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| 1 | MELD score can predict early mortality in patients with rebleeding after band ligation for variceal bleeding显示文摘AIM:To investigate the outcomes,as well as risk factors for 6-wk mortality,in patients with early rebleeding after endoscopic variceal band ligation (EVL) for esophageal variceal hemorrhage (EVH).METHODS:Among 817 EVL procedures performed for EVH between January 2007 and December 2008,128 patients with early rebleeding,defined as rebleeding within 6 wk after EVL,were enrolled for analysis.RESULT:The rate of early rebleeding after EVL for acute EVH was 15.6% (128/817).The 5-d,6-wk,3-mo,and 6-mo mortality rates were 7.8%,38.3%,55.5%,and 58.6%,respectively,in these early rebleeding patients.The use of beta-blockers,occurrence of hypovolemic shock,and higher model for end-stage liver disease (MELD) score at the time of rebleeding were independent predictors for 6-wk mortality.A cut-off value of 21.5 for the MELD score was found with an area under ROC curve of 0.862 (P < 0.001).The sensitivity,specificity,positive predictive value,and negative predictive value were 77.6%,81%,71.7%,and 85.3%,respectively.As for the 6-mo survival rate,patients with a MELD score ≥ 21.5 had a significantly lower survival rate than patients with a MELD score < 21.5 (P < 0.001).CONCLUSION:This study demonstrated that the MELD score is an easy and powerful predictor for 6-wk mortality and outcomes of patients with early rebleeding after EVL for EVH. | Chun-Yen Lin I-Shyan Sheen Tsung-Nan Lin Chun-Jung Lin Wen-Juei Jeng Chien-Hao Huang Yu-Pin Ho Cheng-Tang Chiu | 2011 | World Journal of Gastroenterology2011，17，16： | 18 |
| 2 | Is p53 gene mutation an indicatior of the biological behaviors of recurrence of hepatocellular carcinoma?显示文摘AIM: To evaluate mutant p53 gene in primary hepatocellular carcinoma and to investigate the correlation between it and the recurrence of hepatocellular carcinoma.METHODS: Mutations of p53 gene were examined using antihuman p53 monoclonal antibody and immunohistochemical staining in 79 resected hepatocellular carcinomas. The correlations among variables of p53 positivity and invasiveness, disease free interval and survival were studied.In addition, in those who developed recurrence, the correlation among p53 positivity, clinical features and postrecurrence survival were also studied.RESULTS: Of these 79 cases, 64 (81%) had p53 mutation.Those patients with mutant p53 positivityhad significantly more tumor recurrence (76.6 % vs 40.0 %, P=0.0107).However, the COX proportional hazards model showed that p53 overexpression had only weak correlations with recurrence free interval and survival time (P=0.088 and 0.081), which was probably related to the short duration of follow-up. The invasiveness variables may be predictors of HCC recurrence. On univariate analysis, more patients with mutant p53 positivity had vascular permeation [78.1vs 40.0 %, P=0.0088, O.R. (odds ratio) =5.3], grade Ⅱ-ⅣV differentiation (98.4 vs 80.0 %, P=0.0203, O.R. =15.7), no complete capsule (82.8 vs 53.3 %, P=0.0346, O.R. =4.2)and daughter nodules (60.9 vs. 33.3 %, P=0.0527, O.R.=3.1) than patients with negative p53 staining. Onmultivariate analysis, only vascular permeation and grade of differentiation remained significant (P=0.042 and 0.012).There was no statistically significant correlation betweenthe status of p53 in the primary lesion and the clinical features of recurrent hepatocellular carcinomas examined,including extrahepatic metastasis (P=0.1103) and the number of recurrent tumors (P= 1.000) except for diseaseover more than one segment in the extent of recurrent tumors (P=0.0043). The post-recurrence median survival was lower in patients in whom p53 mutation had been detected in the primary lesion with a weak significance (3.42 months vs 11.0 months, P=0.051).
