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| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Is Percutaneous Nephrolithotomy in Solitary Kidneys Safe?显示文摘 | Kathie Alexina Wong Arun Sahai Amit Patel Kay Thomas Matthew Bultitude Jonathan Glass | 2013 | Urology2013，，： | 2 |
| 3 | Gallbladder perforation:A single-center experience in north India and a step-up approach for management显示文摘Background: Spontaneous gallbladder perforation(GBP) is an uncommon diagnosis. This study presented the experience of managing spontaneous GBP over nine years at a large, tertiary care university hospital in north India and investigated the outcomes and treatment strategies. Methods: A retrospective review of prospectively maintained digital database of consecutive patients was performed. All patients received medical and/or surgical treatment for spontaneous GBP in our department between January 2010 and June 2018. Results: We identifed 151 patients(81 females and 70 males) with mean age of 53 years. Most common presenting features were pain(96.7%), fever(54.3%) and jaundice(31.1%). Most common cause was gallbladder stones(84.8%) followed by common bile duct stones(30.5%), xanthogranulomatous cholecystitis(17.9%) and malignancy(11.9%). As per Niemeier classifcation, 8.6% had type 1 GBP(free perforation in peritoneal cavity), 76.2% had type 2 GBP(localized perforation) and 13.2% had type 3 GBP(cholecystoenteric fstula). About 60% of the perforations were diagnosed preoperatively. Type 1 was more common in patients with diabetes and also had the worst prognosis. Surgery was performed in 109 patients(72.2%). Seven patients(4.6%) had a postoperative morbidity of Clavien-Dindo Ⅲ or higher. There were three mortalities in patients who underwent surgery. Conclusions: High index of suspicion is required for preoperative diagnosis of GBP, especially in types 2 and 3. Laparoscopic cholecystectomy can be difficult in these patients and patients may require open or partial cholecystectomy. Early diagnosis and step-up approach for the treatment of GBP is critical. | Vivek Gupta Abhijit Chandra Vishal Gupta Ravi Patel Amit Dangi Ajay Pai | 2022 | Hepatobiliary & Pancreatic Diseases International2022，21，2： | 2 |
| 4 | Omeprazole improves the anti‐obesity and antidiabetic effects of exendin‐4 in db/db mice (奥美拉唑改善唾液素‐4 对 db/db 小鼠的减肥与降糖作用)*显示文摘 | Vishal Patel Amit Joharapurkar Tejal Gandhi Kirti Patel Nirav Dhanesha Samadhan Kshirsagar Vipin Dhote Jaysukh Detroja Rajesh Bahekar Mukul Jain | 2013 | Journal of Diabetes2013，，2： | 1 |
| 5 | Enzymatic acetylation of 10-deacetylbaccatin III to baccatin III by C-10 deacetylase from Nocardioides luteus SC 13913显示文摘 | Ramesh N. Patel Amit Banerjee Venkata Nanduri | 2000 | Enzyme and Microbial Technology2000，，6： | 1 |
| 6 | Preparation and characterization of nanoparticles for solubility and dissolution rate enhancement of meloxicam 显示文摘 | Amit J Raval Madhabahi M Patel | 2011 | International Research Journal of Pharmaceutics2011，1，2： | 1 |
| 7 | Office Based Flexible Cystoscopy May be Less Painful for Men Allowed to View the Procedure显示文摘 | Amit R. Patel J. Stephen Jones Shelley Angie Denise Babineau | 2007 | The Journal of Urology2007，，5： | 1 |
