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| 1 | Coagonist of glucagon-like peptide-1 and glucagon receptors ameliorates kidney injury in murine models of obesity and diabetes mellitus显示文摘AIM To investigate the role of glucagon-like peptide-1(GLP-1)/glucagon receptors coagonist on renal dysfunction associated with diabetes and obesity. METHODS Chronic high-fat diet fed C57 BL/6 J mice, streptozotocintreated high-fat diet fed C57 BL/6 J mice and diabeticC57 BLKS/J db/db mice were used as models of diabetes-induced renal dysfunction. The streptozotocintreated high-fat diet fed mice and db/db mice were treated with the GLP-1 and glucagon receptors coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) for twelve weeks, while in chronic high-fat diet fed mice, coagonist(Aib2 C24 Chimera2, 150 μg/kg, sc) treatment was continued for forty weeks. Kidney function, histology, fibrosis, inflammation, and plasma biochemistry were assessed at the end of the treatment. RESULTS Coagonist treatment decreased body weight, plasma lipids, insulin resistance, creatinine, blood urea nitrogen, urinary albumin excretion rate and renal lipids. In kidney, expression of lipogenic genes(SREBP-1 C, FAS, and SCD-1) was decreased, and expression of genes involved in β-oxidation(CPT-1 and PPAR-α) was increased due to coagonist treatment. In plasma, coagonist treatment increased adiponectin and FGF21 and decreased IL-6 and TNF-?. Coagonist treatment reduced expression of inflammatory(TNF-α, MCP-1, and MMP-9) and pro-fibrotic(TGF-β, COL1 A1, and α-SMA) genes and also improved histological derangement in renal tissue.CONCLUSION Coagonist of GLP-1 and glucagon receptors alleviated diabetes and obesity-induced renal dysfunction by reducing glucose intolerance, obesity, and hyperlipidemia. | Vishal J Patel Amit A Joharapurkar Samadhan G Kshirsagar Brijesh K Sutariya Maulik S Patel Hiren M Patel Dheerendra K Pandey Rajesh H Bahekar Mukul R Jain | 2018 | World Journal of Diabetes2018，9，6： | 5 |
| 2 | Omeprazole improves the anti‐obesity and antidiabetic effects of exendin‐4 in db/db mice (奥美拉唑改善唾液素‐4 对 db/db 小鼠的减肥与降糖作用)*显示文摘 | Vishal Patel Amit Joharapurkar Tejal Gandhi Kirti Patel Nirav Dhanesha Samadhan Kshirsagar Vipin Dhote Jaysukh Detroja Rajesh Bahekar Mukul Jain | 2013 | Journal of Diabetes2013，，2： | 1 |
| 3 | Isolation and characterization of avian influenza viruses,including highly pathogenic H5N1,from poultry in live bird markets in Hanoi,Vietnam,in 2001显示文摘 | Doan C N Timothy M U Samadhan J | 2005 | Journal of Virology2005，79，7： | 1 |
| 4 | Walekar,Turn-on fluorescence probe for selective and sensitive detection of d-penicillamine by Cd S quantum dots in aqueous media:Application to pharmaceutical formulation显示文摘 | Samadhan PP Anil H Laxman S | 2015 | Sens Actuators B Chem2015，209，： | 1 |
| 5 | Isolation and Characterization of Avian Influenza Viruses,Including Highly Pathogenic I -ISN1 ,from Poultry in Live Bird Markets in Hanoi显示文摘 | NGUYEN D C UYEKI T M SAMADHAN JADHAO | 2005 | Journal of Virology2005，79，7： | 1 |
| 6 | Malignant epidermoid arising from the third ventricle:A case report显示文摘BACKGROUND Third epidermoid tumors are a rare finding. The appearance of these tumors often makes them difficult to diagnose, and thus they require multimodality imaging. CASE SUMMARY A 48-year-old male patient reported to our hospital with complaints of vomiting and severe headache. The patient also complained of involuntary micturition for the past five days. We used a combination of computed tomography (CT) and magnetic resonance imaging (MRI) imaging modalities to confirm the presence of a malignant epidermoid cyst arising from the third ventricle. A contrastenhanced CT of the head demonstrated minimal perilesional enhancement while an MRI revealed a large, lobulated and septated T2 hyperintense mass arising from the third ventricle. The maximum size of the lesion measured 73 mm × 65 mm × 64 mm in size. CONCLUSION Malignant epidermoid arising from the third ventricle in an adult male was reported using a combination of CT, MRI, and MR spectroscopy. | Samadhan Pawar Chaitanya Borde Atul Patil Rajnish Nagarkar | 2019 | World Journal of Radiology2019，11，5： | 0 |
