|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Botulinum toxin injections after surgery for Hirschsprung disease:Systematic review and meta-analysis显示文摘BACKGROUND A large proportion of patients with Hirschsprung disease experience persistent obstructive symptoms after corrective surgery.Persistent obstructive symptoms may result in faecal stasis that can develop into Hirschsprung-associated enterocolitis,a potential life-threatening condition.Important treatment to improve faecal passage is internal anal sphincter relaxation using botulinum toxin injections.AIM To give an overview of all empirical evidence on the effectiveness of botulinum toxin injections in patients with Hirschsprung disease.METHODS A systematic review and meta-analysis was done by searching PubMed,EMBASE and the Cochrane Library,using entry terms related to:(1)Hirschsprung disease;and(2)Botulinum toxin injections.14 studies representing 278 patients met eligibility criteria.Data that were extracted were proportion of patients with improvement of obstructive symptoms or less enterocolitis after injection,proportion of patients with adverse effects and data on type botulinum toxin,mean dose,average age at first injection and patients with associated syndromes.Random-effects meta-analysis was used to aggregate effects and random-effects meta-regression was used to test for possible confounding factors.RESULTS Botulinum toxin injections are effective in treating obstructive symptoms in on average 66%of patients[event rate(ER)=0.66,P=0.004,I2=49.5,n=278 patients].Type of botulinum toxin,average dose,average age at first injections and proportion of patients with associated syndromes were not predictive for this effect.Mean 7 duration of improvement after one botulinum toxin injections was 6.4 mo and patients needed on average 2.6 procedures.There was a significant higher response rate within one month after botulinum toxin injections compared to more than one month after Botulinum toxin injections(ER=0.79,vs ER=0.46,Q=19.37,P<0.001).Botulinum toxin injections were not effective in treating enterocolitis(ER 0.58,P=0.65,I2=71.0,n=52 patients).There were adverse effects in on average 17%of patients(ER=0.17,P<0.001,I2=52.1,n=187 patients),varying from temporary incontinence to mild anal pain.CONCLUSION Findings from this systematic review and meta-analysis indicate that botulinum toxin injections are effective in treating obstructive symptoms and that adverse effects were present,but mild and temporary. | Danielle Roorda Zarah AM Abeln Jaap Oosterlaan Lodewijk WE van Heurn Joep PM Derikx | 2019 | World Journal of Gastroenterology2019，25，25： | 4 |
| 2 | A Pilot Study on the Noninvasive Evaluation of Intestinal Damage in Celiac Disease Using I-FABP and L-FABP显示文摘 | Joep P. M. Derikx Anita C. E. Vreugdenhil Anita M. Van den Neucker Joep Grootjans Annemarie A. van Bijnen Jan G. M. C. Damoiseaux L. W. Ernest van Heurn Erik Heineman Wim A. Buurman | 2009 | Journal of Clinical Gastroenterology2009，，8： | 2 |
| 3 | The value of machine perfusion perfusate biomarkers for predicting kidney transplant outcome 显示文摘 | Moers C Varnav OC Van Heurn E | 2010 | Transplantation2010，90，9： | 1 |
| 4 | Antioxidant peptides isolated from the marine rotifer,Brachionus rotundiformis显示文摘 | Hee-Guk Byun Jung Kwon Lee Heurn Gi Park | 2009 | Process Biochemistry2009，44，： | 1 |
| 5 | Non -heartbeating donation of kidneys for transplantation 显示文摘 | Kootstra G van Heurn E | 2007 | Nat Clin Pract Nephrol2007，3，3： | 1 |
| 6 | Traumatic dissection and thrombosis of the popliteal artery in a child显示文摘 | J.-M. Bakia J.H.M. Tordoir L.W.E. van Heurn | 2012 | Journal of Pediatric Surgery2012，，6： | 1 |
| 7 | Biological modulation of renal ischemia-reperfusion injury显示文摘 | Snoeijs MG van Heurn LW Buurman WA | | 0，，02： | 1 |
| 8 | kidney transplantation: results and measures to improve outcome显示文摘 | Hoogland E R Snoeijs M G van Heurn LWDCD | 2010 | Curr Opin Organ Transplant2010，15，2： | 1 |
| 9 | The value of machine perfusion perfusate biomarkers for predicting kidney transplant outcome显示文摘 | Moers C Varnav OC van Heurn E | 2010 | Transplantation2010，90，9： | 1 |
| 10 | Prospective randomized trial of high versus low vaccum drainage after axillary lymphadenectomy显示文摘 | Brink PR | 1995 | Br J Surg1995，82，： | 1 |
| 11 | Kidney donation from children after cardiac death显示文摘 | de Vries EE Snoeijs MG van Heurn E | 2010 | Crit Care Med2010，38，1： | 1 |
| 12 | Preservation techniques for donors after cardiac death kidneys显示文摘 | Wind J Hoogland ERP van Heurn LWE | 2011 | Cur Opin Organ Transplant2011，16，： | 1 |
| 13 | Controlled donation after cardiac death:a European perspective显示文摘 | Snoeijs MG van Heurn LW van Mook WNKA | | 0，，： | 1 |
| 14 | Machine perfusion viability testing显示文摘 | van Smaalen TC Hoogland ER van Heurn LW | 2013 | Curt Opin Organ Transplant2013，18，2： | 1 |
| 15 | Biological modula- tion of renal ischemia-reperfusion injury 显示文摘 | Snoeijs MG van Heurn LW Buurman WA | 2010 | Curr Opin Organ Transplant2010，15，2： | 1 |
| 16 | Non-heartbeating donation of kidneys for transplantation显示文摘 | Kootstra G van Heurn E | 2007 | Nat Clin Pract Nephrol2007，3，3： | 1 |
| 17 | Transplantation: prolonged agonal time-not a contraindication for transplantation 显示文摘 | van Heurn LW | 2011 | Nat Rev Nephrol2011，7，8： | 1 |
| 18 | Anomalies associated with oesophageal atresia in Asians and Europeans显示文摘 | Van Heurn LW Cheng W De Vries B | 2002 | Pediatr Surg Int2002，18，4： | 1 |
| 19 | Cholangitis after hepatic portoenterostomy for biliary atresia: A multivariate analysis of risk factors显示文摘 | Ernest van Heurn LW Saing H Tam PK | 2003 | J Pediatr2003，142，5： | 1 |
| 20 | Biological modulation of renal ischemia-reperfusion injury显示文摘 | Snoeijs MG van Heurn LW Buurman WA | | 0，，02： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员