|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Enhancing precision in fs-laser material processing by simultaneous spatial and temporal focusing显示文摘In recent years,femtosecond(fs)-lasers have evolved into a versatile tool for high precision micromachining of transparent materials because nonlinear absorption in the focus can result in refractive index modifications or material disruptions.However,when high pulse energies or low numerical apertures are required,nonlinear side effects such as self-focusing,filamentation or white light generation can decrease the modification quality.In this paper,we apply simultaneous spatial and temporal focusing(SSTF)to overcome these limitations.The main advantage of SSTF is that the ultrashort pulse is only formed at the focal plane,thereby confining the intensity distribution strongly to the focal volume and suppressing detrimental nonlinear side effects.Thus,we investigate the optical breakdown within a water cell by pump-probe shadowgraphy,comparing conventional focusing and SSTF under equivalent focusing conditions.The plasma formation is well confined for low pulse energies,2 mJ,but higher pulse energies lead to the filamentation and break-up of the disruptions for conventional focusing,thereby decreasing the modification quality.In contrast,plasma induced by SSTF stays well confined to the focal plane,even for high pulse energies up to 8 mJ,preventing extended filaments,side branches or break-up of the disruptions.Furthermore,while conventional focusing leads to broadband supercontinuum generation,only marginal spectral broadening is observed using SSTF.These experimental findings are in excellent agreement with numerical simulations of the nonlinear pulse propagation and interaction processes.Therefore,SSTF appears to be a powerful tool to control the processing of transparent materials,e.g.,for precise ophthalmic fs-surgery. | Robert Kammel Roland Ackermann Jens Thomas Jorg Gotte Stefan Skupin Andreas Tunnermann Stefan Nolte | 2014 | Light(Science & Applications)2014，3，1： | 11 |
| 2 | Loss of the vitamin D receptor in human breast and prostate cancers strongly induces cell apoptosis through downregulation of Wnt/β-catenin signaling显示文摘Vitamin D co-regulates cell proliferation, differentiation and apoptosis in numerous tissues, including cancers. The known anti-proliferative and pro-apoptotic actions of the active metabolite of vitamin D,1,25-dihydroxy-vitamin D [1,25(OH)2 D] are mediated through binding to the vitamin D receptor(VDR). Here,we report on the unexpected finding that stable knockdown of VDR expression in the human breast and prostate cancer cell lines, MDA-MB-231 and PC3, strongly induces cell apoptosis and inhibits cell proliferation in vitro. Implantation of these VDR knockdown cells into the mammary fat pad(MDA-MB-231),subcutaneously(PC3) or intra-tibially(both cell lines) in immune-incompetent nude mice resulted in reduced tumor growth associated with increased apoptosis and reduced cell proliferation compared with controls.These growth-retarding effects of VDR knockdown occur in the presence and absence of vitamin D and are independent of whether cells were grown in bone or soft tissues. Transcriptome analysis of VDR knockdown and non-target control cell lines demonstrated that loss of the VDR was associated with significant attenuation in the Wnt/β-catenin signaling pathway. In particular, cytoplasmic and nuclear β-catenin protein levels were reduced with a corresponding downregulation of downstream genes such as Axin2, Cyclin D1,interleukin-6(IL-6), and IL-8. Stabilization of β-catenin using the GSK-3β inhibitor BIO partly reversed the growth-retarding effects of VDR knockdown. Our results indicate that the unliganded VDR possesses hitherto unknown functions to promote breast and prostate cancer growth, which appear to be operational not only within but also outside the bone environment. These novel functions contrast with the known anti-proliferative nuclear actions of the liganded VDR and may represent targets for new diagnostic and therapeutic approaches in breast and prostate cancer. | Yu Zheng Trupti Trivedi Ruby CY Lin Colette Fong-Yee Rick Nolte Jeline Manibo Yunzhao Chen Musharraf Hossain Konstantin Horas Colin Dunstan Hong Zhou Markus J Seibel | 2017 | Bone Research2017，5，3： | 4 |