| 8 | Simultaneous bilateral shoulder and bilateral central acetabular fracture dislocation: What to do?显示文摘 | Hardik Sheth Abhijeet Ashok Salunke Ramesh Panchal Jimmy Chokshi G.I. Nambi Saranjeet Singh Amit Patel Ranu Sheth | 2016 | Chinese Journal of Traumatology2016，19，1： | 1 |
| 9 | Rapid Estimation of Left Ventricular Function Using Echocardiographic Speckle-Tracking of Mitral Annular Displacement显示文摘 | Wendy Tsang Homaa Ahmad Amit R. Patel Lissa Sugeng Ivan S. Salgo Lynn Weinert Victor Mor-Avi Roberto M. Lang | 2010 | Journal of the American Society of Echocardiography2010，，5： | 1 |
| 10 | Lymph node density in oral cavity cancer: results of the International Consortium for Outcomes Research显示文摘 | Patel SG Amit M Yen TC | 2013 | Br J Cancer2013，109，8： | 1 |
| 11 | Multipotent Menstrual Blood Stromal Stem Cells: Isolation, Characterization,and Differentiation 显示文摘 | Amit N Patel Eulsoon Park Michael Kuzman | 2008 | Cell transpl2008，17，： | 1 |
| 12 | The Association of the Human Development Index With Global Kidney Cancer Incidence and Mortality显示文摘 | Amit R. Patel Sandip M. Prasad Ya-Chen Tina Shih Scott E. Eggener | 2012 | The Journal of Urology2012，，6： | 1 |
| 13 | Presurgical Serum Cystatin C and Risk of Acute Kidney Injury After Cardiac Surgery显示文摘 | Michael G. Shlipak Steven G. Coca Zhu Wang Prasad Devarajan Jay L. Koyner Uptal D. Patel Heather Thiessen-Philbrook Amit X. Garg Chirag R. Parikh | 2011 | American Journal of Kidney Diseases2011，，3： | 1 |
| 14 | Vari- able Forgetting Factor LS Mgorithm for Polynomial Channel Model显示文摘 | Amit Kumar Kohli Amrita Rai Meher Krishna Patel | 2011 | ISRN Signal Processing2011，，2011： | 1 |
| 15 | Warm ischemia less than 30 minutes is not necessarily safe during partial nephrectomy: Every minute matters显示文摘 | Amit R. Patel Scott E. Eggener | 2011 | Urologic Oncology: Seminars and Original Investigations2011，，6： | 1 |
| 16 | Implications of family history of myocardial infarction in young women显示文摘 | Mahesh J. Patel James A. de Lemos Binu Philips Sabina A. Murphy Patrice C. Vaeth Darren K. McGuire Amit Khera | 2007 | American Heart Journal2007，，3： | 1 |
| 17 | Prognosis of Myocardial Damage in Sarcoidosis Patients With Preserved Left Ventricular Ejection Fraction: Risk Stratification Using Cardiovascular Magnetic Resonance显示文摘 | Gillian Murtagh Luke J. Laffin John F. Beshai Francesco Maffessanti Catherine A. Bonham Amit V. Patel Zoe Yu Karima Addetia Victor Mor-Avi Joshua D. Moss D. Kyle Hogarth Nadera J. Sweiss Roberto M. Lang Amit R. Patel | 2016 | Circulation: Cardiovascular Imaging2016，，1： | 1 |
| 18 | The Anti-Oxidative Capacity of High-Density Lipoprotein Is Reduced in Acute Coronary Syndrome But Not in Stable Coronary Artery Disease显示文摘 | Parin J. Patel Amit V. Khera Kashif Jafri Robert L. Wilensky Daniel J. Rader | 2011 | Journal of the American College of Cardiology2011，，20： | 1 |
| 19 | Presurgical Serum Cystatin C and Risk of Acute Kidney Injury After Cardiac Surgery显示文摘 | Michael G. Shlipak Steven G. Coca Zhu Wang Prasad Devarajan Jay L. Koyner Uptal D. Patel Heather Thiessen-Philbrook Amit X. Garg Chirag R. Parikh | 2011 | American Journal of Kidney Diseases2011，，3： | 1 |
| 20 | Cell surface engineering to enhance mesenchymal stem cell migration toward an SDF-1 gradient显示文摘 | Young-Wook Won Amit N. Patel David A. Bull | 2014 | Biomaterials2014，，21： | 1 |
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