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| 1 | 他汀、高密度脂蛋白胆固醇与冠状动脉粥样硬化消退显示文摘背景:他汀类药物可以降低低密度脂蛋白胆固醇(low—density lipoprotein cholesterol,LDL—C)水平并减缓冠状动脉粥样硬化的进展。然而,对于他汀类药物所致高密度脂蛋白胆固醇(high—density lipoprotein cholesterol,HDL—C)变化与疾病进展的关系,目前仍无相关数据描述。目的:了解LDL—C和HDL—C水平变化与动脉粥样硬化的相互关系。设计、地点及患者:对4项前瞻性随机试验(1999~2005年在美国、北美、欧洲和澳大利亚进行)的原始数据进行事后分析。其中1455例经血管造影证实的冠心病患者在接受他汀治疗(18个月或24个月)时进行了系列血管内超声扫描。所有超声分析均在相同的核心实验室中进行。主要观测指标:脂蛋白水平变化与冠状动脉粥样斑块体积的相互关系。结果:他汀治疗期间,LDL—C平均(SD)水平从124.0(38.3)mg,/dL(3.2[0.99]mmol/L)降至87.5(28.8)mg,/dL(2.3[0.75]mmol/L)(下降23.5%;P〈0.001),HDL—C水平从42.5(11.0)mg/dL(1.1[0.28]mmol/L)升至45.1(11.4)mg/dL(1.2[0.29]mmol/L)(上升7.5%;P〈0.001)。LDL—C与HDL—C比值从平均(SD)3.0(1.1)降至2.1(0.9)(下降26.7%;P〈0.001)。这些变化同时伴随平均(SD)百分粥样斑块体积的增加(从39.7%[9.8%]增至40.1%[9.7%])(增加0.5%[3.9%];P=0.001)以及平均(SD)总粥样斑块体积的减小(2.4[23.6]mm^3;P〈0.001)。在单变量分析中,LDL—C、总胆固醇、非HDL胆固醇、载脂蛋白B以及载脂蛋白B与载脂蛋白A-1比值平均水平和治疗引起的变化与动脉粥样硬化进展速率显著相关,而治疗所致HDL—C变化则与动脉粥样斑块体积负相关。在多变量分析中,平均LDL—C水平(β系数,0.11[95%可信区间,0.07~0.15])以及HDL—C升高(β系数,-0.26[95%可信区间,-0.41--0.10])依然为动脉粥样硬化消退的独立预测因子。动脉硬化显著消退(动脉粥样斑块体积减少≥5%)见于治疗期间LDL—C水平低于均值(87.5mg/dL)和HDL—C升高百分比大于均值(7.5%;P〈0.001)的患者。临床事件的发生未见显著差异。结论:在LDL—C显著降低以及HDL上升〉7.5%时,他汀治疗与冠状动脉粥样硬化消退相关。这些结果提示他汀治疗的获益源自致动脉粥样硬化脂蛋白的降低以及HDL.C的升高。尽管血脂水平的这些变化与动脉粥样硬化消退相关,但是后者是否可以转化为临床事件的显著减少,并改善临床预后仍有待进一步研究确定。 | Stephen J. Nicholls, MBBS, PhD E. Murat Tuzcu, MD IIke Sipahi, MD Adam W. Grasso, MD Paul Schoenhagen, MD Tingfei Hu, MS Kathy Wolski, MPH Tim Crowe, BS Milind Y. Desai, MD Stanley L. Hazen, MD, PhD Samir R. Kapadia, MD Steven E. Nissen, MD 李呈亿(译) | 2007 | 美国医学会杂志(中文版)2007，26，3： | 48 |
| 2 | Fluorescence enhancement effect and the interaction between donor and acceptor显示文摘A new theoretical equation for fluorescence enhancement effect between donor and acceptor has been introduced.By using it we determined the binding constants and numbers of binding sites of five medicines,including chlorogenic acid,forsythiaside norfloxacin,Ciprofloxacin and fluorenone,to γ-globulin. | Yang, P Yang, MM Yang, BS | 1996 | Chinese Journal of Chemistry1996，14，2： | 23 |
| 3 | 2019年美国突发性聋临床实践指南(更新版)显示文摘突发性聋(sudden hearing loss,SHL)是一种容易引起患者恐慌并紧急求医的疾病,患者常伴有耳鸣和/或眩晕,患病率为5~27/10万,美国每年新增约6.6万例。本指南适用于年龄≥18岁的患者,为SHL的患者诊断、治疗和随访提供了最新的循证建议。 | 钟萍 卢兢哲(编译) 郑芸 刘蓬(审校) Chandrasekhar SS Tsai Do BS Schwartz SR | 2020 | 听力学及言语疾病杂志2020，28，4： | 14 |
| 4 | 目击者实施心肺复苏(CPR)应减少障碍显示文摘心脏骤停(sudden cardiac arrest,SCA)在美国及加拿大是导致死亡的首要原因。在美国,每年约有33万人因冠心病死于院外或急诊室,其中〉15万例心脏骤停发生于院外。虽然已经推出了电击除颤以及近年来实施了目击者除颤方案,但大多数患者未能存活至到达医院。近15年的研究表明,在美国加州的洛杉矶,院外心脏骤停的患者中约1.4%可存活至出院;在伊利诺州的芝加哥为2%;在密执安州的底特律〈1%。 | Abella BS Aufderheide TP Eigel B 钱方毅(译) 李宗浩(译) | 2008 | 中国急救复苏与灾害医学杂志2008，3，11： | 13 |
