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| 1 | Liver biochemistry profile,significance and endoscopic management of biliary tract complications post orthotopic liver transplantation显示文摘AIM: To correlate the significance of liver biochemical tests in diagnosing post orthotopic liver transplantation (OLT) biliary complications and to study their profile before and after endoscopic therapy. METHODS: Patients who developed biliary complications were analysed in detail for the clinical information,laboratory tests,treatment offered,response to it,follow up and outcomes. The profile of liver enzymes was determined. The safety,efficacy and outcomes of endoscopic retrograde cholangiography (ERC) were also analysed. RESULTS: 40 patients required ERC for 70 biliary complications. GGT was found to be > 3 times (388.1 ± 70.9 U/mL vs 168.5 ± 34.2 U/L,P = 0.007) and SAP > 2 times (345.1 ± 59.1 U/L vs 152.7 ± 21.4 U/L,P = 0.003) the immediate post OLT values. Most frequent complication was isolated anastomotic strictures in 28 (40%). Sustained success was achieved in 26 (81%) patients. CONCLUSION: Biliary complications still remain an important problem post OLT. SAP and GGT can be used as early,non-invasive markers for diagnosis and also to assess the adequacy of therapy. Endoscopic management is usually effective in treating the majority of these biliary complications. | Yogesh M Shastri Nicolas M Hoepffner Bora Akoglu Christina Zapletal Wolf O Bechstein Wolfgang F Caspary Dominik Faust | 2007 | World Journal of Gastroenterology2007，13，20： | 6 |
| 2 | SEMS vs cSEMS in duodenal and small bowel obstruction:High risk of migration in the covered stent group显示文摘AIM:To compare clinical success and complications of uncovered self-expanding metal stents(SEMS)vs covered SEMS(cSEMS)in obstruction of the small bowel.METHODS:Technical success,complications and outcome of endoscopic SEMS or cSEMS placement in tumor related obstruction of the duodenum or jejunum were retrospectively assessed.The primary end points were rates of stent migration and overgrowth.Secondary end points were the effect of concomitant biliary drainage on migration rate and overall survival.The data was analyzed according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines.RESULTS:Thirty-two SEMS were implanted in 20 patients.In all patients,endoscopic stent implantation was successful.Stent migration was observed in 9 of16 cSEMS(56%)in comparison to 0/16 SEMS(0%)implantations(P=0.002).Stent overgrowth did not significantly differ between the two stent types(SEMS:3/16,19%;cSEMS:2/16,13%).One cSEMS dislodged and had to be recovered from the jejunum by way of laparotomy.Time until migration between SEMS and cSEMS in patients with and without concomitant biliary stents did not significantly differ(HR=1.530,95%CI0.731-6.306;P=0.556).The mean follow-up was 57±71 d(range:1-275 d).CONCLUSION:SEMS and cSEMS placement is safe in small bowel tumor obstruction.However,cSEMS is accompanied with a high rate of migration in comparison to uncovered SEMS. | Oliver Waidmann Jrg Trojan Mireen Friedrich-Rust Christoph Sarrazin Wolf Otto Bechstein Frank Ulrich Stefan Zeuzem Jrg Gerhard Albert | 2013 | World Journal of Gastroenterology2013，19，37： | 4 |
| 3 | Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis显示文摘 | Sven Jonas Wolf O. Bechstein Thomas Steinmüller Martin Herrmann Cornelia Radke Thomas Berg Utz Settmacher Peter Neuhaus | 2001 | Hepatology2001，，5： | 4 |
| 4 | Einteilung und Behandlung von Gallengangverletzungen nach laparoskopischer Cholecystektomie显示文摘 | P. Neuhaus S. C. Schmidt R. E. Hintze A. Adler W. Veltzke R. Raakow J. M. Langrehr W. O. Bechstein | 2000 | Der Chirurg2000，，2： | 3 |
| 5 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial显示文摘 | Gunnar Folprecht Thomas Gruenberger Wolf O Bechstein Hans-Rudolf Raab Florian Lordick J?rg T Hartmann Hauke Lang Andrea Frilling Jan Stoehlmacher Jürgen Weitz Ralf Konopke Christian Stroszczynski Torsten Liersch Detlev Ockert Thomas Herrmann Eray Goekkurt | 2010 | Lancet Oncology2010，，1： | 3 |