CONCLUSION: Our findings suggest that p53 mutation correlates significantly with invasiveness including vascular permeation, grade of cellular differentiation, incomplete capsule and multinodular lesions. Hepatocellular carcinomas with p53 mutations had more tumor recurrence and p53mutation may also influence disease recurrence interval and survival time. Hepatocellular carcinomas with p53 mutations recur more extensively with a shorter survival. Therefore,p53 mutation in the primary lesion is useful as an indicator of the biological behavior of recurrent hepatocellular carcinomas. | I-Shyan Sheen Kuo-Shyang Jeng Ju-Yann Wu | 2003 | World Journal of Gastroenterology2003，9，6： | 14 |
| 3 | Is the expression of γ-glutamyl transpeptidase messenger RNA an indicator of biological behavior in recurrent hepatocellular carcinoma?显示文摘AIM: To investigate the correlation between gammaglutamyl transpeptidase (γ-GTP) expression in the primary HCC and post-resection recurrence and its biological behaviors.METHODS: Forty consecutive patients having curative resection for HCC were included in this study. The primers for reverse-transcription polymerase chain reaction (RTPCR) were corresponding to the 5'-noncoding human γ-GTP mRNA of fetal liver (type A), HepG2 cells (type B),and placenta (type C). Both the cancer and non-cancerous tissues of the resected liver were analyzed. The correlations between the expression of γ-GTP and the clinicopathological variables and outcomes (recurrence and survival) were studied.RESULTS: Those with type B γ-GTP mRNA in cancer had significant higher recurrence rate than those without it (63.6 % vs 14.3 %). Both those with type B in cancer and in non-cancer died significantly more than those without it (45.5 % vs 0 % and 53.6 % vs 0 %, respectively). By multivariate analysis, the significant predictors of recurrence included high serum AFP (P=0.0108), vascular permeation (P=0.0084), and type B γ-GTP mRNA in non-cancerous liver (P=0.0107). The significant predictors of postrecurrence death included high serum AFP (P=0.0141),vascular permeation (P=0.0130), and daughter nodules (P=0.0053). As to the manifestations (recurrent number ≥2, recurrent extent≥2 segments, extra-hepatic metastasis, and death) in recurrent patients, there were no statistical significant differences between those with type B in the primary tumor and those without it. The difference between those with type B in non-cancerous liver and those without it also was not significant.CONCLUSION: Patients of HCC with type B γ-GTP mRNA both in cancer and in non-cancerous tissue had a worse outcome, earlier recurrence, and more post-recurrence death. | I-Shyan Sheen Kuo-Shyang Jeng Yi-Chun Tsai | 2003 | World Journal of Gastroenterology2003，9，3： | 14 |
| 4 | 外语教学中使用对比分析的优势显示文摘在70年代的北美,语言教学材料中的对比分析输入语言(CA input)遭到了否定,这种否定不是由实验数据表明了它的不适当而引起的,而是由它跟受攻击的结构法(structural method)有密切联系而引起的。80年代由于Dulay、Butr和Krashen(1982)的误差分析(Error Analysis)研究结果得到了选择性的引用,它在该领域中的“不受欢迎”地位得到了进一步“加强”。但是,尤其在欧洲,有关归纳法和演绎法的比较研究并没有证实这些研究结果,这些比较研究表明,以对比分析和解释为基础的演绎法最有效。与此同时,第二语言习得(SLA)领域的研究人员重新对负向转移,即现在所称的跨语言影响(Crosslinguistic InfIuence(CUI))产生了兴趣,但他们的发现尚未对教材编写产生影响。因此,我们有必要对外语教学中对比分析输入语言的有效性重新进行评估。这里所报告的实验研究就是为了满足这种需要而做的。本研究假设,使用对比分析输入语言的演绎法在减少误差率(error rates)方面比不使用对比分析输入语言的归纳法更有效。研究结果不仅证实了假设,也给外语教学提供了启发。 | Ronald Sheen 黄子东 | 1998 | 外语教学理论与实践1998，，1： | 7 |
