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| 1 | Phased,chromosome-scale genome assemblies of tetraploid potato reveal a complex genome,transcriptome,and predicted proteome landscape underpinning genetic diversity显示文摘Cultivated potato is a clonally propagated autotetraploid species with a highly heterogeneous genome.Phased assemblies of six cultivars including two chromosome-scale phased genome assemblies revealed extensive allelic diversity,including altered coding and transcript sequences,preferential allele expression,and structural variation that collectively result in a highly complex transcriptome and predicted proteome,which are distributed across the homologous chromosomes.Wild species contribute to the extensive allelic diversity in tetraploid cultivars,demonstrating ancestral introgressions predating modern breeding efforts.As a clonally propagated autotetraploid that undergoes limited meiosis,dysfunctional and deleterious alleles are not purged in tetraploid potato.Nearly a quarter of the loci bore mutations are predicted to have a high negative impact on protein function,complicating breeder’s efforts to reduce genetic load.The StCDF1 locus controls maturity,and analysis of six tetraploid genomes revealed that 12 allelic variants of StCDF1 are correlated with maturity in a dosage-dependent manner.Knowledge of the complexity of the tetraploid potato genome with its rampant structural variation and embedded deleterious and dysfunctional alleles will be key not only to implementing precision breeding of tetraploid cultivars but also to the construction of homozygous,diploid potato germplasm containing favorable alleles to capitalize on heterosis in F1 hybrids. | Genevieve Hoopes Xiaoxi Meng John P.Hamilton Sai Reddy Achakkagari Fernanda de Alves Freitas Guesdes Marie E.Bolger Joseph J.Coombs Danny Esselink Natalie R.Kaiser Linda Kodde Maria Kyriakidou Brian Lavrijssen Natascha van Lieshout Rachel Shereda Heather K.Tuttle Brieanne Vaillancourt Joshua C.Wood Jan Mde Boer Nolan Bornowski Peter Bourke David Douches Herman Jvan Eck Dave Ellis Max J.Feldman Kyle M.Gardner Johannes C.P.Hopman Jiming Jiang Walter S.De Jong Joseph C.Kuhl Richard G.Novy Stan Oome Vidyasagar Sathuvalli Ek Han Tan Remco A.Ursum M.Isabel Vales Kelly Vining Richard G.F.Visser Jack Vossen G.Craig Yencho Noelle L.Anglin Christian W.B.Bachem Jeffrey B.Endelman Laura M.Shannon Martina V.Stromvik Helen H.Tai Bjorn Usadel C.Robin Buell Richard Finkers | 2022 | Molecular Plant2022，15，3： | 4 |
| 2 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 3 |
| 3 | Bilateral uveitis associated with nivolumab therapy for metastatic melanoma: a case report显示文摘Dear Editor,I am Dr.Daniel Russell Richardson from the West Virginia University Eye Institute in Morgantown,West Virginia,United States.I write to present a case of uveitis associated with nivolumab,which is a promising new immune checkpoint inhibitor(ICI)for metastatic melanoma and non-small cell lung carcinoma with expanding indications.As the use of nivolumab continues to increase,ophthalmologists must be aware of uveitis as an adverse event.Modulating | Daniel Russell Richardson Brian Ellis Inderjit Mehmi Monique Leys | 2017 | International Journal of Ophthalmology(English edition)2017，10，7： | 3 |
| 4 | Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites显示文摘 | Brian K. Zebrowski MD Wenbiao Liu MD Karen Ramirez BS Yoshito Akagi MD Gordon B. Mills MD Lee M. Ellis MD | 1999 | Annals of Surgical Oncology1999，，4： | 2 |
| 5 | Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano ?(Revised)显示文摘 | Mark H. Whiteford M.D. John Kilkenny M.D. Neil Hyman M.D. W. Donald Buie M.D. Jeffrey Cohen M.D. Charles Orsay M.D. Gary Dunn M.D. W. Brian Perry M.D. C. Neal Ellis M.D. Jan Rakinic M.D. Sharon Gregorcyk M.D. Paul Shellito M.D. Richard Nelson M.D. Joe J. | 2005 | Diseases of the Colon & Rectum2005，，7： | 2 |
| 6 | Proof of super valent doping in olivine LiFePO4 显示文摘 | Marnix Wagemaker Brian L Ellis | 2008 | Chem Mater2008，，20： | 1 |