| 5 | 维生素C在应激管理中的作用显示文摘维生素C在应激管理中的作用BalkarS.Bains著周桂莲摘译高宇清校在养禽生产实践中,常用“应激”一词来描述某些环境因素或非特异性因素对禽类的影响。特别是在没有确切诊断方法或有效治疗及预防措施时,应激是一种可供选择的补救方法。生理应激在商业化家禽... | Bain.,BS 周桂莲 | 1996 | 国外畜牧科技1996，23，6： | 5 |
| 6 | Prevalence of fatty liver in Japanese children and relationship to obesity显示文摘 | Kunihiko Tominaga MD Dr Ph John H. Kurata PhD Dr. Yang K. Chen MD Edward Fujimoto DHSc MPH Shouhei Miyagawa Ichiro Abe MSA Yoshimasa Kusano BS | | Digestive Diseases and Sciences0，，： | 5 |
| 7 | 中国六城市多种危险因素对脑血管病影响的分析(病例—对照研究)显示文摘本文对我国六城市神经系病流调发现的脑血管病(CVD)435例进行了病例及对照多种危险因素影响分析。系在单因素分析基础上用 Logistic 逐步回归方法。结果说明高血压史为各类 CVD 的最危险因素,CVD 家族史、糖尿病史、过食咸食、心脏病史分别为所有 CVD、脑梗塞、出血性 CVD、TIA 的主要危险因素。 | 欧阳珊 王可嘉 Schoenberg BS Dambrosia JM Price TR 李世绰 王忠诚 程学铭 | 1991 | 中风与神经疾病杂志1991，8，3： | 4 |
| 8 | Expression of matrix metallo-proteinase-28 in human normal cytotrophoblast cells and a choriocarcinoma cell line,JEG-3显示文摘There are striking similiarities present between the behavior of invasive placentaL cells and that of invasive cancer cells. Matrix metalloproteinases (MMPs) are one of the most important mediators. MMP-28, the new member of MMPs, was sequenced and identified recently. Expression of MMP-28 mRNA and protein in the cytotrophoblast cells and a choriocarcinoma cell line, JEG-3 cell, was conducted by zymography, RT-PCR and Northern blot. There is MMP-28 mRNA expression in both the cytotrophoblast cells and JEG-3 cells by RT-PCR. The activity of MMP-28 in cytotrophoblast cells was significantly weaker than that in JEG-3 (P < 0.01) by zymography. Furthermore, mRNA expression of MMP-28 was significantly stronger (P < 0.001) in JEG-3 than in human cytotrophoblast cells in a time-dependent way by Northern Blot. Our results suggest that MMP-28 may play a role in some of the tissue-remodeling events associated with normal pregnancy and tumor progression. | Zhang, J Cao, YJ Liu, WM Zhao, BS Zeng, GQ Duan, EK | 2002 | Chinese Science Bulletin2002，47，9： | 4 |
| 9 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 10 | Associations of subtypes of hemoglobin with aminolevulinic acid dehydratase genotype and dimercaptosuccinic acid-chelatable lead levels显示文摘 | Schwartz BS Lee BK Stwart W | 1997 | Arch Environ Health1997，52，： | 3 |
| 11 | Thermal Enhancement of New Chemotherapeutic Agents at Moderate Hyperthermia显示文摘 | Faheez Mohamed MBChB MRCS Pierre Marchettini MD O. Anthony Stuart BS M. Urano MD Paul H. Sugarbaker MD FACS FRCS | 2003 | Annals of Surgical Oncology2003，，4： | 3 |
| 12 | ASYMPTOTIC STABILITY FOR GAUSS METHODS FOR NEUTRAL DELAY DIFFERENTIAL EQUATIONS显示文摘In [4] we proved that all Gauss methods areNT(O)-compatible for neutral delay differential equations (NDDEs) of the form where a, b, c are real, r > 0, g(t) is a continuous real valued function. In this paper we are going to use the theory of order stars to characterize the asymptotic stability properties of Gauss methods for NDDEs. And then proved that all Gauss methods are Nr(0)-stable. | Sidibe, BS Liu, MZ | 2002 | Journal of Computational Mathematics2002，20，2： | 3 |