| 3 | ESPEN Guidelines on Enteral Nutrition: Liver disease显示文摘 | M. Plauth E. Cabré O. Riggio M. Assis-Camilo M. Pirlich J. Kondrup P. Ferenci E. Holm S. vom Dahl M.J. Müller W. Nolte | 2006 | Clinical Nutrition2006，，2： | 3 |
| 4 | Controlling the gelation temperature of biomimetic polyisocyanides显示文摘Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature(LCST) is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo(ethylene glycol)-substituted polyisocyanides(PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol(EG) tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels. | Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 5 | Preservatio of functional and regu latory domains of expressed bcl-2 genes in non-Hodgkins lymphoma显示文摘 | Nolte M Werner M | 1996 | Lea kemia1996，10，： | 1 |
| 6 | Long-term control of Myeobacterium tuberculosis infection is mediated by dynamic immune response显示文摘 | Lazarevic V Nolt D Flynn JL | 2005 | Immunol2005，175，5： | 1 |
| 7 | Low flow anaesthesia withisoflurane and sevoflurane in the dog显示文摘 | Kramer S Alyakine H Nolte I | 2008 | Berl Munch TierarztlWochenschr2008，121，12： | 1 |
| 8 | Diffusion mapping without susceptibility artifacts: whole brain studies using diffusion weighted single-shot STEAM MR imaging显示文摘 | Nolte VG Finsterbusch J Frahm J | 2000 | MRM2000，44，： | 1 |
| 9 | Skeletal muscle respiratory uncoupling prevents diet induced obesity and insulin resistance in mice显示文摘 | Li B Nolte L A Ju J S | 2000 | Nat Med2000，6，： | 1 |
| 10 | Putative human male germ cells from bone marrow stem cells显示文摘 | Drusenheimer N Wulf G Nolte J | 2007 | Soc Reprod Fertil Suppl2007，63，： | 1 |
| 11 | Sugar levels modulate differential expression of maize sucrose synthase genes显示文摘 | Koch K E Nolte K D Duke E R | 1992 | Plant Cell1992，，4： | 1 |
| 12 | Coronary pressure-flow relations as basis for the understanding of coronary physiology显示文摘 | Tim P. van de Hoef Froukje Nolte M. Cristina Rolandi Jan J. Piek Jeroen P.H.M. van den Wijngaard Jos A.E. Spaan Maria Siebes | 2011 | Journal of Molecular and Cellular Cardiology2011，，： | 1 |
| 13 | Use of real-time polymerase chain reaction to identify cell- and tissue-type-selec- ire peptides by phage display显示文摘 | Jaye DL Nolte FS Mazzucchelli L et ol | 2003 | Am J Pathol2003，162，5： | 1 |
| 14 | Basic principles of CAOS显示文摘 | Lutz P Nolte | 2004 | Injury2004，35，： | 1 |
| 15 | Systemic and splanchnic endotoxin-1 plasma levels in liver cirrhosis before and after transjugular intrahepatic portosystemic shunt(TIPS)显示文摘 | NOLTE W EHRENREICH H WILTFANG J | 2000 | Liver2000，20，： | 1 |
| 16 | Ropivacaine for spinal anesthesia,a dose finding study显示文摘 | Wabedi W Nolte H | 1996 | Anaesthesist1996，45，： | 1 |
| 17 | Effect of the Valsalva ma- neuver on cardiac - coronary interaction assessed by wave intensity analysis显示文摘 | Rolandi M Remmelink M Nolte F | 2010 | Conf Proc IEEE Eng Med Biol Soc2010，2010，： | 1 |
| 18 | Femtosecond, picosecond and nanosecond laser ablation of solids 显示文摘 | CHICHKOV B N MOMMA C NOLTE S | 1996 | Applied Physics A1996，63，： | 1 |
| 19 | Regula- tion of GLUT4 biogenesis in muscle:evidence for involve- ment of ampk and ca2~ 显示文摘 | OJUKA E O JONES T E NOLTE L A | 2001 | Am J Phy2001，282，5： | 1 |
| 20 | Highly polar organic compounds present in meat smoke显示文摘 | Nolte C G Schauer J J Cass G R | 1999 | Environment Science Technology1999，33，19： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员