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| 1 | Thioredoxins Play a Crucial Role in Dynamic Acclimation of Photosynthesis in Fluctuating Light显示文摘 | Ina Thormahlen Arkadius Zupok Josephin Rescher Jochen Leger Stefan Weissenberger Julia Groysman Anne Orwat Gilles Chatel-lnnocenti Emmanuelle Issakidis-Bourguet Ute Armbruster Peter Geigenberger | 2017 | Molecular Plant2017，10，1： | 4 |
| 2 | Redox Regulation of Arabidopsis Mitochondrial Citrate Synthase显示文摘柠檬酸盐 synthase 在 tricarboxylic (TCA ) 有一个关键角色所有有机体的线粒体骑车,当它催化是在 oxaloacetate 和乙酰 CoA 之间的一张 carboncarbon 契约的熔化的首先承诺的步。TCA 周期功能的规定在植物是特别重要的,自从活动不得不与光合作用被协调的 mitochondrial。在植物的 TCA 周期活动的 posttranslational 规定几乎因此是远的完全未经勘探。尽管几 TCA 周期酶在 vitro 作为 thioredoxin 目标被识别了,为喀尔文周期知道的任何 thioredoxin 依赖的规定的存在,还尚待被示威。这里,我们由它的六半胱氨酸残余的指导地点的 mutagenesis 调查了 Arabidopsis 柠檬酸盐 synthase 酶的氧化还原作用规定。我们的结果显示氧化由混合二硫化物的形成禁止酶活动,当部分氧化的柠檬酸盐 synthase 酶形成大氧化还原作用依赖者总数。而且,我们能证明 thioredoxin 能象分子间的二硫化物桥一样劈开多样的 intra- ,它强烈提高酶的活动。有酶的半胱氨酸变体的活动大小揭示了影响全部的酶活动以及酶的氧化还原作用敏感的重要半胱氨酸残余。 | Elisabeth Schmidtmann Ann-Christine Konig Anne Orwat Dario Leister Markus Hartl Iris Finkemeier | 2014 | Molecular Plant2014，7，1： | 2 |
| 3 | Discovery of 1-(4-methoxyphenyl ) -7-oxo-6-( d-( 2-oxopiperidin-1-yl ) phenyl )-4,5,6, 7-tetrahydro-1 H-pyrazolo pyridine-3 -carboxamide ( apixa- ban, BMS-562247 ) , a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa 显示文摘 | PINTO JP D ORWAT JM KOCH S | 2007 | J Med Chem2007，50，22： | 1 |
| 4 | 1-(4-Methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo pyridine-3-carboxamide (Apixaban,BMS-562247),a highly potent,selective,efficacious,and orally bioavailable inhibitor of blood coagulation factor Xa显示文摘 | Pinto DJ Orwat MJ Koch S | 2007 | J Med Chem2007，50，22： | 1 |
| 5 | Discovery of 1- -N-3-fluro-2'-( methylsulfonyl) - -4 - yl ] -3 - ( trifluoromethyl ) -1 - H-pyrazole-5-carboxamide( DPCA23 ), a highly potent, selective, and orally vioavailable inhibitor of blood co- agulation factor xa'显示文摘 | Donald J P Pinto Michael J Orwat | 2001 | Journal of Medicinal Chemistry2001，44，4： | 1 |
| 6 | Discovery of 1-(4-methoxy- phenyl ) -7-oxo-6- ( 4-( 2-oxopiperidin-1 -yl ) phenyl ) 4,5,6,7- tetrahydro-lH-pyrazolo pyridine-3-carboxamide ( apixa- ban, BMS-562247 ), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa 显示文摘 | Pinto DJ Orwat MJ Koch S | 2007 | J Med Chem2007，50，22： | 1 |
| 7 | 1-[3-Aminobenzisoxazol-5′-yl]-3-trifluoromethyl-6-[2′-(3-( R )-hydroxy- N -pyrrolidinyl)methyl-[1,1′]-biphen-4-yl]-1,4,5,6-tetrahydropyrazolo-[3,4- c ]-pyridin-7-one (BMS-740808) a highly potent, selective, efficacious, and orally bioavailable inhibitor o显示文摘 | Donald J.P. Pinto Michael J. Orwat Mimi L. Quan Qi Han Robert A. Galemmo Eugene Amparo Brian Wells Christopher Ellis Ming Y. He Richard S. Alexander Karen A. Rossi Angela Smallwood Pancras C. Wong Joseph M. Luettgen Alan R. Rendina Robert M. Knabb Lawrenc | 2006 | Bioorganic & Medicinal Chemistry Letters2006，，15： | 1 |