| 7 | CdS nanocrystals as fluorescent probe for detection of dolasetron mesylate in aqueous solution:Application to biomedical analysis显示文摘A simple and straightforward method for the determination of dolasetron mesylate(DM) in aqueous solution was developed based on the fluorescence quenching of 3-Mercaptopropionic acid(MPA) capped Cd S quantum dots(QDs).The structure,morphology,and optical properties of synthesized QDs were characterized by using UV-Vis absorption spectroscopy,fluorescence spectroscopy,transmission electron microscopy(TEM) and dynamic light scattering(DLS) measurements.Under the optimum conditions,the MPA-Cd S QDs fluorescence probe offered good sensitivity and selectivity for detecting DM.The probe provided a highly specific selectivity and a linear detection of DM in the range of 2–40 μg/m L with detection limit(LOD) 1.512 μg/m L.The common excipients did not interfere in the proposed method.The fluorescence quenching mechanism of Cd S QDs is also discussed.The developed sensor was applied to the quantification of DM in urine and human serum sample with satisfactory results. | Samadhan P.Pawar Laxman S.Walekar Uttam R.Kondekar Dattatray B.Gunjal Anil H.Gore Prashant V.Anbhule Shivajirao R.Patil Govind B.Kolekar | 2016 | Journal of Pharmaceutical Analysis2016，6，6： | 0 |
| 8 | Oxygen Functionalization-Induced Charging Effect on Boron Active Sites for High-Yield Electrocatalytic NH_(3) Production显示文摘Ammonia has been recognized as the future renewable energy fuel because of its wide-ranging applications in H_(2) storage and transportation sector.In order to avoid the environmentally hazardous Haber-Bosch process,recently,the third-generation ambient ammonia synthesis has drawn phenom-enal attention and thus tremendous efforts are devoted to developing efficient electrocatalysts that would circumvent the bottlenecks of the electrochemical nitrogen reduction reaction(NRR)like competitive hydrogen evolution reac-tion,poor selectivity of N_(2) on catalyst surface.Herein,we report the synthesis of an oxygen-functionalized boron carbonitride matrix via a two-step pyrolysis technique.The conductive BNCO(1000)architecture,the compatibility of B-2p_(z) orbital with the N-2p_(z) orbital and the charging effect over B due to the C and O edge-atoms in a pentagon altogether facilitate N_(2) adsorption on the B edge-active sites.The optimum electrolyte acidity with 0.1 M HCl and the lowered anion crowding effect aid the protonation steps of NRR via an associative alternating pathway,which gives a sufficiently high yield of ammonia(211.5μg h^(−1) mg_(cat)^(−1))on the optimized BNCO(1000)catalyst with a Faradaic efficiency of 34.7%at−0.1 V vs RHE.This work thus offers a cost-effective electrode material and provides a contemporary idea about reinforcing the charging effect over the secured active sites for NRR by selectively choosing the electrolyte anions and functionalizing the active edges of the BNCO(1000)catalyst. | Ashmita Biswas Samadhan Kapse Ranjit Thapa Ramendra Sundar Dey | 2022 | Nano-Micro Letters2022，14，12： | 0 |
| 9 | A monolithic single-chip point-of-care platform for metabolomic prostate cancer detection显示文摘There is a global unmet need for rapid and cost-effective prognostic and diagnostic tools that can be used at the bedside or in the doctor’s office to reduce the impact of serious disease.Many cancers are diagnosed late,leading to costly treatment and reduced life expectancy.With prostate cancer,the absence of a reliable test has inhibited the adoption of screening programs.We report a microelectronic point-of-care metabolite biomarker measurement platform and use it for prostate cancer detection.The platform,using an array of photodetectors configured to operate with targeted,multiplexed,colorimetric assays confined in monolithically integrated passive microfluidic channels,completes a combined assay of 4 metabolites in a drop of human plasma in under 2 min.A preliminary clinical study using L-amino acids,glutamate,choline,and sarcosine was used to train a cross-validated random forest algorithm.The system demonstrated sensitivity to prostate cancer of 94%with a specificity of 70%and an area under the curve of 0.78.The technology can implement many similar assay panels and hence has the potential to revolutionize low-cost,rapid,point-of-care testing. | Valerio F.Annese Samadhan B.Patil Chunxiao Hu Christos Giagkoulovits Mohammed A.Al-Rawhani James Grant Martin Macleod David J.Clayton Liam M.Heaney Ronan Daly Claudio Accarino Yash D.Shah Boon C.Cheah James Beeley Thomas R.Jeffry Evans Robert Jones Michael P.Barrett David R.S.Cumming | 2021 | Microsystems & Nanoengineering2021，7，2： | 0 |
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