| 13 | 一种应用光学相干断层扫描报道黄斑增厚改变的标准化方法显示文摘目的:描述一种应用光学相干断层扫描(OCT)报道黄斑增厚定量改变的标准化方法。
方法:我们所推荐的方法由以下内容组成:用OCT计算中心凹增厚的实际改变值(治疗前的原始厚度减去治疗后的厚度)并除以可能变化值(治疗前的原始厚度减去根据标准值确定的正常厚度)。作为总体黄斑水肿改善的百分比。我们将这种方法称为标准化黄斑增厚改变(SCMT)。为阐明这种方法的有效性。我们对2项评价不同治疗方案治疗顽固性黄斑水肿的研究作了回顾性复阅。
结果:接受玻璃体内注射丙酮化曲安奈德治疗顽固性糖尿病黄斑水肿的患者在1,3和6个月随诊检查时的总体SCMT值分别近似为75%。78%和55%。研究组中超过半数的(16例患者中的9例)患者在末次随访时的SCMT大于80%。接受玻璃体切割手术治疗牵拉性增厚的后部玻璃体膜患者oCT显示在3个月和末次随诊(平均数,19个月)时SCMT好转分别大约是78%和87%。对激光光凝不敏感但没有玻璃体黄斑牵拉迹象而接受玻璃体切割手术治疗糖尿病性黄斑水肿的患者在3个月和末次随诊(平均数。17个月)时SCMT分别是37%和20%。
结论:我们所推荐的这种方法为评价和比较不同治疗方案的功效提供了一种客观而又直观的准则。 | Annie Chan, BS Jay S. Duker 耿韶辉(译) 申敏如(校) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 3 |
| 14 | 气候对苜蓿夏收干物质产量的影响显示文摘 | Shar.,BS 蒲金涌 | 1990 | 国外农学(农业气象)1990，，1： | 2 |
| 15 | Brain renin-angiotensin system and ouabain-induced sympathetic hyperactivity and hypertension in Wistar rats 显示文摘 | Huang BS Leenen FHH | 1999 | hypertension1999，34，1： | 2 |
| 16 | 过套管电阻率测井:二维和三维失真及校正技术显示文摘最近几年,过套管电阻率测量证实了由Alpin(1939)提出并得到Kaufman(1990)和Vail(1991)确认和完善的一种独特的构想。一种工业用测井仪器已能用来监测生产井、控制注水以及寻找在废弃井和生产井中的死油气。这项具有广阔潜在市场的新技术鼓舞了许多作者去研究它的可能性和局限性。过套管电阻率测量技术有几个困难。信号电平一般在nV范围内,用直流电仪器记录如此的信号有困难。 | Sing.,BS 徐飒 | 1996 | 测井科技1996，，4： | 2 |
| 17 | Safety monitoring of the coliseum technique for heated intraoperative intraperitoneal chemotherapy with mitomycin C显示文摘 | O. Anthony Stuart BS Arvil D. Stephens BS Laura Welch MD Paul H. Sugarbaker MD | 2002 | Annals of Surgical Oncology2002，，2： | 2 |
| 18 | 可靠性、维修性和安全性系统设计与研制的重要因素显示文摘在过去的许多工程项目中,一直没有成功地将可靠性、维修性和安全性(RMS)要求综合到新系统的设计(或已有系统的再设计)过程中。结果使得系统的寿命周期费用非常高,而且许多正在使用的系统既没有满足用户的期望,也没有实现经济有效的使用与保障。在RMS领域,任何一种方法都要求在工程项目的开始就要明确和规定RMS要求,并在以后通过适当的系统工程过程实现这些要求的综合。讨论RMS要求以及系统寿命周期过程中的相关活动,重点放在系统设计与研制的早期阶段。 | 甘茂治 Blan.,BS | 1998 | 中国机械工程1998，9，12： | 2 |
| 19 | TIS10,a phorbol ester tumour promoter-inducible mRNA from swiss 3T3 cells encodes a novel prostaglandin synthese/cyclooxygenase homologue显示文摘 | Kujubu DA Fletcher BS Varnum BC | 1991 | J Biol Chem1991，266，12： | 2 |
| 20 | Allogeneic partially HLA-matched dendritic cells pulsed with autologous tumor cell lysate as a vaccine in metastatic renal cell cancer显示文摘 | Anne Fl?rcken Joachim Kopp Antje van Lessen Kamran Movassaghi Anna Takvorian Korinna J?hrens Markus M?bs Constanze Sch?nemann Birgit Sawitzki Karl Egerer Bernd D?rken Antonio Pezzutto J?rg Westermann | 2013 | Human Vaccines & Immunotherapeutics2013，，： | 2 |
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