| 6 | Effect of thrombectomy on oedema progression and clinical outcome in patients with a poor collateral profile显示文摘Background and purpose The impact of the cerebral collateral circulation on lesion progression and clinical outcome in ischaemic stroke is well established.Moreover,collateral status modifies the effect of endovascular treatment and was therefore used to select patients for therapy in prior trials.The purpose of this study was to quantify the effect of vessel recanalisation on lesion pathophysiology and clinical outcome in patients with a poor collateral profile.Materials and methods 129 patients who had an ischaemic stroke with large vessel occlusion in the anterior circulation and a collateral score(CS)of 0-2 were included.Collateral profile was defined using an established 5-point scoring system in CT angiography.Lesion progression was determined using quantitative lesion water uptake measurements on admission and follow-up CT(FCT),and clinical outcome was assessed using modified Rankin Scale(mRS)scores after 90 days.Results Oedema formation in FCT was significantly lower in patients with vessel recanalisation compared with patients with persistent vessel occlusion(mean 19.5%,95%CI:17%to 22%vs mean 27%,95%CI:25%to 29%;p<0.0001).In a multivariable linear regression analysis,vessel recanalisation was significantly associated with oedema formation in FCT(ß=−7.31,SD=0.015,p<0.0001),adjusted for CS,age and Alberta Stroke Program Early CT Score(ASPECTS).Functional outcome was significantly better in patients following successful recanalisation(mRS at day 90:4.5,IQR:2-6 vs 5,IQR:5-6,p<0.001).Conclusion Although poor collaterals are known to be associated with poor outcome,endovascular recanalisation was still associated with significant oedema reduction and comparably better outcome in this patient group.Patients with poor collaterals should not generally be excluded from thrombectomy. | Gabriel Broocks Andre Kemmling Tobias Faizy Rosalie McDonough Noel Van Horn Matthias Bechstein Lukas Meyer Gerhard Schon Jawed Nawabi Jens Fiehler Helge Kniep Uta Hanning | 2021 | Stroke & Vascular Neurology2021，6，2： | 2 |
| 7 | Recurrent hepatocellular carcinoma after liver transplantation – an emerging clinical challenge显示文摘 | Martin‐Walter Welker Wolf‐Otto Bechstein Stefan Zeuzem Joerg Trojan | 2012 | Transplant International2012，，2： | 2 |
| 8 | Diagnosis of and Therapy for Hepatocellular Carcinoma显示文摘 | T. Greten N. Malek S. Schmidt J. Arends P. Bartenstein W. Bechstein T. Bernatik M. Bitzer A. Chavan M. Dollinger D. Domagk O. Drognitz M. Düx S. Farkas G. Folprecht P. Galle M. Gei?ler G. Gerken D. Habermehl T. Helmberger K. Herfarth R. Hoffmann M. Holtma | 2013 | Z Gastroenterol2013，，11： | 1 |
| 9 | Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis显示文摘 | Jonas S Bechstein WO Steinmuller T | 2001 | Hepatology2001，33，： | 1 |
| 10 | Trends and perspectives in pancreas and simultaneous pancreas-kidney transplantation 显示文摘 | Kahl A Bechstein WO Frei U | 2001 | Curr Opin Urol2001，11，2： | 1 |
| 11 | Tumor necrosis factor-alpha during continuous high-flux hemodialysis in sepsis with acute renal failure显示文摘 | Lonnemann G Bechstein M Linnenweber S | 1999 | Kidney Int Suppl1999，，72： | 1 |
| 12 | Complement and Neutrophil Function Changes After Liver Resection in Humans显示文摘 | Christoph Werner Strey Britta Siegmund Saskia Rosenblum Rosa Maria Marquez-Pinilla Elsie Oppermann Markus Huber-Lang John D. Lambris Wolf O. Bechstein | 2009 | World Journal of Surgery2009，，12： | 1 |
| 13 | Technique and results of biliary reconstruction using side-to-side choledochocholedochostomy in 300 orthotopic liver transplants 显示文摘 | Neuhaus P Blumhardt G Bechstein WO | 1994 | Ann Surg1994，219，4： | 1 |
| 14 | Posthepatectomy liver failure显示文摘 | SCHRECKENBACH T LIESE J BECHSTEIN W O MOENCH C | 2012 | Dig Surg2012，29，： | 1 |
| 15 | Extended resections for hilar cholangiocarcinoma显示文摘 | Neuhaus P Jonas S Bechstein WO | 1999 | Annals of Surgery1999，，03： | 1 |
| 16 | Increased Serum Levels of C-Reactive Protein Precede Anastomotic Leakage in Colorectal Surgery显示文摘 | Guido Woeste Christine Müller Wolf O. Bechstein Christoph Wullstein | 2010 | World Journal of Surgery2010，，1： | 1 |
| 17 | Extended resections for hilar cholangiocarcinoma 显示文摘 | Neuhaus P Jonas S Bechstein WO | 1999 | Ann Surg1999，230，6： | 1 |
| 18 | Recurrence-free survival after liver transplantation for small hepatocellular carcinoma显示文摘 | Bechstein WO Guckelberger O Kling N | 1998 | Transpl Int1998，11，： | 1 |
| 19 | Tumor necrosis factor-alpha during continuous high -flux hemodialysis in sepsis with acute renal failure显示文摘 | Lonnemann G Bechstein M Linnenweber S | 1999 | Kidney Int1999，56，7： | 1 |
| 20 | Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial 显示文摘 | Folprecht G Gruenberger T Bechstein WO | 2010 | Lancet Oncol2010，11，1： | 1 |
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