| 5 | IFN-a production by human mononuclear cells infected with varicella-zoster virus through TLR9-dependent and-independent pathways显示文摘Understanding the defense mechanisms of the host of an organism is important for infection control.In previous studies,we demonstrated that interferon-a(IFN-a),but not IL-12,was produced by human peripheral blood mononuclear cells infected with varicella-zoster virus(VZV).Here,we investigated what kind of cell(s)and which signal molecule(s)are involved in IFN-a production.Using cell isolation and ELISA,we found that plasmacytoid dendritic cells(pDCs)were responsible for IFN-a production during VZV infection.We also found that Toll-like receptor 9(TLR9)was involved in VZV-induced IFN-a production because inhibitory CpG oligodeoxynucleotide inhibited IFN-a production.UV-inactivated VZV-induced IFN-a production was lower than that of active VZV,indicating another TLR9-independent pathway.Further studies demonstrated that double-stranded RNA-dependent protein kinase,but not DNA-dependent protein kinase was involved in VZV-induced IFN-a production.Together,these results suggest that pDCs play an important role in IFN-a production during VZV infection through TLR9-dependent and-independent pathways. | Hong-Ren Yu Hsin-Chun Huang Ho-Chang Kuo Jiunn-Ming Sheen Chia-Yo Ou Te-Yao Hsu Kuender D Yang | 2011 | Cellular & Molecular Immunology2011，8，2： | 7 |
| 6 | Long-term outcome after spontaneous HBeAg seroconversion in patients with chronic hepatitis B显示文摘 | Yao-Shih Hsu Rong-Nan Chien Chau-Ting Yeh I-Shyan Sheen Hung-Yi Chiou Chia-Ming Chu Yun-Fan Liaw | 2002 | Hepatology2002，，6： | 6 |
| 7 | Risks of rapid decline renal function in patients with type 2 diabetes显示文摘Progressive rising population of diabetes and related nephropathy, namely, diabetic kidney disease and associated end stage renal disease has become a major global public health issue. Results of observational studies indicate that most diabetic kidney disease progresses over decades; however, certain diabetes patients display a rapid decline in renal function, which may lead to renal failure within months. Although the definition of rapid renal function decline remained speculative, in general,it is defined by the decrease of estimated glomerular filtration rate(e GFR) in absolute rate of loss or percent change. Based on the Kidney Disease: Improving Global Outcomes 2012 clinical practice guidelines, a rapid decline in renal function is defined as a sustained declinein e GFR of > 5 m L/min per 1.73 m2 per year. It has been reported that potential factors contributing to a rapid decline in renal function include ethnic/genetic and demographic causes, smoking habits, increased glycated hemoglobin levels, obesity, albuminuria, anemia, low serum magnesium levels, high serum phosphate levels, vitamin D deficiency, elevated systolic blood pressure, pulse pressure, brachial-ankle pulse wave velocity values, retinopathy, and cardiac autonomic neuropathy. This article reviews current literatures in this area and provides insight on the early detection of diabetic subjects who are at risk of a rapid decline in renal function in order to develop a more aggressive approach to renal and cardiovascular protection. | Yi-Jing Sheen Wayne HH Sheu | 2014 | World Journal of Diabetes2014，5，6： | 5 |
| 8 | Quality of life assessment in patients with chronic pancreatitis receiving antioxidant therapy显示文摘AIM:To undertake a baseline study comparing quality of life(QoL) in patients with chronic pancreatitis(CP) on Antox to those with CP,matched for disease duration,who were not on this medication.METHODS:CP was defined according to the Zurich classification.Sixty eight consecutive patients with CP who were taking Antox(antioxidants) were compared with 69 consecutive control CP patients not on Antox.European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core questions 30 and Pancreatic Modification(28 questions) were used to assess QoL.Out of a total of 137 patients 