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您的检索式：作者名="Stanley L Fan"
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| 1 | Increasing the use of biocompatible,glucose-free peritoneal dialysis solutions显示文摘A major concern inhibiting some clinicians from embracing peritoneal dialysis(PD) as the preferred first modality of dialysis is the effects of PD solutions on the peritoneal membrane. These anatomical and functional changes predispose to complications like peritonitis,encapsulating peritoneal sclerosis and ultrafiltration failure. In recent years, 'biocompatible' and glucosesparing PD regimens have been developed to minimize damage to the peritoneal membrane. Can the use of these more expensive solutions be justified on current evidence? In this review of the literature, we explore how we may individualize the prescription of biocompatible PD fluid. | Ahad Qayyum Elizabeth Ley Oei Klara Paudel Stanley L Fan | 2015 | World Journal of Nephrology2015，4，1： | 10 |
| 2 | Is overhydration in peritoneal dialysis patients associated with cardiac mortality that might be reversible?显示文摘AIM To study the relationship between overhydration(OH) in peritoneal dialysis(PD) patients and cardiac mortality.METHODS OH, as measured by body composition monitor(BCM), is associated with increased mortality in dialysis patients. BCM has been used to guide treatment on the assumption that correcting OH will improve cardiac morbidity and mortality although data demonstrating causality that is reversible is limited. We wished to determine if OH in PD patients predicted cardiac mortality, and if there was a correlation between OH and cardiac troponin-T(cT n T) levels. Finally, we wished to determine if improving OH values would lead to a decrement in cT n T. All prevalent PD patients over the study period of 57 mo who had contemporaneous BCM and cT nT measurements were followed irrespective of transplantation or PD technique failure. We also studied a cohort of patients with who had severe OH(> +2L).The Fresenius Body Composition Monitor was used to obtain hydration parameters. cT nT levels were done as part of routine clinical care. Data was analysed using SPSS version 20.0.RESULTS There were 48 deaths in the 336 patients. The patients that died from cardiac or non-cardiac causes were similar with respect to their age, incidence of diabetes mellitus, gender, ethnicity and cause of renal failure. However, the patients with cardiac causes of death had significantly shorter dialysis vintage(10.3 mo vs 37.0 mo, P < 0.0001) and were significantly more overhydrated by BCM measurement(2.95 L vs 1.35 L, P < 0.05). The mean(standard error of the means) hydration status of the 336 patients was +1.15(0.12) L and the median [interquartile range(IQR)] cT nT level was 43.5(20-90) ng/L. The cT nT results were not normally distributed and were therefore transformed logarithmically. There was a statistically significant correlation between Log(cT nT) with the OH value(Spearman r value 0.425, P < 0.0001). We identified a sub-group of patients that were severely overhydrated; median(IQR) hydration at baseline was +2.7(2.3 to 3.7) L. They were followed up for a minimum of 6 mo. Reduction in OH values in these patients over 6 mo correlated with lowering of cT nT levels(Spearman r value 0.29, P < 0.02). CONCLUSION Patients that were overhydrated had higher cT nT, and had deaths that were more likely to be cardiac related. Reduction in OH correlated with lowering of cT nT. | Elizabeth Oei Klara Paudel Annemarie Visser Hazel Finney Stanley L Fan | 2016 | World Journal of Nephrology2016，5，5： | 4 |
| 3 | 骨扫描下的横纹肌溶解症显示文摘一例伴高胆固醇血症的血液透析患者因左下肢溃疡被收住院。入院不久,患者感觉全身疼痛、行动困难。因怀疑下肢溃疡并发骨髓炎行99Tc标记的二磷酸盐骨扫捕。扫描结果届示受损肌肉大量摄入99Tc标记的二磷酸盐,符合横纹肌溶解征象(附图)。血清肌酸激酶水平显著升高。阿伐他汀(患者在家并未服用该药,入院后才开始服用)可能是引起横纹肌溶解的原因。停用阿伐他汀后患者症状与牛化指标迅速恢复正常:1个月后复查99Tc同位素扫捕正常。骨质摄入99Tc标记的二磷酸盐的分布经γ闪烁照相检测正常。 | Stephen Walsh Stanley L Fan 李豪刚(译) | 2009 | 世界临床医学2009，3，2： | 0 |
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