| 8 | Discovery of 1- -N-3-fluro-2'-(methylsulfonyl)- -4-y1] -3(tfifluoromethyl)-1-H-pyrazole-5-carboxamide(DPC423),a highly potent,selective,and orally bioavailable inhibitor of blood coagulation factor xa'显示文摘 | DONALD J P MICHAEL J ORWAT J | 2001 | Journal of Medicinal Chemistry2001，44，4： | 1 |
| 9 | Discovery of l-(4-Methoxyphenyl)7-ox o-6-(4-(2-oxopiperidin-1yl)phenyl)-4,5,6,7-tetrahydro 1 H-pyrazolo[3,4-c]pyridine-3carboxamide (Apixaban,BMS562247),a Highly Potent,Selective,Efficacious,and Orally Bioavailable Inhibitor of Blood Coagulation Factor Xa显示文摘 | Pinto DJ Orwat MJ Koch S | | 0，，22： | 1 |
| 10 | Discovery of 1-(4- methoxyphenyl)-7-oxo-6-( 4 ( 2-oxopiperidin-1 yl) phenyl )-4, 5,6,7 tetrahydro-1 H-pyrazolo pyridine-3 carhoxamide (apixaban, BMS-562247), a highly potent, selective, effica-cious, and orally bioavailable inhibitor of blood coagulation factor Xa显示文摘 | Pinto D J P Orwat M J Koch S | 2007 | J Med Chem2007，50，22： | 1 |
| 11 | Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl) phenyl)-4,5,6,7-tetrahydro-1 H-pyrazolopyridine-3-carboxamide (Apixaban,BMS-562247),a highly potent,selective,efficacious,and orally bioavailable inhibitor of blood coagulation factor Xa显示文摘 | Pinto DJ Orwat MJ Koch S | 2007 | J Med Chem2007，50，22： | 1 |
| 12 | Discovery of l--N-3- fluro-2'-(methylsul fonyl)--4-y 1 ]-3- (trifluoromethyl)- 1-H-pyrazole-5-carboxamide(DPC423), a Highly Potent, Selective, and Orally Bioavailable Inhibitor'of Blood Coagulation Factor Xa'显示文摘 | PINTO D P ORWAT M J | 2001 | Journal of Medicinal Chemistry2001，44，4： | 1 |
| 13 | Discovery of 1-(4- methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-l-yl)phenyl)- 4,5,6,7-tetrahydro- 1H-pyrazolo pyridine-3 -carbox- amide (apixaban, BMS-562247), a highly potent, selec- tive, efficacious, and orally bioavailable inhibitor of blood coagulation factor X a 显示文摘 | Pinto D J Orwat MJ Koch S | 2007 | J Med Chem2007，50，22： | 1 |
| 14 | Discovery of 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin- 1-yl) phenyl)-4,5,6,7-tetrahydro-lH-pyrazolopyridine-3- carboxamide (apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor X a 显示文摘 | Pinto D J Orwat M J Koch S | 2007 | J Med Chem2007，50，22： | 1 |
| 15 | Towards per- vasive computing in health care -- A literature review 显示文摘 | ORWAT C GRAEFE A FAULWASSER T | 2008 | BMC Medical Informatics and Decision Making2008，8，1： | 1 |
| 16 | La ser-ultrasonic generation of Lamb waves in the reac tion force range显示文摘 | SHI Yijun WOOH Shi-chang ORWAT Mark | 2003 | Ultrasonics2003，41，： | 1 |
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