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| 1 | Life and death at the mucosal-luminal interface: New perspectives on human intestinal ischemia-reperfusion显示文摘Intestinal ischemia is a frequently observed phenomenon. Morbidity and mortality rates are extraordinarily high and did not improve over the past decades. This is in part attributable to limited knowledge on the pathophysiology of intestinal ischemia-reperfusion(IR) in man, the paucity in preventive and/or therapeutic options and the lack of early diagnostic markers for intestinal ischemia. To improve our knowledge and solve clinically important questions regarding intestinal IR, we developed a human experimental intestinal IR model. With this model, we were able to gain insight into the mechanisms that allow the human gut to withstand short periods of IR without the development of severe inflammatory responses. The purpose of this review is to overview the most relevant recent advances in our understanding of the pathophysiology of human intestinal IR, as well as the(potential) future clinical implications. | Joep Grootjans Kaatje Lenaerts Wim A Buurman Cornelis HC Dejong Joep PM Derikx | 2016 | World Journal of Gastroenterology2016，22，9： | 11 |
| 2 | 早期生态免疫肠内营养对梗阻性黄疸患者术后免疫和肠黏膜屏障的影响显示文摘目的探讨早期生态免疫肠内营养支持对老年梗阻性黄疸患者术后免疫和肠黏膜屏障功能影响。方法 48例研究对象随机分为术后生态免疫肠内营养(EIEN)组、普通肠内营养(EN)组和肠外营养(PN)组,每组各16例,分别给予营养支持7~10 d。术前、术后1、7 d分别检测免疫指标、T淋巴细胞亚群、血D-乳酸水平和血内毒素水平变化。结果与术前比较,术后1 d三组患者体液免疫指标下降,血D-乳酸水平和血内毒素指标升高明显(P<0.05);CD3、CD4阳性细胞数及CD4/CD8比值降低,CD8阳性细胞数升高(P<0.05)。术后7 d,EIEN组体液免疫指标和CD3、CD4阳性细胞数及CD4/CD8比值基本恢复至术前水平,且高于EN组和PN组(P<0.05,P<0.01),而3组血D-乳酸水平和血内毒素水平仍较高(P<0.05),3组患者术后并发症发生率有差异(P<0.05)。结论早期生态免疫肠内营养支持可改善老年梗阻性黄疸患者术后免疫和促进肠黏膜屏障功能恢复。 | 王庆华 管清海 陈强谱 | 2015 | 中国老年学杂志2015，35，6： | 11 |
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