| 7 | Positive electrode materials for Li-Ion and Li-batteries显示文摘 | Ellis Brian L Lee Kyu Tae Nazar Linda F | 2010 | Chemistry of Materials2010，22，3： | 1 |
| 8 | PositiveElect rode Materials for Li-Ion and Li-Batteries显示文摘 | Brian L Ellis Kyu Tae Lee Linda F Nazar | | 0，，03： | 1 |
| 9 | Robust simple sequence repeat markers for spruce (Picea spp.) from expressed sequence tags显示文摘 | Dainis Rungis Yanik Bérubé Jun Zhang Steven Ralph Carol E. Ritland Brian E. Ellis Carl Douglas J?rg Bohlmann Kermit Ritland | 2004 | Theoretical and Applied Genetics2004，，6： | 1 |
| 10 | Plant residue chemistry impacts soil processes and microbial community structure: A study with Arabidopsis thaliana cell wall mutants显示文摘 | Shamim Gul Joann K. Whalen Brian E. Ellis Sue J. Grayston | 2012 | Applied Soil Ecology2012，，： | 1 |
| 11 | 1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R )-hydroxy- N -pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c ]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor o显示文摘 | Donald J.P. Pinto Michael J. Orwat Mimi L. Quan Qi Han Robert A. Galemmo Eugene Amparo Brian Wells Christopher Ellis Ming Y. He Richard S. Alexander Karen A. Rossi Angela Smallwood Pancras C. Wong Joseph M. Luettgen Alan R. Rendina Robert M. Knabb Lawrenc | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，15： | 1 |
| 12 | Plant residue chemistry impacts soil processes and microbial community structure: A study with Arabidopsis thaliana cell wall mutants显示文摘 | Shamim Gul Joann K. Whalen Brian E. Ellis Sue J. Grayston | 2012 | Applied Soil Ecology2012，，： | 1 |
| 13 | Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano ?(Revised)显示文摘 | Mark H. Whiteford John Kilkenny Neil Hyman W. Donald Buie Jeffrey Cohen Charles Orsay Gary Dunn W. Brian Perry C. Neal Ellis Jan Rakinic Sharon Gregorcyk Paul Shellito Richard Nelson Joe J. Tjandra Graham Newstead | 2005 | Diseases of the Colon & Rectum2005，，7： | 1 |
| 14 | Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance显示文摘 | James A. McCubrey Linda S. Steelman William H. Chappell Stephen L. Abrams Ellis W.T. Wong Fumin Chang Brian Lehmann David M. Terrian Michele Milella Agostino Tafuri Franca Stivala Massimo Libra Jorg Basecke Camilla Evangelisti Alberto M. Martelli Richard | 2006 | BBA - Molecular Cell Research2006，，8： | 1 |
| 15 | Composition of gestational weight gain impacts maternal fat retention and infant birth weight显示文摘 | Nancy F Butte Kenneth J Ellis William W Wong Judy M Hopkinson E.O’Brian Smith | 2003 | American Journal of Obstetrics and Gynecology2003，，： | 1 |
| 16 | Mitogen-activated protein kinase cascades in plants: a new nomenclature显示文摘 | MAPK Group (Kazuya Ichimura et al.) Kazuya Ichimura Kazuo Shinozaki Guillaume Tena Jen Sheen Yves Henry Anthony Champion Martin Kreis Shuqun Zhang Heribert Hirt Cathal Wilson Erwin Heberle-Bors Brian E Ellis Peter C Morris Roger W Innes Joseph R Ecker Die | 2002 | Trends in Plant Science2002，，7： | 1 |
| 17 | 显示文摘 | Ellis Brian L Lee Kyu Tae Nazar Linda F | 2010 | Chem Mater2010，22，3： | 1 |
| 18 | Practice Parameters for the Treatment of Perianal Abscess and Fistula-in-Ano ?(Revised)显示文摘 | Mark H. Whiteford M.D. John Kilkenny M.D. Neil Hyman M.D. W. Donald Buie M.D. Jeffrey Cohen M.D. Charles Orsay M.D. Gary Dunn M.D. W. Brian Perry M.D. C. Neal Ellis M.D. Jan Rakinic M.D. Sharon Gregorcyk M.D. Paul Shellito M.D. Richard Nelson M.D. Joe J. | 2005 | Diseases of the Colon & Rectum2005，，7： | 1 |
| 19 | Hepatic and renal pathology of intraperitoneally administered microcystin-LR in rainbow trout ( Oncorhynchus mykiss )显示文摘 | Brian G. Kotak Souleh Semalulu David L. Fritz Ellie E. Prepas Steve E. Hrudey Robert W. Coppock | 1996 | Toxicon1996，，5： | 1 |
| 20 | Markedly Elevated Levels of Vascular Endothelial Growth Factor in Malignant Ascites显示文摘 | Brian K. Zebrowski MD Wenbiao Liu MD Karen Ramirez BS Yoshito Akagi MD Gordon B. Mills MD Lee M. Ellis MD | 1999 | Annals of Surgical Oncology1999，，4： | 1 |
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