28 in each group were matched for disease duration(within 12 mo).Median disease duration was 8(1-22) years in the Antox group and 7(1-23) years in the Non-Antox cohort(P = NS,Mann-Whitney U-test).Other parameters(age,gender,etiology,endocrine and exocrine insufficiency) were similar between groups.RESULTS:Median visual analogue pain score in the Antox group was 3(0-8) compared with 6(0-8) in the Non-Antox group(P < 0.01).Perceptions of cognitive,emotional,social,physical and role function were impaired in the Non-Antox group compared to Antox patients(P < 0.0001,P = 0.0007,P = 0.0032 and P < 0.005 and P < 0.001,respectively).Analgesics and opiate usage was significantly lower in the Antox group(P < 0.01).Overall physical health and global QoL was better in the Antox group(P < 0.0001,95% CI:1.5-3).CONCLUSION:Contemporary quality of life assessments show that after correction for disease duration and cigarette smoking,patients with CP taking antox had better scores than non-antox controls. | Nehal S Shah Alistair J Makin Aali J Sheen Ajith K Siriwardena | 2010 | World Journal of Gastroenterology2010，16，32： | 4 |
| 9 | Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma显示文摘 | Jaw-Ching Wu Yi-Hsiang Huang Gar-Yang Chau Chien-Wei Su Chung-Ru Lai Pui-Ching Lee Teh-Ia Huo I-Jane Sheen Shou-Dong Lee Wing-Yiu Lui | 2009 | Journal of Hepatology2009，，5： | 4 |
| 10 | Topological and evolutional relationships between HCV core protein and hepatic lipid vesicles: Studies in vitro and in conditionally transgenic mice显示文摘AIM: To investigate a specific association between hepatic steatosis and hepatitis C virus (HCV) core. METHODS: HeLa cells and primary mouse hepatocytes were transfected with HCV core plasmid, and conditional transgenics in which hepatic over-expression of HCV core is regulated by the tetracycline-off system, were developed. The expression of the HCV core was assessed over one to six months after withdrawal of doxycycline (dox) by immunohistochemistry (IHC) and Western blotting and by sequential liver biopsy. Hepatic steatosis was evaluated using oil red stain. 8-hydroxydeoxyguanosine (8-OHdG) stains and caspase levels were conducted to clarify hepatic oxidative stress and apoptosis rate. Serum aminotransferase was checked. RESULTS: The transfected hepatocytes had globular cores under the lipid vesicles. In transgenic mice on control diet, core expression was robust, localized to the cytoplasmic vesicle membrane and strongly associatedwith microvesicular steatosis, which was gradually replaced by macrovesicular steatosis. However, both steatosis and core positive hepatocytes diminished with time. Increases in aminotransferase, caspase and 8-OHdG were associated with peak core expression. CONCLUSION: The core protein was readily detected and morphologically associated with steatosis in individual hepatocytes both in vitro and in vivo. In vivo, oxidative stress caused by the core potentially reduced the number of core positive hepatocytes and in parallel the level of steatosis. To our knowledge, this is the f irst animal model that directly shows topological relationship between HCV core and hepatic lipid vesicles. | Ming-Ling Chang Jeng-Chang Chen Chau-Ting Yeh I-Shyan Sheen Dar-In Tai Ming-Yu Chang Cheng-Tang Chiu Deng-Yn Lin D Montgomery Bissell | 2007 | World Journal of Gastroenterology2007，13，25： | 4 |
| 11 | The effects of focused and unfocused written corrective feedback in an English as a foreign language context显示文摘 | Rod Ellis Younghee Sheen Mihoko Murakami Hide Takashima | 2008 | System2008，，3： | 3 |
