulation1998，98，10： | 1 |
| 13 | Mutations in SUFU predispose to medulloblastoma 显示文摘 | Taylor MD Liu L Raffel C | 2002 | Nature Genet2002，31，3： | 1 |
| 14 | Current Microbiology显示文摘 | Laura A Silo-Suh Eric V Stabb Sandra J Raffel | 1998 | 37(1):6-111998，37，1： | 1 |
| 15 | In Vivo Diagnosis of Plaque Erosion and Calcified Nodule in Patients with Acute Coronary Syndrome by Intravascular Optical Coherence Tomography显示文摘 | Haibo Jia Farhad Abtahian Aaron D. Aguirre Stephen Lee Stanley Chia Harry Lowe Koji Kato Taishi Yonetsu Rocco Vergallo Sining Hu Jinwei Tian Hang Lee Seung-Jung Park Yang-Soo Jang Owen C. Raffel Kyoichi Mizuno Shiro Uemura Tomonori Itoh Tsunekazu Kakuta S | 2013 | Journal of the American College of Cardiology2013，，： | 1 |
| 16 | Elevated B-type natriuretic peptide despite normal left ventricular function on rest and exercise stress echocardiography in mitral regurgitation显示文摘 | Kerr AJ Raffel OC Whalley GA | 2008 | Eur Heart J2008，29，3： | 1 |
| 17 | Spontaneous recanal- ization of a coronary artery after thrombotic occlusion: in vivo demonstration with optical coherence tomography 显示文摘 | Cho JM Raffel OC Stone JR | 2010 | J Am Coil Cardiol2010，55，： | 1 |
| 18 | Cardiac sympathetic dysinnervation in diabetes impjlications for enhanced cardiovascu- lar risk显示文摘 | Stevens M J Raffel D M Allman K C | 1998 | Circulation1998，98，10： | 1 |
| 19 | Increased expression of thioredoxin - 1 in human eolorectal cancer is associated with decreased patient survival显示文摘 | Raffel J Bhattachoryya AK Gallegos A | 2003 | J Lab Clin Med2003，142，1： | 1 |
| 20 | Elevated B-type natriuretic peptide despite normal left ventricular function on rest and exercise stress echo- cardiography inmitral regurgitation 显示文摘 | KERR A J RAFFEL O C WHALLEY G A | 2008 | Eur Heart J2008，29，： | 1 |
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