| 12 | Interferon therapy in HBeAg positive chronic hepatitis reduces progression to cirrhosis and hepatocellular carcinoma显示文摘 | Shi-Ming Lin Ming-Lung Yu Chuan-Mo Lee Rong-Nan Chien I-Shyan Sheen Chia-Ming Chu Yun-Fan Liaw | 2006 | Journal of Hepatology2006，，1： | 3 |
| 13 | Genotypes and Viremia of Hepatitis B and D Viruses Are Associated With Outcomes of Chronic Hepatitis D Patients显示文摘 | Chien–Wei Su Yi–Hsiang Huang Teh–Ia Huo Hsuan Hui Shih I–Jane Sheen Su–Wen Chen Pui–Ching Lee Shou–Dong Lee Jaw–Ching Wu | 2006 | Gastroenterology2006，，6： | 3 |
| 14 | Are gap junction gene connexins 26,32 and 43 of prognostic values in hepatocellular carcinoma?A prospective study显示文摘AIM: To investigate the prognostic value of the expression of connexin (Cx) 26, 32 and 43 messenger RNA (mRNA) in hepatocellular carcinoma (HCC) tissues. METHODS: Using a reverse-transcriptase polymerase chain reaction (RT-PCR), Cx 26, Cx 32 and Cx 43 mRNAs were determined in the liver tissues of 15 controls and in HCC tissues of 25 patients undergoing curative hepatic resection. The patients were followed up clinically.RESULTS: Cx 26 and Cx 32 mRNAs were significantly lower in HCC tissues compared with controls (both P<0.01). By multivariate analysis, a lower level of Cx 26 and Cx 32 mRNA correlated significantly with a risk of HCC recurrence (P = 0.033) and recurrence-related mortality (P = 0.031,P= 0.031). Cx 43 mRNA was higher in HCC tissues compared with controls but did not correlate with postoperative recurrence or recurrence-related mortality. Other significant predictors of HCC recurrence included cellular dedifferentiation (P = 0.033), less encapsulation (P = 0.050), vascular permeation (P= 0.046), and daughter nodules (P= 0.046). Significant variables related to recurrence-related mortality consisted of cell dedifferentiation (P = 0.031), vascular permeation (P = 0.048), and daughter nodules (P = 0.048).The levels of Cx 26 and Cx 32 mRNAs correlated significantly with cell differentiation (P= 0.031). CONCLUSION: A low expression of Cx 26 and Cx 32 mRNAs in HCC tissues is predictive of postoperative recurrence of HCCs. | I-Shyan Sheen Kuo-Shyang Jeng Po-Chuan Wang Shou-Chuan Shih Wen-Hsing Chang Horng-Yuan Wang Chung-Chu Chen Li-Rung Shyung | 2004 | World Journal of Gastroenterology2004，10，19： | 2 |
| 15 | Prolonged Rapamycin Treatment Inhibits mTORC2 Assembly and Akt/PKB显示文摘 | Dos D. Sarbassov Siraj M. Ali Shomit Sengupta Joon-Ho Sheen Peggy P. Hsu Alex F. Bagley Andrew L. Markhard David M. Sabatini | 2006 | Molecular Cell2006，，2： | 2 |
| 16 | Reduction of fiber alignment shift in add/drop filter module packaging显示文摘 | Kuang J H Sheen M T Chen J M | 2001 | Lasers and Electro-Optics2001，2，： | 2 |
| 17 | Endless Hide-and-Seek: Dynamic Co-evolution in Plant-Bacterium Warfare显示文摘植物拥有天生的免疫系统阻止很潜在的感染。古老、保存的天生的免疫反应被联系微生物的分子的模式(MAMP ) 触发并且在用途广泛的防卫起重要作用。然而,成功的细菌的病原体发展了类型 III 毒力受动器压制调停 MAMP 的免疫。幸存,植物进一步开发了高度特定的抵抗(R) 基因触发 gene-for-gene-mediatedimmunity 并且把剧毒的病原体变成无毒害的。我们这里在植物细菌相互作用的这动态 coevolution 总结最近的进展。 | Libo Shan Ping He Jen Sheen | 2007 | Journal of Integrative Plant Biology2007，49，1： | 2 |
| 18 | Non-fluorinated superamphiphobic surfaces through sol-gel processing of methyltriethoxysilane and tetraethoxysilane 显示文摘 | SHEEN Y C CHANG W H CHEN W C | 2009 | Materials Chemistry and Physics2009，114，1： | 1 |
| 19 | A Prospective Randomized Comparison of Bilateral Subtotal Thymidectomy Versus Unilateral Total and Contralateral Subtotal Thyroidectomy for Graves,diseaso显示文摘 | Hsei KC Sheen SM | 2005 | World J Surg2005，29，2： | 1 |
| 20 | Intrahepatic cholangiocarcinoma in hepatolithiasis: a frequently overlooked disease显示文摘 | Sheen Chen Sm Chou FF Eng HL | 1991 | J Surg Oncol1991，47，： | 1 |
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